Clinical trials: Adhesion
Tissue Adhesions, Surgery-Induced
Post Approval Study to Evaluate the Safety and Performance of GENTA-FOIL Resorb® in Hand Surgery
Single arm study to evaluate the safety and performance of Genta-Foil resorb® for the prevention of tissue adhesions
- Trial name
- NCT04482140
- Testing
- Genta-Foil resorb®
- Where
- 3 sites in Greece, United Kingdom
- Volunteers
- 15 people
- Sponsor
- Advanced Medical Solutions Ltd.
Adhesion Properties of Wound Care Devices
Evaluation of Adhesion Properties in Wound Care Devices
Molnlycke manufactures and markets self-adhesive wound care devices intended to protect various types of wounds during treatment.
- Trial name
- NCT06392165
- Testing
- self-adhesive device
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Molnlycke Health Care AB
Healthy
Pharmacokinetics and Adhesion of Lidocaine Topical System 1.8% With Water Exposure
The objectives of this study are to evaluate the adhesion performance and pharmacokinetics of ZTlido (lidocaine topical system) 1.8% during swimming, showering, and under normal conditions.
- Trial name
- NCT04784728
- Testing
- Lidocaine topical system 1.8%
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Scilex Pharmaceuticals, Inc.
Advanced Adenocarcinoma
Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.
The objective of this study is to assess safety and efficacy of BA3182 in Advanced Adenocarcinoma
- Trial name
- NCT05808634
- Testing
- BA3182
- Where
- 9 sites in United States
- Volunteers
- 168 people
- Sponsor
- BioAtla, Inc.
Healthy Volunteers
Study to Assess Bioequivalence and Adhesion Properties Between Two Granisetron Transdermal Patches.
The study is designed to evaluate the BE and adhesion properties of granisetron transdermal patches manufactured at 2 different sites. The study has been designed in accordance with the FDA Guidance for Industry.
- Trial name
- NCT05027646
- Testing
- Sancuso - Part 1, Sancuso - Part 2
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin, Inc.
Cholecystitis, Acute
Usefulness of the CADISS® System for the Cleavage of Severe Adhesions in Cholecystectomy
Acute cholecystitis is the most common complication of cholelithiasis. Acute cholecystitis is inflammation of the gallbladder that develops over hours, usually due to an obstruction of the cystic duct by a gallstone.
- Trial name
- NCT05041686
- Testing
- CADISS® System
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- AuXin Surgery SA
Tissue Adhesion, Surgery-Induced
Anti-adhesive Effect and Safety of MEDICURTAIN Applied to Undergoing Thyroid Surgery (Pivotal Study)
This study was designed to demonstrate the non-inferiority of MEDICURTAIN® (investigational device) compared to commercially available GUARDIX-SG® (control device) in treatment of subject who underwent total thyroidectomy for…
- Trial name
- NCT05058027
- Testing
- GUARDIX-SG®, Medicurtain®
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Advanced Solid Tumors
FAK Inhibitor in Patients With Advanced Solid Tumors
This is A Phase I/Ib Study，aimed to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Efficacy of Focal Adhesion Kinase Inhibitor IN10028 as Monotherapy and Combination Therapy in Patients with…
- Trial name
- NCT07596381
- Testing
- IN10028
- Where
- China
- Volunteers
- 75 people
- Sponsor
- InxMed (Shanghai) Co., Ltd.
Pelvic Adhesions
A Clinical Study of Alanyl-Glutamine for Reduction of Post-Myomectomy Adhesions
This study evaluates whether L-Alanyl-L-Glutamine can reduce the incidence, extent and severity of adhesions after myomectomy. Half of the participants will receive L-Alanyl-L-Glutamine and the other half of participants will…
- Trial name
- NCT01701193
- Testing
- L-Alanyl/L-Glutamine, Physiologic saline
- Where
- Ukraine
- Volunteers
- 47 people
- Sponsor
- Temple Therapeutics BV
Healthy
Bioequivalence of Two Transdermal Clonidine Administrations in Healthy Volunteers
To establish the bioequivalence and adhesion properties of transdermal clonidine prepared with Oppanol® brands of polyisobutylene (PIB) vs.
- Trial name
- NCT02096744
- Testing
- Catapres-TTS-1, Intervention 1: Catapres-TTS-3, Intervention 2: Catapres-TTS-3
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Advanced Solid Tumors
A Study of SIGX1094R in Patients With Advanced Solid Tumors
This is a phase I clinical, first-in-human study of SIGX1094R monotherapy. The goal of this trial is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), anti-tumor activity and food effect of…
- Trial name
- NCT06739291
- Testing
- SIGX1094R
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Signet Therapeutics
Adhesion
Efficacy and Dose Ranging Study of Seroguard
This trial was a multi-center, double-blind, randomized, parallel group, placebo-controlled, phase II study in adult hospitalized female patients with the confirmed diagnosis of pelvic adhesive disease in Study centres in Russia.
- Trial name
- NCT03660787
- Testing
- Seroguard
- Where
- 14 sites in Russia
- Volunteers
- 114 people
- Sponsor
- Pharmasyntez
Adhesion
PMCF Study for COSEAL® in Gynecologic Surgery
The study is a single-arm, retrospective, chart review with a patient questionnaire intended to supplement the patient chart, when necessary.
- Trial name
- NCT05996809
- Testing
- Coseal
- Where
- 2 sites in United States, Italy
- Volunteers
- 200 people
- Sponsor
- Baxter Healthcare Corporation
Symptomatic Vitreomacular Adhesion
Follow-up Study to Assess Visual Function in Subset of Patients Who Have Previously Participated in the TG-MV-006 and TG-MV-007 Ocriplasmin Studies
The primary objective of this study is to assess visual function in up to 44 patients who have previously participated in either of the placebo controlled, ocriplasmin Phase III studies (TG-MV-006 or TG-MV-007).
- Trial name
- NCT01287988
- Testing
- ocriplasmin
- Where
- 2 sites in United States, Belgium
- Volunteers
- 24 people
- Sponsor
- ThromboGenics
Endometriosis, Adhesive
Prevention of Adhesions During Celioscopy for Endometriosis. Impact of the Use of Anti-adhesion Treatment on Clinical Signs and Fertility at One Year
Thus is a longitudinal, prospective, multicentric observational study performed in mainland France, among a sample of gynaecology surgeons practising at endometriosis "expert" centres.
- Trial name
- ENDHY (NCT02612818)
- Testing
- Coelioscopy
- Where
- France
- Volunteers
- 364 people
- Sponsor
- Nordic Pharma SAS
Nephrectomy, Prostatectomy
HYbrid RObotic Surgery MulTiCentric Study
The purpose of this clinical investigation, HYROS-MTC-I, is to confirm the effectiveness of the combined use of ROB-Bitrack System, its corresponding ElectroSurgical Endoscopic instruments and Non-ElectroSurgical Endoscopic…
- Trial name
- HYROS-MTC-I (NCT06849271)
- Testing
- Radical Nephrectomy (RN), Partial nephrectomy (PN), Radical Prostatectomy (RP)
- Where
- 5 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Rob Surgical Systems S.L.
Pain
An Assessment of Buprenorphine Transdermal Delivery System (BTDS) Patch Adhesion
The purpose of this study is to assess the adhesion of BTDS patch 40 µg/h.
- Trial name
- NCT02431624
- Testing
- BTDS
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mundipharma Research Limited
Healthy Female Participants, Postmenopause
A Study to Assess the Bioavailability and Adhesion of Estradiol/Levonorgestrel TDS in Healthy Post-Menopausal Female Participants
The purpose of this study is to compare the bioequivalence and adhesion performance of a test estradiol/levonorgestrel transdermal delivery system (TDS) with the reference product, Climara Pro® (estradiol/levonorgestrel…
- Trial name
- NCT07851649
- Testing
- Test Estradiol/Levonorgestrel Transdermal Delivery System, Climara Pro® (Estradiol/Levonorgestrel Transdermal System)
- Where
- India
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Congenital Heart Disease in Children
BAX602 in Preventing the Adhesion Around Great Cardiac Vessels in Pediatric Patients With Congenital Heart Disease Undergoing Re-do Open Heart Surgery (Japan Trial)
Congenital heart disease occurs in about 1% of live births and can range from (1) naturally curable conditions that require no treatment to (2) conditions that require multiple immediate operations or refractory severe…
- Trial name
- NCT05647161
- Testing
- BAX602, No Intervention
- Where
- 6 sites in Japan
- Volunteers
- 34 people
- Sponsor
- Baxter Healthcare Corporation
Melanoma
Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)
Substudy 02C is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study.
- Trial name
- NCT04303169
- Testing
- Pembrolizumab, Vibostolimab, Gebasaxturev
- Where
- 29 sites in United States, Australia and 4 more
- Volunteers
- 146 people
- Sponsor
- Merck Sharp & Dohme LLC