Clinical trials: Adenomas
Mesothelioma, Mesotheliomas Pleural
Immune Microenvironment and Gene Expression Profiling in Mesothelioma
Pleural and peritoneal mesotheliomas (PPM) are rare cancers mostly related to asbestos-exposure, which are characterized by a complex histopathological diagnosis and staging, few therapeutic options and a dismal prognosis.
- Conditions
- Mesothelioma, Mesotheliomas Pleural, Mesothelioma; Lung
- Trial name
- Imaging-Meso (NCT06581549)
- Testing
- Translation analysis
- Where
- 10 sites in Italy
- Volunteers
- 125 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Colorectal Adenoma
Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence
Berberine hydrochloride is a conventional component in Chinese medicine. In recent years, anticancer activity of berberine hydrochloride have been explored.
- Trial name
- NCT02226185
- Testing
- Berberine hydrochloride
- Where
- 7 sites in China
- Volunteers
- 1,108 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pituitary Adenoma
Surgical Debulking of Pituitary Adenomas
This is a randomized, multicenter trial with stratification done by a single radiologist at the coordinating center (NYU), and patients with comparable disease will be randomized to Sandostatin LAR treatment administered 1 time…
- Trial name
- NCT01371643
- Testing
- Octreotide LAR, transsphenoidal surgery
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- NYU Langone Health
Pancreatic Cancer, Pancreatic Neuroendocrine Tumor
Safety and Efficacy of an Ablation Catheter for the Treatment of Pancreatic Premalignant Cyctic Lesions.
This study aims to evaluate the safety and efficacy of new ablation catheter developed by MEDICAL TAEWOONG for the treatment of pancreatic premalignant and early malignant cystic lesion.
- Conditions
- Pancreatic Cancer, Pancreatic Neuroendocrine Tumor, Pancreatic Cyst, Pancreatic Cancer Stage
- Trial name
- yes (NCT03417843)
- Testing
- EUSRA RF electrode
- Volunteers
- 20 people
- Sponsor
- HaEmek Medical Center, Israel
Colonoscopy
A Clinical Validation Study of a Computerized Movement Analysis of the Colonoscope
Colonoscopy is the considered gold standard for diagnosing diseases in the colon. A colonoscopy is normally divided into the insertion from anus to cecum, the technical difficult part, and a retraction or diagnostic part.
- Trial name
- NCT03587935
- Testing
- 3D-Colonoscopy Progression Score, 3D-Colonoscopy Retraction Score
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Colorectal Cancer, Adenoma Colon
Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection
This is an multicenter study that will test the diagnostic accuracy of a blood test (i.e., a liquid biopsy) for the diagnosis of colorectal cancer (CRC), advanced adenomas (AAs), as well as Lynch-syndrome associated cancers.
- Conditions
- Colorectal Cancer, Adenoma Colon, Adenoma Colon Polyp, Colon Adenoma
- Trial name
- BEACON (NCT07450612)
- Testing
- BEACON
- Where
- 4 sites in Italy
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- San Raffaele University
Mesothelioma
Do Your Genes Put You at a Higher Risk of Developing Mesothelioma
The purpose of this research study is to investigate the possibility that a person's genes put a person at a higher risk of developing mesothelioma.
- Trial name
- NCT01590472
- Where
- 6 sites in United States
- Volunteers
- 69 people
- Sponsor
- Wake Forest University
Pleomorphic Adenoma of the Parotid Gland
Quadrant Versus Superficial Parotidectomy
The most common benign tumor of the parotid gland is the so called pleomorphic adenoma. Although benign, this tumor may recur after surgical removal due to tumor cells left behind during the surgical operation.
- Trial name
- NCT01607866
- Testing
- Quadrant parotidectomy, Superficial parotidectomy
- Where
- Egypt
- Sponsor
- Mansoura University
Pancreatic Cancer, Diagnose Disease
AI-Powered Precision Decision-Making for Pancreatic Diseases
This multicenter clinical trial evaluates an artificial intelligence (AI) system designed to assist in the diagnosis and management of pancreatic diseases.
- Conditions
- Pancreatic Cancer, Diagnose Disease, IPMN, Pancreatic, Pancreatic Cystic Lesions
- Trial name
- NCT07439757
- Testing
- Diagnosis by Artificial Intelligence model
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Pituitary Adenoma
Endocrine Outcome of Surgery for Pituitary Adenoma
Prospective and randomized compare between microsurgical and endoscopic transsphenoidal MRI assisted resection of pituitary adenomas.
- Trial name
- NCT03515603
- Testing
- Endoscopic resection, Microsurgical resection
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Ulm
Gastric Epithelial Neoplasm of Fundic-gland Mucosa
Clinicopathological Features and Treatment Strategies for Gastric Epithelial Neoplasm of Fundic-gland Mucosa Lineage
Gastric epithelial neoplasm of fundic-gland mucosa lineage (GEN-FGML) is a rare pathological type of gastric cancer characterized by unique endoscopic features, including specific morphology, color, and changes in the surface and…
- Trial name
- NCT07230054
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Pleural Mesothelioma, Non-small Cell Lung Cancer
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Lung Cancer or Mesothelioma (Pegathor Lung 202)
The Primary Objective was: -To determine the antitumor activity of SAR444245 in combination with other anticancer therapies. The Secondary Objectives were: To confirm the dose and to assess the safety profile of SAR444245 when…
- Trial name
- NCT04914897
- Testing
- THOR-707, Pembrolizumab
- Where
- 35 sites in United States, Argentina and 9 more
- Volunteers
- 106 people
- Sponsor
- Sanofi
Resectable, Non-functioning Pituitary Adenoma
Exploratory Study of Farletuzumab to Treat Resectable, Non-functioning Pituitary Adenomas
The purpose of this study is to evaluate whether therapy with farletuzumab is effective and safe in the treatment of resectable, non-functioning pituitary adenomas.
- Trial name
- NCT01203618
- Testing
- Farletuzumab
- Where
- United States
- Sponsor
- Morphotek
Mesothelioma, Malignant Mesothelioma (MM)
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma
Background: Mesothelioma is a rare cancer typically caused by exposure to asbestos and related fibers. Most people with mesothelioma survive less than 5 years after diagnosis.
- Conditions
- Mesothelioma, Malignant Mesothelioma (MM), Early-stage Mesothelioma, Subclinical Mesothelioma
- Trial name
- NCT06654050
- Testing
- alrizomadlin
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Von Hippel-Lindau Disease, Hemangioblastoma
Visualizing Vascular Endothelial Growth Factor (VEGF) Producing Lesions in Von Hippel-Lindau Disease
Von Hippel Lindau disease (VHLD) is an inherited syndrome characterized by vascular malformations, kidney cancer, adrenal gland and pancreas tumors.
- Conditions
- Von Hippel-Lindau Disease, Hemangioblastoma, Renal Cell Carcinoma, Pheochromocytoma
- Trial name
- VHLimage (NCT00970970)
- Testing
- 89Zr bevacizumab PET scan
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- University Medical Center Groningen
Pituitary Adenoma
OCT-angiography as a Pronostic Marker for Visual Impairment in Patients Undergoing Neurosurgery for Compressive Macroadenoma : a Prospective Study.
The aim of the study is to assess accurancy of OCT angiography as a pronostic marker for patients undergoing neurosurgery for compressiver macroadenoma as compared with visual acuity, visual field and OCT.
- Trial name
- FIRST (NCT04074642)
- Testing
- Neurosurgery
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Rectal Adenoma
Efficiency of Two Dimensional High Definition vs Three Dimensional Endoscopic Systems in Transanal Endoscopic Surgery
Introduction: The usual surgical technique for large adenomatous tumors and rectal cancer is anterior resection of the rectum or abdominoperineal resection.
- Trial name
- NCT01498354
- Testing
- 2-D high definition vision systems, transanal endoscopic operation (TEO), Transanal endoscopic microsurgery (TEM)
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Corporacion Parc Tauli
Biliary Tract Cancer, Breast Cancer
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2001 in patients with advanced solid tumors.
- Conditions
- Biliary Tract Cancer, Breast Cancer, Cervical Cancer, Colon Cancer
- Trial name
- NCT06239194
- Testing
- MDX2001
- Where
- 6 sites in United States
- Volunteers
- 330 people
- Sponsor
- ModeX Therapeutics, An OPKO Health Company
Adenoma, Bile Duct
The Effects of An Addition of Water Enema to PEG for Colon Preparation
The purpose of this study is to compare the preparation quality by using Ottawa Bowel Preparation Scale between the standard PEG preparation and the addition of water enema in participants scheduled for CRC screening
- Trial name
- NCT03270046
- Testing
- Water enema
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Relapsed Malignant Mesothelioma
A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant Mesothelioma
The purpose of this study is to evaluate rising dose levels of VS-5584 administered in combination with a fixed dose of VS-6063 in subjects with relapsed malignant mesothelioma to determine a recommended Phase 2 dose (RP2D) for…
- Trial name
- NCT02372227
- Testing
- VS-5584 and VS-6063
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 21 people
- Sponsor
- Verastem, Inc.