Clinical trials: Adenocarcinoma, open to volunteers
Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary
First-line Maintenance Treatment With Fluzoparib Plus Bevacizumab in Advanced BRCA Wild Type Ovarian Cancer
This is an open-label, multi-center Phase II study of fluzoparib combined with bevacizumab for maintenance therapy after first-line platinum-containing chemotherapy in patients with BRCA wild-type advanced ovarian cancer.
- Conditions
- Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary, High Grade Endometrioid Ovarian Cancer, Primary Peritoneal Cancer
- Trial name
- NCT06063070
- Testing
- Fluzoparib Capsules, Bevacizumab
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Sun Yat-sen University
Lung Adenocarcinoma
Efficacy and Safety of Tislelizumab for Lung Adenocarcinoma With Asymptomatic Brain Metastatic
Brain metastasis of lung cancer is one of the most important metastasis pathways in patients with life-threatening diseases. This study explore the efficacy and safety of Tislelizumab combining with platinum-containing drug…
- Trial name
- NCT06056115
- Testing
- Tislelizumab,Platinum
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Hebei Medical University Fourth Hospital
Pancreatic Cancer, Pancreatic Cyst
Improving Pancreatic Cancer Care by the Use of Computational Science and Technology
The goal of the IMPACT project is to set up a data sharing infrastructure between expert centers for pancreatic surgery that enables training, testing and validation of computer science tools to improve quality of care for…
- Conditions
- Pancreatic Cancer, Pancreatic Cyst, Pancreatic Adenocarcinoma, Pancreatic Diseases
- Trial name
- IMPACT (NCT06055010)
- Testing
- No interventions
- Where
- Netherlands
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Lung Adenocarcinoma, Lymph Node Metastasis
Selective Lymph Node Dissection for cT1N0M0 Invasive NSCLC With CTR>0.5 Located in the Apical Segment (ECTOP-1018)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1018. The goal of this clinical trial is to confirm the theraputic effect of selective lymph node dissection for cT1N0M0…
- Trial name
- NCT06031246
- Testing
- Selective Lymph Node Dissection
- Where
- China
- Volunteers
- 634 people
- Sponsor
- Fudan University
Cancer of Stomach, Adenocarcinoma
Perioperative FLOT vs Adjuvant XELOX for CA Stomach
This is a single centre randomised controlled trial, comparing perioperative FLOT versus adjuvant XELOX for locally advanced gastric and esophagogastric junction cancers.
- Trial name
- NCT05264896
- Testing
- 5-FU, Leucovorin, Oxaliplatin, Docetaxel, XELOX
- Where
- Hong Kong
- Volunteers
- 110 people
- Sponsor
- Chinese University of Hong Kong
Adenocarcinoma of the Stomach, Adenocarcinoma of Esophagogastric Junction
Perioperative Chemotherapy Plus Toripalimab for Epstein-Barr Virus-associated Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma
This study is a prospective, single arm, multi-center phase II clinical trial designed to evaluate the efficacy and safety of perioperative SOX combined with toripalimab in participants with Epstein-Barr Virus-associated locally…
- Conditions
- Adenocarcinoma of the Stomach, Adenocarcinoma of Esophagogastric Junction, Epstein-Barr Virus-Associated Gastric Carcinoma
- Trial name
- NCT05970627
- Testing
- Toripalimab, Oxaliplatin, S1
- Where
- 8 sites in China
- Volunteers
- 30 people
- Sponsor
- Yu jiren
Lung Adenocarcinoma
Comparison of Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm
This study aims to evaluate the superiority in recurrence-free survival of lobectomy compared with segmentectomy in patients with lung adenocarcinoma ≤ 2 cm with micropapillary and solid subtype positive by intraoperative frozen…
- Trial name
- NCT05838053
- Testing
- Lobectomy with systemic lymph node dissection, Segmentectomy with systemic lymph node dissection
- Where
- China
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Adenocarcinoma of the Stomach, Adenocarcinoma of Esophagogastric Junction
Perioperative Chemotherapy Plus Toripalimab for dMMR Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma
This study is a prospective, multi-center, randomized controlled phase II trial to compare the efficacy of perioperative SOX plus toripalimab, toripalimab monotherapy with SOX regimen in participants with dMMR locally advanced…
- Conditions
- Adenocarcinoma of the Stomach, Adenocarcinoma of Esophagogastric Junction, Mismatch Repair Deficiency
- Trial name
- NCT05729646
- Testing
- Toripalimab, Oxaliplatin, S1
- Where
- 8 sites in China
- Volunteers
- 90 people
- Sponsor
- Yu jiren
Pancreatic Neoplasm, Pancreatic Adenocarcinoma
Preoperative mFOLFIRINOX (or Gem-Nab-P) +/- Isotoxic High-dose SBRT for Borderline Resectable Pancreatic Adenocarcinoma
Surgical resection is the only potentially curative treatment for patients with pancreatic cancer with the aim of curative R0 resection and related improvement of survival.
- Conditions
- Pancreatic Neoplasm, Pancreatic Adenocarcinoma, Borderline Resectable Pancreatic Adenocarcinoma
- Trial name
- STEREOPAC (NCT05083247)
- Testing
- mFOLFIRINOX or Gemcitabine nab-paclitaxel, Isotoxic High-Dose (iHD)-SBRT, Surgery
- Where
- 10 sites in Belgium
- Volunteers
- 256 people
- Sponsor
- Erasme University Hospital
PDAC - Pancreatic Ductal Adenocarcinoma
Prospective Registry of Young-Adult Patients Diagnosed With Pancreatic Cancer
The objective of the present registry is the creation of a prospective registry collecting clinico-pathological and genomic data, along with survival outcomes, of individuals diagnosed with PDAC at or before the age of 55 years…
- Trial name
- PanC-YOUNG (NCT05845801)
- Testing
- Register
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Locally Advanced Gastric Adenocarcinoma, Chemotherapy Effect
Study of Comparing of With and Without Sequential Therapy of S-1
The goal of this single arm clinical trial is to learn about sequential S-1 adjuvant therapy in patient wich locally advanced gastric cancer.
- Trial name
- NCT05813015
- Testing
- Docetaxel, Tegafur-Gimeracil-Oteracil
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhejiang University
Third-line Treatment, Dvanced Duodenal Adenocarcinoma
Clinical Study on Third-line Treatment of Advanced Duodenal Adenocarcinoma by Fuquinitinib Combined With Sindillimab
This research project is a single-center, retrospective clinical exploration study. It aims to retrospectively analyze data from 20 patients with advanced duodenal adenocarcinoma who received third-line treatment with…
- Conditions
- Third-line Treatment, Dvanced Duodenal Adenocarcinoma, Furquinelone Combined With Sintilimab
- Trial name
- NCT05810142
- Testing
- furquimatinib and sintilimab
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Gastric Adenocarcinoma
Paclitaxel (Albumin-bound) Combined With Oxaliplatin and S-1 Conversion Therapy for Gastric Adenocarcinoma
To evaluate the efficacy and safety of Paclitaxel (albumin-bound) combined with Oxaliplatin and S-1 conversion therapy for initial unresectable local progression or potential resectable metastatic gastric adenocarcinoma.
- Trial name
- NCT04047953
- Testing
- Paclitaxel (albumin-bound) combined with Oxaliplatin and S-1
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Peking University Cancer Hospital & Institute
Pancreas Adenocarcinoma
Safety of Cyberknife in Patients With Borderline Resectable or Locally Advanced Pancreatic Adenocarcinoma
The hypothesize that SBRT will limit or reverse tumor growth and thereby convert the borderline resectable disease or locally advanced disease in to a resectable tumor.
- Trial name
- NCT04998552
- Testing
- Cyberknife
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Capital Health System, Inc
Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Adenocarcinoma
Modifying Metabolic Syndrome and Cardiovascular Risk for Prostate Cancer Patients on ADT Using a Risk Factor Modification Program and Continuous Fitbit Monitoring
This phase II trial studies how well an exercise program and continuous Fitbit monitoring work for managing metabolic syndrome and cardiovascular disease risk in patients with prostate cancer that has spread to other places in…
- Conditions
- Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Adenocarcinoma, Stage IV Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
- Trial name
- NCT05054296
- Testing
- Educational Intervention, Exercise Intervention, FitBit
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- M.D. Anderson Cancer Center
Barrett's Esophagus, Gastroesophageal Reflux Disease
Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry
The purpose of this study is to determine or evaluate the risk factors such as smoking, family history etc. that cause esophageal cancer and to determine the genetic changes that lead to esophageal cancer.
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux Disease, Esophageal Adenocarcinoma
- Trial name
- NCT00574327
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Advanced Biliary Tract Carcinoma, Advanced Colorectal Carcinoma
CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors
This phase II trial tests how well CPI-613 (devimistat) in combination with hydroxychloroquine (HCQ) and 5-fluorouracil (5-FU) or gemcitabine works in patients with solid tumors that may have spread from where they first started…
- Conditions
- Advanced Biliary Tract Carcinoma, Advanced Colorectal Carcinoma, Advanced Gastroesophageal Junction Adenocarcinoma, Advanced Lung Adenocarcinoma
- Trial name
- NCT05733000
- Testing
- Biospecimen Collection, Computed Tomography, Devimistat
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Northwestern University
Gastric Cancer, Gastric Adenocarcinoma
MalnutritiOn Assessment With biOelectrical impedaNce Analysis in gastRic Cancer patIentS Undergoing Multimodal trEatment
The aim of this single-arm prospective, multicenter, cross-sectional study is to evaluate the nutritional status and body composition on tumor regression grade with bioelectrical impedance analysis in gastric cancer patients…
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Malnutrition, Cachexia
- Trial name
- MOONRISE (NCT05723718)
- Testing
- Observational Survey
- Where
- Poland
- Volunteers
- 125 people
- Sponsor
- Medical University of Lublin
Non Small Cell Lung Cancer, Lung Cancer Metastatic
I3LUNG: Integrative Science, Intelligent Data Platform for Individualized LUNG Cancer Care With Immunotherapy
I3LUNG is an international project aiming to develop a medical device to predict immunotherapy efficacy for NSCLC patients using the integration of multisource data (real word and multi-omics data).
- Conditions
- Non Small Cell Lung Cancer, Lung Cancer Metastatic, Lung Cancer, Nonsmall Cell, Lung Adenocarcinoma
- Trial name
- NCT05537922
- Where
- 4 sites in United States, Greece and 2 more
- Volunteers
- 2,200 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Barrett Esophagus, Esophageal Adenocarcinoma
A Multicenter Prospective Cohort Study Comparing Random Biopsies Versus Wide-Area Transepithelial Brush-Sampling (WATS) for Surveillance of Barrett's Esophagus, the WATS-EURO2 Study
The investigators aim to study the rate of developing a biopsy-based diagnosis of high-grade dysplasia (HGD) and EAC in BE patients in a prospective cohort of 208 BE patients at high risk of progression (i.e.
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Diagnosis
- Trial name
- WATSEURO2 (NCT05642338)
- Testing
- WATS3D
- Where
- Netherlands
- Volunteers
- 416 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)