Clinical trials: Addison Disease
Sphingolipidoses, Enzyme Deficiency
SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)
This protocol aims to gather information about sphingosine phosphate lyase insufficiency syndrome (SPLIS), also known as NPHS14, and to create a SPLIS patient registry.
- Trial name
- SPLIS-OSPRI (NCT04885179)
- Testing
- no intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Addison Disease
Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease
Addison's disease is a rare disease, wherein the adrenals can not produce sufficient steroid hormones (cortisol and aldosterone).
- Trial name
- NCT01271296
- Testing
- Liquorice, Grapefruit Juice
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- Haukeland University Hospital
Addison's Disease
Glucocorticoid Treatment in Addison's Disease
Addison's disease is a rare condition which in most cases is caused by autoimmune destruction of the adrenals, leading to deficiency of cortisol, aldosterone and adrenal androgens.
- Trial name
- NCT01063569
- Testing
- Solu-Cortef (hydrocortisone), Cortef (hydrocortisone)
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 33 people
- Sponsor
- Haukeland University Hospital
Addison Syndrome
Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure
Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects of physiological cortisol substitution and withdrawal is studied and related to the clinical syndrome of adrenal insufficiency.
- Trial name
- NCT00442390
- Testing
- hydrocortisone substitution therapy versus withdrawal
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Primary Adrenal Insufficiency
Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal Insufficiency
This study is a double-blind, double-dummy, two-way cross-over, randomised, Phase II study to be conducted at approximately 6 investigational sites in 2 countries.
- Trial name
- CHAMPAIN (NCT05222152)
- Testing
- Chronocort, Plenadren
- Where
- 8 sites in Germany, United Kingdom
- Volunteers
- 58 people
- Sponsor
- Neurocrine UK Limited
Primary Adrenal Insufficiency
Screening and Stimulation Testing for Residual Secretion of Adrenal Steroid Hormones in Autoimmune Addison's Disease
In autoimmune adrenal insufficiency, or Addison's disease (AD), the immune system attacks the adrenal cortex. As a result, the adrenal cells producing hormones such as cortisol and aldosterone are destroyed, leaving the body with…
- Trial name
- NCT03793114
- Testing
- Cosyntropin stimulation test, Baseline blood tests, 30-hour ambulatory sampling of intestinal fluid
- Where
- 3 sites in Germany, Norway and 1 more
- Volunteers
- 200 people
- Sponsor
- University of Bergen
Obesity, Addison's Disease
The Hypothalamic-Pituitary-Adrenal (HPA) Axis as an Effector System in Weight Regulation
Replacing glucocorticoid in a dose dependent manner (including doses within the physiological range) to subjects with adrenal insufficiency will increase visceral fat accumulation independently of total fat mass.
- Trial name
- NCT00688987
- Testing
- Hydrocortisone, Isocaloric Diet
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Addison Disease
A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT)
DOSCORT is a 2-dose, cross-over study primarily aiming to identify and validate novel biological markers (biomarkers) of glucocorticoid effect in the human body.
- Trial name
- NCT03210545
- Testing
- Betamethasone
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Göteborg University
Adrenocortical Insufficiency
Optimization of the Evaluation of the Adrenal Function After Discontinuation of a Prolonged Therapy With Corticosteroids
The study (forward-looking and opened) will concern 70 subjects having had a systemic prolonged treatment with corticosteroids for intestinal chronic inflammatory disease, recruited in the services of gastroenterology and…
- Trial name
- NCT01053754
- Testing
- "long" synacthen stimulation test
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism
Growing up With the Young Endocrine Support System (YESS!)
Transition from paediatric to adult endocrinology is a challenge for adolescents, families and doctors. Up to 25% of young adults with chronic endocrine disorders are lost to follow-up ('drop-out') once the young adult moves out…
- Conditions
- Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism, Growth Hormone Deficiency, Combined Pituitary Hormone Deficiency
- Trial name
- YESS (NCT04252001)
- Testing
- YESS! game, Snake '97, Transition-toolkit
- Where
- 7 sites in Belgium, Netherlands and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Adrenal Insufficiency, Addison's Disease
Survey in Patients With Chronic Adrenal Insufficiency in Germany
The purpose of this survey is to assess patients with chronic primary or secondary adrenal failure regarding subjective health status, incidence and causes of adrenal crisis, hormone replacement regimens and concomitant endocrine…
- Trial name
- NCT00444119
- Where
- 2 sites in Germany
- Sponsor
- University of Wuerzburg
Addison Disease
Effect of Cortisol on Physical Exertion in Patients With Primary Adrenal Failure
The conventional glucocorticoid replacement therapy in primary adrenal insufficiency- Addison's disease,renders the cortisol levels unphysiological, which may cause symptoms and long-term complications.
- Trial name
- NCT01847690
- Testing
- Hydrocortisone
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Adrenal Insufficiency
Residual Adrenal Function in Addison's Disease
The main aim of this study is to assess the role of 11-deoxycortisol as surrogate marker of Residual adrenal function. 11-deoxycortisol levels will be assessed in all recruited patients
- Trial name
- ADD-RES (NCT06309498)
- Testing
- blood test
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Auxologico Italiano
Type 1 Diabetes, Hashimoto Disease
Telehealth Music Therapy for Adults With Endocrine Disorder and Depression
The goal of this clinical trial is to explore if a telehealth music therapy intervention helps with quality of life, depression symptoms, anxiety symptoms. It will also explore the participants' relationship to music.
- Conditions
- Type 1 Diabetes, Hashimoto Disease, Graves Disease, Addison Disease
- Trial name
- NCT07413874
- Testing
- Telehealth Resource Oriented Music Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Appalachian State University
SCAD, Addison Disease
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
- Conditions
- SCAD, Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome
- Trial name
- NCT03941184
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic
Addison Disease
Does Relative Hypoglycaemia &/or Sleep Disturbance Contribute to the Lethargy Observed in Addison's Disease
Addison's disease is a condition that leads to a reduction in production of steroid hormones from the adrenal glands. These hormones, particularly cortisol have many important roles in the body, one of which is increasing blood…
- Trial name
- NCT05515055
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Coronary Artery Disease, Mitral Valve Regurgitation
Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery
The purpose of this study is to evaluate the effect of a single dose of etomidate for patients undergoing cardiac surgery with the use of cardiopulmonary bypass (CPB) on post-CPB adrenocortical responsiveness, on requirements of…
- Trial name
- NCT00415701
- Testing
- Etomidate, Propofol, Hydrocortisone
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Addison Disease
Biomarker(s) for Glucocorticoids
The investigators have shown that patients with adrenal insufficiency (Addison's disease), a rare disorder, have doubled the expected mortality rate in Sweden despite Standard of Care glucocorticoid (GC) replacement.
- Trial name
- BIOCORT (NCT02152553)
- Testing
- Hydrocortisone
- Where
- Sweden
- Volunteers
- 11 people
- Sponsor
- Vastra Gotaland Region
Primary Adrenal Insufficiency, Secondary Adrenal Insufficiency
Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM)
This is a randomized, controlled, open, three-armed, multi-centre study designed to compare the effects of dual-release hydrocortisone preparations versus conventional glucocorticoid therapy on anthropometric parameters…
- Trial name
- DREAM (NCT02277587)
- Testing
- Plenadren, Conventional glucocorticoid therapy
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Adrenal Gland Hypofunction
Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Suppression of the adrenal function is a common, potentially dangerous and unpredictable consequence of short term high dose glucocorticoid treatment. Identification of patients at risk would be of high clinical importance.
- Trial name
- NCT00975078
- Testing
- adrenal insufficiency testing, prednisone
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland