Clinical trials: Addiction
Nicotine Addiction, Cigarette Smoking
Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use
Three hundred-twenty (320) adult smokers of menthol or non-menthol combustible cigarettes will be recruited and randomly assigned to one of five groups (n=64/group), who will be asked to switch for 12 weeks to ad libitum use of…
- Trial name
- DUAL (NCT02870218)
- Testing
- Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Pathological or "at Risk" Gambling
Transversal Multiaxial Evaluation and 5-year Follow-up of a Cohort of French Gamblers (JEU)
This study is divided into two stages. The first stage is a transversal study and corresponds to the recruitment of participants, which will last about two years.
- Trial name
- NCT01207674
- Testing
- Summons of patients and filling questionnaire
- Where
- 7 sites in France
- Volunteers
- 641 people
- Sponsor
- Nantes University Hospital
PTSD, Depression
Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care
The most common reasons Veterans seek VA addiction and mental health care is for help with opioid and alcohol misuse, depression and PTSD.
- Conditions
- PTSD, Depression, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- NCT04356274
- Testing
- Participatory System Dynamics (PSD), Audit and Feedback (AF)
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Obesity & Overweight, Cardiometabolic Health Indicators
Tirzepatide Impact Assessment Study
This study examines how two different weight-loss strategies affect heart and metabolic health, as well as changes at the molecular level in the body.
- Conditions
- Obesity & Overweight, Cardiometabolic Health Indicators, Addiction, Eating Disorders
- Trial name
- TIA (NCT07740291)
- Testing
- GLP-1 Receptor Agonist Therapy, Structured Lifestyle Intervention
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Alcohol Dependance
Cortical rTMS as a Tool to Change Brain Reactivity to Alcohol Cues
The goal of this investigation is to determine if, in heavy alcohol users, a single session of transcranial magnetic brain stimulation (TMS) over a brain region involved in craving (medial prefrontal cortex) and a brain region…
- Trial name
- ARC4 (NCT02939313)
- Testing
- medial prefrontal cortex, dorsolateral prefrontal cortex
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Adolescent Behavior, Social Media Addiction
Evaluation of a Family-centered Program for Problematic Gaming/Excessive Screen Use
The Family-Centered Program for Problematic Gaming and Excessive Screen Use (FAME) is a pioneering initiative designed to address the growing challenges of excessive screen use and gaming among children and adolescents…
- Conditions
- Adolescent Behavior, Social Media Addiction, Gaming Disorder, Family Relations
- Trial name
- S-FAME (NCT07245862)
- Testing
- Family-centered Program for Problematic Gaming/Excessive Screen Use in a child and adolescent population within Social Services, Control
- Where
- Sweden
- Volunteers
- 170 people
- Sponsor
- Region Skane
Opiate Dependence
Low Dose Naltrexone-buprenorphine Transfer to Vivitrol Injection in Opioid Dependence
The purpose of this study is to evaluate a very low dose naltrexone-buprenorphine treatment to transfer opioid dependent individuals to extended release naltrexone injection (Vivitrol).
- Trial name
- BUP/NXT-VIVI (NCT01690546)
- Testing
- very low dose naltrexone, extended release naltrexone, buprenorphine/naloxone
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Paolo Mannelli
Cocaine Dependence
Double Blind Study of Vigabatrin for the Treatment of Cocaine Dependence
The primary objective of this study is to assess the efficacy of vigabatrin for the treatment of cocaine dependence, based on the twice-weekly qualitative urine toxicologies for cocaine.
- Trial name
- NCT00527683
- Testing
- Vigabatrin, Group therapy
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Substance-Related Disorders, Personality Disorders
Feasibility and Acceptability Study of the "O'Dide" Application in People Suffering From an Addiction
Substance Use Disorders (SUD) are associated with cognitive schemas that lead to care attrition and mistrust towards care. Considering this within SUD management, it is important to establish a confident relation between the…
- Trial name
- FA-O'DIDE (NCT04659954)
- Testing
- Application O'DIDE
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Smartphone Addiction
Meditation-Based Online Psychological Intervention
As the primary users of smartphones, emerging adults represent a key population for such research. Using a randomised controlled trial, the investigators compared mindfulness-of-death meditation with traditional mindfulness…
- Trial name
- NCT07379541
- Testing
- Mindfulness of Death (MoD) - 16-Day Online Meditation Course, Mindful Breathing Practice (MBP) - 16-Day Online Meditation Course
- Where
- China
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Beijing Normal University
Cocaine Addiction
A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
The problem of cocaine dependence remains a major medical, social, and legal concern. Several studies have suggested that disulfiram may be beneficial for the treatment of cocaine dependence.
- Trial name
- NCT00729300
- Testing
- disulfiram
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Nicotine Dependence
Brain Networks and Addiction Susceptibility
Background: The risk for becoming addicted to drugs varies from person to person, even among those using similar drugs in a similar way.
- Trial name
- NCT01924468
- Testing
- Oral methylphenidate and Oral haloperidol
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Community Reinforcement And Family Training, Family Health
Scalable Digital Delivery of Evidence-based Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to develop and evaluate the technical feasibility and commercial viability of a scalable digital counselor training program for CRAFT.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT05875142
- Testing
- Behavioral: Digital Tutorial Overview, Behavioral: Training Materials, Behavioral: Feedback and Coaching
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Cigarette Smoking, Nicotine Addiction
STOP Study: Effectiveness of Zyban in a Clinical Population
Despite the significant health, social and economic costs of cigarette smoking, 17% of Ontarians still currently smoke. Use of smoking cessation pharmacotherapy such as Zyban (bupropion HCl) has been shown to double quit rates…
- Conditions
- Cigarette Smoking, Nicotine Addiction, Smoking Cessation
- Trial name
- NCT01015170
- Testing
- bupropion HCl
- Where
- 24 sites in Canada
- Volunteers
- 454 people
- Sponsor
- Centre for Addiction and Mental Health
Internet Gaming Disorder
The Behavioral and Brain Mechanism of IGD
This project aims to investigate whether anodal tDCS of dlPFC enhances cognitive regulation over craving an emotions.
- Trial name
- NCT02550405
- Testing
- Craving behavioral intervention
- Where
- China
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Beijing Normal University
Stroke
Addiction & Stroke
Modifiable stroke risk-factors, which include poor lifestyle habits, account for 90 % of the risk of stroke. Disability Adjusted Life Years (DALYs) related to cerebrovascular disorders rely on three main factors, including the…
- Trial name
- ADDICT-STROKE (NCT06187025)
- Testing
- Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), Ecological Momentary Assessment (EMA)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bordeaux
Marijuana Dependence
Effect of Oxytocin on Stress in Marijuana Users
The purpose of this study is to evaluate how people who frequently use marijuana respond to a stressful task, and if a medication (oxytocin) affects this response.
- Trial name
- NCT01335789
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
Cigarette Smoking-Related Carcinoma
Electronic Cigarette Use During Pregnancy
Aim 1: To compare the overall toxicant exposure in pregnant women who use electronic cigarettes (e-cigs, vapor, e-liquid, e-juice, vape, vaping devices) compared to women who smoke conventional cigarettes. Aim 2.
- Trial name
- NCT03480373
- Where
- 6 sites in United States
- Volunteers
- 182 people
- Sponsor
- UConn Health
Chiari Malformation Type I, Proprioceptive Disorders
Investigation of the Effects of Exercise on Patients With Chiari Malformation
Chiari Malformation (CM) is a posterior brain anomaly caused by the displacement of the brain stem and cerebellum into the cervical spinal canal.
- Conditions
- Chiari Malformation Type I, Proprioceptive Disorders, Coordination and Balance Disturbances, Syringomyelia
- Trial name
- NCT04220541
- Testing
- Motor learning based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Hacettepe University
Stimulant Dependence, Methamphetamine-dependence
Pilot TMS for Methamphetamine Use Disorder
This is a pilot study to test the feasibility of a recruitment strategy and study protocol to examine the effects of a dual target transcranial magnetic stimulation treatment in methamphetamine use disorder.
- Conditions
- Stimulant Dependence, Methamphetamine-dependence, Addiction, Drug
- Trial name
- NCT04449055
- Testing
- Transcranial Magnetic Stimulation--DPFC first, MPFC second, Transcranial Magnetic Stimulation--MPFC first, DPFC second
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ryan M. Carnahan