Clinical trials: Addiction, Drug
Substance Dependence
Memory Reconsolidation Blockade for Treating Drug Addiction
The treatment involves administering propranolol, a medication indicated for treating high blood pressure. Propranolol is hypothesized to reduce the strength of drug or alcohol cravings (an integral factor involved in relapse)…
- Trial name
- NCT01634347
- Testing
- Propranolol and memory reactivation
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- Douglas Mental Health University Institute
Drug Abuse
Hotline Service for Drug-abusing Youth and Young Adults
Aim: Providing peer counselling service delivered by student counsellors with a medical background via a hotline to drug-abusing youth and young adult aged 35 or below. Objectives: i.
- Trial name
- NCT04461314
- Testing
- peer-led counselling
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Opioid Related Disorders, Opiate Addiction
Evaluation of Drug Utilization Patterns for Extended Release/Long Acting Opioids and Comparator Products
A drug utilization study will be performed to describe trends in the number of prescriptions and patients for class REMS ER/LA opioids and comparator products.
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02925806
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 5,575,834 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Nicotine Dependence
GABA (Gamma Amino Butyric Acid) Medication for Tobacco
The goal of this study is to examine the effects of a GABA (gamma amino butyric acid)-enhancing medication, pregabalin (300 mg/day), on smoking behavior, tobacco withdrawal and cigarette craving in smokers.
- Trial name
- NCT00644137
- Testing
- pregabalin, cigarettes
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
Drug Use Disorders, Addiction, Drug
A Electronic System to Improve Recovery Outcomes in Patients With Drug Use Disorder
Background: Relapse is very common in patients with illicit drug use disorder and contributes to a series of bad consequences that substantially impact patients' physical and social functions.
- Trial name
- NCT03451344
- Testing
- Integrated rehabilitation group, Community-based rehabilitation group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Nicotine Addiction, Drug Addiction
Clinical Trial of Smoking Cessation Mobile Phone Program
The Sponsor is doing a research study to assess the effects of a smartphone program designed to help users smoke less and eventually quit. When participants join, their involvement in the core study will last 8 weeks.
- Conditions
- Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder
- Trial name
- NCT02656745
- Testing
- Mobile Smoking Cessation Solution
- Where
- United States
- Volunteers
- 416 people
- Sponsor
- Click Therapeutics, Inc.
Substance Abuse, Intravenous
The Long-Term Treatment of Drug Addiction and Unemployment
The purpose of this clinical trial is to evaluate the effectiveness and economic benefits of a Wage Supplement Model of arranging long-term exposure to employment-based abstinence reinforcement.
- Trial name
- NCT02487745
- Testing
- Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Johns Hopkins University
Depression, Dual Diagnosis
A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users
Methamphetamine (MA) addiction is a public health concern that causes substantial harm to individual users, and imposes an economic burden in the U.S. totaling up to $48.3 billion annually.
- Conditions
- Depression, Dual Diagnosis, Drug Addiction
- Trial name
- NCT02192931
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Perry Renshaw
Opioid Use, Opioid-Related Disorders
Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients
Risk of long-term opioid dependence increases with initial opioid dose/duration, but despite recent Centers for Disease Control and Prevention (CDC)-endorsed minimum doses for initial opioid prescription, primary care providers…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Abuse, Prescription Drug Abuse and Dependency
- Trial name
- NCT03377855
- Testing
- Default Prescribing Change
- Where
- 2 sites in United States
- Volunteers
- 948 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Buprenorphine, HIV
Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)
The purpose of this study is to assess the feasibility, cost and effectiveness of interventions designed to integrate buprenorphine treatment for opioid dependence into HIV primary care in ten HIV care centers in the U.S.
- Conditions
- Buprenorphine, HIV, Drug Abuse, Drug Addiction
- Trial name
- BELIEVE (NCT00798538)
- Testing
- Services will be provided at one site, Services remain dispersed; i.e., not centralized to one-location or provider.
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Drug Abuse, Drug Dependence
Prometa Pharmacotherapy for Methamphetamine Dependence
The purpose of this study is to assess the efficacy of the PROMETA pharmacotherapy compared to placebo for initiating abstinence and for preventing relapse to methamphetamine use in treatment-seeking individuals meeting criteria…
- Trial name
- NCT00260481
- Testing
- Prometa
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Substance Abuse, Drug Addiction
Integrating Mindfulness-Based Skills Training Into Brief Outpatient Treatment for Substance Abusing Youth
The proposed study will evaluate the clinical effectiveness of integrating mindfulness-based skills training into a standardized brief group intervention for youth (ages 16 to 24) identified as having problematic substance use.
- Trial name
- NCT00244699
- Testing
- MI Alone or Plus Mindfulness-Based Skills Training
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Hepatitis B, Hepatitis C
UCLA-Amity Parolee Health Promotion Study
The purpose of this study is to conduct a prospective, three-group study that randomly assigns 700 parolees, in a community residential drug treatment program, to enter one of three groups: 1) a PCPC (Parolee Comprehensive Care +…
- Conditions
- Hepatitis B, Hepatitis C, HIV, Drug Addiction
- Trial name
- NCT01844414
- Testing
- Parolee Comprehensive Care + Phone Coach, Parolee Brief HBV Program + Phone Coach, Usual Care Group
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Opioid-use Disorder, Addiction
Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
Collaboration Leading to Addiction Treatment and Recovery from Other Stresses (CLARO) is a five-year project that tests whether delivering care using a collaborative model helps patients with both opioid use disorders and mental…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post-traumatic Stress Disorder
- Trial name
- CLARO (NCT04559893)
- Testing
- Collaborative Care
- Where
- 16 sites in United States
- Volunteers
- 729 people
- Sponsor
- RAND
Nicotine Dependence, Opiate Dependence
Developing a Smoking Cessation Intervention for Methadone Maintained Smokers
The purpose of this study is to pilot and evaluate, in a randomized controlled trial, the immediate and long-term effects of a newly developed, tailored, intensive smoking cessation intervention among methadone maintained smokers…
- Trial name
- NCT01393392
- Testing
- Intensive, tailored intervention, NJ Quitline Referral
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Rutgers, The State University of New Jersey
Cocaine-Related Disorders, Substance-Related Disorders
Quetiapine for Cocaine Use and Cravings
The purpose of this study was to collect pilot data on whether quetiapine may be effective in the reduction of cocaine use and cravings in cocaine dependent individuals.
- Trial name
- NCT00232336
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Opiate Addiction, Borderline Personality Disorder
Evaluation of DBT Compared to Drug Counseling for Opiate Addicts
The purpose of this study is to compare a one year treatment program of Dialectical Behavior Therapy (DBT) + suboxone for opiate addicted individuals meeting criteria for borderline personality disorder (BPD) to a one year…
- Trial name
- NCT00117741
- Testing
- Dialectical Behavior Therapy, Drug Counseling
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Washington
Opioid-related Disorders, Opioid Addiction
ER/LA Opioid Surveillance for Emergency Department Visits and Hospitalizations for Overdose and Poisoning
Study to evaluate the impact of the ER/LA opioid REMS program on the incidence of Emergency Department visits and hospitalizations for overdose/poisoning and death among patients prescribed ER/LA opioid analgesics.
- Conditions
- Opioid-related Disorders, Opioid Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02866266
- Testing
- Retrospective database review
- Volunteers
- 183,452 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Drug Addiction
Construction of Early Warning Model for the New Psychoactive Substances Using in Adolescents
Based on the biological-psychology-sociological medicine pattern, this study aims to construction an early warning model of the New Psychoactive Substances (NPS) using for adolescents aged 14-35 years old.
- Trial name
- NCT05958641
- Testing
- Questionnaires
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD
Cocaine Dependence
D-Serine for Cocaine Dependence Pilot
The primary objective of this study is to collect pilot data on the efficacy of D-serine, relative to placebo, as a cocaine dependence treatment. Secondary objectives include evaluating D-serine, relative to placebo, on: 1.
- Trial name
- STED-CD (NCT01715051)
- Testing
- D-serine, Cognitive Behavioral Therapy
- Where
- United States
- Sponsor
- Theresa Winhusen