Clinical trials: Adaptive Radiotherapy
Cancer Survivors, Cardiotoxicity
In-Bedroom Renewed Air as Anti-inflammatory Adjuvant Therapy in Cancer Survivors
The BREATHS trial aims to investigate whether overnight in-bedroom air filtration reduces inflammation and cardiac biomarkers in adult survivors of cancer who are at high risk for cardiovascular complications.
- Conditions
- Cancer Survivors, Cardiotoxicity, Cardiovascular Toxicity Induced by Antitumoral Drugs
- Trial name
- BREATHS (NCT06778122)
- Testing
- High efficiency particulate air filtration system (nightly administration), High efficiency particulate air filtration system (nightly and daily administration)
- Where
- 3 sites in Spain
- Volunteers
- 10 people
- Sponsor
- University College, London
Head and Neck Cancer
Image-Guided Adaptive Radiotherapy for in Detecting Tumors During Treatment in Patients With Head and Neck Cancer
This clinical trial studies image-guided adaptive radiotherapy in detecting tumors during treatment in patients with head and neck cancer.
- Trial name
- NCT01843673
- Testing
- computed tomography, cone-beam computed tomography, radiography
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Commonwealth University
Localized Prostate Adenocarcinoma
Feasibility of MR-Informed Adaptive Marker-less SBRT in Patients With Bilateral Hip Prostheses Undergoing SBRT for Localized Prostate Cancer
Hip replacements and prostate cancer are independently and both together increasing prevalent in the aging population. In the United States, the prevalence of hip prostheses among men was 1.1 million in 20101, with approximately…
- Trial name
- HIP-PRO (NCT07042256)
- Testing
- Low-field MR-informed adaptive marker-less SBRT for definitive treatment of localized prostate cancer in patients with bilateral hip prostheses
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- University of Zurich
Uterine Cervical Neoplasm, Endometrial Neoplasms
Online Adaptive Radiotherapy for Postoperative Treatment of Endometrial and Cervical Cancer
Online adaptive radiotherapy (oART) has demonstrated to be feasible to reduce planning target volume (PTV) margins for postoperative treatment of endometrial and cervical cancer.
- Trial name
- NCT05869123
- Testing
- Online adaptive radiotherapy
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Cancer, Adaptive Radiotherapy
Moderated Hypofractionated Online Adaptive Radiotherapy in Cervical Cancer
The most common external beam radiotherapy fractionation scheme for cervical cancer is 45-50.4 Gy delivered in 25-28 fractions. However, prolonged treatment duration can lead to insufficient availability of medical resources.
- Trial name
- NCT06641635
- Testing
- Moderated hypofractionated online adaptive radiotherapy, Conventional radiotherapy
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Peking Union Medical College Hospital
Non-small Cell Lung Cancer
Adaptive Hypofractionated Radiotherapy for Locally Advanced NSCLC Based on Dynamic Enhanced MRI
This study is a randomized phase III trial that aiming to investigate the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) guided hypofractionated radiotherapy (hypo-RT) in patients with locally advanced…
- Trial name
- NCT06545747
- Testing
- DCE-MRI based split-course hypo-RT, CT based split-course hypo-RT, Concurrent chemotherapy
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Sun Yat-sen University
Glioblastoma
Multiparametric MR-Guided High Dose Adaptive Radiotherapy With Concurrent Temozolomide in Patients With Newly Diagnosed Glioblastoma
This study will investigate whether or not intensified radiation therapy adapted during the radiation treatment course to high-risk, treatment-resistant tumor regions will improve overall survival in patients with newly diagnosed…
- Trial name
- NCT04574856
- Testing
- Dose-Intensified Radiotherapy, Temozolomide, Adjuvant temozolomide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan Rogel Cancer Center
Prostate Cancer (Adenocarcinoma)
Adaptive Radiation Therapy for Men With Intermediate- or High-Risk Prostate Cancer
The goal of this clinical trial is to evaluate if adaptive stereotactic body radiation therapy (SBRT) is a safe and effective way to treat prostate cancer in adults. It will assess the safety profile of adaptive SBRT over time.
- Trial name
- DE-CART (NCT07219303)
- Testing
- adaptive stereotactic body radiation therapy (SBRT) with a SIB
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Fox Chase Cancer Center
Head and Neck Cancer
Adaptive Dose-Escalated Multi-modality Image-guided RadiothErapy
Patients with primary head and neck squamous cell carcinoma (HNSCC) planned for treatment with radiotherapy with or without chemotherapy in curative setting will be treated with an adaptive radiotherapy scheme.
- Trial name
- ADMIRE (NCT03376386)
- Testing
- Adaptive dose-Escalated multi-modality image-guided radiotherapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- The Netherlands Cancer Institute
Cervical Cancer, Online Adaptative Radiation Therapy
MR-Only Based Adaptive External Beam Radiation Therapy of Cervical Cancer on Ethos Therapy: Feasibility Study
Current management of patients treated with External Beam Radiation Therapy (EBRT) for cervical cancer with a classical Image-guided Radiation Therapy (IGRT) strategy involves a complex, not entirely satisfactory, treatment…
- Conditions
- Cervical Cancer, Online Adaptative Radiation Therapy, MRI
- Trial name
- Ethos Col (NCT05909111)
- Testing
- Magnetic resonance imaging
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Recherche clinique
Fibrosis Syndrome, Lymphedema
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer.
- Conditions
- Fibrosis Syndrome, Lymphedema, Head &Amp; Neck Cancer, Fibrosis
- Trial name
- NCT06912763
- Testing
- Pravastatin (drug), Pentoxifylline, ketoprofen
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Deformable Image Registration for Breast Adaptive Tomotherapy
The radiotherapy treatment plan (also called dosimetry) used for all treatment sessions is based on the dosimetric scanner. During the sessions, the anatomy of the breast may vary, and these variations may impact the quality of…
- Trial name
- DIRB-ATOM (NCT05383144)
- Testing
- Complete Positioning scans
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Institut de cancérologie Strasbourg Europe
Rectal Cancer
Total Neoadjuvant Treatment Combined With Adaptive Radiotherapy for Rectal Cancer
Diarrhea was the most frequently reported severe adverse event in the treatment regime of pre-operative sequential short-course radiotherapy followed by chemotherapy (so called total neo-adjuvant treatment).
- Trial name
- TNT-RECORD (NCT05883800)
- Testing
- On-couch adaptive radiotherapy
- Where
- Norway
- Volunteers
- 61 people
- Sponsor
- Haukeland University Hospital
Esophageal Adenocarcinoma, Esophageal Adenocarcinoma (EAC)
Combination of Chemotherapy and Adaptive MR-Guided Radiotherapy to Improve Outcomes in Patients With Esophageal Adenocarcinoma
Rationale: Esophageal cancer (EC) is the seventh most frequently diagnosed cancer and the sixth leading cause of cancer-related death worldwide.
- Conditions
- Esophageal Adenocarcinoma, Esophageal Adenocarcinoma (EAC), Adenocarcinoma - Gastroesophageal Junction (GEJ)
- Trial name
- MERGE (NCT07359443)
- Testing
- MRI guided radiotherapy
- Where
- Netherlands
- Volunteers
- 39 people
- Sponsor
- UMC Utrecht
Esophagogastric Cancer
PET-MRI Esophagus Feasibility Study
This is a single arm, single centre, investigator initiated study to investigate the feasibility of using PET-MRI imaging in radiation treatment workflow in up to 15 patients with esophagogastric cancer.
- Trial name
- PET-MRI (NCT05796102)
- Testing
- PET-MRI
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Lymphoma of the Mucosa Associated Lymphoid Tissue (MALT)
AI-Assisted Optimization of Online Adaptive Radiotherapy for Gastric Lymphoma
The goal of this clinical trial is to evaluate CBCT image-based triggered online adaptive radiotherapy (ART) and assess its clinical benefits in protecting organs at risk (OARs).
- Trial name
- GLORIA (NCT07609355)
- Testing
- ART
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Sun Yat-sen University
Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment
Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer
This pilot study aims to trial multimodal early response assessment to enable therapy adaptions in the context of non-operative therapy strategies of locally advanced rectal cancer (LARC) for development of a non-invasive…
- Conditions
- Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment, Radiotherapy, Adaptive Treatment
- Trial name
- PRIMO (NCT05524012)
- Testing
- Blood sample, MRI scan
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Jena University Hospital
Laryngeal Cancer, Hypopharynx Cancer
Tislelizumab and Induction Chemotherapy for Larynx Preservation in Resectable Advanced Laryngeal/Hypopharyngeal Cancer
This study is a prospective, single-arm, single-center, phase II study. The goal of this clinical trial is to explore the therapeutic value of the treatment model of "tislelizumab combined with chemotherapy followed by…
- Conditions
- Laryngeal Cancer, Hypopharynx Cancer, Laryngeal Neoplasms
- Trial name
- NCT06554028
- Testing
- chemotherapy TP regimen combined with Tislelizumab
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Henan Cancer Hospital
Hepatic Metastasis
Magnetic Resonance-guided Adaptive Stereotactic Body Radiotherapy for Hepatic Metastases
Stereotactic body radiotherapy (SBRT) is an established local treatment method for patients with hepatic oligometastases. Liver metastases often occur in close proximity to radiosensitive organs at risk (OARs).
- Trial name
- MAESTRO (NCT05027711)
- Testing
- ITV (Internal target volume)-based Stereotactic Body Radiotherapy (ITV-SBRT), MRgSBRT (Magnetic Resonance-guided Stereotactic Body Radiotherapy)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Heidelberg
Stage IV Cervical Cancer FIGO 2018, Adenosquamous Carcinoma of Cervix
Personalized Ultra-fractionated Stereotactic Adaptive Radiotherapy for Metastatic Cervical Cancer
To improve overall survival in patients with metastatic cervical cancer by loco-regional therapy with personalized ultra-fractionated radiation
- Conditions
- Stage IV Cervical Cancer FIGO 2018, Adenosquamous Carcinoma of Cervix, Cervical Cancer, Metastasis
- Trial name
- NCT05021237
- Testing
- Ultra-fractionated radiation therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center