Clinical trials: Adaptive Radiotherapy
Pelvis Neoplasms
Pelvis Adaptive Radiotherapy (ART)
Pelvis Adaptive radiotherapy (ART) is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for cancer patients having radiotherapy in the pelvic region.
- Trial name
- Pelvis ART (NCT06650033)
- Testing
- Adaptive radiotherapy +/- margin reduction, Image guided radiotherapy
- Where
- Australia
- Volunteers
- 280 people
- Sponsor
- Royal North Shore Hospital
Esophageal Squamous Cell Carcinoma (ESCC), Esophageal Cancer, Squamous Cell
MR-Guided Radiotherapy Dose Escalation Trial for Esophageal Squamous Cell Carcinoma
SUMMARY Rationale: Esophageal cancer (EC) is the seventh most frequently diagnosed cancer and the sixth leading cause of cancer-related death worldwide.
- Trial name
- ESCALATE (NCT07359417)
- Testing
- Radiation: MRI guided radiotherapy
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Pelvic Tumor, Thoracic Tumor
Pelvic Cancer Registry for Online Adapted Radiotherapy
This prospective registry-based trial will include patients with pelvic or thoracic tumors with an indication for radiotherapy treated with oART or IGRT.
- Trial name
- PRoART (NCT06185062)
- Where
- Germany
- Volunteers
- 846 people
- Sponsor
- University Medical Center Goettingen
Non-Small Cell Lung Cancer
Adaptive Radiotherapy in Locally Advanced Non-Small Cell Lung Cancer (LARTIA Trial)
Anatomical change of tumor during radiotherapy contributes to target missing. However, in the case of tumor shrinkage, adaptation of volume could result in an increased incidence of recurrence in the area of target reduction.
- Trial name
- LARTIA (NCT03583723)
- Testing
- Radiotherapy Group
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Campus Bio-Medico University
Brain Metastases From Solid Tumors
Comparison of the Therapeutic Effects of Methylprednisolone and Dexamethasone on Peritumoral Edema During Radiotherapy for Brain Metastases:
This study is a multicenter, open label, randomized controlled, adaptive phase II/III seamless design clinical trial aimed at comparing the efficacy and safety of methylprednisolone (MP) and dexamethasone (DEX) in the treatment…
- Trial name
- NCT07542288
- Testing
- Methylprednisolone (Corticosteroid), Dexamethasone
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Second Affiliated Hospital of Hainan Medical University
Non-Small Cell Lung Cancer
Assessing the Efficacy and Safety of Selective Metabolically Adaptive Radiation Dose Escalation in Locally Advanced Non-Small Cell Lung Cancer Receiving Definitive Chemoradiotherapy
A randomized phase II trial to assess the efficacy and safety of selective metabolically adaptive radiation dose escalation in locally advanced non-small cell lung cancer receiving definitive chemoradiotherapy.
- Trial name
- PET-BOOST (NCT02788461)
- Testing
- Chemoradiotherapy, Chemoradiotherapy with Integrated Boost Dose
- Where
- 7 sites in Canada
- Volunteers
- 78 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Head and Neck Cancer
PET/MR in Radiotherapy for Head and Neck Cancer Pilot
This is a pilot non-intervention study that aims to introduce PET/MRI, a state of the art new imaging technique, into the radiotherapy treatment pathway of patients with head and neck cancer.
- Trial name
- NCT02952625
- Testing
- Imaging
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Prostate Cancer, Prostate Adenocarcinoma
Two-Fraction Ultrahypofractionated Radiotherapy With Focal Boost for Intermediate Risk, Localized Prostate Cancer
The goal of this clinical trial is to assess the non-inferiority irradiating low and intermediate risk, localized prostate cancer in two fractions of radiotherapy, compared to five fractions of radiotherapy which is the standard…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Localized Prostate Carcinoma
- Trial name
- TURBO (NCT06518226)
- Testing
- Ultrahypofractionated MRgRT in 2 fractions, Standard of care: MRgRT in 5 fractions
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- UMC Utrecht
Endometrial Cancer, Radiotherapy, Adjuvant
MR-guided Adaptive Stereotactic Radiotherapy for Endometrial Cancer
Rationale: External beam radiotherapy (EBRT) is an important cornerstone in treatment to reduce locoregional relapse in high(-intermediate) risk endometrial cancer (EC) patients.
- Trial name
- MASTEC (NCT07514325)
- Testing
- MR-guided adaptive radiotherapy (MGART) with reduced PTV margins, including 5 times 6Gy to the vaginal vault and pelvic nodal areas, 2 times a week
- Volunteers
- 61 people
- Sponsor
- Radboud University Medical Center
Uterine Cervical Neoplasm, Endometrial Neoplasms
Optimal Margin Evaluation of Online Adaptive Radiotherapy for Postoperative Treatment of Endometrial and Cervical Cancer
Online adaptive radiotherapy has demonstrated to be feasible to reduce inter-fractional radiotherapy errors as it re-optimizes treatment plan every fraction.
- Trial name
- NCT05682950
- Testing
- online adaptive radiotherapy
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Peking Union Medical College Hospital
Lung Cancer
3-Dimensional Conformal Radiation Therapy Versus Intensity Modulated Radiation Therapy
Primary Objective: Developing Common Toxicity Criteria (CTC) 3.0 grade > 3 treatment related pneumonitis (TRP) or Developing local-regional recurrence among patients treated with 3D conformal radiation therapy (CRT) (Arm 1) or…
- Trial name
- NCT00520702
- Testing
- Intensity Modulated Radiation Therapy, 3-Dimensional Conformal Radiation Therapy
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer
Docetaxel, Androgen Ablation, and External-Beam Radiation Therapy in Patients With High-Risk Localized Prostate Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NRR (NCT00225420)
- Testing
- docetaxel, leuprolide acetate, radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Prostate Cancer
Assessment of 3D Transperineal Ultrasound Imaging w/ Matrix Array Transducers in Prostate Radiotherapy
SPECIFIC STUDY AIMS 1. To evaluate congruence between pelvic anatomical structures segmented on MRI and/or CT scans co-registered with transperineal US scans acquired with an optically and/or electromagnetically tracked matrix…
- Trial name
- NCT02432820
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Stanford University
Prostate Cancer, Cancer of the Prostate
Adaptive Stereotactic Body Radiation Therapy to the Prostate and Pelvic Nodes With Simultaneous Integrated Boost to the MR-detected Nodule for Patients With High-risk and Unfavorable Intermediate-risk Prostate Cancer
This trial is a prospective clinical trial designed to demonstrate the safety and feasibility of whole-pelvis adaptive prostate stereotactic body radiation therapy (SBRT) with a tumor boost to the magnetic resonance (MR)-detected…
- Trial name
- NCT05628363
- Testing
- Ethos Varian treatment system, Adaptive stereotactic body radiotherapy, Androgen deprivation therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Washington University School of Medicine
Cervix Cancer
Image-guided Adaptive Radiotherapy for Cervix Cancer: Patient Image Acquisition
Within this study patient data are collected from different imaging and motion monitoring devices that will be used to develop and test strategies for image-guided adaptive radiotherapy in cervix cancer patients.
- Trial name
- NCT00571415
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Virginia Commonwealth University