Clinical trials: Adaptation
Lupus
Improving Quality of Life for African American Female Adolescents With Lupus
This study will evaluate a program designed to help African American adolescents with lupus (systemic lupus erythematosus or SLE) cope with the disease.
- Trial name
- NCT00068874
- Testing
- Coping skills and cognitive restructuring techniques, Educational training
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Medical University of South Carolina
Cervical Intraepithelial Neoplasia
Comparison of Cervical CIN II/III Treatment Outcomes With Thermal Ablation Device
The purpose of this academic-industrial partnership will be to compare two thermoablation modalities using devices adapted to low and middle income countries (LMICs) to traditional CO2-based cryotherapy for the treatment of…
- Trial name
- NCT03429582
- Testing
- Standard C02 Cryotherapy, Single Tip Thermoablation, Multiple Tip Thermoablation
- Where
- 2 sites in China, El Salvador
- Volunteers
- 1,154 people
- Sponsor
- The Cleveland Clinic
Triple Negative Breast Cancer, Breast Cancer
Neoadjuvant TIL- and Response-Adapted Chemoimmunotherapy for TNBC
This study will assess if the presence of immune system cells in and around the tumor impacts tumor shrinkage in patients receiving neoadjuvant chemoimmunotherapy for triple-negative breast cancer.
- Trial name
- NeoTRACT (NCT05645380)
- Testing
- Carboplatin, Docetaxel, Doxorubicin
- Where
- 7 sites in United States
- Volunteers
- 139 people
- Sponsor
- University of Kansas Medical Center
Overweight
Evaluation of SODB® in Metabolic Adaptations in Overweight Women
The objective of this study is to evaluate the influence of a 3 months SODB® supplementation in adipose tissue modulations of overweight women, in comparison to a placebo.
- Trial name
- SORESCAL (NCT02667691)
- Testing
- SODB Dimpless, caloric restriction
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Robertet SA
Effects of High Altitude, Hypoxia
Induced Changes in Ventilatory Responsiveness and Altitude Exposure
The main purpose of this study is to determine if a drug (acetyl-cysteine or ACCY) can increase the amount of oxygen in your body at a high altitude of 11,500 feet.
- Conditions
- Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
- Trial name
- NCT01241513
- Testing
- NAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Aging Hands
Neural Substrates Underlying Adaptations in Manual Dexterity of Older Adults
Age-related declines in motor function can compromise independence and quality of life. This project examines how practice and somatosensory stimulation reshape the neural control of hand muscles in older adults, leveraging…
- Trial name
- NCT07011160
- Testing
- Transcutaneous electrical nerve stimulation (TENS), Familiarization
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Iodine Deficiency
The Next Step Towards the Elimination of Iodine Deficiency and Preventable Iodine-related Disorders in Europe
In the EUthyroid2 intervention, measures are being developed and implemented in educational settings across the UK, Germany, Slovenia, the Republic of Cyprus, Bangladesh, and Pakistan to effectively raise awareness of the risks…
- Trial name
- EUthyroid2 (NCT06801691)
- Testing
- Experimental: Intervention group
- Where
- 6 sites in Bangladesh, Cyprus and 4 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- EUthyroid
Neurologic Neglect Syndrome
Potentiation of the Effects of Prismatic Adaptation by Transcranial Direct Current Stimulation (tDCS) : Evaluation of Functional Interest in Negligence Rehabilitation
Following stroke, over 50% of patients keep severe neurological deficiency whose unilateral neglect, mostly following a right hemispheric lesion.
- Trial name
- PRIStiM1 (NCT02213640)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Hospices Civils de Lyon
Substance Use Disorders, Family Members
Testing Effectiveness of the Community Reinforcement Approach and Family Training (CRAFT) With American Indians
It is important to address the substantial substance-related health disparities of American Indians (AI). This project aims to examine the effectiveness of a culturally tailored Community Reinforcement and Family Training (CRAFT)…
- Trial name
- CRAFT-AI (NCT03203889)
- Testing
- CRAFT-AI, TSF-CSO
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Alzheimer Disease
Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
The purpose of this trial is to test the ability of the non-steroidal anti-inflammatory medications naproxen and celecoxib to delay or prevent the onset of AD and age-related cognitive decline.
- Trial name
- NCT00007189
- Testing
- Naproxen Sodium (Aleve), Celecoxib (Celebrex)
- Where
- 6 sites in United States
- Volunteers
- 2,625 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Heat Stroke
Development of an Active Heat Dissipation Device Based on Thermoelectric Cooling Technology: Aiming to Improve Endurance Sports Performance
This project investigates the effectiveness of pre-exercise active cooling using a temperature-controlled cooling vest in reducing heat-related physiological strain during endurance-type aerobic exercise in non-regularly trained…
- Trial name
- DAHDD-TCT (NCT07539714)
- Testing
- TEC Vest, No Pre-Cooling (Without Vest), Water Cooled Vest
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Mild Intellectual Disability
Comparison of Sensory-Adapted and Regular Dental Environments in Patients With Mild Intellectual Disability and Moderate Dental Anxiety
This study compared a sensory-adapted dental environment (SADE) with a regular dental environment (RDE) in 6-7-year-old children with mild intellectual disability and moderate dental anxiety.
- Trial name
- SADE vs RDE (NCT07413016)
- Testing
- SADE, RDE
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Oasi Research Institute-IRCCS
Healthy Normal Weight Women, Constitutionally Lean Women
Management of Constitutional Thinness Through an Adapted Physical Activity Program, Whether or Not Associated With Food Supplementation. Interventional Study Compared to Matched Controls: NUTRILEAN + Study
The main aim of the present study is to compare the effect of a 12-week physical activity program on body weight gain and body composition changes between normal weight and constitutionally lean individuals.
- Trial name
- NUTRILEAN + (NCT04749706)
- Testing
- Physical training alone, physical training + protein intake
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Health Education
Turkish Adaptation, Validity and Reliability of the Approaches and Study Skills Inventory in Physiotherapy Students
The quality and quantity of learning are determined by the learning approach adopted by the student. When learning and studying approaches are mentioned, individual differences between learners' learning intentions during a…
- Trial name
- NCT06297733
- Testing
- Translating the Questionnaire into Turkish and Related Processes, Validity, Reliability
- Where
- Turkey (Türkiye)
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Addiction, Alcohol
Recovery of Individuals With Alcohol Use Disorders Based on Roy Adaptation Model
Abstract Aim: This study aimed to determine the effect of individualized nursing interventions based on the Roy Adaptation Model on the recovery of alcohol addicts.
- Trial name
- NCT06114316
- Testing
- individualized nursing interventions based on the Roy Adaptation Model /experimental
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Izmir Katip Celebi University
Altitude Hypoxia
Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance
The investigators expect to find that different intensity and altitude exposure levels will show what kind of intermittent exposure protocol is more beneficial to athletes and healthy individuals that experience acute exposure to…
- Trial name
- NCT03743610
- Testing
- Simulated altitude
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hepatocellular Carcinoma (HCC)
Ipilimumab and Nivolumab With SBRT in Locally Advanced Hepatocellular Cancer
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally, with Native Hawaiian and Pacific Islander (NHPI) populations experiencing significantly higher mortality rates compared to other groups in Hawaii.
- Trial name
- NCT07075120
- Testing
- Ipilimumab and Nivolumab, Stereotactic Body Radiotherapy (SBRT)
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Hawaii
Pain
The Norwegian "iCanCope With Pain" App
Background: Research evidence shows that prevalence of pain in adolescents is increasing and is therefore recognized as a growing health problem.
- Trial name
- NCT03551977
- Testing
- iCanCope with Pain, iCanCope with Pain control
- Where
- Norway
- Volunteers
- 112 people
- Sponsor
- University of Agder
Depressive Disorder
Effect of Adapted Physical Activity on Emotion Regulation in People With Depressive Disorders
Depression is associated with difficulties in emotion regulation. Adapted physical activity (APA) may help improve emotional regulation in people with depressive disorders.
- Trial name
- REAPAD (NCT07780695)
- Testing
- Classical Adapted Physical Activity Program, Adapted Physical Activity Program
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Georges Mazurelle
Post-Traumatic Stress Disorder in Children, Post-traumatic Stress Disorder
Adaptation of the PCIP for Children Aged 6 to 11
This study will implement a brief Post-traumatic Stress Disorder (PTSD) intervention for children, the Primary Care Intervention for PTSD (PCIP) delivered through telehealth (computer or smartphone delivery), to 10 youth age 6-11…
- Trial name
- NCT05606172
- Testing
- Primary Care Intervention for PTSD (PCIP) Youth aged 6 -11, Waitlist Treatment as Usual
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles