Clinical trials: Acute Sinusitis
Acute Respiratory Infection, Sinusitis
Middle Meatal Bacteriology During Acute Respiratory Infection in Children
The purpose of this study is to find out whether the children with respiratory infection and the presence of pathogenic bacteria (S. pneumoniae, H. influenzae or M.
- Trial name
- NCT00545961
- Testing
- amoxicillin clavulanate acid
- Where
- 3 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Oulu University Hospital
Sinusitis
A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Bacterial Sinusitis(Sinus Infection) in Adults.
The purpose of this study is to evaluate the effectiveness and safety of two antibiotic regimens in the treatment of acute bacterial sinusitis (sinus infection) in non-hospitalized adult patients.
- Trial name
- NCT00236522
- Testing
- levofloxacin
- Volunteers
- 784 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Rhino Sinusitis
Safety Evaluation of Intranasal Use of DSM 32444 Postbiotic in Humans
Rhinitis is a type of upper respiratory infection with a common nasal pathology especially in Southeast Asia, which is characterized by the presence of one or more of the following symptoms: itchy nose, sneezing, runny nose, and…
- Trial name
- NCT05984004
- Testing
- 0.9% NaCl isotonic saline solution, Bacillus subtilis DSM32444, inactivated
- Where
- Vietnam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huro Biotech Joint Stock Company
Rhinitis, Sinusitis
Topical Irrigation Therapy for CRS
The purpose of the study is to evaluate the physiologic response of quinine-saline irrigations for acute exacerbation of uncomplicated chronic rhinosinusitis following endoscopic sinus surgery.
- Trial name
- QSIND (NCT02630472)
- Testing
- Quinine Sulfate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Sinusitis, Cystic Fibrosis
Pulmozyme in Cystic Fibrosis With Sinusitis
The hypothesis is that the intranasal use of Pulmozyme will decrease the severity of sinusitis in Cystic Fibrosis and lead to an improved quality of life.
- Trial name
- NCT01155752
- Testing
- Pulmozyme single use ampule
- Where
- United States
- Sponsor
- Milton S. Hershey Medical Center
Sinusitis
Efficacy of Azithromycin Prophylaxis in Preventing Recurrent Acute Sinusitis in Children
The purpose of this study is to evaluate efficacy of azithromycin prophylaxis in preventing recurrent acute sinusitis in children.
- Trial name
- NCT00944515
- Testing
- azithromycin
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Rhinosinusitis, Intracranial Extension
Role of Imaging in Complications of Sinusitis
This study aims to assess the diagnostic performance of CT and MRI in the diagnosis of complications of rhinosinusitis in comparison to clinical and operative findings.
- Conditions
- Rhinosinusitis, Intracranial Extension, Rhinosinusitis Chronic, Rhinosinusitis Acute
- Trial name
- NCT05836935
- Testing
- Multislice CT scan of the paranasal sinuses., MRI examination of the paranasal sinuses
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Maxillary Sinusitis
A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 mg for 5 Days.
The purpose of this study is to evaluate the effectiveness and safety of a once-daily administration of 750 milligrams levofloxacin (an antibiotic) for five days, in treating bacterial sinus infections.
- Trial name
- NCT00236652
- Testing
- levofloxacin
- Volunteers
- 18 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
ACUTE SINUSITIS, Sinusitis
Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)
This study is being conducted at multiple hospitals and clinics to better understand whether antibiotics truly help children feel better when they have a sinus infection (acute sinusitis).
- Trial name
- MEASURE (NCT07732699)
- Testing
- Amoxicillin, Amoxi Clavulanate
- Where
- 5 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Nader Shaikh
Sinusitis
Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate
The aim is to determine if high-dose amoxicillin/clavulanate is more effective than standard-dose amoxicillin/clavulanate in treating acute bacterial sinusitis in adults seen at a primary care office.
- Trial name
- NCT02340000
- Testing
- standard dose amoxicillin/clavulanate, high dose amoxicillin/clavulanate
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Acute Rhinosinusitis
Non-interventional Study of Ectoin Nasal Douche (END01) in Patients With Acute Viral Rhinosinusitis
The goal of this non interventional study is to investigate the efficacy, tolerability and safety of the newly developed Ectoin Nasal Douche END01.
- Trial name
- NCT03480100
- Testing
- Xylometazoline Nasal Spray, Ectoin Nasal Douche
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Bitop AG
Maxillary Sinusitis
Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox
This study evaluated the time to bacteriological eradication of common pathogens during moxifloxacin therapy for acute bacterial maxillary sinusitis.
- Trial name
- SPEED (NCT00668304)
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- 35 sites in United States, Argentina
- Volunteers
- 192 people
- Sponsor
- Bayer
Sinusitis
BAY12-8039: 5 Days for Sinusitis vs Placebo
The purpose of the study is to evaluate the effectiveness and safety of Avelox in a 5 day treatment of adult patients with acute bacterial sinusitis and to measure the amount of time it takes for symptom relief.
- Trial name
- NCT00492024
- Testing
- Moxifloxacin (Avelox, BAY12-8039)
- Where
- 51 sites in United States
- Volunteers
- 374 people
- Sponsor
- Bayer
Chronic Sinusitis, Acute Sinusitis
Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:
This double-blind, randomized controlled trial (BEE-SONIC) aims to evaluate the efficacy of bee venom phonophoresis in the treatment of chronic sinusitis.
- Conditions
- Chronic Sinusitis, Acute Sinusitis, Rhinosinusitis
- Trial name
- BEE-SONIC (NCT07151313)
- Testing
- Bee Venom Phonophoresis, Standard Care (oral decongestants + saline nasal irrigation)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sinai University
Tonsillitis Acute, Pneumonia - Bacterial
Comparative Study of Adherence to Antibiotic Therapy Among Pediatric Patients: Hospital Emergency Department vs. Primary Care Center
This study was initiated because of the limited litterature available on this topic. The objective was to compare adherence to antibiotic therapy among a pediatric population treated in two healthcare settings in France: the…
- Conditions
- Tonsillitis Acute, Pneumonia - Bacterial, Otitis Media Acute, Cystitis Acute
- Trial name
- ObsATBGignaUrg (NCT07711756)
- Volunteers
- 191 people
- Sponsor
- University Hospital, Montpellier
Sinusitis, Maxillary Sinusitis
A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with amoxicillin/clavulanate potassium in the treatment of adults with rapid onset of severe inflammation/infection of…
- Trial name
- NCT00249210
- Testing
- levofloxacin
- Volunteers
- 614 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Rhinosinusitis
Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis
The trial was conducted as a prospective, randomized, multinational, multicenter, double-blind study in 4 parallel groups of patients.
- Trial name
- NCT04123405
- Testing
- acetylcysteine
- Where
- 37 sites in Bulgaria, Germany and 2 more
- Volunteers
- 944 people
- Sponsor
- Sandoz
Sinusitis Bacterial
Point-of-Care Immunoassay for Detection of Bacterial Sinusitis
This study is conducted to evaluate the performance of a rapid, point-of-care in vitro diagnostic device (Sinu-Test®) for the qualitative detection of the three most common pathogens responsible for causing bacterial sinusitis.
- Trial name
- NCT03584737
- Testing
- rapid in vitro diagnostic test, bacterial culture, PCR assay
- Where
- 7 sites in United States
- Volunteers
- 800 people
- Sponsor
- ENTvantage Dx
Acute Otitis Media, Acute Sinusitis
Comparative Effectiveness of Antibiotics for Respiratory Infections
The purpose of this study is to identify and use patient centered outcomes to compare narrow-spectrum and broad-spectrum antibiotics for the treatment of common acute respiratory tract infections (ARTIs) in children.
- Conditions
- Acute Otitis Media, Acute Sinusitis, Group A Streptococcal Pharyngitis
- Trial name
- CEARI (NCT02297815)
- Testing
- Broad-spectrum antibiotics, Narrow-spectrum antibiotics
- Where
- United States
- Volunteers
- 2,472 people
- Sponsor
- Children's Hospital of Philadelphia
Maxillary Sinusitis
A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Sinus Infections in Adults
The objectives of the study were to confirm that a single, 2.0-g dose of azithromycin sustained release (SR) was at least as effective to 10 days of oral levofloxacin 500 mg once a day, when used to treat adults with…
- Trial name
- NCT00643409
- Testing
- azithromycin SR (Zithromax; compound: CP-62,993), levofloxacin
- Where
- 89 sites in United States, Argentina and 11 more
- Volunteers
- 541 people
- Sponsor
- Pfizer