Clinical trials: Acute Respiratory Disease
Hematologic Disease
Early Application of CPAP in Hematologic
The purpose of this study is to evaluate the use of CPAP in the prevention of acute respiratory failure in neutropenic ( or hematologic malignancy ) patients .CPAP applied preventively in hematological patients with high risk of…
- Trial name
- HEMOCPAP (NCT00507533)
- Testing
- Continuous positive airway pressure
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Turin, Italy
Myocardial Disease
Cardiovascular Events for a Long Time End of COVID 19 Infection
In the follow-up of partecipants with Covid-19 infection, persistence of cardiovascular symptoms is common. Studies on the acute phase of Covid-19 infection have demonstrated a significant prevalence of acute myocardial damage…
- Trial name
- LONGCOVIDWP3 (NCT05729152)
- Testing
- Sample blood
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome
Anti-CD14 Treatment With IC14 in Hospitalized ARDS Patients
Hospitalized patients with ARDS will be randomized to intravenous treatment with a monoclonal antibody against CD14, called IC14, or placebo. They will be followed for 28 days.
- Conditions
- Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT06513949
- Testing
- Atibuclimab
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Implicit Bioscience
Chronic Obstructive Pulmonary Disease
BACE Trial Substudy 2 - FarmEc Substudy
A second sub-analysis of the BACE trial will include a detailed cost-effectiveness study.
- Trial name
- FarmEc (NCT02205255)
- Testing
- Azithromycin
- Where
- 20 sites in Belgium
- Volunteers
- 350 people
- Sponsor
- Wim Janssens
SARS-CoV-2, COVID-19
Data Analysis of the Cytokine Adsorption Treatment on Coronavirus Disease-19 (COVID-19) Patients With Respiratory Failure
Severe sepsis and septic shock are some of the leading causes of mortality in intensive care unit (ICU) admitted COVID-19 patients.
- Trial name
- CYTOAID (NCT04422626)
- Sponsor
- University of Pecs
Respiratory Syncytial Virus Infections
Identification and Clinical Validation of Biomarkers Associated With Clinical Severity in Adults Infected With RSV
A short description, 5000 characters Intro: Respiratory Syncytial Virus (RSV) is a frequent, ubiquitous agent of respiratory viral infections.
- Trial name
- ARF-RSV (NCT06197152)
- Testing
- Nasopharyngeal swabs and biological collection
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19, COVID-19 Respiratory Infection
Standardized Olive Leaf Capsules; as a Co-therapy in the Treatment of COVID-19 Patients
Starting from December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused a tremendous economic loss and unprecedented health crisis across the globe.
- Conditions
- Covid19, COVID-19 Respiratory Infection, Symptoms and Signs, COVID-19 Acute Bronchitis
- Trial name
- NCT04873349
- Testing
- Nusapure standardized olive leaves capsule, 750 mg (50% oleuropein)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Shimaa M. Abdelgawad
ARDS, Human, COVID-19 Acute Respiratory Distress Syndrome
Characterization of the microVAScular Dysfunction in Covid-19 ARDS
The primary endpoint of this research is to establish that the alveolar dead space is significantly higher in patients with COVID-19 ARDS, compared to patients with non-COVID-19 ARDS.
- Trial name
- VASCOV (NCT05074758)
- Testing
- alveolar dead-space quantification, Coagulation activation and impaired fibrinolysis explorations, Endothelial activation / endothelial senescence
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome, Adult
Early Versus Delayed Enteral Feeding to Treat People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN Study)
Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are medical conditions that occur when there is severe inflammation and increased fluids in both lungs, making it difficult for the lungs to function…
- Trial name
- EDEN (NCT00883948)
- Testing
- Minimal (Trophic) Feeding, Full Feeding
- Where
- 39 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Severe Acute Respiratory Syndrome
Study of Alferon® LDO (Low Dose Oral) in Normal Volunteers
The purpose of this trial is to conduct a randomized dose-ranging study to evaluate the safety and activity of orally administered low dose interferon alfa-n3 as an antiviral and immunomodulator in asymptomatic subjects with…
- Trial name
- NCT00215826
- Testing
- Alferon LDO
- Where
- Hong Kong
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AIM ImmunoTech Inc.
Covid19, SARS-CoV Infection
Prognosis and Course of COVID-19 Infection in Hospitalised Patients
The aim of the cohort prospective observational study is to define the major factors influencing the course of COVID-19 infections and its prognosis in hospitalised patients.
- Trial name
- NCT04752085
- Testing
- Chitotriosidase activity
- Where
- 2 sites in Russia
- Volunteers
- 345 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Acute Respiratory Distress Syndrome, Nosocomial Infection
Nosocomial Infections in ECMO Patients
Nosocomial Infections (NI) are a common and dreadful complication for patients suffering from Acute Respiratory Distress Syndrome (ARDS) treated with Extracorporeal Membrane Oxygenation (ECMO).
- Conditions
- Acute Respiratory Distress Syndrome, Nosocomial Infection, Extracorporeal Membrane Oxygenation Complication
- Trial name
- INF-ECMO (NCT05566665)
- Testing
- Collection of blood and bronchoalveolar samples to study Pharmacokinetics of ceftazidime/avibactam, meropenem/varbobactam, ceftolozane/tazobactam, or cefiderocol
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Policlinico Hospital
Hypoxia, Normobaric Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Normobaric Hypoxia, Altitude Hypoxia, Right Heart Function
- Trial name
- RIVER-H (NCT07431567)
- Testing
- Normobaric Hypoxia
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mona Lichtblau
Acute Lung Injury (ALI) Associated With COVID-19, Inflammatory Lung Conditions Associated With COVID-19
First in Human SAD and MAD Study of Inhaled TD-0903, a Potential Treatment for ALI Associated With COVID-19
This is a phase 1 study in healthy subjects to evaluate the safety, tolerability and pharmacokinetics of single (Part A and B) and multiple (Part B) doses of inhaled TD-0903.
- Trial name
- NCT04350736
- Testing
- TD-0903
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Acute Respiratory Distress Syndrome
To Evaluate The Safety and Initial Efficacy of STSA-1002 Injection in Patients With Acute Respiratory Distress Syndrome
To evaluate the safety and initial efficacy of STSA-1002 injection in patients with acute respiratory distress syndrome.
- Trial name
- NCT06038916
- Testing
- STSA-1002 Injection
- Where
- 30 sites in China
- Volunteers
- 47 people
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection
Efficacy, Safety, Tolerability of AXA1125 in Fatigue After COVID-19 Infection
This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving muscle function (metabolism) following moderate exercise in subjects with fatigue-Predominant Post-Acute…
- Trial name
- NCT05152849
- Testing
- AXA1125
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Axcella Health, Inc
Obesity
Impact of Black Pepper on Energy Expenditure and Substrate Utilization
As obesity rates worldwide continue to increase, there is a focus on identifying active food ingredients which increase metabolic rate which can be used as a dietary supplement in the treatment of overweight and obesity.
- Trial name
- NCT01729143
- Testing
- 24-hour energy expenditure and substrate utilization
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Congenital Diaphragmatic Hernia, Acute Kidney Injury
Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia
The main aim of this project is to elucidate the incidence of acute kidney injury (AKI) in newborns with congenital diaphragmatic hernia during stay in the Pediatric intensive care unit. (PICU).
- Conditions
- Congenital Diaphragmatic Hernia, Acute Kidney Injury, Multiple Organ Failure, Pulmonary Hypertension
- Trial name
- NCT06050525
- Where
- Sweden
- Volunteers
- 109 people
- Sponsor
- Karolinska Institutet
Sepsis, Acute Lung Injury
Statins for Acutely Injured Lungs From Sepsis
Objective: assess the efficacy and safety of oral rosuvastatin in patients with sepsis-induced Acute Lung Injury (ALI). Hypothesis: Rosuvastatin therapy will improve mortality in patients with sepsis-induced ALI.
- Trial name
- SAILS (NCT00979121)
- Testing
- Rosuvastatin
- Where
- 40 sites in United States
- Volunteers
- 745 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COVID-19
Treatment of COVID-19 Patients With Anti-interleukin Drugs
The purpose of this study is to test the safety and effectiveness of individually or simultaneously blocking IL-6 and IL-1 versus standard of care on blood oxygenation and systemic cytokine release syndrome in patients with…
- Trial name
- COV-AID (NCT04330638)
- Testing
- Usual Care, Anakinra, Siltuximab
- Where
- 15 sites in Belgium
- Volunteers
- 342 people
- Sponsor
- University Hospital, Ghent
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