Clinical trials: Acute Pancreatitis
Pancreatitis, Acute Necrotizing
Evaluation of Effect of Integrated Treatment by Traditional Chinese and Western Medicine for Severe Acute Pancreatitis
With multicenter randomized control clinical evaluation investigations, the scheme of integrated medicine treatment of severe acute pancreatitis (SAP) was further improved, and the therapeutic effects, safety and indications…
- Trial name
- NCT00506337
- Testing
- Qingyi granules
- Where
- 3 sites in China
- Volunteers
- 300 people
- Sponsor
- Tianjin Nankai Hospital
Endoscopic Retrograde Cholangiopancreatography (ERCP), Choledocholithiasis
Role of Prophylactic Aggressive Hydration to Prevent Post-ERCP Pancreatitis
Endoscopic Retrograde Cholangiopancreatography, also called ERCP, is a procedure used to diagnose and treat disorders of the bile ducts and pancreas.
- Conditions
- Endoscopic Retrograde Cholangiopancreatography (ERCP), Choledocholithiasis, Bile Duct Disorder, Biliary Obstruction
- Trial name
- NCT07417020
- Testing
- Aggressive intravenous hydration with lactated Ringer's solution, Standard intravenous hydration with lactated Ringer's solution
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Lahore General Hospital
Acute Necrotizing Pancreatitis, Portosplenomesenteric Venous Thrombosis
Acute Pancreatitis and Thrombosis (PATHRO)
Severe acute pancreatitis (AP) is a pathology with high morbidity and mortality. Portosplenomesenteric vein thrombosis is a well-known local complication of AP with a variable incidence, which can reach up to 50% in case of…
- Trial name
- PATHRO (NCT04642794)
- Testing
- observational study
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Nantes University Hospital
Acute Pancreatitis Due to Gallstones
Inmediate Feeding Tolerance in Acute Pancreatitis
Objective: Determine tolerance of immediate oral intake (8 hours posterior to the beginning of treatment) against traditional management (early feeding at 48hr) in patients with mild acute pancreatitis of biliary origin.
- Trial name
- NCT03354065
- Testing
- TIME OF FEEDING
- Volunteers
- 59 people
- Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"
Acute Pancreatitis
Treatment of Acute Pancreatitis With Ketorolac
Patients with acute pancreatitis will be randomly assigned in either study group to receive oral (injection) Ketorolac or the control group. In patients who cannot tolerate oral medications, ketorolac injection will be used.
- Trial name
- NCT02885441
- Testing
- Ketorolac
- Where
- Iran
- Volunteers
- 56 people
- Sponsor
- Ilam University of Medical Sciences
Pancreatitis, Acute
Prophylaxis of Post-ERCP Acute Pancreatitis
This study aims to compare indomethacin and the combination of indomethacin and aggressive lactated Ringer infusion in terms of efficacy in preventing post-ERCP acute pancreatitis (PEP).
- Trial name
- PEPPER (NCT05381428)
- Testing
- Indomethacin suppository, Indomethacin suppository and high-flow lactated ringer infusion combination
- Where
- 10 sites in Italy
- Volunteers
- 184 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Hyperchylomicronemia
CS-121 APOC3 Base Editing in Children and Adolescents With Hyperchylomicronemia
This is a Prospective, Single-center, Open-label, Single-arm Clinical Study to Evaluate the Safety and Efficacy of CS-121, an In Vivo Base Editing Therapy Delivered by Lipid Nanoparticles Targeting APOC3, in Children and…
- Trial name
- NCT07371767
- Testing
- CS-121
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Acute Pancreatitis (AP), Inflammatory Indices
Utilization of CBC-Derived Inflammatory Indices in Assessing Severity and Prognosis of Acute Pancreatitis.
Utilization of CBC-Derived Inflammatory Indices in Assessing Severity and Prognosis of Acute Pancreatitis.
- Trial name
- NCT07233551
- Testing
- CBC derived inflammatory indices
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Kidney Injuries
C-reactive Protein & Albumin Ratio IN AKI
Acute pancreatitis (AP), defined as acute inflammation of the pancreas, it's one of the most common diseases of the gastrointestinal tract leading to hospital admission.(1) The global incidence of AP is reported between 20 and 40…
- Trial name
- NCT07335757
- Testing
- C-reactive protein to albumin ratio
- Volunteers
- 150 people
- Sponsor
- Assiut University
Pancreatic Necrosis
Predicting Pancreatic Necrosis Using mitDNA
Multiple predictors have been used for early pancreatic necrosis, prediction, detection, and monitoring. These include clinical score systems and circulating biomarkers.
- Trial name
- NCT03788928
- Testing
- serum mitochondrial DNA
- Volunteers
- 25 people
- Sponsor
- Assiut University
Acute Pancreatitis, Necrotizing Pancreatitis
Timing of Transmural Stent Removal in Necrotizing Pancreatitis
Although metal stents have been widely used in the endoscopic step-up approach for necrotizing pancreatitis, the exact timing of transmural stent removal has not been well studied.
- Conditions
- Acute Pancreatitis, Necrotizing Pancreatitis, Walled-Off Necrosis
- Trial name
- TTSRNP (NCT04963868)
- Testing
- Stent removed by the novel strategy, Stent removed by the conventional strategy
- Where
- China
- Volunteers
- 156 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Familial Chylomicronemia Syndrome (FCS)
CS-121 APOC3 Base Editing in FCS
This is an open-label, single-arm, dose-escalation Phase I clinical trial to evaluate the safety, tolerability, pharmacodynamics (PD), and pharmacokinetics (PK) of CS-121, an in vivo base editing therapy delivered by lipid…
- Trial name
- NCT07176923
- Testing
- CS-121
- Where
- China
- Volunteers
- 15 people
- Sponsor
- CorrectSequence Therapeutics Co., Ltd
Acute Pancreatitis, Intra-Abdominal Hypertension
Predictive Ability of Intra-Abdominal Pressure for Mortality in Patients With Severe Acute Pancreatitis
Severe Acute Pancreatitis (SAP) is an acute inflammatory condition of the pancreas characterized by organ dysfunction and increased mortality.
- Trial name
- NCT04525027
- Testing
- intra-abdominal pressure in severe acute pancreatitis
- Where
- India
- Volunteers
- 360 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Pancreatitis
Effects of Peripherally Acting µ-opioid Receptor Antagonists on Acute Pancreatitis
This study will investigate the effect of peripheral acting opioid antagonist (PAMORA) on the disease course of patients with acute inflammation of the pancreas (acute pancreatitis).
- Trial name
- NCT04743570
- Testing
- Methylnaltrexone treatment
- Where
- 4 sites in Denmark
- Volunteers
- 105 people
- Sponsor
- Asbjørn Mohr Drewes
Acute Pancreatitis
Evaluation of Intravenous Fluid Therapy Within Dallas Acute Pancreatitis Protocol
Acute pancreatitis (AP) is a common disease of the gastrointestinal tract that can result in emotional, physical, and financial burdens on the patient.
- Trial name
- NCT06223594
- Testing
- Intravenous Fluid Therapy
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Methodist Health System
Acute Pancreatitis
Study of SGC001 Injection for Predicted Severe Acute Pancreatitis to Assess Safety, Tolerability and Preliminary Efficacy
This is an early phase clinical study. Patients who are at high risk of developing severe acute pancreatitis will be screened. Participants will be randomly assigned to receive either SGC001 injection or a placebo injection that…
- Trial name
- NCT07803965
- Testing
- SGC001 injection
- Where
- 15 sites in China
- Volunteers
- 129 people
- Sponsor
- Beijing Sungen Biomedical Technology Co., Ltd
Post-ERCP Acute Pancreatitis
Post-ERCP Pancreatitis Prevention by Stent Insertion
The presented study is designed to analyze the efficacy of pancreatic stent insertion in patients undergoing ERCP with accidental cannulation of the pancreatic duct.
- Trial name
- PEPSI (NCT01673763)
- Testing
- Stent insertion into the main pancreatic duct
- Where
- 4 sites in Belgium, Germany and 2 more
- Volunteers
- 169 people
- Sponsor
- Technical University of Munich
Acute Pancreatitis, Severe Acute Pancreatitis
Fecal Microbiota Transplantation (FMT) in Patients With Moderate to Severe Acute Pancreatitis
This study is a randomized, double-blind and placebo-controlled study. The purpose of this study is to evaluate the efficacy and safety of FMT in patients with moderate to severe acute pancreatitis.
- Trial name
- NCT07153809
- Testing
- FMT
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Changhai Hospital
Pancreatitis, Acute
COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis
Acute pancreatitis is the most common and feared complication of ERCP, occurring after 1% to 30% of procedures. Since 2012, a multicenter RCT was published in NEJM, indomethacin use in high risk patients was considered a…
- Trial name
- NCT02964403
- Testing
- Cox-2, Indomethacin
- Volunteers
- 2,700 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pancreatitis, Acute
Election of the Optimal Moment of Colecistectomy After Mild Biliary Pancreatitis
Introduction Acute pancreatitis is the third gastrointestinal cause of hospital admission. It is estimated that 35-60% have a biliary origin, and most of them are mild.
- Trial name
- NCT04625712
- Testing
- Cholecystectomy
- Volunteers
- 220 people
- Sponsor
- Consorci Sanitari Integral