Clinical trials: Acute Pain
Coronary Artery Disease, Atherosclerosis of Coronary Artery
Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold System in the Treatment of Subjects With Long de Novo Lesions
The study objective is the assessment of safety and clinical performance of Freesolve 35- and 40-mm in de novo coronary artery lesions up to 38 mm length.
- Conditions
- Coronary Artery Disease, Atherosclerosis of Coronary Artery, Myocardial Ischemia, Ischemic Heart Disease
- Trial name
- BIOMAG-LL (NCT07091682)
- Testing
- Implantation of a Sirolimus-Eluting Resorbable Coronary Magnesium Scaffold
- Where
- 14 sites in Germany, Hungary and 5 more
- Volunteers
- 100 people
- Sponsor
- Biotronik AG
Sickle Cell Anemia Crisis
Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
The purpose of this study is to determine whether IV acetaminophen can decrease the need for subsequent opioid administration in the acute management of sickle cell crisis pain in the pediatric emergency room.
- Trial name
- NCT03541980
- Testing
- Acetaminophen, Normal saline
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Newark Beth Israel Medical Center
Arthroplasty, Replacement, Hip
Effects of Photobiomodulation Therapy (PBMT) in Total Hip Arthroplasty
Osteoarthritis (OA), a chronic degenerative muscle disease characterized by cartilage wear, causes progressive joint deformity and loss of function leading to the indication of total hip arthroplasty (THA), when conservative…
- Trial name
- NCT02970890
- Testing
- Portable Pain Away™
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Adriane Aver Vanin
Post Operative Pain, Acute
Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment
This randomized controlled trial aims to evaluate the effect of two different concentrations of sodium hypochlorite (2.5% and 5.25%) on post-operative pain following single-visit root canal treatment.
- Trial name
- NaOCl-RCT (NCT07618182)
- Testing
- Sodium Hypochlorite Irrigation
- Volunteers
- 116 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Pancreatitis, Chronic Pancreatitis
Internet-Delivered Pain Self-Management for Persons With Acute Recurrent and Chronic Pancreatitis Pain
Severe and disabling abdominal pain is common in individuals with chronic pancreatitis. Although pain is associated with reduced quality of life and high economic and societal costs, there are limited effective options for pain…
- Conditions
- Pancreatitis, Chronic Pancreatitis, Acute Recurrent Pancreatitis
- Trial name
- IMPACT-2 (NCT06386224)
- Testing
- Internet-delivered pain self-management (CBT Condition), Education Program
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Seattle Children's Hospital
Acute Abdomen, Ileus
Rectus Sheath Catheters Following Midline Laparotomy
Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC.
- Conditions
- Acute Abdomen, Ileus, Colorectal Carcinoma
- Trial name
- NCT07099924
- Testing
- Ropivacaine 0.2%, Saline 0.9%
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Acute Pain
Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy
Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in…
- Trial name
- NCT02645903
- Testing
- Transversus Abdominis Plane Block, standard general anesthesia
- Volunteers
- 50 people
- Sponsor
- Inonu University
Pancreatitis, Acute, Pain, Acute
Comparison of the Effectiveness of Paracetamol With Ibuprofen or Paracetamol With Metamizole in Treating Pain in Acute Pancreatitis in Children
The aim of the study is to assess the effectiveness and tolerance of pain treatment in AP in children using intravenous paracetamol in combination with ibuprofen or paracetamol in combination with metamizole.
- Conditions
- Pancreatitis, Acute, Pain, Acute, Pancreatic Disease, Pancreatic Diseases
- Trial name
- NCT07024199
- Testing
- The initial pain assessment, Drug administration according to protocol (paracetamol + ibuprofen OR paracetamol + metamizol), The effectiveness of the treatment
- Where
- Poland
- Volunteers
- 78 people
- Sponsor
- Medical University of Warsaw
Anemia; Sickle-Cell, With Crisis, Acute Pain
Ketamine Infusion for Sickle Cell Pain Crisis
The purpose of this study is to prospectively study the efficacy of low dose ketamine infusions in treating patients who are admitted to the hospital with a sickle cell pain crisis.
- Trial name
- NCT04005209
- Testing
- Ketamine, Pain management
- Where
- United States
- Sponsor
- Duke University
Pain
Hydrocodone/Acetaminophen for Acute Pain Following Third Molar Tooth Extraction
The purpose of this study was to evaluate analgesic efficacy and safety of hydrocodone/acetaminophen compared to placebo in moderate to severe pain following molar extraction.
- Trial name
- NCT00935311
- Testing
- ABT-712 Extended-release, Hydrocodone/Acetaminophen Immediate-release
- Where
- 3 sites in United States
- Volunteers
- 122 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Acute Pain, Bunionectomy
A Clinical Trial of GRT7040 in Adults With Acute Pain Following Bunionectomy
This is a Phase 2 clinical trial of GRT7040, currently being developed for the treatment of moderate-to-severe acute pain. The primary purpose of this trial is to assess efficacy and safety of GRT7040 compared with placebo in…
- Trial name
- NCT07807644
- Testing
- GRT7040, Hydrocodone bitartrate/ acetaminophen (HB/APAP)
- Volunteers
- 400 people
- Sponsor
- Grünenthal GmbH
Back Pain, Muscle Pain
Transcutaneous Electrical Nerve Stimulation for Back Pain in the Emergency Department (TENS-ED)
The effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) to reduce pain scores for patients with acute back pain in an ambulatory emergency department (ED) population will be examined in this dual-center, cluster…
- Conditions
- Back Pain, Muscle Pain, Acute Pain, Lower Back Pain
- Trial name
- TENS-ED (NCT05601843)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sam Brophy
Musculoskeletal Pain
Acetaminophen (APAP) +/- Oxycodone
This is an emergency department based randomized study of oxycodone/ acetaminophen versus acetaminophen alone for patients with acute musculoskeletal pain refractory to ibuprofen
- Trial name
- NCT04122443
- Testing
- Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- Montefiore Medical Center
Pain, Acute, Pain, Chronic
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
Evaluation of the effect of the AI500™ SINGLE-DOSE GEL medical device in patients with reduced knee function
- Conditions
- Pain, Acute, Pain, Chronic, Knee Injuries, Knee Osteoarthritis
- Trial name
- NCT05886608
- Testing
- AI 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Diaphragm Injury
Comparison of Supraclavicular and Costoclavicular Brachial Plexus Blocks in Adult Patients
Hemidiaphragmatic paresis is a common side effect of brachial plexus blocks such as supraclavicular or infraclavicular block techniques.
- Trial name
- NCT06329440
- Testing
- Ultrasonographic measurement of diaphragm thickness
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Post Operative Pain, Acute
A Comparative Study Between Ultrasound Guided Thoracic Paravertebral Block VS Serrartus Anterior Muscle Block in VATS as Regard Their Effectiveness in Post-operative Analgesia
A comparative study between ultrasound guided thoracic paravertebral block VS ultrasound guided serrartus anterior muscle block in video-assisted thoracoscopic surgeries as regard their effectiveness in post-operative analgesia
- Trial name
- NCT05971368
- Testing
- thoracic paravertebal block, serratus anterior muscle block
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Migraine, Pain
A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain
A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain.
- Conditions
- Migraine, Pain, Nausea, Vomiting
- Trial name
- NCT03877718
- Testing
- Arm 1: CL-H1T, Arm 2: CL-H1T, Arm 3: Sumatriptan Succinate 100 mg capsule
- Where
- 3 sites in United States
- Volunteers
- 475 people
- Sponsor
- Charleston Laboratories, Inc
Pain, Postoperative, Acute Pain
Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures
The purpose of this study is to assess the effectiveness of pre-operative administration of gabapentin 900 mg in management of acute post-operative pain in patients undergoing oral and maxillofacial surgical procedures.
- Conditions
- Pain, Postoperative, Acute Pain, Facial Pain
- Trial name
- NCT02957097
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Pain, Acute
Bilateral Quadraus LUMBORUM Block in Patients Under Going Cystectomy
ultrasound guided quadratus lumborum will be given for patients under going partial or complete urinary bladder removal.
- Trial name
- NCT03853460
- Testing
- epidural catheter, nerve block catheter
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Preventive Medicine
Preventing Chronicity of Sub-acute Low Back Pain by Altering the Neural Emotional Response to Pain
Aim of the study It could be stated that chronification of low back pain in some respects depends on the emotional reactions to the acute pain state.
- Trial name
- NCT05450263
- Testing
- Interoceptive exposure
- Where
- Finland
- Sponsor
- Orton Orthopaedic Hospital