Clinical trials: Acute Illness
Acute Respiratory Distress Syndrome, Critical Illness
Prevention of Ulinastatin on Acute Respiratory Distress Syndrome (ARDS)
Since strategies were applied in intensive care medicine, including low tidal volume ventilation, fluid resuscitation, use of antibiotics, restrictive transfusion strategy and bundle of ventilator therapy, the incidence of Acute…
- Trial name
- NCT03089957
- Testing
- Ulinastatin, Usual care
- Where
- 10 sites in China
- Volunteers
- 840 people
- Sponsor
- Peking University Third Hospital
Acute Respiratory Failure, Critically Ill
Heparin Binding Protein in Patients With Acute Respiratory Failure Treated With GCSF (Filgrastim)
This is a study of plasma HBP -levels of a previously published trial of G-CSF in critically ill patients (Pettila et al. Critical Care Medicine 2000).
- Trial name
- HBP-Neupogen (NCT01713309)
- Testing
- Filgrastim
- Where
- Finland
- Volunteers
- 59 people
- Sponsor
- Helsinki University Central Hospital
Acute Lung Injury, Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation in Acute Lung Injury
The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Mechanical Ventilation
- Trial name
- NCT00750204
- Testing
- APRV, Conventional MV
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Acute Respiratory Distress Syndrome, Critical Illness
A Study Promoting Critical Illness Recovery in the Elderly
This proposal will test the hypothesis that EARLY application of a novel early rehabilitation therapy in critically ill patients will improve functional outcomes, and change the functional trajectory of this population.
- Conditions
- Acute Respiratory Distress Syndrome, Critical Illness, Critical Care
- Trial name
- ASPIRE (NCT02963558)
- Testing
- cycle ergometry
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Community-Acquired Pneumonia (CAP), Pneumonia
Clinical Impact of Rapid Molecular Testing for Pathogens in Patients With Severe Acute Respiratory Illness : A Pragmatic Trial
Community-acquired pneumonia (CAP) is among the most common reasons for emergency department (ED) visits. A clear understanding of the likely pathogens is essential for the rapid institution of adequate antimicrobial therapy.
- Trial name
- CIRT-RMT-SARI (NCT06605352)
- Testing
- The BIOFIRE®FILMARRAY® Pneumonia Panel
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- National Taiwan University Clinical Trial Center
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent
Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment
With the aging of society, the use of cardiac pacing in patients with irreversible bradycardia is increasingly widespread. As early as the 1950s, right ventricular pacing (RVP) began to be used in patients with atrioventricular…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- NCT05575557
- Testing
- Right heart catheterization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Acute Mountain Sickness, Healthy
Training in Hypoxia to Prevent Acute Mountain Sickness
Some studies suggest that high-altitude related illnesses - like acute mountain sickness - could be prevented by acclimatisation, reached at low altitude using training in simulated altitude.
- Trial name
- NCT00886912
- Testing
- hypoxia, normoxia
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Acute Febrile Illness, Melioidosis
Diagnostic Accuracy of the DPP II Assay
Burkholderia pseudomallei is responsible for melioidosis, a disease that can present a range of signs and symptoms and can be treated by a specific drug regimen.
- Conditions
- Acute Febrile Illness, Melioidosis, Diagnoses Disease
- Trial name
- NCT04299412
- Testing
- DPP Fever Panel II assay
- Where
- Australia
- Volunteers
- 104 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Acute Mountain Sickness
The Effect of Continuous Positive Pressure Ventilation on Symptoms of Acute Mountain Sickness
Acute Mountain Sickness (AMS) is a common condition affecting individuals traveling to elevations greater than 2500 meters (8200 feet).
- Trial name
- NCT06145113
- Testing
- Continuous positive airway pressure (CPAP), ResMed AirMini
- Where
- Nepal
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Critical Illness, Selenium Deficiency
The Prognostic Impact of Selenium On Critical Surgical Patients
Selenium is an important trace element for human for its multiple roles such as the antioxidant activity. Previous evidences showed that critically ill patients may benefit from selenium supplement but the dose and results are…
- Conditions
- Critical Illness, Selenium Deficiency, Trace Element Deficiency, Acute Abdomen
- Trial name
- NCT04662242
- Testing
- Selenium Supplement, normal saline
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Respiratory Failure
Randomized Trial of Sedative Choice for Intubation
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death.
- Trial name
- RSI (NCT05277896)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 2,367 people
- Sponsor
- Vanderbilt University Medical Center
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Illness
Care Anywhere With Community Paramedics Program to Reduce Hospitalization
The purpose of this research is to compare the effectiveness of the Care Anywhere with Community Paramedics program with usual care in a pragmatic randomized controlled trial.
- Trial name
- NCT05232799
- Testing
- Care Anywhere with Community Paramedics program
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Mayo Clinic
Respiratory Disorders
Infectious Pathogens in Acute Respiratory Illness in Adults and Elderly
The aim of this study is to generate epidemiological data to further explore determinants of Chronic Obstructive Pulmonary Disease (COPD) and the contribution of bacterial and viral pathogens to Acute Exacerbation of COPD…
- Trial name
- NCT01360398
- Testing
- Blood sample, Sputum sample, Nasopharyngeal swab
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- GlaxoSmithKline
Critical Illness, Heart Failure
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress
Serious acute heart and lung illnesses like heart failure, severe COVID, and sepsis often leave survivors struggling not only physically, but also with lasting depression, anxiety, and stress.
- Conditions
- Critical Illness, Heart Failure, Sepsis, Ards
- Trial name
- Lift 3 (NCT07634419)
- Testing
- Lift mobile mindfulness, Enlighten Recovery education program
- Where
- 3 sites in United States
- Volunteers
- 450 people
- Sponsor
- Duke University
Acute Viral Bronchitis, Hypoxemic Respiratory Failure
NHF vs. COT in Hypoxemic Pandemic Viral Illness
The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
- Conditions
- Acute Viral Bronchitis, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- HIVI (NCT04750408)
- Testing
- Standard oxygen, Nasal high-flow
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Jens Bräunlich
Influenza, Influenza -Like Illness
Efficacy and Safety of Norketotifen in Uncomplicated Influenza-like Illness
This is a Phase 2b, multi-center, double-blind, randomized, placebo-controlled, parallel-group study of NKT versus placebo in otherwise healthy adults presenting with acute uncomplicated ILI due to influenza or other respiratory…
- Trial name
- NCT04610047
- Testing
- Norketotifen
- Where
- 20 sites in United States
- Volunteers
- 315 people
- Sponsor
- Emergo Therapeutics, Inc.
Multiple Chronic Conditions, Acute Disease
Digital, Innovative, Sustainable, and Knowledge-based Acute Municipal Healthcare Services Illness and Trauma
Through introducing physicians in front in the medical assessment and decision-making processes in acute and sub-acute illness in the municipalities, as well as including machine learning in analyzing prospective and…
- Trial name
- NCT05708768
- Testing
- Receiving physician manned rapid response car services
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Ostfold University College
Healthy, Chronic Stable Illness
Study Assessing the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Repeated Subcutaneous Doses of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (REGN10933+REGN10987) in Adult Volunteers as Related to COVID-19
The primary objectives are: To assess the occurrence of adverse events of special interest (AESIs) in participants treated with repeated subcutaneous (SC) doses of REGN10933+REGN10987 compared to placebo To assess the…
- Trial name
- NCT04519437
- Testing
- REGN10933+REGN10987
- Where
- 7 sites in United States
- Volunteers
- 974 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Fever, Orthostatic Hypotension
Orthostatic Hypotension in Children With Acute Febrile Illness
Objective:to determent if children suffering from acute febrile illness has higher rate of orthostatic hypotension compared with children with no febrile illness. Design: a prospective cohort study.
- Trial name
- NCT00452712
- Testing
- All subjects will have their blood pressure measured in supine position (after 5 minute of rest) and after 3 minute of standing.
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center