Clinical trials: Acute Hypoxemic Respiratory Failure
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients
High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding…
- Trial name
- PRO-WEAN HFNC (NCT07452406)
- Testing
- Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Rush University Medical Center
ARDS (Moderate or Severe), AHRF
STimulation to Activate RespIration
Multi-center, randomized, controlled, open-label Phase 2 feasibility trial. Subjects on mechanical ventilation (MV) for acute hypoxemic respiratory failure (AHRF) with lung injury (including subjects who meet criteria for acute…
- Conditions
- ARDS (Moderate or Severe), AHRF, Mechanically Ventilated ICU Patients
- Trial name
- STARI (NCT06832306)
- Testing
- Phrenic Nerve Stimulation
- Where
- 7 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Lungpacer Medical Inc.
Respiratory Failure Without Hypercapnia, Respiratory Failure With Hypercapnia
Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)
Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations.
- Conditions
- Respiratory Failure Without Hypercapnia, Respiratory Failure With Hypercapnia, Postoperative Respiratory Complication
- Trial name
- NCT06988111
- Testing
- BIPAP, Vapotherm
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Assiut University
Acute Hypoxemic Respiratory Failure
Bag CPAP vs Standard Oxygen Therapy in Acute Hypoxemic Respiratory Failure
Acute Hypoxemic Respiratory Failure (AHRF) is one of the prevalent causes of admission around the world and is associated with high mortality in resource-limited settings.
- Trial name
- BAGCPAP-R (NCT07460427)
- Testing
- Bag CPAP, Standard oxygen
- Where
- Rwanda
- Volunteers
- 250 people
- Sponsor
- Prof RWABIHAMA Jean Paul
Acute Hypoxemic Respiratory Failure, Sepsis
EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) remains a major cause of respiratory failure and mortality in critically ill patients.
- Conditions
- Acute Hypoxemic Respiratory Failure, Sepsis, ARDS (Acute Respiratory Distress Syndrome)
- Trial name
- EARLY-SARDS (NCT07281911)
- Testing
- Serial bronchoalveolar lavage and biological-physiological assessment
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Hypoxemic Respiratory Failure, COVID 19
Predictive Model for High-Flow Nasal Cannula Failure in COVID-19-related Acute Hypoxemic Respiratory Failure Based on Metabolomics and Clinical Data
The aim of this prospective observational cohort study is to develop a predictive model for high-flow nasal cannula (HFNC) failure in patients with acute hypoxemic respiratory failure (AHRF) caused by SARS-CoV-2.
- Trial name
- COVIDOMICS (NCT06695442)
- Where
- Spain
- Volunteers
- 111 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Acute Respiratory Failure
Non-Positive Pressure Ventilation in Hypoxemic Patients
The study is aimed to assess the possible benefit of non-positive pressure mechanical support in front of conventional ventilation in patients admitted to the intensive care unit (ICU) because of pure hypoxemic respiratory…
- Trial name
- NCT00925860
- Testing
- non positive pressure mechanical ventilatory support
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Hospital Provincial de Castellon
Acute Hypoxemic Respiratory Failure
Prediction of Duration of Mechanical Ventilation in Acute Hypoxemic Respiratoty Failure
Acute hypoxemic respiratory failure (AHRF) is a common cause of admission in intensive care units (ICUs) worldwide. We will assess machine learning (ML) techniques for prediction of prolonged duration (> or = to 7 days) of…
- Trial name
- PREMIER (NCT06815523)
- Testing
- Machine learning and logistic regression for the training/testing cohort and validation cohort
- Where
- 2 sites in Spain
- Volunteers
- 1,241 people
- Sponsor
- Jesus Villar
Acute Respiratory Failure (ARF)
The Effects of Different Non-invasive Respiratory Support
Patients with acute hypoxemic respiratory failure (AHRF) typically present with pathophysiological alterations characterized by the coexistence of respiratory dysfunction and hypoxemia.
- Trial name
- NCT07247318
- Testing
- Continuous Positive Airway Pressure, Non-invasive ventilation, High-flow nasal oxygen
- Volunteers
- 60 people
- Sponsor
- Southeast University, China
Acute Respiratory Insufficiency
Prevalence and Outcome of Acute Hypoxemic Respiratory Failure
This study is an extension of the Spanish Initiative for Epidemiology, Stratification and Therapies of Acute respiratory failure (SIESTA) Network.
- Trial name
- PANDORA (NCT03145974)
- Testing
- mechanical ventilation
- Where
- 24 sites in Spain
- Volunteers
- 1,400 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Acute Hypoxemic Respiratory Failure
Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia
Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia.
- Trial name
- PROSA (NCT06931938)
- Testing
- Awake Prone Positioning
- Where
- Germany
- Volunteers
- 342 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Respiratory Failure
Physiologic Effects of High Flow Nasal Therapy in Patients With Acute Hypoxemic Respiratory Failure (OPTIFLOW)
The aim of the study is to assess, in patients with acute hypoxemic respiratory failure, the short term physiologic effects of the high flow oxygen nasal therapy (Optiflow), in term of inspiratory muscle effort, gas exchange…
- Trial name
- NCT01056952
- Testing
- O2stand, CPAP, Optiflow
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bordeaux
Acute Hypoxemic Respiratory Failure
Impact of End-tidal Oxygen Monitoring During Preoxygenation Before Intubation for Acute Hypoxemic Respiratory Failure in ICU Setting
The main objective of this pilot study is to determine if our protocole using EtO2 monitoring during preoxygenation before intubation is feasible in a population of critically ill patients in acute hypoxemic respirator failure…
- Trial name
- PFOX (NCT06198504)
- Testing
- Protocol using end-tidal oxygen monitoring during preoxygenation before intubation
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Grenoble
Pneumonia-associated Acute Hypoxemic Respiratory Failure
Non-invasive Ventilation Versus High Flow Oxygen
The purpose of the study is to compare the efficacy of alternating Non Invasive Ventilation NIV and High Flow Oxygen HFO compared to High Flow Oxygen HFO alone on gas exchanges and prognosis in pneumonia-associated acute…
- Trial name
- HFO (NCT03758508)
- Testing
- High Flow Oxygen nasal cannula, Noninvasive ventilation
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Niguarda Hospital
Sleep Quality, Hypoxemic Acute Respiratory Failure
Sleep Quality and Risk of Intubation in Intensive Care Units Patients With Hypoxemic Acute Respiratory Failure
The aim of the study is to evaluate the impact of sleep quality on intubation rate in intensive care units patients with acute respiratory failure
- Conditions
- Sleep Quality, Hypoxemic Acute Respiratory Failure, Intubation Risk
- Trial name
- HIGH SLEEP (NCT02907008)
- Testing
- Polysomnography
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Poitiers University Hospital
Acute Viral Bronchitis, Hypoxemic Respiratory Failure
NHF vs. COT in Hypoxemic Pandemic Viral Illness
The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
- Conditions
- Acute Viral Bronchitis, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- HIVI (NCT04750408)
- Testing
- Standard oxygen, Nasal high-flow
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Jens Bräunlich
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT)
High flow nasal oxygen therapy (HFNO) is an established modality in the supportive treatment of patients suffering from acute hypoxemic respiratory failure.
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure, Respiratory Depression, Respiratory Failure
- Trial name
- CLOUDHFOT (NCT06374589)
- Testing
- Closed-loop FiO2 controller, Conventional
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Acute Hypoxemic Respiratory Failure
Impact of Current Volume Under High-rate Nasal Oxygen Therapy During Acute Hypoxemic Respiratory Failure de Novo
De novo acute hypoxemic respiratory failure (AHRF) is associated with high overall mortality, which increases significantly with the use of orotracheal intubation.
- Trial name
- IVOXY (NCT03919331)
- Testing
- Assessment of tidal volume using Electrical Impedance Tomography (EIT) during high flow nasal canula(HFNC)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, Critical Illness
Impact and Sequelae of High Ventilatory Drive in Critically Ill COVID-19 Patients
Critically ill COVID-19 patients with acute respiratory failure, in the intensive care unit (ICU), often feature high respiratory drive, determining large inspiratory efforts resulting in high pressures and global and regional…
- Conditions
- COVID-19, Critical Illness, Hypoxemic Respiratory Failure, Neurocognitive Dysfunction
- Trial name
- NCT05363332
- Where
- 3 sites in Spain
- Volunteers
- 126 people
- Sponsor
- Corporacion Parc Tauli