Clinical trials: Acute Hypoxemic Respiratory Failure
Hypoxemic Acute Respiratory Failure, Non Invasive Ventilation (NIV)
Bioelectric Impedance in Non-invasive Ventilated Patients: The NIVAR Study.
Investigators performed a retrospective observational single-centre study in a cohort of COVID-19 patients with AHRF who required NIV support and intensive care unit (ICU) admission from May 2021 to January 2022.
- Conditions
- Hypoxemic Acute Respiratory Failure, Non Invasive Ventilation (NIV), Bioimpedance Measurement Capacity
- Trial name
- NIVAR (NCT06996197)
- Testing
- Bioimpedance analysis
- Where
- 2 sites in Spain
- Volunteers
- 74 people
- Sponsor
- Hospital Universitari de Bellvitge
Acute Hypoxemic Respiratory Failure
Respiratory Mechanics Assessment During Assisted Mechanical Ventilation
To verify the association between respiratory system mechanical properties (ΔP, ΔPL,dyn, Pmus, Pplat and CRS and CL,dyn) assessed during assisted modes of ventilation (as average over the first three days since enrollment) and…
- Trial name
- ICEBERG (NCT05203536)
- Where
- 8 sites in Canada, Germany and 3 more
- Volunteers
- 298 people
- Sponsor
- University of Milano Bicocca
Acute Hypoxemic Respiratory Failure
Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation
Pressure support ventilation (PSV) is used to assist the breathing of the intubated patient with some pressure from the ventilator.
- Trial name
- PUMA (NCT06494085)
- Testing
- Measuring Respiratory Mechanics, Randomized Pressure Support
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
EIT-Guided Ventilator Settings in AHRF
This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and…
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NCT06936618
- Testing
- Electrical Impedance Tomography (EIT), Enlight 2100
- Where
- Thailand
- Volunteers
- 17 people
- Sponsor
- Mahidol University
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure
The current standard of care (SOC) for treatment of patients with acute respiratory distress syndrome (ARDS), inhalation injury, volume overload, and/or pulmonary dysfunction is mechanical ventilation (MV).
- Conditions
- Acute Hypoxemic Respiratory Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT06938217
- Testing
- Low-flow ECMO
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Institute for Extracorporeal Life Support
Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure
The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
While most studies in the medical literature that indicate "music" as an intervention may recognize its impact and capacity to decrease pain perception, anxiety, and/or its role in the regulation of cardiac and respiratory…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
- Trial name
- NCT03642002
- Testing
- Toning, Ocean drum & SOK melody, SOK
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure
Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout.
The goal of this pilot randomized cross-over study is to compare the effect of a full-face mask with expiratory washout to a conventional full face mask on non-invasive ventilation (NIV) in patients with acute hypercapnic, and…
- Trial name
- NCT06007495
- Testing
- Investigational full-face mask with expiratory washout, Conventional full-face mask - single-limb, Conventional full-face mask - dual-limb
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- Fisher and Paykel Healthcare
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Oxygen Therapy
Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial
Acute hypoxemic respiratory failure (AHRF) is a common indication for admission to an intensive care unit (ICU), with mortality exceeding 50% in cases where invasive mechanical ventilation is needed.
- Conditions
- Acute Hypoxemic Respiratory Failure, High-Flow Nasal Oxygen Therapy, Noninvasive Ventilation, Continuous Positive Airway Pressure (CPAP)
- Trial name
- TRIPOD (NCT06795971)
- Testing
- Continuous Positive Airway Pressure, High-flow nasal oxygen, Non-invasive ventilation
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Southeast University, China
Hypoxemic Acute Respiratory Failure
Closed Loop Oxygen Control in INtubated Critically Ill Patients
The deleterious effects of alveolar hyperoxia and (severe) hyperoxaemia are well described. Achieving safe and efficient oxygenation may be challenging.
- Trial name
- CLOC-IN (NCT06829732)
- Testing
- closed-loop oxygen control (CLOC), 2. manual oxygen titration (MOT)
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Parc Taulí Hospital Universitari
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT)
High flow nasal oxygen therapy (HFNO) is an established modality in the supportive treatment of patients suffering from acute hypoxemic respiratory failure.
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure, Respiratory Depression, Respiratory Failure
- Trial name
- CLOUDHFOT (NCT06374589)
- Testing
- Closed-loop FiO2 controller, Conventional
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Acute Hypoxemic Respiratory Failure, Diaphragm Injury
Feasibility of Transvenous Phrenic Nerve Stimulation for Diaphragm Protection in Acute Respiratory Failure
This is a single-center proof-of-concept clinical trial designed to establish the feasibility of transvenous phrenic-nerve stimulation (PNS) to maintain diaphragm activation over the first 24 hours and for up to seven days of…
- Conditions
- Acute Hypoxemic Respiratory Failure, Diaphragm Injury, Lung Injury
- Trial name
- STIMULUS (NCT05465083)
- Testing
- Lungpacer AeroPace Protect System
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Acute Hypoxemic Respiratory Failure
A Novel Index to Predict the Failure of High-flow Nasal Cannula in Patients with Acute Hypoxemic Respiratory Failure
High-flow nasal cannula (HFNC) is increasingly used in patients with acute hypoxemic respiratory failure (AHRF) and has been shown to improve outcome in specific patient categories, including community acquired pneumonia and…
- Trial name
- NCT05549882
- Testing
- no intervention
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Southeast University, China
Acute Hypoxemic Respiratory Failure, COVID 19
Predictive Model for High-Flow Nasal Cannula Failure in COVID-19-related Acute Hypoxemic Respiratory Failure Based on Metabolomics and Clinical Data
The aim of this prospective observational cohort study is to develop a predictive model for high-flow nasal cannula (HFNC) failure in patients with acute hypoxemic respiratory failure (AHRF) caused by SARS-CoV-2.
- Trial name
- COVIDOMICS (NCT06695442)
- Where
- Spain
- Volunteers
- 111 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Acute Hypoxemic Respiratory Failure
Predictors of HFNC Failure in Patients With AHRF Using Diaphragm Ultrasound
Ultrasound of the diaphragm is an easily reproducible bedside tool that provides a non-invasive measurement of inspiratory muscle function and respiratory efficiency.
- Trial name
- ULTRAFLOW (NCT06096376)
- Testing
- Diaphragm Ultrasound
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Acute Hypoxemic Respiratory Failure
Predictors of HFNC Failure in Patients With AHRF Using Echocardiography Parameters
Right ventricular dysfunction (RVD) and right ventricular-pulmonary arterial (RV-PA) uncoupling detected by transthoracic echocardiography (TTE) in acute respiratory distress syndrome (ARDS) are associated with poor survival.
- Trial name
- AHRF-ECHO (NCT06096363)
- Testing
- Transthoracic Echocardiography
- Where
- Hong Kong
- Volunteers
- 28 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Acute Hypoxemic Respiratory Failure
ROX Index for the Timing of Intubation in Nasal High Flow
Late or delayed intubation in patients with acute hypoxemic respiratory failure (AHRF) treated with nasal high flow (NHF) is associated with increased patient mortality.
- Trial name
- ROX-1 (NCT04707729)
- Testing
- ROX index algorithm
- Where
- 12 sites in United States, China and 1 more
- Volunteers
- 630 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Hypoxemic Respiratory Failure
Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study
About 65,000 Canadians develop acute respiratory failure requiring breathing machines (ventilators) to give oxygen to their lungs. Unfortunately, up to 50% of these individuals will not survive their illness.
- Trial name
- AiCLOSE (NCT05196074)
- Testing
- Acute hypoxemic respiratory failure patients on VV-ECMO
- Where
- Canada
- Volunteers
- 299 people
- Sponsor
- Lorenzo delSorbo
Acute Hypoxemic Respiratory Failure
Comparison Physiological Effects According to Preoxygenation Method Using EIT
Hypoxemia during endotracheal intubation is one of this procedure's most frequent and severe complications, which can lead to cardiac arrest and other adverse outcomes.
- Trial name
- PreoxyEIT (NCT05962073)
- Testing
- HFNC
- Where
- South Korea
- Sponsor
- Samsung Medical Center
COVID-19, Acute Hypoxemic Respiratory Failure
Early Versus Delayed Intubation of Patients With COVID-19
Although management of acute hypoxemic respiratory failure associated with coronavirus disease 2019 (COVID-19) often includes mechanical ventilation, the optimal timing of initiation of invasive mechanical ventilation remains…
- Trial name
- EUDOCO (NCT04632043)
- Testing
- Endotracheal intubation
- Where
- Greece
- Volunteers
- 2 people
- Sponsor
- Evangelismos Hospital
Acute Hypoxemic Respiratory Failure
Impact of End-tidal Oxygen Monitoring During Preoxygenation Before Intubation for Acute Hypoxemic Respiratory Failure in ICU Setting
The main objective of this pilot study is to determine if our protocole using EtO2 monitoring during preoxygenation before intubation is feasible in a population of critically ill patients in acute hypoxemic respirator failure…
- Trial name
- PFOX (NCT06198504)
- Testing
- Protocol using end-tidal oxygen monitoring during preoxygenation before intubation
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Grenoble