Clinical trials: Acute Hypoxemic Respiratory Failure
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome
EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure
We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF).
- Trial name
- EPIPHANY (NCT05150483)
- Where
- Greece
- Volunteers
- 350 people
- Sponsor
- Evangelismos Hospital
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT)
High flow nasal oxygen therapy (HFNO) is an established modality in the supportive treatment of patients suffering from acute hypoxemic respiratory failure.
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure, Respiratory Depression, Respiratory Failure
- Trial name
- CLOUDHFOT (NCT06374589)
- Testing
- Closed-loop FiO2 controller, Conventional
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Mechanical Power
Use of 'Mechanical Power' as a Predictor of Increased Serum and Pulmonary Proinflammatory Cytokine Concentrations in Patients With Acute Hypoxemic Respiratory Failure: A Prospective Observational Study
The aim of this study is to report the proportion of patients with acute hypoxemic respiratory failyre (AHRF) undergoing mechanical ventilation who exceed 17 J/min of mechanical power (MP) and the difference in terms of…
- Trial name
- NCT06425354
- Testing
- Mechanical ventilation
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza
Acute Hypoxemic Respiratory Failure
Is Hypoxemia Driving Outcome in Acute Hypoxemic Respiratory Failure? (HOMELAND Study)
Acute hypoxemic respiratory failure (AHRF) is the most common cause of admission in the intensive care units (UCIs) worldwide. The investigators will assess the value of mediation analysis (a statistical method to understand the…
- Trial name
- HOMELAND (NCT07708506)
- Testing
- mediation analysis
- Where
- 18 sites in Spain, United Kingdom
- Volunteers
- 1,241 people
- Sponsor
- Jesus Villar
Acute Hypoxemic Respiratory Failure
HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT
This Randomized Control Trial will directly compare helmet non-invasive ventilation (NIV) combined with high flow nasal oxygen (HFNO) versus HFNO alone in patients with Acute Hypoxemic Respiratory Failure (AHRF).
- Trial name
- HONOUR (NCT05078034)
- Testing
- Helmet Non-Invasive Ventilation (HNIV), High Flow Nasal Oxygen
- Where
- 11 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Acute Respiratory Failure With Hypercapnia
High Flow Nasal Oxygen Therapy in Perioperative Period of the Adult With Hypercapnic and Hypoxemic Respiratory Faliure
The purpose of this study is to determine the impact of hign-flow nasal therapy on the adult with hypercapnia and hpoxemia respiratory faliure in comparison with standard oxygen therapy ang noninvasive ventilation.
- Trial name
- NCT03229460
- Testing
- standard low flow therapy, high flow nasal oxygen therapy, association of high flow nasal oxygen therapy and non invasive positive pressure ventilation
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Acute Hypoxemic Respiratory Failure
Predictors of HFNC Failure in Patients With AHRF Using Diaphragm Ultrasound
Ultrasound of the diaphragm is an easily reproducible bedside tool that provides a non-invasive measurement of inspiratory muscle function and respiratory efficiency.
- Trial name
- ULTRAFLOW (NCT06096376)
- Testing
- Diaphragm Ultrasound
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Acute Respiratory Failure With Hypoxia, Hypoxemia
Conduct of Nasal High Flow Oxygen in Acute Respiratory Failure
Although many studies have investigated the clinical benefits of nasal high flow during acute hypoxemic respiratory failure, there is no data (and even less so recommendations) on how to best conduct this technique, including its…
- Trial name
- DECIPHEROBS (NCT03311087)
- Where
- 10 sites in France
- Volunteers
- 100 people
- Sponsor
- Hôpital Louis Mourier
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Early Switch From Controlled to Assisted Ventilation
The goal of this physiological intervention study is to unravel the (patho)physiological mechanisms and potential clinical benefits of a pre-specified early switch from controlled to assisted ventilation in mechanically…
- Trial name
- SWITCH-SAFE (NCT06438198)
- Testing
- Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome
A Randomized Study to Investigate the Effect of Intravenous Imatinib on the Amount of Oxygen in the Lungs and Blood of Adults With COVID-19 Needing Mechanical Ventilation and Supportive Care.
The COVID-19 pandemic has led to an increase in the number of patients admitted to intensive care units (ICU) with acute respiratory distress syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome, Covid19, ARDS
- Trial name
- IMPRESS COVID (NCT04953052)
- Testing
- Imatinib Mesylate
- Where
- 8 sites in India
- Sponsor
- Exvastat Ltd.
Hypoxemic Acute Respiratory Failure
Apneic Oxygenation With High-flow Nasal Oxygenation After Preoxygenation With Noninvasive Ventilation Before Intubation in Hypoxemic Patients in Intensive Care Unit.
The aim of this clinical study is to assess whether apneic oxygenation with High-Flow Nasal Oxygen (HFNO) would decrease the incidence of severe hypoxemia compared to no apneic oxygenation during the intubation procedure (from…
- Trial name
- APNEIC (NCT07189338)
- Testing
- Apneic oxygenation, Usual Care
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Tours
Pneumonia
A Clinical Trial to Evaluate agenT-797 Plus Standard of Care in Participants With Severe Pneumonia With Moderate to Severe Acute Hypoxemic Respiratory Failure
This clinical trial will evaluate the efficacy and safety of a single intravenous dose of agenT-797 administered in addition to standard of care (SOC), compared with placebo plus SOC, in reducing short-term mortality in adult…
- Trial name
- NCT07615010
- Testing
- agenT-797, Standard of Care (SOC)
- Where
- 4 sites in United States, Ukraine
- Volunteers
- 90 people
- Sponsor
- MiNK Therapeutics
Acute Respiratory Insufficiency
Prevalence and Outcome of Acute Hypoxemic Respiratory Failure in Wales
This study is aimed to establish the epidemiological chacacteristics and clinical outcomes of mechanically ventilated patients with acute hypoxemic respiratory failure admitted in a network of hospitals from Wales (U.K.).
- Trial name
- PANDORAWALES (NCT03358043)
- Testing
- mechanical ventilation
- Where
- 12 sites in United Kingdom
- Volunteers
- 1,100 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Covid 19, Hypoxemic Respiratory Failure
Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia
The COVID-19 outbreak is associated with a surge in ICU bed requirement and substantial mortality (estimated between 0.5% and 1%).
- Trial name
- AIRVM-COVID (NCT04357457)
- Testing
- Almitrine
- Where
- France
- Volunteers
- 181 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Hypoxemic Respiratory Failure, Hematologic Malignancy
Effectiveness of High Flow Oxygen Therapy in Patients With Hematologic Malignancy Acute Hypoxemic Respiratory Failure
Effectiveness of high flow oxygen therapy in patients with hematologic malignancy acute hypoxemic respiratory failure
- Trial name
- HFOT (NCT03133520)
- Testing
- High flow oxygen therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Kursat Gundogan
Respiratory Failure, Hypoxemia
High-flow Nasal Cannula vs. Helmet PSV vs. Helmet CPAP During Respiratory Failure
The investigators designed a cross-over, randomized trial to assess the physiological effects of helmet pressure support ventilation (PSV) and continuous positive airway pressure (CPAP) as compared to high-flow nasal cannula…
- Trial name
- HIGHFLOWHELMET (NCT04241861)
- Testing
- Respiratory support (High-flow oxygen therapy), Respiratory support (Helmet PSV), Respiratory support (Helmet CPAP)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pneumonia, Bacterial, Respiratory Failure
CPAP Therapy Through a Helmet or a Full Face Mask in Patients With Acute Hypoxemic Respiratory Failure: Cross-over Study
Observational and randomized trials have demonstrated the high effectiveness of non-invasive helmet ventilatory support, demonstrating a reduction in intubation rate mortality compared with high-flow and standard oxygen therapy.
- Conditions
- Pneumonia, Bacterial, Respiratory Failure, COVID-19 Pneumonia
- Trial name
- NCT06113432
- Testing
- Arterial blood gases, Respiratory rate (RR), Pulseoximeter
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure
Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout.
The goal of this pilot randomized cross-over study is to compare the effect of a full-face mask with expiratory washout to a conventional full face mask on non-invasive ventilation (NIV) in patients with acute hypercapnic, and…
- Trial name
- NCT06007495
- Testing
- Investigational full-face mask with expiratory washout, Conventional full-face mask - single-limb, Conventional full-face mask - dual-limb
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- Fisher and Paykel Healthcare
Acute Respiratory Failure
Brain-lung Interaction During Acute Respiratory Failure
Acute hypoxemic de novo respiratory failure (AHRF) is a common cause of admission to the intensive care unit (ICU). Its main cause is community-acquired pneumonia.
- Trial name
- BrainFlow (NCT07279831)
- Testing
- EEG/NIRS/EMG
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Hypoxemic Respiratory Failure
Machine Learning Model to Predict Outcome in Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure (AHRF) is the most common cause of admission in the intensive care units (UCIs) worldwide. We will assess the value of machine learning (ML) techniques for early prediction of ICU death in…
- Trial name
- MEMORIAL (NCT06333002)
- Testing
- machine learning analysis
- Where
- 8 sites in Spain
- Volunteers
- 1,241 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín