Clinical trials: Acute Heart Failure, open to volunteers
Heart Failure
HeartMed-HF Digital Therapeutics Improves Exercise Capacity in CHF Patients After AMI
Chronic heart failure (HF) is a severe manifestation and terminal stage of various cardiovascular diseases, with high incidence and mortality rates.
- Trial name
- NCT06478732
- Testing
- health services
- Volunteers
- 710 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Heart Decompensation, Acute, Acute Kidney Injuries
POCUS-Guided Diuresis for Decompensated Heart Failure
Heart failure occurs when the heart cannot pump blood effectively, leading to fluid buildup in the body. This can cause problems such as difficulty breathing, swelling, and extreme tiredness.
- Trial name
- POCUSHF-GD (NCT06921603)
- Testing
- Furosemide (Standard Diuretic) Treatment, POCUS-Assessed Diuretic Management
- Where
- 5 sites in United States
- Volunteers
- 588 people
- Sponsor
- University of Pittsburgh
Heart Failure, Acute Heart Failure
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.
- Trial name
- REDEFINE-HF (NCT06008197)
- Testing
- Finerenone
- Where
- 356 sites in United States, Argentina and 24 more
- Volunteers
- 5,200 people
- Sponsor
- Colorado Prevention Center
Chronic Respiratory Failure, Cardiac Disease, Pulmonary Disease
Advanced Respiratory Monitoring and Oxygen Therapy in Chronically Ill Patients With Acute Respiratory Failure
This study is testing whether a new type of home oxygen therapy, called high-flow nasal cannula (HFNC), can improve breathing comfort and quality of life for people with long-term lung or heart conditions who need oxygen after…
- Conditions
- Chronic Respiratory Failure, Cardiac Disease, Pulmonary Disease, Acute Respiratory Failure (ARF)
- Trial name
- HOME- Oxygen (NCT07157696)
- Testing
- High-Flow Nasal Cannula (HFNC) Oxygen Therapy, Oxygen therapy
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Università degli Studi di Ferrara
Acute Decompensated Heart Failure (ADHF)
Bedside NT-proBNP Monitoring in Acute Heart Failure
The goal of this observational study is to investigate the association between dynamic changes in NT-proBNP levels and clinical decongestion status in patients with acute decompensated heart failure (ADHF) receiving…
- Trial name
- NCT07762521
- Testing
- Serial NT-proBNP Measurement
- Volunteers
- 50 people
- Sponsor
- Mao Chen
Chest Pain, Stroke Acute
Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).
Improving Telephone Triage in Emergency Calls with AI The Coordinating Centre for Urgencies and Emergencies in Andalusia (CCUE) handles thousands of calls every day.
- Conditions
- Chest Pain, Stroke Acute, Respiratory Failure, Cardiac Arrest (CA)
- Trial name
- TrIAje Project (NCT07247669)
- Where
- Spain
- Volunteers
- 5,000,000 people
- Sponsor
- Centro de Emergencias Sanitarias 061 Andalucía
Transplant; Failure, Heart
Non-ischaemic Heart Preservation Versus Standard Cold Storage in Human Heart Transplantation
The overall aim of this study is to compare a new state-of-the-art ex-vivo organ preservation method with standard ischemic cold static storage of donor hearts in adult cardiac transplantation.
- Trial name
- NIHP2 (NCT04066127)
- Testing
- Non-ischemic heart preservation (NIHP), Standard ischemic cold static storage (SCS)
- Where
- Sweden
- Volunteers
- 66 people
- Sponsor
- Region Skane
Inflammation, Cardiovascular Diseases
Inflammation in Acute Cardiovascular Diseases - the CArdiovascular Inflammation Registry (CAIR)
Following acute cardiovascular injury, inflammation is vital to activate reparative mechanisms. However, there is compelling evidence implicating excessive inflammation and dysregulated resolution in fibrosis, ventricular…
- Conditions
- Inflammation, Cardiovascular Diseases, Myocarditis, Pericarditis
- Trial name
- CAIR (NCT06411340)
- Testing
- Observation
- Volunteers
- 1,000 people
- Sponsor
- King's College London
Critically Ill, Acute Respiratory Failure
The EXCEL Registry of Patients Requiring ECMO
ECMO is associated with significant costs, risks and requires specialist training and expertise. EXCEL is a novel, high-quality, detailed prospective registry of patients requiring ECMO in Australia and New Zealand.
- Conditions
- Critically Ill, Acute Respiratory Failure, Acute Heart Failure, Cardiac Arrest
- Trial name
- NCT03793257
- Where
- 29 sites in Australia, New Zealand
- Volunteers
- 3,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Heart Failure With Reduced Ejection Fraction (HFrEF)
Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)
The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy.
- Trial name
- ECHO-LBBp (NCT06689111)
- Testing
- Left bundle branch pacing lead, CRT with the standard method through cs
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital of Patras
Acute Myocardial Infarction, Heart Failure
Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention
We aimed to identify whether SGLT-2 inhibitor administration before and after coronary intervention is effective in reducing the size of infarction and myocardial remodeling in patients with acute myocardial infarction (AMI) and…
- Trial name
- PRESTIGE-AMI (NCT04899479)
- Testing
- SGLT2 inhibitor, Control
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Acute Heart Failure
a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure
The goal of this observational is to study the prevalence of distinct congestion phenotypes and study their association with response to therapy and outcomes in acute heart failure patients.
- Trial name
- PROFILE-AHF (NCT06587854)
- Where
- Netherlands
- Volunteers
- 270 people
- Sponsor
- University Medical Center Groningen
Cardiogenic Shock, Myocardial Infarction (MI)
BEAT-SHOCK Registry
This regulation defines the purpose, the operational processes, and the organization of the registry BEAT-SHOCK (Basel Evaluation of Acute Therapy in cardiogenic SHOCK).
- Conditions
- Cardiogenic Shock, Myocardial Infarction (MI), Fulminant Myocarditis, Acute Decompensated Heart Failure
- Trial name
- BEAT-SHOCK (NCT07643610)
- Testing
- no internvention
- Where
- Switzerland
- Volunteers
- 8,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Heart Disease (CHD), Cardio-pulmonary Bypass
Protective Effect of EECP Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery
Enhanced external counterpulsation (EECP) is a noninvasive, non-pharmacologic intervention proven to increase nitric oxide bioavailability in patients with coronary artery disease.
- Conditions
- Coronary Heart Disease (CHD), Cardio-pulmonary Bypass, Congestive Heart Failure Chronic, Cardiogenic Shock Acute
- Trial name
- PANDA (NCT06728605)
- Testing
- Enhanced External Counterpulsation (EECP)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanjing Medical University
Heart Failure, Heart Failure Acute
Lesser Poland Cracovian Heart Failure Registry
The goal of Lesser Poland Cracovian Heart Failure Registry (LECRA-HF) is to expand the knowledge about acute heart failure (AHF) and its long-term prognosis.
- Trial name
- LECRA-HF (NCT05746923)
- Where
- Poland
- Volunteers
- 2,500 people
- Sponsor
- Jagiellonian University
Critical Illness, Heart Failure
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress
Serious acute heart and lung illnesses like heart failure, severe COVID, and sepsis often leave survivors struggling not only physically, but also with lasting depression, anxiety, and stress.
- Conditions
- Critical Illness, Heart Failure, Sepsis, Ards
- Trial name
- Lift 3 (NCT07634419)
- Testing
- Lift mobile mindfulness, Enlighten Recovery education program
- Where
- 3 sites in United States
- Volunteers
- 450 people
- Sponsor
- Duke University
Heart Failure
heaRtInsiGHT Alert guIDE: RightAIDE Application of the HeartInsight Acute Heart Failure Predictor in Routine Clinical Practice: Organizational Models and Workflow.
The RightAIDE study is a prospective, multicenter, observational registry designed to evaluate the real-world application of the HeartInsight™ algorithm for predicting acute heart failure (HF) events in patients implanted with a…
- Trial name
- RightAIDE (NCT07281859)
- Where
- 13 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Padova
Heart Failure，Congestive, Atrial Fibrillation
The Cardio-share Telemedicine Cross-sector Collaboration Model for Managing Vulnerable Patients With Heart Failure
The goal of this observational study is to explore the potential of implementing a telemedicine-based cross-sector collaboration model to manage patients with frequent admissions with decompensated heart failure.
- Trial name
- ADHFQUAL-BFH (NCT06176131)
- Testing
- Telemedicine-based cross-sector collaboration for patient management
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Acute MI, Heart Failure
Cardiovascular Kidney and Metabolic Health Assessment and Patient Empowerment
The primary objective of CHAPERONE solution is to evaluate the efficacy of engaging, assessing, and enabling long term treatment strategy with Health Artificial Intelligence (AI) Chatbot, Copilot, Large Language Model (LLM) and…
- Conditions
- Acute MI, Heart Failure, Diabetes Mellitus, Kidney Disease
- Trial name
- CHAPERONE-CKM (NCT07403669)
- Testing
- CHAPERONE AI, CKMiq AI, Quality of Life
- Where
- 5 sites in United States, Sweden
- Volunteers
- 300 people
- Sponsor
- Aventyn, Inc.
Heart Failure, Heart Failure - NYHA II - IV
Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared…
- Conditions
- Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Acute, Acute Heart Failure (AHF)
- Trial name
- US-DASH (NCT07263035)
- Testing
- Furosemide intravenous solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Lakeland Regional Health Systems, Inc.