Clinical trials: Acute Diarrhea
Acute Gastroenteritis
Novel Diagnostics and Probiotics to Improve Management of Paediatric Acute Gastroenteritis
Many children admitted to hospital in Botswana without bloody diarrhoea are presumed to have viral gastroenteritis and so not treated with antibiotics - but they may indeed have a treatable cause for their illness.
- Trial name
- NCT02025452
- Testing
- Rapid diagnostic, Probiotic
- Where
- 3 sites in Botswana
- Volunteers
- 76 people
- Sponsor
- Jeffrey Pernica
Zinc Deficiency, Child Nutrition Disorders
Daily Zinc Supplement Effect on Prevention of Diarrhea and Acute Respiratory Infections in Children Less Than Five Years
Zinc deficiency in children is a major problem which leads to compromised immunity and accordingly repeated infections. This study aims to investigate the effect of supplementing zinc to decrease the incidence of diarrhea and…
- Trial name
- RCTZ (NCT05002101)
- Testing
- zinc
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Acute Childhood Diarrhea
Impact of Training on Diarrhoea Management
Alternative, sustainable interventions in support of zinc treatment for childhood diarrhea need to be identified. Within the NGO sector, direct provision of health services is provided, however some NGOs also work closely with…
- Trial name
- NCT02143921
- Testing
- Training intervention
- Where
- Bangladesh
- Volunteers
- 1,160 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Diarrhea
A Comparison of Three Medications to Treat Diarrhea in Adults.
A comparison of three medications to treat diarrhea in adults.
- Trial name
- NCT00807326
- Testing
- Loperamide/simeticone 2 mg/125 mg caplets, Loperamide/simeticone 2 mg/125 mg chewable tablets, Probiotic Saccharomyces boulardii 250 mg capsules
- Where
- 6 sites in India, Mexico
- Volunteers
- 415 people
- Sponsor
- McNeil AB
Acute Gastroenteritis
Optimizing the Management of Acute Diarrhoeal Disease
Many children admitted to hospital in Botswana without bloody diarrhoea are presumed to have viral gastroenteritis and so not treated with antibiotics - but they may indeed have a treatable cause for their illness.
- Trial name
- NCT02803827
- Testing
- Rapid diagnostics, Probiotic
- Where
- 4 sites in Botswana
- Volunteers
- 276 people
- Sponsor
- Hamilton Health Sciences Corporation
Diarrhea
Influence of Carob and Probiotics on Acute Diarrhea in Children
Comparison of Carob powder with probiotics vs oral hydration solution in diarrhea treatment in children.
- Trial name
- NCT01501305
- Testing
- Mineral solution, Carob powder with probiotics
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
Incidence of Acute Diarrhea, Incidence of Abdominal Pain
Comparing the Efficacy of Different Zinc Formulations in the Treatment of Diarrhea
This project is aimed to evaluate the efficacy of two different zinc formulations (dispersible Zinc tablets versus Zinc suspension) for the treatment of acute diarrhea in hospital based settings.
- Trial name
- Zinc (NCT00682955)
- Testing
- Zinc Sulphate
- Where
- 2 sites in Pakistan
- Volunteers
- 300 people
- Sponsor
- Aga Khan University
Acute Watery Diarrhoea
Efficacy of Zinc Sulfate With Probiotics for the Treatment of Acute Diarrhea in Children
Diarrheal disease is one of the major causes of morbidity and mortality in children under five. Disease is treated symptomatically with oral rehydration (ORS) as a basic measure.
- Trial name
- Zinc (NCT01140074)
- Testing
- Zinc Sulfate
- Where
- 2 sites in Poland
- Volunteers
- 256 people
- Sponsor
- University Hospital No 1 Wroclaw
Diarrhea
Efficacy and Safety Study of Loperamide Hydrochloride/Simethicone Chewable Tablet in Treatment of Acute Diarrhea With Abdominal Discomfort and Flatulence
The purpose of this study is to evaluate the efficacy and safety of combined loperamide hydrochloride and simethicone compared to loperamide hydrochloride monotherapy in treating acute diarrhea associated with abdominal…
- Trial name
- NCT02340481
- Testing
- Loperamide hydrochloride + simethicone chewable tablet, Loperamide hydrochloride
- Where
- 4 sites in China
- Volunteers
- 217 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Gastroenteritis
Efficacy of Two Probiotic Preparations in Children With Acute Diarrhoea
The purpose of this study is to determine which of two different preparations of probiotics is effective in the treatment of acute viral diarrhoea in children.
- Trial name
- NCT02080130
- Testing
- Saccharomyces boulardii, Probiotics combination
- Where
- Mexico
- Sponsor
- Sinaloa Pediatric Hospital
Acute Diarrhea
Effects of Probiotics and/or Prebiotics on the Duration of Diarrhea and Hospitalization in Children
Acute diarrhea continues to be a major cause of childhood morbidity and mortality in developed and developing countries. Prevention and treatment of dehydration are the mainstays of therapy.
- Trial name
- PROBAGE (NCT01927094)
- Testing
- Probiotic, ORS
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 1,280 people
- Sponsor
- Eskisehir Osmangazi University
Diarrhea, Respiratory Infection
Micronutrient Sprinkles in a Daycare Center
Diarrheal diseases are a major cause of morbidity and mortality globally in children less than 5 years of age. Prolonged diarrhea, recurrent infections and growth failure in developing countries are usually a consequence of…
- Trial name
- NCT00967551
- Testing
- Micronutrient Sprinkles with zinc, Micronutrient sprinkles without zinc
- Where
- Brazil
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Emory University
Acute Gastroenteritis
Fortified Oral Rehydration Therapy for Pediatric Diarrhea
The goal of this clinical trial is to compare amino acid-fortified oral rehydration therapy (ORT) to the standard of care ORT in pediatric patients with acute gastroenteritis (AGE).
- Trial name
- fORT (NCT06137014)
- Testing
- Fortified Oral Rehydration Therapy, Standard of Care Oral Rehydration Therapy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Paul A Breslin
Fissure in Ano, Diarrhea
The Efficacy of Asacol (Mesalazine) Suppository on the Treatment of Diarrhea-Induced Acute Fissure
Anal fissure define as a superficial tearing in mucosa on the anoderm surface distal to dentate line . The most important factor is hard stool passing with trauma to anal mucosa.
- Trial name
- NCT05091775
- Testing
- Asacol is used to treat and prevent mild to moderate acute fissure disease
- Where
- Iran
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Severe Acute Malnutrition, Persistent Diarrhea
Trial of Rice-Based F-75 in Severe Malnutrition & Persistent Diarrhea in Children (SAM-RICE Study)
The goal of this study is to find out if a rice-based version of the F-75 therapeutic food helps children with severe acute malnutrition (SAM) and persistent diarrhea recover better than the standard commercial F-75.
- Conditions
- Severe Acute Malnutrition, Persistent Diarrhea, Children
- Trial name
- SAM-RICE (NCT07070856)
- Testing
- WHO-recommended standard therapeutic milk used for stabilization phase in SAM), HO-recommended Rice based therapeutic milk used for stabilization phase in SAM)
- Where
- 2 sites in Pakistan
- Volunteers
- 320 people
- Sponsor
- Children's Hospital and Institute of Child Health, Multan
Acute Infectious Diarrhoea in Children
Isoleucine Added ORS in Children With Diarrhoea
Efforts are continuing to improve the efficacy of oral rehydration solution in terms of reducing the severity (stool volume) and duration of diarrhoea (enhancement of recovery).
- Trial name
- NCT01034228
- Testing
- ORS + Isoleucine, ORS without Isoleucine
- Where
- Bangladesh
- Volunteers
- 50 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Viral Diarrhea
Effect of the Use of Probiotic S. Boulardii on Acute Viral Inflammatory Diarrhea Diagnosed With Multiplex PCR.
Acute diarrhea (AD) has been a public health problem throughout the history of Mexico. According to the epidemiological surveillance system, between 2008-2017, five to six million new cases of AD occurred per year.
- Trial name
- NCT05226052
- Testing
- Saccharomyces boulardii (Floratil 600mg)
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Instituto Mexicano del Seguro Social
Acute Gastroenteritis, Diarrhea
Surveillance Study of Acute Gastroenteritis in Hospitalized Children in Rural Area in Lebanon
Acute gastroenteritis is a common cause of hospitalization in children with significant socioeconomic burden on the health community, we will follow in this observational and analytical study the admitted cases of acute…
- Conditions
- Acute Gastroenteritis, Diarrhea, Rotavirus
- Trial name
- SAGE (NCT02177799)
- Where
- Lebanon
- Volunteers
- 150 people
- Sponsor
- Shaikh Ragheb Harb Hospital
Diarrhea
Clinical Trial in Children Between 3 Months and 14 Years Old to Evaluate the Efficacy and Safety of Gelatin Tannate in the Treatment of Acute Diarrhea (INDIGO)
To evaluate the safety, global efficacy and rapidity of action of GT in children with acute gastroenteritis taking ORS solution.
- Trial name
- INDIGO (NCT04065529)
- Testing
- Gelatin tannate (GT) + oral rehydration solution (ORS) + Zinc supplementation
- Where
- Senegal
- Volunteers
- 150 people
- Sponsor
- Ferrer Internacional S.A.
Acute Watery Diarrhea
Safety and Efficacy of Racecadotril in Children With Acute Watery Diarrhea
Acute watery diarrhea is a common cause of illness and hospitalization in children under five years of age, particularly in developing countries.
- Trial name
- NCT07392931
- Testing
- Racecadotril
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Punjab Rangers Teaching Hospital Lahore