Clinical trials: Acute Chest Pain
Chest Pain, Acute Coronary Syndrome
Computerized Medical History Taking for Acute Chest Pain
The aim is to determine the additional value of computerized, patient-entered medical histories for the management of patients presenting at the emergency department with chest pain.
- Trial name
- CLEOS-CPDS (NCT03439449)
- Testing
- CLEOS software program, Physician taken history
- Where
- Sweden
- Volunteers
- 2,000 people
- Sponsor
- Karolinska Institutet
Coronary Artery Disease, Acute Coronary Syndrome
A Registry Study on Genetics and Biomarkers of Acute Coronary Syndrome
This is a national registry study to determine genetics risk factors and serial biomarkers of Acute Coronary Syndrome.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Acute Myocardial Infarction, Unstable Angina
- Trial name
- ARSGB-ACS (NCT03752515)
- Where
- 6 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Thoracic Surgery, Video-Assisted
Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection
Intercostal cryoanalgesia is a technique that allows extensive and prolonged analgesia of the hemithorax. The aim of this study is to demonstrate the efficacy of intercostal cryoanalgesia as an adjunct to a single-injection…
- Conditions
- Thoracic Surgery, Video-Assisted, Cryotherapy Effect, Paravertebral Block
- Trial name
- CRYO-VATS (NCT05896150)
- Testing
- Cryoanalgesia AND single-injection paravertebral block, Single-injection paravertebral block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Acute Coronary Syndrome, Acute Myocardial Infarction
Switching From Cardiac Troponin I to T
Cardiac troponin is central to the diagnosis of myocardial infarction and high-sensitivity cardiac troponin (hs-cTn) assays are the preferred choice for the assessment of patients with suspected acute coronary syndrome.
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Acute Myocardial Ischemia, Myocardial Injury
- Trial name
- TWITCH-ED (NCT05748691)
- Testing
- Clinical implementation of hs-cTnT
- Where
- United Kingdom
- Volunteers
- 26,000 people
- Sponsor
- University of Edinburgh
Acute Coronary Syndrome (ACS), STEMI - ST Elevation Myocardial Infarction (MI)
Implementing Precision Medicine Approaches to Guide Anti-platelet Selection
The study aims to determine the feasibility and clinical utility of incorporating precision medicine approaches, incorporating both cytochrome P450 2C19 (CYP2C19) genotyping and platelet reactivity phenotyping, with standard of…
- Conditions
- Acute Coronary Syndrome (ACS), STEMI - ST Elevation Myocardial Infarction (MI), NSTEMI - Non-ST Segment Elevation MI, Unstable Angina (UA)
- Trial name
- NCT04090281
- Testing
- CYP2C19 genotyping
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Southern California
Atherosclerosis
Strategy for Unstable Coronary Plaque in Patients Presenting to Emergency Department for Chest Pain Suspected of Coronary Artery Disease
Primary prevention of coronary disease and especially its major complication, inaugural myocardial infarction, is based on any prodromal symptoms identification and on risk profile establishment.
- Trial name
- SPECTRE (NCT06013722)
- Testing
- 18F-Na PET Scan
- Where
- Monaco
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Chest Pain, Surgery
Assessment of Intercostal Block Scheduling in Preventing Acute Surgical and Post-surgical Pain in Thoracoscopic Surgery
It is well known that chest surgery patients suffer from high level pain in the perioperative period. The transition to thoracoscopic approaches reduced surgical pain.
- Trial name
- NCT02469610
- Testing
- Intercostal block Bupivacaine based
- Where
- Israel
- Volunteers
- 65 people
- Sponsor
- Carmel Medical Center
Chest Pain, Acute Coronary Syndrome
Validation of Simple Acute Coronary Syndrome (SACS) Score
This prospective observational study will evaluate and compare the sensitivity and specificity of the Modified TIMI, HEART and SACS Scores for accurately predicting the presence and absence of obstructive coronary artery disease…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Angina, Myocardial Infarction
- Trial name
- SACS (NCT02358148)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Bayfront Health St Petersburg
Acute Coronary Syndromes, Chest Pain
AI-ECG Detection of Occlusion Myocardial Infarction at Emergency Department Triage (TRIACS)
Chest pain is among the most common reasons people attend an emergency department, and the electrocardiogram (ECG) recorded at triage is the first test used to decide who needs urgent treatment for a blocked coronary artery.
- Conditions
- Acute Coronary Syndromes, Chest Pain, Myocardial Infarction (MI), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- TRIACS-MB (NCT07882849)
- Where
- Slovenia
- Volunteers
- 1,000 people
- Sponsor
- University Medical Centre Maribor
Coronary Syndrome
RNA as Prognostic Biomarkers in Patients With Acute Coronary Syndrome
Identify circulating protein-coding (mRNAs) or non-coding (ncRNAs) transcripts (ACS_signature) predictive of ventricular dysfunction in ACS patients undergoing PCI.
- Trial name
- RNAacs (NCT06058182)
- Testing
- blood draws
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS Policlinico S. Donato
Acute Coronary Syndrome, Angina Pectoris
Complex All-comers and Patients With Diabetes or Prediabetes, Treated With Xience Sierra Everolimus-eluting Stents
Drug eluting stents (DES) are widely used for treatment of coronary artery lesions. The Xience Sierra stent has a refined design of the metal stent backbone and is used in patients with various clinical syndromes and in different…
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- NCT04475380
- Testing
- Percutaneous coronary intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 1,757 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Acute Myocardial Infarction, Angina Pectoris
Effects of Telmisartan on Ischemic Cardiovascular Events in High-risk Hypertensive Patients
This study is aimed to investigate whether treatment with Telmisartan is more effective than Candesartan in reducing the ischemic cardiovascular events in high-risk patients with cardiovascular disease.
- Conditions
- Acute Myocardial Infarction, Angina Pectoris, Myocardial Ischemia, Acute Coronary Syndrome
- Trial name
- KCPS (NCT00863980)
- Testing
- Micardis (Telmisartan), Blopress (Candesartan)
- Where
- 32 sites in Japan
- Volunteers
- 1,500 people
- Sponsor
- Kyoto Prefectural University of Medicine
Chest Pain, Acute Coronary Syndrome
IN-HOspital Program to systematizE Chest Pain Protocol (IN-HOPE)
Multicenter Nationwide Study for Analysis of the Potential Impact in Clinical Practice of Early Exclusion Protocols for Acute Myocardial Infarction with High Sensitivity Troponin T
- Trial name
- In-Hope (NCT04756362)
- Where
- Brazil
- Volunteers
- 5,497 people
- Sponsor
- Hospital Samaritano Paulista