Clinical trials: Acute Arterial Ischemic Stroke, open to volunteers
Acute Ischemic Stroke
Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke
The DOWN-SUITE study is multicenter, randomised, controlled, open-label clinical trial with blinded outcome assessment comparing collateral status in patients with acute ischemic stroke treated with an in-hospital application of…
- Trial name
- DOWN-SUITE (NCT06297863)
- Testing
- HEAD DOWN TILT -10° to -15°
- Where
- 6 sites in Italy
- Volunteers
- 118 people
- Sponsor
- University of Milano Bicocca
Stroke, Acute
Early Neurological Clinical Recovery, 3 Months After Endovascular Treatment of an Acute Ischemic Stroke
This trial aims at collecting standardized data concerning the early neurological clinical recovery of patients, 3 months after endovascular treatment of an acute ischemic stroke.
- Trial name
- AVC-endovasc (NCT02879123)
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Ischemic Stroke
Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy
Endovascular thrombectomy (EVT) is a procedure that improves recovery for people who suffer from a stroke by removing blood clots from large blood vessels in the brain.
- Trial name
- LEAST (NCT07511543)
- Testing
- Semaglutide
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS)
Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death.
- Conditions
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- Trial name
- SurvSCA (NCT07112547)
- Where
- 10 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Ischemic Stroke
Randomized a Clinical Trial With Medical Device in Acute Ischemic Stroke
This study seeks to provide high-quality evidence on the potential benefits of the dual stentriever approach, potentially informing future clinical guidelines and improving outcomes in patients with anterior circulation large…
- Trial name
- DOBLE UP (NCT07113184)
- Testing
- dual sr, single sr
- Where
- 3 sites in Spain
- Volunteers
- 220 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Ischemic Stroke
Efficacy and Safety Study of Ultra-early Mobile Stroke Unit Neuroprotection Combined With Revascularization for Acute Ischemic Stroke (EXCELLENT)
EXCELLENT was a prospective, multicenter, randomized, double-blind, placebo-controlled clinical study in which participants were randomized participants were randomized (1:1) to receive either IV thrombolysis + edaravone or IV…
- Trial name
- EXCELLENT (NCT07119021)
- Testing
- Intravenous thrombolysis + edaravone
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijun Ji
Acute Ischemic Stroke, ICAS - Intracranial Atherosclerosis
BASIS Technique for Endovascular Therapy of Acute Large Vessel Occlusion Strokes Due to Intracranial Atherosclerotic Disease
This study will explore the safety and efficacy of BASIS technology in ICAS-LVO lesions through a multicenter, prospective, registry, observational single-arm study.By registering intraoperative recanalization using this…
- Trial name
- NCT06881420
- Testing
- BASIS technique
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fujian Medical University Union Hospital
Acute Ischemic Stroke
Intravenous Tirofiban After Delayed Thrombolysis in Stroke
A multicenter, double-blind, double-dummy, randomized trial evaluating the efficacy and safety of intravenous tirofiban in acute ischemic stroke (AIS) patients without large/medium vessel occlusion, who presented 4.5-24 hours…
- Trial name
- PEARL-TIRO (NCT07111806)
- Testing
- Tirofiban
- Where
- China
- Volunteers
- 852 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Ischemic Stroke
REal-world Clinical evAulation of Medtronic NeurOVascular Products for Acute Ischemic Stroke (RECANOVA Registry)
Post-Market Registry
- Trial name
- RECANOVA (NCT07599904)
- Testing
- Mechanical Thrombectomy
- Where
- 3 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Acute Ischemic Stroke
Safety and Feasibility of NRICM301 Added to Usual Care for Adults With Acute Ischemic Stroke
Acute ischemic stroke occurs when blood flow to part of the brain is blocked. This study will assess the safety and feasibility of adding NRICM301, a food-grade formula also called Taiwan Xingnao No.
- Trial name
- NCT07900503
- Testing
- NRICM301
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- En Chu Kong Hospital
Ischemic Stroke
A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-3 (NCT07645586)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
An Application Provides Personalized Suggestions Based on Secondary Prevention Risk Factors to Stroke Patients
This study applied an application that provides personalized suggestions and explore the effect of this actual intervention on reducing the risk of stroke recurrence
- Trial name
- NCT07098143
- Testing
- Risk factor management
- Volunteers
- 5,092 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Efficacy and Safety of Intra-arterial Tenecteplase in Acute Ischemic Stroke Patients With Medium Vessel Occlusion Stroke (DATE-MeVO)
DATE-MeVO is an investigator-initiated, multicenter, prospective, randomized controlled, open-label, blinded endpoint (PROBE) clinical trial aiming at evaluating the efficacy and safety of tenecteplase combined with standard…
- Trial name
- NCT07469293
- Testing
- Intra-arterial thrombolysis, Standard medical treatment
- Where
- 45 sites in China
- Volunteers
- 488 people
- Sponsor
- Southwest Hospital, China
Acute Ischemic Stroke
A Study to Evaluate the Intracranial Arterial Recanalization With Multiple Doses of LT3001 Drug Product in AIS Participant
This is a phase II, open-label, single-arm, exploratory study to evaluate the intracranial arterial recanalization of multiple doses of LT3001 drug product in participant with acute ischemic stroke (AIS)
- Trial name
- NCT07890298
- Testing
- LT3001 Drug Product
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Acute Ischemic Stroke
Efficacy of Semaglutide in Improving Neurological Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke: A Randomized Double-Blind Controlled Trial
The trial will be a randomized, double-blind, controlled, single-center trial. The purpose of this trial is to determine the efficacy and safety of semaglutide in improving neurological outcomes after endovascular thrombectomy…
- Trial name
- STARS (NCT07030621)
- Testing
- Semaglutide 0.5 mg, Normal Saline
- Where
- China
- Volunteers
- 436 people
- Sponsor
- RenJi Hospital
Acute Ischemic Stroke
SUPERSTAR: Aspiration vs. Stent Retriever in Anterior Circulation LVO
This is a multicenter, open-label, blinded-endpoint, randomized controlled trial comparing super large bore catheter aspiration versus stent retriever thrombectomy as the first-line technique for anterior circulation large vessel…
- Trial name
- SUPERSTAR (NCT07555977)
- Testing
- Super Large Bore Catheter, Stent Retriever Thrombectomy
- Where
- China
- Volunteers
- 708 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Acute Ischemic Stroke
Methylprednisolone With Endovascular Thrombectomy for Large Ischemic Stroke
It is uncertain whether intravenous methylprednisolone improves outcomes for acute anterior circulation large vascular occlusion (LVO) patients with a large infarct core.
- Trial name
- MATCH (NCT06870448)
- Testing
- Methyprednisolone sodium succinate
- Where
- China
- Volunteers
- 1,614 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stroke, Acute Ischemic
Trendelenburg Position for Acute Anterior Circulation Ischemic Stroke With Large Artery Atherosclerosis Etiology (HOPES 3)
The effect of head position as a nonpharmacological therapy on acute ischemic stroke (AIS) remains inconclusive. Recent HOPES2 (Head dOwn-Position for acutE moderate ischemic Stroke with large artery atherosclerosis) suggest the…
- Trial name
- NCT06010641
- Testing
- head-down position
- Where
- China
- Volunteers
- 600 people
- Sponsor
- General Hospital of Shenyang Military Region
Acute Ischemic Stroke
ARTEMIS: UC-MSCs After Mechanical Thrombectomy for Acute Ischemic Stroke
This study will evaluate the safety and feasibility of administering umbilical cord-derived mesenchymal stromal cells (UC-MSCs) following mechanical thrombectomy in adults with acute ischemic stroke.
- Trial name
- ARTEMIS (NCT07913282)
- Testing
- Allogeneic Umbilical Cord-Derived Mesenchymal Stromal Cells (UC-MSCs), Standard Stroke Care Including Mechanical Thrombectomy
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Royan Stem Cell Technology Company
Stroke, Stroke, Acute Ischemic
NeuroAiD Patient-Reported Outcomes in Patients With Mild to Moderate Ischemic Stroke
This is a randomized, controlled, open-label study of MLC901 (NeuroAiD™ II) in patients with mild to moderate ischemic stroke. Eligible participants will be randomized in a 1:1 ratio to receive MLC901 in combination with standard…
- Conditions
- Stroke, Stroke, Acute Ischemic, Stroke, Ischemic, Stroke, Cryptogenic
- Trial name
- NAiD-PRO (NCT07828210)
- Testing
- MLC901, Standard treatment for acute ischemic stroke
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- EVD Pharmacy and Medical Company Limited