Clinical trials: Abuse
Depression, Suicidality
Development and Preliminary Trial of a Brief, Portable Health Intervention for Rural Sexual Minority Emerging Adults
The purpose of this study is to test the feasibility of writing interventions specifically designed for lesbian, gay, and bisexual (LGB) emerging adults (ages 18-29) that are aimed at improving the outcomes: depression…
- Conditions
- Depression, Suicidality, Substance Abuse, HIV
- Trial name
- Project LEAP (NCT03751020)
- Testing
- Expressive Writing (EW) Intervention, Self-Affirmation (SA) Intervention, Control
- Where
- 3 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Abuse, Criminal Behavior
Mindfulness for Alcohol Abusing Offenders
Over half of state and federal prisoners meet clinical criteria for alcohol abuse or dependence, and after release from prison, over three-quarters of offenders are re-arrested within five years.
- Trial name
- MIT (NCT03883646)
- Testing
- Mindfulness, Relapse Prevention
- Where
- United States
- Volunteers
- 392 people
- Sponsor
- The Mind Research Network
HIV Risk Behaviors
Sustainable HIV Risk Reduction Strategies for CJ Systems
The purpose of the Texas Christian University (TCU) Disease Risk Reduction (DRR) Project is to develop and test an intervention designed to increase positive decision-making skills among offenders for healthy living, including…
- Trial name
- DRR (NCT01900210)
- Testing
- WaySafe
- Volunteers
- 1,396 people, healthy volunteers welcome
- Sponsor
- Wayne Lehman
AOD Use, Abuse, and Dependence
Intranasal Oxytocin and Social Cognition, Implicit Preferences and Craving in Alcohol Drinkers
This is a randomized, placebo controlled, double blind crossover study of the effects of intranasal oxytocin on social cognition, implicit preferences and craving in moderate to heavy social alcohol drinkers.
- Trial name
- NCT01829516
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dementia
Delta-THC in Behavioral Disturbances in Dementia
Dementia is a common chronic condition, with predicted increasing prevalence. Nearly all patients with dementia will experience neuropsychiatric symptoms (NPS).
- Trial name
- NCT01302340
- Testing
- Delta-THC
- Where
- 2 sites in Netherlands
- Volunteers
- 22 people
- Sponsor
- Radboud University Medical Center
Drug Abuse
Drug Abuse Among Elective Surgeries: an Observational Study.
Drug abusers and addicts form a challenge to the anesthetist because of the added potential risks involved in the administration of anesthesia to this subset of patients, including potential unforeseen drug-drug interactions.
- Trial name
- NCT05123521
- Testing
- urine analysis
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Cairo University
Opioid Use Disorder, Pregnancy Related
Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD
The primary objective of this study is to evaluate the ability of TOME to increase Medication for Opioid Use Disorder (MOUD) and opioid-overdose knowledge in pregnant and postpartum persons.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse
- Trial name
- TOME (NCT06262347)
- Testing
- Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
- Where
- 6 sites in United States
- Volunteers
- 131 people
- Sponsor
- T. John Winhusen, PhD
Opioid-use Disorder, Substance Use Disorders
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other…
- Trial name
- NCT04197921
- Testing
- Exablate Model 4000 Type 2.0/2.1
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- InSightec
Drug Abuse
Testing a Multilevel Preventive Intervention in Youth Courts
The proposed research is designed to adapt and test an evidence-based drug abuse prevention approach for use in youth courts among first-time, non-violent, adolescent offenders.
- Trial name
- NCT02764099
- Testing
- Life Skills Training
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- National Health Promotion Associates, Inc.
Healthy Volunteer
A Study of The Abuse Liability Potential of RO4917838 in Recreational Drug Users
This randomized, placebo- and active-controlled, crossover study will evaluate the abuse liability potential of RO4917838 in recreational drug users.
- Trial name
- NCT01438749
- Testing
- RO4917838, diazepam
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Unsafe Sex, Physical Violence
HIV/STI Risk Reduction for Incarcerated Women With Interpersonal Violence
The pilot study aims to conduct a randomized pilot trial in a sample of 40 incarcerated women with lifetime interpersonal violence who are 6-10 weeks away from release to demonstrate the feasibility and acceptability of the…
- Conditions
- Unsafe Sex, Physical Violence, Sexual Assault, Sexual Abuse
- Trial name
- NCT01907126
- Testing
- Nutrition Program (NP), Women's Prison CoOp (WPC)
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Brown University
Tobacco Abuse Smoke
CogEcig: Cognitive Functioning and Electronic Cigarette
The aim of the present study is to compare cognitive scores (attention, executive function and working memory) of different e-Cigarette strength with usual cigarettes.
- Trial name
- CogEcig (NCT01735487)
- Testing
- Own Brand cigarette, one high 2,4% nicotine, original 7,4 mg nicotine
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Catania
Alcohol Abuse, Alcohol Addiction
Guided and Unguided Internet Treatment for Problematic Alcohol Use
The purpose of this study was to determine whether a 10-week internet-based program based on cognitive behavioral therapy (CBT) is effective in the treatment of alcohol problems, and if having therapist guidance leads to greater…
- Trial name
- NCT02384304
- Testing
- Choice, Messages, Self help
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Cannabis Use Disorder
Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder
There has been a considerable rise in cannabis consumption in recent years, with estimates of 200 million individual users globally.
- Trial name
- NCT05859347
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia, Dual Diagnosis
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment
The first aim of this study is to determine whether a brain reward center (BRC) deficiency in patients with schizophrenia (SCZ) and cannabis use disorder (CUD) will be normalized when patients are given cannabis or dronabinol.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00946348
- Testing
- Dronabinol, Cannabis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Opioid Abuse (Disorder), Stimulant Use Disorders
Optimizing Pregnancy and Treatment Interventions for Moms 3.0
We want to learn if Patient Navigation helps pregnant Medicaid members with opioid use disorder, with or without stimulant use disorder, stay in care, use medications for opioid use disorder, reduce substance use, and connect…
- Trial name
- OPTI-Mom (NCT07586917)
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 429 people
- Sponsor
- University of Utah
Spinal Cord Injury
Effects of Marijuana on Neuropathic Pain and Spasticity in Spinal Cord Injury Patients
The goal of this clinical trial is to compare effects of marijuana or cannabis on neuropathic pain and spasticity in spinal cord injury patients.
- Trial name
- NCT06190470
- Testing
- Cannabis
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Khon Kaen University
Sleep Disorder
Targeted Intervention on Sleep Disorders During Tobacco or Cannabis Cessation Therapy
During a cessation therapy for tobacco or cannabis, sleep disorders are one of the main risk factors of relapse, and a symptom of substance withdrawing.
- Trial name
- ISAC (NCT07202351)
- Testing
- Screening and management of sleep disorders
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier St Anne
Hypertension
Hemp Seed Protein and Bioactive Peptides Consumption for Hypertension
This clinical trial is being conducted to study the effect of whole hemp seed protein, hemp seed protein hydrolysate derived bioactive peptide and casein protein consumption on systolic and diastolic ambulatory blood pressure.
- Trial name
- NCT03508895
- Testing
- Whole hemp seed protein, Whole hemp seed protein plus bioactive peptides, Casein protein
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of Manitoba
Depression, Anxiety
Evaluating Neuromodulation Technologies in Early Recovery
The study is an open-label comparative effectiveness clinical trial evaluating the impact of three neuromodulation treatment devices to improve the mental health and sobriety status of recovering substance abuse patients.
- Conditions
- Depression, Anxiety, Insomnia
- Trial name
- NCT01993277
- Testing
- Nexalin Brain Stimulator, Fischer Wallace Stimulator, David Delight Stimulator
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Behavioral Health of the Palm Beaches