Clinical trials: Abortion in First Trimester
Retained Product of Conception After First Trimester Medical Abortion
Success Rates of Expectant vs. Medical Management for Retained Products After First-Trimester Abortion: Randomized Controlled Trial
This prospective randomized controlled trial evaluates the success of medical versus expectant management for retained products of conception (RPOC) following medical abortion with mifepristone and misoprostol for delayed…
- Trial name
- NCT07534982
- Testing
- medical management with misoprostol
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Yael Yagur
Pain
Hydrocodone For Pain Control in First Trimester Surgical Abortion
The purpose of this study is to determine whether preoperatively administered hydrocodone/acetaminophen (HC/APAP) reduces pain during a first trimester surgical abortion.
- Trial name
- NCT01330459
- Testing
- Hydrocodone/acetaminophen, Ibuprofen, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 121 people
- Sponsor
- Elizabeth Micks
Abortion Early, Abortion in First Trimester
Delivery of Audiovisual Information on Early Medical Abortion
The majority of abortions in the United Kingdom (UK) are performed before 9 weeks (63 days) gestation using a method known as Early Medical Abortion (EMA).
- Trial name
- EMAVID (NCT03417362)
- Testing
- Animation
- Where
- 3 sites in France, Sweden and 1 more
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Abortion Early, Abortion in First Trimester
Using Telemedicine to Improve Early Medical Abortion at Home
The investigators plan a trial comparing telephone consultations for women requesting early medical abortion (EMA - under 10 weeks pregnant) to regular face-to-face consultations.
- Trial name
- UTAH (NCT04139382)
- Testing
- Telephone Consultation, Face-to-Face Consultation
- Where
- United Kingdom
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Incomplete Abortion, Intrauterine Contraception
Ideal Timing of Intrauterine Contraception Insertion After Medical Management of First Trimester Incomplete Abortion
Background: Unintended pregnancies continue to cause a public health threat in Low and Middle Income countries yet with restrictive abortion laws.
- Conditions
- Incomplete Abortion, Intrauterine Contraception, Misoprostol
- Trial name
- PAIC (NCT05343546)
- Testing
- Use of either copper T380A or Levonorgestrel LNG 52 IUS after medical management of first trimester incomplete abortion
- Where
- Uganda
- Volunteers
- 2,076 people
- Sponsor
- Makerere University
Spontaneous Abortion in First Trimester
Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
First trimester miscarriages are common. When the failed pregnancy does not pass spontaneously on its own, it is called a missed abortion.
- Trial name
- NCT02141555
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Abortion, Induced, Pain
Paracervical Versus Intracervical Lidocaine
The aim of this study is to estimate the efficacy of intracervical versus paracervical block on pain experienced during first trimester suction curettage without the use of preoperative cervical ripening.
- Trial name
- NCT00816751
- Testing
- Paracervical block, Intracervical, Buffered Lidocaine, vasopressin, sodium bicarbonate
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Miscarriage in First Trimester
Misoprostol 400 µg Versus 200 µg for Cervical Ripening in 1st Trimester Miscarriage
Local current protocol for cervical ripening in 1st trimester miscarriage recommends 400 µg of misoprostol intravaginally 3 hours before uterine evacuation. This regime has been recommended by some international guidelines .
- Trial name
- MISO200 (NCT02957305)
- Testing
- Misoprostol 400mcg Tab, Misoprostol 200mcg Tab
- Where
- Brazil
- Volunteers
- 211 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cesarean Scar Pregnancy
Surgery Alone Versus Methotrexate Before Surgery in Cesarean Scar Pregnancy
There are no universal treatment guidelines available. The ultimate purpose of the management of CSP is to simultaneously remove the pregnancy and successfully preserve the woman's fertility (Gonzalez \& Tulandi, 2017).
- Trial name
- NCT04379219
- Testing
- Methotrexate
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Mansoura University
Abortion in First Trimester
Auriculotherapy - Pain Management of Aspiration Abortion
Primary Objective: To assess whether usual care plus auricular acupressure with beads reduces subject-reported maximum pain during first trimester vacuum aspiration compared to usual care plus placebo.
- Trial name
- NCT03896022
- Testing
- Acupressure with Beads, Acupuncture with Needles
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Columbia University
Abortion in First Trimester
Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Management With Medication Abortion Through 70 Days' Gestation
This is a double-blinded, randomized, placebo-controlled trial evaluating the use of High-frequency Transcutaneous Electrical Nerve Stimulation (HfTENS) compared to sham TENS for pain control during medication abortion with…
- Trial name
- NCT03925129
- Testing
- high frequency TENS treatment
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
Abortion in First Trimester
Pharmacist Provision of Medication Abortion
This will be a pilot study among two pharmacists providing start to finish medication abortions to 10 patients utilizing a previously created toolkit.
- Trial name
- NCT04956731
- Testing
- Pharmacist Provision of Medication Abortion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pain, Medical Abortion
Methadone and Medication Abortion
Pain has been recognized to be the most common and predictable side effect of medication abortion, causing significant distress associated with the process.
- Trial name
- NCT04941443
- Testing
- Methadone Pill, Ibuprofen
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Medical Center
Abortion in First Trimester
Telemedicine for First Trimester Abortion in South Africa
The study aim to determine if medical abortion facilitated by a physician online (s.c. telemedicine), combined with a simplified physical exam, is equally effective, safe and acceptable to women in South Africa as standard…
- Trial name
- NCT04336358
- Testing
- Telemedicine
- Where
- 4 sites in South Africa
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Recurrent Spontaneous Abortion
Difference Between Mean Gestational Sac Diameter and Crown-rump Length as a Marker of First-trimester Pregnancy Outcome in Patients With Recurrent Spontaneous Abortion
Objective: To determine the effect and predictive value of the difference between the mean gestational diameter (mGSD) sac and crown-rump length (CRL) of the first trimester on the pregnancy outcomes of patients with recurrent…
- Trial name
- mGSD-CRL& RSA (NCT06081556)
- Testing
- ultrasonic testing
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Preeclampsia, Pregnancy Loss
Early Pregnancy Antioxidant Supplementation in the Prevention of Preeclampsia
Use of Juice Plus+ food supplements, when initiated in the first trimester and used continuously thereafter, will result in a lower incidence of preeclampsia and pregnancy complications.
- Trial name
- NCT00583635
- Where
- United States
- Volunteers
- 684 people
- Sponsor
- University of Mississippi Medical Center
Cervical Preparation
Mifepristone vs Misoprostol
The Investigator team hypothesizes that in a randomized trial comparing mifepristone-alone or misoprostol-alone for cervical preparation for procedural abortions at 12 to 16 weeks in hospital-based care, the proportion of…
- Trial name
- NCT06502158
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Miscarriage
Misoprostol for Management of Women With an Incomplete Miscarriage
Miscarriage is defined as the spontaneous loss of a pregnancy before 24 weeks gestation, that is, before fetal viability. The clinical signs of miscarriage are usually vaginal bleeding associated with abdominal pain and cramping.
- Trial name
- NCT05088720
- Testing
- misoprostol 800 µg, misoprostol 400 µg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Pain
Lidocaine-Prilocaine Cream in Conjunction With Paracervical Block for Pain With Abortion
The investigators theorize that the application of a lidocaine-prilocaine cream 5-10 minutes prior to the administration of a paracervical block could decrease pain associated with its administration and pain with abortion…
- Trial name
- NCT03508804
- Testing
- Lidocaine-Prilocaine Cream, 1% Lidocaine Paracervical Block
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Miscarriage
Misoprostol in Termination of First Trimester Missed Abortion
The purpose of this study is to determine whether oral versus vaginal misoprostol is effective in termination of first trimester missed abortion and to compare between two different routes.
- Trial name
- NCT00797693
- Testing
- Misoprostol ( Cytotec) 200 microgram a tablet
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Hawler Medical University