Clinical trials: Abortion
Abortion, Induced
Misoprostol Dose and Timing Before Surgical Abortion at 13 to 16 Weeks' Gestation: a Randomized Trial
This study is a blinded randomized trial to compare two different doses and intervals of buccal misoprostol for cervical preparation before surgical abortion at 13 to 16 weeks' gestation: 400 mcg administered 3 hours before D\&E…
- Trial name
- NCT02279914
- Testing
- Misoprostol 400 mcg 3 hours prior to procedure, Misoprostol 600 mcg 90 minutes prior to procedure
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
IUC Insertion After Medical Abortion
Intrauterine Contraception (IUC) After Medical Abortion
Today a large proportion of early abortions are medical, in accordance to the woman's choice. The main objective of the present study was to compare, in a randomised fashion, initiation of intrauterine contraception (IUC) at…
- Trial name
- NCT01537562
- Testing
- Timing of IUC insertion
- Where
- Sweden
- Volunteers
- 129 people
- Sponsor
- Karolinska Institutet
Abortion
Gestational Age is Underestimated by Menstrual Dating Compared to Ultrasound Dating in Those Undergoing Abortion up to 20 Weeks
Several large trials report gestational dating by last menstrual period (LMP) overestimates gestational age (GA) vs. ultrasound (US) by approximately one week. Previous studies examined only term pregnancies.
- Trial name
- NCT00884403
- Where
- Canada
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
First Trimester Abortion, Surgical Abortion
Impact of Music Intervention on Pain Control In First Trimester Surgical Abortion Under Local Anesthesia
A surgical abortion under local anesthesia is potentially painful. A protocol using analgetic is systematically used. Also the protocol is relevant , the question of taking care of the pain in a safe manner remains.
- Conditions
- First Trimester Abortion, Surgical Abortion, Music Intervention, Local Anesthesia
- Trial name
- AlgoMusic (NCT02922504)
- Testing
- Music intervention group, Controlled group
- Volunteers
- 159 people
- Sponsor
- University Hospital, Angers
Medical; Abortion, Fetus
Evaluation of Efficacy of Two Therapeutic Strategies for Cervical Maturation Before Medical Termination
Reducing the time patients spend in the labor and delivery room saves money and reduces patient discomfort as well and reducing complications.
- Trial name
- IMEGYN (NCT03194126)
- Testing
- Mifepristone + Misoprostol OR oxytocine + laminaria, Mifepristone + Misoprostol OR oxytocine
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Medical Abortion
Medical Abortion at Gestational Age of 8 to ≤9 Weeks Versus >9 to ≤12 Weeks
The purpose of this study is to assess the effectiveness, safety, and acceptability of home-administered medical abortion at gestational age of 8 to ≤9 weeks versus >9 to ≤12 weeks among a cohort of women in Mexico City.
- Trial name
- NCT02745093
- Testing
- Mifepristone, Misoprostol
- Where
- 3 sites in Mexico
- Volunteers
- 648 people
- Sponsor
- Ibis Reproductive Health
Abortion, Second Trimester, PPROM
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from diagnosis of nonviable…
- Conditions
- Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise
- Trial name
- MIST (NCT05322252)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
High Risk Pregnancy
Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies
Pregnancies resulting in IUGR and also in preeclampsia are strongly associated with typical underlying placental pathology revealing small placentas and maldevelopment of the decidual blood vessels, suggesting under-perfusion…
- Trial name
- NCT01355822
- Testing
- PETN
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- University of Jena
Induced Abortion
Study of the Sensitivity of Manual vs Electric Aspiration to Detect Completed Early Abortion
With sensitive urine pregnancy tests, women are now able to confirm very early pregnancies. However, approximately one third of abortion facilities do not offer abortions at less than six weeks of pregnancy.
- Trial name
- NCT01085825
- Testing
- D & C abortion
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
First-trimester Pregnancy
Abortions at Strasbourg University Hospitals
The number of abortions in France and Strasbourg has been stable for several years. In 2017, 1847 were performed in the Gynecology-Obstetrics Department for 6146 deliveries (23% of all pregnancies).
- Trial name
- NCT04101175
- Testing
- Evaluation of the procedure of abortion
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Strasbourg, France
Placenta, Retained, Postpartum Hemorrhage
Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption
Interruption of a pregnancy after 14 weeks gestation may be required when the fetus is dead, severely malformed or in cases of maternal illness.
- Trial name
- NCT00120042
- Testing
- Misoprostol, Oxytocin
- Where
- Australia
- Volunteers
- 251 people
- Sponsor
- The University of Western Australia
Contraception
Continuation of Subcutaneous and Intramuscular Depot Medroxyprogesterone Acetate in Post-abortion Patients
Multiple prior studies have compared self-administered Subcutaneous Depot Medroxyprogesterone Acetate(DMPA-SC) to both provider-administered DMPA-SC and Intramuscular Depot Medroxyprogesterone Acetate (DMPA-IM) and found that…
- Trial name
- NCT05505435
- Testing
- Depot-Medroxyprogestereone Acetate
- Where
- United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Ultrasound-guided Manual Vacuum Aspiration, First Trimester Spontaneous Abortion
Ultrasound-guided Manual Vacuum Aspiration (USG-MVA)
This is a retrospective study to review the current experience of USG-MVA in Hong Kong and also evaluate the effectiveness of USG-MVA in cytological analysis in the management of first trimester miscarriage.
- Trial name
- NCT05413525
- Testing
- ultrasound-guided manual vacuum aspiration (USG- MVA)
- Where
- 2 sites in Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Pain, Abortion, Spontaneous
Topic Cervical Anesthesia Plus Paracervical Blockade for Pain Control During Endouterine Manual Aspiration
To compare the effectiveness of lidocaine gel plus paracervical blockade vs. lidocaine gel alone in the management of pain during endouterine manual aspiration.
- Trial name
- NCT04791020
- Testing
- Lidocain topical + paracervical blockade, Lidocaine topical
- Where
- Panama
- Volunteers
- 100 people
- Sponsor
- Saint Thomas Hospital, Panama
Letrozole, Misoprostol
Letrozole Plus Misoprostol Versus Misoprostol Only in Induction of Missed Abortion
This study aimed to evaluate the effect of letrozole plus misoprostol to terminate non-viable pregnancies in first trimester compared with the use of misoprostol alone.
- Conditions
- Letrozole, Misoprostol, Induction, Missed Abortion
- Trial name
- NCT07636317
- Testing
- Letrozole + Misoprostol, Misoprostol
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Sohag University
Abortion, Missed
Misopristol Versus Pitocin for Second Trimester Abortion
Second trimester abortion can be done surgically or medically. Medical abortion with mifepristone and misopristol is one of the common protocol, but misopristol have high rate side effect.
- Trial name
- NCT00784797
- Testing
- mifepristone and misopristol, mifepristone and oxytocin
- Where
- Israel
- Volunteers
- 145 people
- Sponsor
- Hadassah Medical Organization
Pregnancy
Serum Concentrations of Pregnancy-associated Proteins for Assessment of Gestational Age Before Abortion
This will be a case-series multicenter study enrolling 800 pregnant people. Serum will be collected from people seeking abortion and assayed at a qualified laboratory.
- Trial name
- NCT04232189
- Testing
- no intervention
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- Gynuity Health Projects
Antepartum Bleeding, Preterm Birth
Progesterone and Second Trimester Bleeding
Working hypothesis and aims: To investigate whether progesterone treatment affects the incidence of preterm labor compared to placebo, among women with 2nd trimester bleeding.
- Trial name
- NCT01269450
- Testing
- micronized progesterone 200 mg (Utrogestan)
- Where
- 3 sites in Israel
- Volunteers
- 128 people
- Sponsor
- HaEmek Medical Center, Israel
Abortion in First Trimester, Abortion Early
A Patient Decision Aid for Method of Early Abortion: a Randomized Control Trial
Introduction: There are two options for women seeking early pregnancy termination in Canada; either surgical or medication abortion.
- Conditions
- Abortion in First Trimester, Abortion Early, Decision Aid, Clinical Decision-making
- Trial name
- NCT05182008
- Testing
- Decision aid, Usual care
- Where
- Canada
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Effect of Drug
Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration
Miscarriage is one of the major causes of early pregnancy losses. Incomplete miscarriage is a major cause of maternal morbidity and mortality.
- Trial name
- NCT06539143
- Testing
- Lidocaine
- Where
- Nigeria
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji