Clinical trials: Abdominal Injuries, open to volunteers
Blunt Trauma to Abdomen, Wounds and Injuries
A Research Study of Abdominal Ultrasound (FAST) in Children With Blunt Torso Trauma
Bleeding from intra-abdominal injuries is a leading cause of traumatic deaths in children. Abdominal CT is the reference standard test for diagnosing intra-abdominal injuries.
- Conditions
- Blunt Trauma to Abdomen, Wounds and Injuries, Abdomen Injury, Abdominal Injury
- Trial name
- FAST (NCT05910567)
- Testing
- Focused Assessment with Sonography for Trauma (FAST) Examination, No Intervention: Standard of Care - Without the FAST Examination
- Where
- 6 sites in United States
- Volunteers
- 4,650 people
- Sponsor
- University of California, Davis
Dehiscence Wound
Efficacy Evaluation of ActiGraft in Secondary Closure of Abdominal Surgical Wound Dehiscence
This is a prospective, single arm study, consisting of 20 women with abdominal surgical wound dehiscence that requires secondary closure.
- Trial name
- NCT04899466
- Testing
- ActiGraft
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- RedDress Ltd.
Chest Trauma, Abdominal Trauma
Phased-Array Versus Curvilinear Probe for FAST Ultrasonography
Background: FAST ultrasound is a crucial technique in emergency medicine, enabling rapid assessment of trauma patients. By allowing visualization of an effusion in a trauma patient in a far more sensitive and specific way than…
- Trial name
- PAC-FAST (NCT07037797)
- Testing
- Order of the FAST echography
- Volunteers
- 2,660 people
- Sponsor
- Centre Hospitalier Memorial France Etats-Unis
Abdominal Injury, Pelvic Fracture
Developing a Decision Instrument to Guide Abdominal-pelvic CT Imaging of Blunt Trauma Patients
Unrecognized abdominal and pelvic injuries can result in catastrophic disability and death. Sporadic reports of "occult" injuries have generated concern, and physicians, fearing that they may miss such an injury, have adopted the…
- Conditions
- Abdominal Injury, Pelvic Fracture, Genital Hemorrhage, Lumbar Spine Injury
- Trial name
- NEXUS AP CT (NCT04937868)
- Testing
- There are no interventions associated with this study
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- University of California, Los Angeles
Infection, Pneumonia
Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery
PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery.
- Conditions
- Infection, Pneumonia, Surgical Site Infection, Wound Infection
- Trial name
- PENGUIN (NCT04256798)
- Testing
- Chlorhexidine mouthwash, Oxygen
- Where
- 37 sites in Brazil, India and 3 more
- Volunteers
- 12,942 people
- Sponsor
- University of Birmingham
Intraoperative Hypotension
Hypotension Prediction Index and Intraoperative Hypotension Incidence
This study aim to implement intraoperative hemodynamic monitoring and management guided with HPI algorithm in frail patients undergoing elective abdominal surgery.
- Trial name
- NCT06909786
- Testing
- HPI guided hemodynamic management, standard arterial line
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Postoperative Acute Kidney Injury
Processed Electroencephalography-guided General Anesthesia and Outcomes in Major Abdominal Surgery
This study aims to evaluate whether the reduction in the amount of intraoperative norepinephrine required to prevent hypotension, facilitated by processed electroencephalography (pEEG) -guided general anesthesia, will lead to a…
- Trial name
- NCT06753409
- Testing
- Processed electroencephalography (pEEG) Guided General Anesthesia, Non-pEEG-Guided General Anesthesia (with blinded pEEG monitoring)
- Where
- Egypt
- Volunteers
- 162 people
- Sponsor
- Assiut University
Elective Abdominal Surgery
Comparison of the Risk of Surgical Site Infections Between Dressings Stopped at Postoperative Day 1 vs Dressings Stopped at Postoperative Day 6+/-1 After Elective Abdominal Surgery
The daily changing of postoperative dressings is a widespread practice, often continuing until the 5th-7th day after surgery. In theory, dressings aim to reduce the risk of superficial surgical site infections (SSIs).
- Trial name
- PAN-STOP (NCT06569862)
- Testing
- Postoperative day 1 dressing, Postoperative day 6+/-1 dressing
- Where
- France
- Volunteers
- 1,288 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Umbilical Hernia Repair
Topical Tranexamic Acid Spray Versus No Spray on Postoperative Outcomes Following Mesh Repair of Umbilical Hernia
Umbilical hernia is a type of ventral hernia that occurs commonly in adulthood, and mesh reinforcement is well established since there is a reduced recurrence rate when compared to suture repair.
- Trial name
- NCT07845370
- Testing
- Topical Tranexamic Acid Spray, No Topical Tranexamic acid
- Where
- Pakistan
- Volunteers
- 252 people
- Sponsor
- Dr Mudassar Saeed Pansota
Intra-abdominal Surgery, Anesthesia
Open Lung Protective Extubation Following General Anesthesia
Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development.
- Conditions
- Intra-abdominal Surgery, Anesthesia, Lung Injury, Ventilator-Induced Lung Injury
- Trial name
- OLEXT-3 (NCT06296173)
- Testing
- Protective "open-lung" extubation, Conventional extubation
- Where
- 5 sites in Canada
- Volunteers
- 270 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Open Abdomen, Incisional Hernia
Synthetic Mesh for Prevention of HernIa After opEn Abdomen cLosure stuDy
The aim of this clinical trial is to evaluate whether placement of a synthetic prophylactic onlay mesh during definitive fascial closure can reduce the incidence of incisional hernia in adult patients managed with an open abdomen…
- Conditions
- Open Abdomen, Incisional Hernia, Definitive Fascial Closure, Emergency Abdominal Surgery
- Trial name
- SHIELD (NCT07835334)
- Testing
- Definitive Fascial Closure Without Prophylactic Mesh, Prophylactic Onlay Mesh Placement
- Volunteers
- 30 people
- Sponsor
- Hospital San Juan de Dios Tenerife
Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection
Myriad™ Augmented Soft Tissue Reconstruction Registry
This is an observational study designed to evaluate the safety and clinical outcomes of Myriad™ in soft tissue reconstruction procedures.
- Conditions
- Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus
- Trial name
- MASTRR (NCT05243966)
- Testing
- Myriad Matrix™ and Myriad Morcells™
- Where
- 15 sites in United States
- Volunteers
- 800 people
- Sponsor
- Aroa Biosurgery Limited
Surgical Wound Infection
Closed Incision Negative Pressure Wound Therapy for the Prevention of Surgical Site Infections in Abdominal Surgery
Surgical site infections (SSI) are a frequent complication in abdominal surgery. SSI lead to worse outcomes for the affected patients and significantly higher healthcare costs.
- Trial name
- CISSI (NCT06068517)
- Testing
- Closed incision negative pressure wound therapy, Standard dressing
- Where
- Switzerland
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Exanguination, Polytrauma
Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage in the Prehospital and Emergency Room Setting
This study seeks to evaluate the feasibility of a Abdominal Aortic Balloon Occlusion of the Aorta (AAJT-S) in exanguinating trauma patients with non-compressible truncal haemorrhage in the emergency room and the pre-hospital…
- Conditions
- Exanguination, Polytrauma, NCTH
- Trial name
- NCT07274150
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
C.Surgical Procedure; Disruption of Wound, Suture
Use of Stratafix Symmetric™ to Prevent Incisional Hernia in Gastrointestinal and Abdominal Surgery
Comparing the use of Stratafix Symmetric™ sutures to standard laparotomy closure sutures.
- Trial name
- STRATA-G (NCT06063577)
- Testing
- Stratafix suture, Standard of care suture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- West Michigan Cancer Center
Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block
Plasma Kinetics of Levobupivacaine After Transversus Abdominis Plane (TAP) Block in Abdominal Surgery
This prospective single-center observational pharmacokinetic study will evaluate plasma levobupivacaine concentrations after ultrasound-guided transversus abdominis plane (TAP) block in adult patients undergoing elective…
- Conditions
- Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block, Pharmacokinetic Analysis, Levobupivacaine
- Trial name
- LEVO-TAP-PK (NCT07581275)
- Testing
- Ultrasound-Guided Transversus Abdominis Plane Block with Levobupivacaine
- Volunteers
- 26 people
- Sponsor
- University of Liege
Abdominal Trauma, Damage Control Surgery
Clinical Outcomes of Non-Indicated Staged Laparotomies in Abdominal Trauma
The goal of this observational study is to understand how often staged operations are performed in abdominal trauma patients without meeting standard clinical criteria, and to explore related clinical characteristics and…
- Conditions
- Abdominal Trauma, Damage Control Surgery, Laparotomy
- Trial name
- NCT07110350
- Testing
- Laparotomy refers to a definitive single-stage exploratory abdominal surgery. Damage Control Surgery refers to a staged surgical approach including initial abbreviated laparotomy followed by planned.
- Where
- Taiwan
- Volunteers
- 350 people
- Sponsor
- Far Eastern Memorial Hospital
Postoperative Abdominal Wall Wound Complications, Surgical Wound Infection
Arterial Stiffness During Negative Pressure Wound Therapy for Abdominal Wall Wounds
WALLAS is a small observational study of 30 adults with complex wounds in the abdominal wall after surgery. All participants will receive negative pressure wound therapy (NPWT) because their treating team considers it…
- Conditions
- Postoperative Abdominal Wall Wound Complications, Surgical Wound Infection, Surgical Wound Dehiscence, Mesh-Associated Wound Complications
- Trial name
- WALLAS (NCT07907705)
- Testing
- Negative Pressure Wound Therapy (NPWT)
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Dávid Ágoston Kovács
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania