Clinical trials: Abdominal Fat, open to volunteers
Overweight and Obesity, Metabolic Syndrome
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans.
- Trial name
- EAT 2 (NCT04583514)
- Testing
- Control, Overfeeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Visceral Obesity, Metabolic Syndrome
Polygonatum Sibiricum Reduces Visceral Fat in Obese Adults
This study is being done to find out if a traditional Chinese herb called Polygonatum sibiricum (Huangjing) can help reduce belly fat and improve metabolic health in adults with visceral obesity.
- Trial name
- NCT07759323
- Testing
- Polygonatum sibiricum, Lifestyle Intervention
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhejiang Provincial Tongde Hospital
Subcutaneous Fat
A Study to Evaluate the Efficacy, Safety, and Tolerability of CBL-514 Injection for Reducing Abdominal Subcutaneous Fat
A phase 2b, randomized, placebo-controlled study with long-term re-treatment to evaluate the efficacy, safety, and tolerability of CBL-514 injection for reducing abdominal subcutaneous fat.
- Trial name
- NCT07608757
- Testing
- CBL-514 Injection
- Where
- Australia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Non-Alcoholic Fatty Liver Disease, Obesity, Morbid
Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention
The study is aimed To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Obesity, Morbid, Brown Fat, Metabolic Disease
- Trial name
- NCT03875625
- Testing
- Bariatric surgery, Dietitian led life style modification intervention, Conventional care (control)
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH)
How Abnormal Function of Fat Tissue in Type 1 Diabetes Contributes to Fat in the Liver
Steatotic liver disease associated with metabolic dysfunction (MASLD) is a disease caused by excess fat storage in the liver. Excessive fat delivery to the liver and MASLD typically occurs in people with abdominal obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH), Type 1 Diabetes Mellitus
- Trial name
- AGL14 (NCT07133854)
- Testing
- Imaging PET/MRI, Stable isotope infusions, meal test
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Obesity, Abdominal
Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue
A fully functional brown fat helps maintain a healthy weight and decreases the risk of metabolic diseases such as type II diabetes (T2DM).
- Trial name
- BATNAD (NCT06627868)
- Testing
- NAD+ precursor
- Where
- Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Turku
Central Obesity, Time Restricted Eating
Impact of Chronotype-Based Time-Restricted Eating on Visceral Fat and Metabolic Health in Physically Inactive Adults With Central Obesity
Time-restricted eating (TRE) has gained attention as a promising dietary strategy for enhancing body composition and metabolic health.
- Trial name
- NCT07062315
- Testing
- Chronotype-matched time-restricted eating, Chronotype-unmatched time-restricted eating
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Subcutaneous Fat
A Study to Evaluate the Efficacy and Safety of CBL-514 Injection for Reducing Subcutaneous Fat
A phase 3, randomized, double-blinded, placebo-controlled study to evaluate the efficacy, safety, and tolerability of CBL-514 injection for reducing abdominal subcutaneous fat.
- Trial name
- SUPREME-01 (NCT07140939)
- Testing
- CBL-514 Injection, 0.9% Sodium Chloride
- Where
- 13 sites in United States, Canada
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Obesity, Type 2 Diabetes Mellitus
Radiomics of Intra-abdominal and Subcutaneous Adipose Tissue Predict the Efficacy of Bariatric Surgery (RISABS)
Using radiomics of intra-abdominal and subcutaneous adipose tissue and clinical features to predict the weight loss efficacy and remission of type 2 diabetes mellitus after bariatric surgery.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Bariatric Surgery
- Trial name
- NCT06169033
- Where
- China
- Volunteers
- 800 people
- Sponsor
- China-Japan Friendship Hospital
Subcutaneous Fat
A Study to Evaluate the Efficacy, Safety, and Tolerability of CBL-514 Injection for Reducing Abdominal Subcutaneous Fat
A phase 2b, randomized, placebo-controlled study with long-term re-treatment to evaluate the efficacy, safety, and tolerability of CBL-514 injection for reducing abdominal subcutaneous fat
- Trial name
- NCT07608770
- Testing
- CBL-514 Injection, 0.9% Sodium Chloride
- Where
- Australia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Menopause
Midlife Empowerment and Longevity Through Optimizing Wellness
The goal of this observational longitudinal study is to understand how lifestyle behaviours, menopausal symptoms, and digital health data change over time in women experiencing perimenopause or menopause, and to evaluate whether…
- Trial name
- MELOW (NCT07713862)
- Testing
- MELOW
- Volunteers
- 200 people
- Sponsor
- National University Health System, Singapore
Non Invasive Body Contouring
Clinical Evaluation of Linear Z for Body Contouring
This clinical study will evaluate the safety and effectiveness of LinearZ, a non-invasive focused ultrasound device, for body contouring of the lower abdomen and flanks.
- Trial name
- NCT07802431
- Testing
- High Intensity Focused Ultrasound
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Jeisys Medical Inc
Epicardial Fat Tissue (EFT), Chronic Non-Communicable Diseases (NCDs)
Epicardial Fat Tissue and Cardiometabolic Risk in Russian and Asian Populations
Visceral obesity is a well-established risk factor for the development of chronic non-communicable diseases (NCDs). Epicardial fat tissue (EFT) is located on the surface of the myocardium and may directly affect cardiac function…
- Conditions
- Epicardial Fat Tissue (EFT), Chronic Non-Communicable Diseases (NCDs), Visceral Obesity
- Trial name
- EPIGRAPH (NCT07604610)
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Subcutaneous Fat
A Study to Evaluate the Efficacy and Safety of CBL-514 Injection for Reducing Subcutaneous Fat ( SUPREME-02 )
A phase 3, randomized, double-blinded, placebo-controlled study to evaluate the efficacy, safety, and tolerability of CBL-514 injection for reducing abdominal subcutaneous fat.
- Trial name
- NCT07526974
- Testing
- CBL-514 Injection, 0.9% Sodium Chloride
- Where
- 14 sites in United States, Australia and 1 more
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Subcutaneous Fat
A Study to Evaluate the Maintenance of Efficacy and Long-term Safety of CBL-514 Injection for Reducing Subcutaneous Fat (Stage 1)
A Phase 3b, Multicenter, Two stage, Double-blind, Long term Follow up and Open-label Extension Study of Participants Who have Completed the CBL-0301 or CBL-0302 Study for Reducing Abdominal Subcutaneous Fat (Stage 1)
- Trial name
- NCT07733947
- Testing
- CBL-514 Injection, 0.9 % sodium chloride
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Caliway Biopharmaceuticals Co., Ltd.
Obesity, Abdominal, Feeding Patterns
Circadian Rhythms in Human Adipose
The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.
- Trial name
- NCT06891534
- Testing
- Continuous Feeding, Intermittent feeding
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Respiratory Mechanics
Ultrasonographic Abdominal Fat Thickness and Driving Pressure During Prone Spinal Surgery
This prospective observational study aims to evaluate the association between preoperative abdominal subcutaneous fat thickness measured by ultrasonography and intraoperative driving pressure in adult patients undergoing elective…
- Trial name
- NCT07723690
- Volunteers
- 120 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Abdominal Fat
A Study of MI226 Injection for Abdominal Fat Accumulation
This is a Phase 1, randomized, double-blind (with open-label sentinel cohorts), placebo-controlled, single-ascending-dose study designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of MI226 Injection in…
- Trial name
- NCT07749742
- Testing
- MI226 injection（dose 1）, MI226 Injection（dose 2）, MI226 Injection（dose 3）
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Nanjing Minova Pharmaceutical Co., Ltd.
Differenciation of Stromal-vascular Fraction Cells
A Study Using Human Abdominal Adipose Tissue Biopsies to Characterize the Role of Endocannabinoids in Adipocyte Differentiation
Abdominal obesity and type 2 diabetes are associated with hyperactivation of the endocannabinoid system. Several animal and human studies indicate that circulating endocannabinoid levels correlate with body fat mass.
- Trial name
- ECTADIF (NCT07567287)
- Testing
- Collection of adipose tissue samples
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes
Osaka Cardiometabolic Epidemiological Study: Ohtori Study Part 2
The aim of this study is to investigate the relationship between body fat distribution measured by CT scan and related risk factors with the risk of incident metabolic and cardiovascular disease in a prospective cohort study of…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes, Diabetes Mellitus, Hypertension
- Trial name
- OCES-2 (NCT06694012)
- Where
- Japan
- Volunteers
- 2,000 people
- Sponsor
- Osaka Metropolitan University