Clinical trials: ART Adherence
HIV-1-infection
mHealth for ART Adherence by HIV+ African Americans
The objective of this grant is to create and test a mobile app to support ART adherence among HIV+ African American adults.
- Trial name
- NCT04557332
- Testing
- On the Dot Mobile app
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Environment and Health Group, Inc.
HIV Infections, Contraception
Kuwa Free! - Live Free!
The study investigators are conducting foundational pharmacokinetic (PK) and qualitative studies, among 15-24 years old (inclusive) adolescent girls and young women living with HIV (AGYWLHIV) already on oral antiretroviral…
- Conditions
- HIV Infections, Contraception, Drug-drug Interaction
- Trial name
- NCT05044962
- Testing
- Cabotegravir/ Rilpivirine, Etonogestrel (ETG) implant, Intramuscular depo-medroxyprogesterone acetate (IM DMPA)
- Where
- Kenya
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hiv, Medication Adherence
Development of a Silica Microparticle Taggant System to Measure ART Adherence
Developing technologies to help measure and provide tools to support medication-taking behaviors (medication adherence) is an important step to ending the human immunodeficiency virus (HIV) epidemic.
- Conditions
- Hiv, Medication Adherence, Compliance, Medication
- Trial name
- TruTag (NCT06465862)
- Testing
- TruTag System, Biktarvy Pill
- Sponsor
- Brigham and Women's Hospital
Substance Related Disorders, HIV
Yoga Intervention for Substance Use and ART Adherence in Community Reentry
People with HIV and a substance use disorder who are reentering the community from prison or jail face the dual risks of relapse and interruptions in adherence to antiretroviral therapy (ART) medication.
- Trial name
- NCT02492893
- Testing
- Hatha yoga
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
ART Adherence, PMTCT
HIV Self Testing of Male Partners of Women in PMTCT
The investigators will conduct a randomized trial to evaluate whether provision of oral HIV self-test kits (HIVST) to HIV-positive pregnant women to provide to their male partner, increases the proportion of male partners who…
- Conditions
- ART Adherence, PMTCT, Linkage to Care, HIV
- Trial name
- NCT03484533
- Testing
- HIV self-test kit, Standard of Care (invitation letters for fast-track HIV testing in the clinic)
- Where
- Uganda
- Volunteers
- 736 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections, AIDS
A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa
The RESOLVE trial is an open, parallel arm, randomized clinical trial which aims to determine the optimal strategy for management of virologic failure on antiretroviral therapy (ART) with tenofovir, lamivudine, and dolutegravir…
- Conditions
- HIV Infections, AIDS, Virologic Failure
- Trial name
- RESOLVE (NCT05373758)
- Testing
- Standard of Care treatment strategy, Individualized Care treatment strategy, Immediate Switch
- Where
- 3 sites in South Africa, Uganda
- Volunteers
- 648 people
- Sponsor
- Massachusetts General Hospital
HIV, HIV Treatment
Evaluating the Impact of Using the B-OK Bottles for HIV and ART Literacy in South Africa
Consistent use of antiretroviral therapy (ART) is essential for achieving suppression among people with HIV (PWH). Yet despite improvements in access to ART and improving viral suppression rates, an estimated one-third of PWH…
- Trial name
- NCT07703891
- Testing
- B-OK Bead Bottles Intervention (delivered in person), B-OK Bottles Intervention (delivered by video), Control
- Where
- South Africa
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV
HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP)
Black men who have sex with men (MSM) Pre-Exposure Prophylaxis (PrEP) Study with Client Centered Care Coordination (C4) Component.
- Trial name
- NCT01808352
- Testing
- Observational
- Where
- 3 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- HIV Prevention Trials Network
HIV/AIDS
INcentives and ReMINDers to Improve Long-term Medication Adherence
The study will test the feasibility and acceptability of using text messages and behavioral economics-based incentives to support anchoring Anti-Retroviral Therapy (ART) adherence to an existing routine in order to improve…
- Trial name
- INMIND (NCT05131165)
- Testing
- Daily Text Messages, Incentivization based on timely ART adherence
- Where
- Uganda
- Volunteers
- 166 people
- Sponsor
- RAND
HIV
Same-Day HIV Testing and Treatment Initiation to Improve Retention in Care
The purpose of this study is to determine if same-day HIV testing and antiretroviral therapy (ART) initiation improves retention in care (as measured by the proportion of participants who are alive and in-care with an…
- Trial name
- NCT01900080
- Testing
- Same-Day HIV testing and ART initiation, Standard ART Initiation, Sub-Study: Same-Day ART, CD4 Count >500
- Where
- Haiti
- Volunteers
- 814 people
- Sponsor
- Brigham and Women's Hospital
HIV Infection
Use of Incentives to Retain Drug Users in HIV Therapy
In many urban centres including Vancouver's Downtown Eastside, there is a high rate of HIV infection among users of illicit drugs.
- Trial name
- Incentives-2 (NCT01488942)
- Testing
- monetary reinforcer
- Where
- Canada
- Volunteers
- 139 people
- Sponsor
- University of British Columbia
HIV, HIV Antiretroviral Therapy (ART) Adherence
Selection of Resistant Mutations to Dolutegravir in PLWH Treated in Mozambique
The HIV infection not fully controlled, despite being under antiretroviral treatment, could make virus resistance against the antiretroviral treatments, making hardest the well control of HIV infection.
- Trial name
- REDOCH (NCT06607588)
- Testing
- Not applicable- observational study
- Where
- Mozambique
- Volunteers
- 200 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Healthy, Digital Health
Personalized NFTs as a Trial Participation Incentive
NFTs are blockchain-based digital and physical assets traded on digital marketplaces. Current and exploratory NFT use cases include art, collectibles, in-game items, real estate, ticketing, events, fintech, licenses, IDs, and…
- Conditions
- Healthy, Digital Health, Incentive Interventions
- Trial name
- AvatarDTx (NCT06647030)
- Testing
- CURATE.DTx sessions, Interview
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Institute for Digital Medicine (WisDM)
Patient Satisfaction
The Use of an Online Learning and Consent Platform in Infertility Treatment
The primary purpose of this study is to objectively assess if interactive multimedia tutorials (online videos) enhances patients' comprehensive understanding of assisted reproductive technology (ART) adding EngagedMD, an online…
- Trial name
- NCT03962257
- Testing
- EngagedMD online learning platform
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infection, Adherence, Medication
Next Generation Ingestible Sensors for Medication Adherence Measurement
This study will investigate the use of a next-generation Reader as part of a digital pill system (DPS; ID-Cap System) to measure adherence to both antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) in people living…
- Conditions
- HIV Infection, Adherence, Medication, Adherence, Treatment, Pre-Exposure Prophylaxis
- Trial name
- NextGen (NCT05592613)
- Testing
- Next-generation Reader and ID-Cap System, Truvada for pre-exposure prophylaxis (PrEP), Biktarvy for antiretroviral therapy (ART)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
HIV
CombinADO: Evaluation of an Intervention Aimed At Improving HIV Outcomes Among Adolescents and Young Adults Living with HIV in Mozambique
This is a cluster-randomized trial designed to compare the effectiveness of the CombinADO strategy versus optimized standard of care (SOC) on viral suppression, antiretroviral therapy (ART) adherence and retention in HIV care…
- Trial name
- NCT04930367
- Testing
- Radio Ads, Community Sensitization Campaign, Informational Posters
- Where
- 12 sites in Mozambique
- Volunteers
- 1,715 people
- Sponsor
- Columbia University
Stimulant Use (Diagnosis), Hiv
Contingency Management in HIV Care for Both Stimulant Use & ART Adherence
Methamphetamine use and associated sequelae have been rising, and represent a major barrier to successful control of the HIV epidemic.
- Trial name
- CoMBo (NCT06564792)
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of California, San Francisco
Human Immunodeficiency Virus
Evaluation of Problem Management Plus in Pregnant Women With HIV in Kenya
This study includes secondary quantitative analysis, qualitative methods, and hybrid type 2 implementation-effectiveness pilot trial.
- Trial name
- Tatua (NCT05841797)
- Testing
- In-Person Program Management Plus (PM+), Mobile Program Management Plus (mHealth PM+)
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
HIV/AIDS, Medication Adherence
Measuring and Monitoring Adherence to ART With Pill Ingestible Sensor System
Introduction of antiretroviral therapy (ART) has transformed HIV-infection from a fatal to manageable disease but adherence to ART remains critical to optimize outcomes.
- Trial name
- NCT02797262
- Testing
- Proteus digital health feedback (PDHF) system
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of California, Los Angeles
HIV
Improving ART Retention and Adherence in Uganda: The WiseMama Study
WiseMama is designed to improve our understanding of interventions that are feasible and effective in helping HIV-positive pregnant and postpartum women to maintain high adherence to antiretroviral medications.
- Trial name
- WiseMama (NCT02396394)
- Testing
- Two-Step Adherence Feedback
- Where
- Uganda
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Boston University