Clinical trials: ART
HIV-1-infection, DRM
Primary and Secondary Drug Resistance Mutations (DRMs) in HIV As a Risk Factor of Failure of ART, Including Two Drugs Based Regimens.
The presence of drug resistance mutations (DRMs) in HIV plays an important role in ART effectiveness. Despite very good results of ART, there is constant concern about the emergence of HIV strains with DRMs, what may lead to…
- Conditions
- HIV-1-infection, DRM, DRM Gene Mutation, ART
- Trial name
- NCT06661317
- Testing
- no intervention
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
HIV-1 Infection
To Investigate the Safety and Efficacy of UB-421 Monotherapy in HIV Infected Adults
The purpose of this phase II study is to evaluate the safety, tolerability and efficacy of two multi-dose regimens of UB-421 monotherapy in replacement of HAART in HIV-1 infected adults with virological suppression.
- Trial name
- NCT02369146
- Testing
- UB-421
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- United BioPharma
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
225 IU Versus 300 IU Starting FSH Dose in PPOS for Good-Prognosis Women
This randomized controlled trial will compare two starting doses of follicle-stimulating hormone (FSH), 225 IU and 300 IU, during progestin-primed ovarian stimulation (PPOS) in women undergoing in vitro fertilization (IVF) who…
- Trial name
- FSH-PPOS (NCT07772375)
- Testing
- Follitropin Alfa (Follitrope)
- Where
- Vietnam
- Volunteers
- 380 people
- Sponsor
- Vietnam Military Medical University
Martial Arts, Body Building
Lower Limb Performance, Balance and Coordination Differences Between the Muay Thai Athletes and Recreational Bodybuilders
Purpose: The aim of this study was to compare balance, coordination and lower extremity functional performances of Muay Thai (MT) athletes and bodybuilders (BB).
- Conditions
- Martial Arts, Body Building, Functional Performance
- Trial name
- NCT04563312
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
HIV/AIDS, Osteoporosis
Preventing Bone Loss Among Chinese Patients With HIV on ART
The major goal of this study will be to conduct a randomized, double-blind, placebo-controlled, clinical trial of intermittent high-dose vitamin D3 supplementation (180,000IU) given at the point of care (every 3 months) after…
- Conditions
- HIV/AIDS, Osteoporosis, Bone Loss
- Trial name
- NCT03598556
- Testing
- Vitamin D3
- Where
- 6 sites in China
- Volunteers
- 600 people
- Sponsor
- Peking Union Medical College Hospital
HIV
Differentiated Care for Improved Health Systems Efficiency and Health Outcomes in Zambia
This study seeks to create generalizable knowledge about the implementation process as well as the effectiveness and efficiency of a differentiated care system, by measuring patient health outcomes and implementation outcomes…
- Trial name
- CommART (NCT02776254)
- Testing
- START, CAG, UAG
- Where
- Zambia
- Volunteers
- 3,100 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
HIV Infections, ART
Evaluation of Secondary Distribution of HIV Self-screening Tests by Women With HIV
Many South African men do not visit clinics or get tested due to multiple real and perceived barriers. Nkangala District has significant gaps to identifying PLHIV who are not on ART, reaching their ART targets, especially in…
- Conditions
- HIV Infections, ART, HIV Seropositivity
- Trial name
- HIVSSSA (NCT05074251)
- Testing
- HIV self test, Counseling and referral for partner testing
- Where
- South Africa
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Sterility, Infertility
The Use of GnRH Agonist Trigger for Final Follicle Maturation in Women Undergoing Assisted Reproductive Technologies
This is a prospective comparative randomized controlled trial investigating the effect of two GnRH agonist trigger protocols on the ongoing pregnancy rate in hyper-responder women undergoing assisted reproductive technology.
- Trial name
- NCT03169166
- Testing
- Triptorelin
- Where
- Lebanon
- Volunteers
- 277 people
- Sponsor
- American University of Beirut Medical Center
Alcohol Drinking, HIV
Reducing Hazardous Alcohol Use & Human Immunodeficiency Virus (HIV) Viral Load
The purpose of this study is to compare the effectiveness of two interventions [a Brief Intervention (BI) and a Motivational Enhancement Therapy+Cognitive Behavioral Therapy (MET+CBT) Intervention], against each other and with an…
- Trial name
- REDART (NCT02720237)
- Testing
- Brief Intervention, Motivational Enhancement Therapy (MET) Intervention, Cognitive Behavioral Therapy (CBT) Intervention
- Where
- Vietnam
- Volunteers
- 441 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV
Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics
This study evaluated the blood and blood cell concentrations of zidovudine and lamivudine in men versus women and in those with versus without HIV infection.
- Trial name
- NCT01386970
- Testing
- zidovudine 300mg and lamivudine 150mg as Combivir
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Fertility Disorders, Assisted Reproductive Technology
The Clinical Cohort Study of Reproductive Health
The study will conduct a multicenter prospective clinical cohort study to collect comprehensive health information and essential specimens from pre-pregnancy to postpartum offspring development.
- Conditions
- Fertility Disorders, Assisted Reproductive Technology, Offspring Health
- Trial name
- NCT05164029
- Testing
- Completion questionnaires/providing biological samples
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
HIV-1 Infection, HIV Reservoir
Intestinal Tissue-Resident Memory T Cells and HIV-1 Persistence During Antiretroviral Therapy
The study aims to better characterize intestinal tissue-resident memory T cells (TRM) in people living with HIV-1 receiving suppressive antiretroviral therapy (ART).
- Conditions
- HIV-1 Infection, HIV Reservoir, Antiretroviral Therapy
- Trial name
- ANRSGALT-2 (NCT07656077)
- Testing
- Colonic Mucosal Biopsies
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Healthy
ECA-enhanced Document Explanation RCT
The investigators will evaluate a computer-animated character that explains medical illustrations to people, comparing the character to having people understand the illustrations on their own, and also comparing the computer…
- Trial name
- NCT06435819
- Testing
- Embodied Conversational Agent (ECA)
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Post-Traumatic Headache, PTSD
Art Therapy QEEG Study for Service Members with a Traumatic Brain Injury and Posttraumatic Stress Symptoms
Service members and/or recently separated veterans with post traumatic stress symptoms and mild traumatic brain injury may participate in 8 sessions including 2 sessions including interviews and questionnaires as well as 6…
- Conditions
- Post-Traumatic Headache, PTSD, TBI, TBI (Traumatic Brain Injury)
- Trial name
- ArtTherapy (NCT04776304)
- Testing
- Art Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Walter Reed National Military Medical Center
Infertility, Pregnancy
Sexual Absorption of Vaginal Progesterone
The purpose of this study is to determine if sexual intercourse lowers serum progesterone in women using vaginal progesterone gel (Crinone®), and increases serum progesterone in their male sexual partners.
- Trial name
- NCT01959464
- Testing
- Crinone vaginal progesterone gel
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Malaria
Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria
The purpose of this study is to compare the efficacy and safety of the fixed combination of pyronaridine artesunate (Pyramax®, PA) (180:60 mg) with that of standard chloroquine therapy in children and adults with acute…
- Trial name
- NCT00440999
- Testing
- Pyronaridine artesunate, Chloroquine
- Where
- 5 sites in Cambodia, India and 2 more
- Volunteers
- 456 people
- Sponsor
- Medicines for Malaria Venture
HIV-1 Infection, HIV Infections
A Pilot Study of a Dendritic Cell Vaccine in HIV-1 Infected Subjects
The purpose of the study is to find out whether an experimental autologous dendritic cell vaccine is safe, well tolerated, and whether it can strengthen the immune system's response to HIV.
- Trial name
- PARC002 (NCT00833781)
- Testing
- mRNA-transfected autologous dendritic cells, autologous dendritic cells with no mRNA transfection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
HIV
Leveraging Pharmacy Technicians to Advance the Reach of Modern Antiretroviral Therapy (PHARM ART) in Community Clinics
Long-acting injectable HIV medication is an important new innovation in HIV treatment, but complex delivery logistics have resulted in limited access for people with HIV (PWH).
- Trial name
- PHARM ART (NCT07553949)
- Testing
- Pharmacy-technician based model
- Volunteers
- 465 people
- Sponsor
- University of Chicago
Feasibility Study
Visual Arts Interventions With Older Adults
The present study investigates the feasibility, acceptability, and preliminary effects of a novel visual arts-based intervention in an older adult population.
- Trial name
- NCT06645652
- Testing
- Training in observational drawing, Arts engagement through digital galleries
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Hypercholesterolemia, HIV Infections
Addition of Ezetimibe (Ezetrol®) to Ongoing Therapy With Rosuvastatin (Crestor®) in HIV Positive Patients Not Reaching Cholesterol Targets
This study involves comparing the effectiveness of treatments in HIV positive patients who may be predisposed to heart attack or stroke.
- Trial name
- NCT00908011
- Testing
- Ezetimibe, Rosuvastatin (standard care)
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of British Columbia