Clinical trials: AKI - Acute Kidney Injury
Sepsis, ARDS (Acute Respiratory Distress Syndrome)
Research on Risk Assessment and Early Warning Models for Adverse Clinical Outcomes in Critically Ill Patients
This is a medical research study that uses information from past patient hospital records. It focuses on three serious conditions that often affect critically ill patients: sepsis (a life-threatening body-wide infection), ARDS (a…
- Conditions
- Sepsis, ARDS (Acute Respiratory Distress Syndrome), AKI - Acute Kidney Injury
- Trial name
- NCT07317817
- Testing
- No intervention (Observational study)
- Where
- China
- Volunteers
- 55,940 people
- Sponsor
- Chongqing Medical University
Ischemic Reperfusion Injury
Single-cycle Remote Ischemic Preconditioning and Postconditioning for Prevention of Contrast-Induced Nephropathy
This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning for prevention of contrast-induced acute kidney injury in…
- Trial name
- NCT02729155
- Testing
- RIPre, RIPost
- Where
- Thailand
- Volunteers
- 596 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Cardiac Surgery
Individualized Blood Pressure Management in Patients Undergoing Cardiac Surgery
This pilot randomized-controlled study will determine the feasibility of large study comparing individualized versus standard blood pressure (BP) management in patients undergoing cardiac surgery under cardiopulmonary bypass…
- Trial name
- PRECISE (NCT03784690)
- Testing
- Individualized intraoperative BP management, Standard intraoperative BP management
- Where
- Russia
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Critical Illness, Acute Kidney Failure
Implementation of CRRT KPI Reports to Standardize and Improve the Quality of CRRT Delivery in Alberta "QUALITY CRRT"
Acute kidney replacement therapy (i.e., dialysis) is used in 6-10% of patients admitted to intensive care units (ICUs). The amount of acute kidney replacement therapy use has increased in Canadian ICUs over the last several…
- Trial name
- QUALITY-CRRT (NCT04221932)
- Testing
- CRRT KPI Reports
- Where
- 14 sites in Canada
- Volunteers
- 945 people
- Sponsor
- University of Alberta
Cardiac Surgery, Acute Kidney Injury
Reduction of Occurence of Acute Kidney Injury (AKI) Through Administration of Glutamine
The aim of this study is to evaluate whether the application of glutamine versus control in patients with high risk for AKI identified by biomarkers can reduce kidney damage after cardiac surgery.
- Trial name
- Glacé (NCT04019184)
- Testing
- L-Alanyl/L-Glutamine
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- University Hospital Muenster
Acute Kidney Injury, Fluid Overload
Prospective, Multi-center, Single-arm, Observational Study. US FDA 522 Pediatric Post Market Surveillance Study.
The post market surveillance study will employ a prospective, multi-center, single-arm, observational design to capture data on children who undergo CRRT using the Carpediem™ system.
- Trial name
- NCT04608149
- Testing
- Carpediem System
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- Mozarc Medical US LLC
Primary Outcome : Compare Percent CRP Reduction, Secondary Outcome : 30-day Mortality, Renal Recovery, Length of Hospital Stay
Efficacy of Convection-based HDF Compare With Diffusion-based HD in Sepsis-associated AKI
Acute kidney injury (AKI) is a common complication among patient admitted in the hospital worldwide, with estimates of prevalence ranging from less than 1% to 66%.1, 2 In critically ill patients approximately 49% were acute…
- Trial name
- NCT06227104
- Testing
- Convection-based Hemodiafiltration
- Where
- Thailand
- Volunteers
- 28 people
- Sponsor
- Ramathibodi Hospital
Cirrhosis, Hepatorenal Syndrome
Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney Injury
This prospective study focuses on the interest of the echocardiography for cirrhotic patients, who present acute kidney injury corresponding to the criteria of hepatorenal syndrome.
- Conditions
- Cirrhosis, Hepatorenal Syndrome, Acute Kidney Injury, Diastolic Function
- Trial name
- CIRREN (NCT02097784)
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hospices Civils de Lyon
Liver Failure, Acute Kidney Injury
Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT)
The study is interventional, non-pharmacological, single-center. The aim of this study is to test the possible added value of CRRT in the surgery room during liver transplantation, compared to the investigators center current…
- Conditions
- Liver Failure, Acute Kidney Injury, Kidney Disease, Chronic
- Trial name
- CRRT-OLT (NCT06844435)
- Testing
- continuous renal replacement therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Kidney Injury, Extracorporeal Circulation; Complications
Protein Kinase N1 Level in Patients Undergoing Cardiac Surgery
Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as…
- Conditions
- Acute Kidney Injury, Extracorporeal Circulation; Complications, Surgery
- Trial name
- NCT05386940
- Testing
- PKN1 level
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhongnan Hospital
Acute Kidney Injury
Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury
This study aims to investigate, through the collection of valid scientific evidence necessary to determine safety and effectiveness, the potential use of Allogeneic Hope Biosciences Adipose-derived Mesenchymal Stem Cells…
- Trial name
- AKI (NCT06654193)
- Testing
- Allogeneic HB-adMSCs, Normal Saline
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Hope Biosciences LLC
Bariatric Surgery, Acute Kidney Injury
Post Bariatric Surgery Acute Kidney Injury: Incidence and Risk Factors
Bariatric surgery is the most effective means of inducing and maintaining sustained weight loss. Apart from the weight loss effect, bariatric surgery leads to the remission of chronic metabolic disorders such as type 2 diabetes…
- Trial name
- NCT06697743
- Volunteers
- 30 people
- Sponsor
- Georgina Tharwat Abdelmasih
Acute Kidney Injury
Recombinant Human C1 Esterase Inhibitor in the Prevention of Contrast-induced Nephropathy in High-risk Subjects
Iodinated contrast media have been causally linked to acute kidney injury known as contrast-induced nephropathy (CIN), which is the consequence of CM-induced local renal ischemia and direct toxic effects.
- Trial name
- PROTECT (NCT02869347)
- Testing
- Conestat alfa, Sodium chloride 0.9%
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Kidney Injury
Preoperative Serum Albumin and Duration of Intraoperative Hypotension on Postoperative Acute Kidney Injury
Acute kidney injury is one of major adverse postoperative complications. research about postoperative acute kidney injury conclude that low preoperative albumin and intraoperative hypotension is associated to postoperative acute…
- Trial name
- NCT03882658
- Where
- China
- Volunteers
- 37,610 people
- Sponsor
- Peking University First Hospital
Continuous Renal Replacement Therapy
Continuous Versus Conventional Volume Management During CRRT (Continuous Renal Replacement Therapy)
Use of on-line blood volume monitoring during continuous renal replacement therapy can improve volume management in acute kidney injury patients requiring renal replacement
- Trial name
- NCT01405092
- Testing
- use of continuous renal replacement machine for renal replacement, use of blood volume monitoring device in conjunction with machine used for continuous renal replacement to assess and determine volume removal
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Dallas VA Medical Center
Thrombotic Microangiopathy
Ravulizumab in Thrombotic Microangiopathy Associated With a Trigger
This study will investigate the efficacy and safety of ravulizumab compared to placebo in adult participants with thrombotic microangiopathy (TMA) associated with a trigger.
- Trial name
- NCT04743804
- Testing
- Ravulizumab, Best Supportive Care
- Where
- 97 sites in United States, Belgium and 11 more
- Volunteers
- 16 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Renal Impairment After Cardiac Surgery, Renal Impairment
Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes
Patients with renal insufficiency who undergo cardiac surgery with cardiopulmonary bypass (CPB) are at significant risk for exacerbation of renal dysfunction postoperatively.
- Conditions
- Renal Impairment After Cardiac Surgery, Renal Impairment, Acute Kidney Injury
- Trial name
- GRADIENT (NCT07017933)
- Testing
- Renal assist device
- Where
- 7 sites in United States, Poland
- Volunteers
- 124 people
- Sponsor
- 3ive Labs
Acute Kidney Injury, Chronic Kidney Diseases
Improving Continuous Renal Replacement Therapy Outcomes in Neonates and Infants Through Interdisciplinary Collaboration
To date, little knowledge exists related to the use of hemodialysis (HD) in infants and has been limited to mainly single center studies.
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Renal Dialysis
- Trial name
- ICONIIC (NCT05161078)
- Testing
- CARPEDIEM
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Glomerulonephritis, IGA, Kidney Diseases
Trial of Plasma Exchange for Severe Crescentic IgA Nephropathy
Crescentic IgA nephropathy (CreIgAN) has a poor prognosis despite aggressive immunosuppressive therapy. The efficacy of plasma exchange (PE) in CreIgAN is not well defined.
- Conditions
- Glomerulonephritis, IGA, Kidney Diseases, Acute Renal Insufficiency, Rapidly Progressive Glomerulonephritis
- Trial name
- RESCUE (NCT02647255)
- Testing
- Plasma Exchange (PE), Methylprednisolone pulse
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Peking University First Hospital
Acute Kidney Injury
Dcr3 Levels in Blood and Urine on Renal and Patient Prognosis in Patients With Acute Kidney Injury
Kidney diseases represent a global public health problem due to the aging of the population, the increasing prevalence of diabetes, hypertension, obesity and immune disorders.
- Trial name
- NCT05735093
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kırıkkale University
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