Clinical trials: AKI
Acute Kidney Injury
Prospective Validation of AKI Prediction
The purpose of this prospective observational study is to implement, deploy, and quantify accuracy of an existing Pediatric Early AKI Risk Score algorithm.
- Trial name
- NCT06804200
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Adam C Dziorny
Acute Kidney Injury
European Registry of Dialysis Treatment of Pediatric Acute Kidney Injury (AKI)
Acute kidney injury (AKI) is a frequent clinical condition in hospitalized, in particular, in critically ill children. Moreover, AKI is an independent predictor of mortality.
- Trial name
- EurAKID (NCT02960867)
- Where
- Italy
- Volunteers
- 1,892 people
- Sponsor
- Mariella Enoc
Acute Kidney Injury, Hepatorenal Syndrome
Study of Accuracy of NGAL, a Renal Injury Biomarker, in Patients With Cirrhosis
The purpose of this study is to test the accuracy of urinary neutrophil-gelatinase associated lipocalin (NGAL) and other biomarkers (plasma renin, norepinephrine) to predict acute kidney injury (AKI) development in patients with…
- Trial name
- NCT02049125
- Where
- 4 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- University of Sao Paulo
Acute Kidney Injury, Renal Artery Blood Flow
Characteristics of Renal Blood Flow in AKI Patients in ICU and Its Clinical Significance
To study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical…
- Conditions
- Acute Kidney Injury, Renal Artery Blood Flow, Renal Venous Return, Renal Microcirculation
- Trial name
- NCT06090773
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking Union Medical College Hospital
Septic Shock and Acute Kidney Injury
Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI
Consecutive patients with ACLF (Acute on Chronic Liver Failure) and septic shock with AKI (Acute Kidney Injury) who give written informed consent will be included in this prospective trial at ILBS.
- Trial name
- NCT03343340
- Testing
- Early CRRT, Late CRRT, Standard Medical Therapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Transcatheter Aortic Valve Implantation (TAVI), Blood Transfusion
Transfusion Requirements in Transcatheter Aortic Valve Implantation (TRITAVI) Study
Periprocedural bleeding events are frequent during transcatheter aortic valve implantation (TAVI), mainly driven by vascular complications and are associated to a worse prognosis.
- Conditions
- Transcatheter Aortic Valve Implantation (TAVI), Blood Transfusion, AKI, Prognosis
- Trial name
- TRITAVI (NCT03740425)
- Testing
- Blood Transfusion
- Where
- Italy
- Volunteers
- 3,235 people
- Sponsor
- G. d'Annunzio University
Timing of RRT in Mechanically Ventilated Patients
Timing of Renal Replacement Therapy In Mechanically Ventilated Patients
This is a randomized controlled study that will be conducted on acute kidney injury (AKI) patients, who are mechanically ventilated, to assess the impact of implementation of early renal replacement therapy (RRT) compared to late…
- Trial name
- NCT05382598
- Testing
- Renal replacement therapy
- Where
- Egypt
- Volunteers
- 94 people
- Sponsor
- Alexandria University
AKI
Separation Versus Integrated Approach in Combining ECMO With CRRT
This study aimed to compare circuit lifespan of CRRT between Integration and Separation techniques during ECMO support.
- Trial name
- E-CRRT (NCT05036616)
- Testing
- Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Chulalongkorn University
Intraabdominal Hypertension, Abdominal Compartment Syndrome
Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry
The Accuryn Registry Study is an open-ended, global, multi-center, retrospective and prospective, single-arm data collection study with an FDA cleared device. The target population are cardiovascular surgery patients.
- Conditions
- Intraabdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury, Cardiovascular Surgery
- Trial name
- NCT04669548
- Testing
- Accuryn Monitoring System
- Where
- 9 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Potrero Medical
Acute Kidney Injury, Acute Kidney Injury (AKI)
Hamburg Acute Kidney Injury Study (HAKIS)
The Hamburg Acute Kidney Injury Study (HAKIS) is a prospective observational cohort study aimed at investigating the mechanisms, risk factors, and clinical determinants of acute kidney injury (AKI) trajectories and consequences.
- Trial name
- HAKIS (NCT07338669)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Kidney Injury
Role of Neuronal Guidance Proteins as Diagnostic Markers for Acute Kidney Injury (AKI)
Acute kidney failure remains one of the most challenging entities to diagnose in clinical medicine, especially in the field of intensive care.
- Trial name
- NEUKID (NCT05924269)
- Volunteers
- 600 people
- Sponsor
- University Hospital Tuebingen
Cardiovascular Surgery
Cardiovascular Surgery Early Prediction System for AKI :CARDS-AKI Registry
This multicenter, prospective study prospectively enrolled patients undergoing cardiovascular surgery. Detailed perioperative clinical data and biospecimens were collected at multiple time points.
- Trial name
- NCT07330453
- Testing
- Observation
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
AKI
The Impact of CRRT Modality on Filter Life
The investigators plan to start patients who need CRRT on either CVVH or CVVHD by block randomization, and then to measure filter life.
- Trial name
- NCT04762524
- Testing
- CVVH vs CVVHD
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Iowa
Acute Renal Failure (ARF), Acute Kidney Injury (AKI)
Retrospective Analysis of Prismaflex HF20 Set Versus ppCRRT Registry
A retrospective multicenter, observational design intended to capture data on pediatrics (weighing between 8 - 20 kg) who underwent continuous renal replacement therapy (CRRT) using the HF20 set.
- Conditions
- Acute Renal Failure (ARF), Acute Kidney Injury (AKI), Fluid Overload in Dialysis Patients
- Trial name
- NCT06633029
- Testing
- Prismaflex HF20
- Where
- 5 sites in United States
- Volunteers
- 59 people
- Sponsor
- Vantive Health LLC
Renal Insufficiency, Acute Kidney Injury
Renal Assist Device (RAD) for Patients With Renal Insufficiency Undergoing Cardiac Surgery
The study is a prospective, non-randomized early feasibility study intended to evaluate the safety and performance of the JuxtaFlow System (also known as the JuxtaFlow Renal Assist Device (RAD)) in participants with pre-existing…
- Trial name
- BIPASS-AKI (NCT05990660)
- Testing
- JuxtaFlow System
- Where
- 3 sites in Poland, Serbia
- Volunteers
- 10 people
- Sponsor
- 3ive Labs
Shock
Crystalloids for AKI in Shock Patients
Fluid resuscitation is important in shock therapy, but the choice of fluids, especially the choice of crystalloid is under debate.
- Trial name
- NCT03188614
- Testing
- Fluid resuscitation
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Hepatorenal Syndrome, Acute Kidney Injury
Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome
This study aims to evaluate the safety, tolerability and efficacy of R2R01 combined with terlipressin as compared to terlipressin alone in the treatment of patients with HRS-AKI
- Trial name
- NCT05875948
- Testing
- R2R01, Terlipressin
- Where
- 7 sites in United States
- Volunteers
- 95 people
- Sponsor
- River 2 Renal Corp.
Acute Kidney Injury, Corona Virus Infection
Acute Kidney Injury and Acute Kidney Disease in COVID-19
Acute kidney injury (AKI) has been identified as an independent risk factor for in-hospital mortality. The present study aims to investigate the incidence of AKI and renal recovery of inpatients diagnosed with COVID-19.
- Trial name
- NCT04353583
- Where
- Germany
- Volunteers
- 900 people
- Sponsor
- University of Giessen
Liver Cirrhosis, Acute Kidney Injury
International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project
The aims of this study will be to identify the clinical characteristics, the management and the outcomes of acute kidney injury in patients with cirrhosis worldwide. Specific aims: 1.
- Conditions
- Liver Cirrhosis, Acute Kidney Injury, Hepatorenal Syndrome
- Trial name
- GLOBAL-AKI (NCT05387811)
- Testing
- Crystalloids, albumin, vasoconstrictors, diuretics, renal replacement therapy
- Where
- 38 sites in United States, Argentina and 19 more
- Volunteers
- 1,456 people
- Sponsor
- Azienda Ospedaliera di Padova
Acute Kidney Injury
Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis
Critically ill patients are at risk of developing a sudden decrease of kidney function which may be detected by a decrease in urine output or is diagnosed on the basis of blood tests for substances normally eliminated by the…
- Trial name
- RESCUE-AKI (NCT06180551)
- Testing
- DKK-3
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Universität des Saarlandes