Clinical trials: AIS
Adolescent Idiopathic Scoliosis, Scoliosis Idiopathic
Effects of Vertebral Derotation on Pulmonary Functions
This study was conducted to determine the physiological and mechanical effects of physical training post surgical correction of adolescent scoliosis using vertebral derotation.
- Trial name
- NCT05805995
- Testing
- vertebral derotation
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Metastatic Castrate-resistant Prostate Cancer, Adenocarcinoma, Prostate
Phase 1/2A Study of TRC253, an Androgen Receptor Antagonist, in Metastatic Castration-resistant Prostate Cancer Patients
This is a multi-center, first-in-human, open-label, Phase 1/2A dose-escalation study in which eligible patients with metastatic castration-resistant prostate carcinoma (mCRPC) will receive oral doses of TRC253.
- Trial name
- NCT02987829
- Testing
- TRC253
- Where
- 5 sites in United States
- Volunteers
- 72 people
- Sponsor
- Tracon Pharmaceuticals Inc.
Lung Adenocarcinoma, Frozen Section
Sublobar Resection for Adenocarcinoma in Situ/Minimally Invasive Adenocarcinoma Diagnosed by Intraoperative Frozen Section (ECTOP-1019)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1019. The goal of this clinical trial is to confirm the therapeutic effect of sublobar resection for AIS/MIA diagnosed by…
- Conditions
- Lung Adenocarcinoma, Frozen Section, Sublobar Resection
- Trial name
- NCT06031181
- Testing
- Sublobar Resection
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Fudan University
Adolescent Idiopathic Scoliosis
Effectiveness of Acceptance and Commitment Therapy Versus Active Controls in Improving Psychological Functions of Parents and Children With Adolescent Idiopathic Scoliosis: A Randomized Controlled Trial
Systematic reviews revealed that Acceptance and Commitment Therapy (ACT) for parents had medium-to-large effect sizes in improving parental depression/anxiety (d > 0.50), dysfunctional parenting styles (ds = 0.61-0.77), and…
- Trial name
- NCT05919459
- Testing
- 5-week online synchronous ACT intervention, asynchronous online AIS education
- Where
- Hong Kong
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Papillomavirus Infections, Uterine Cervical Neoplasms
Safety and Immunogenicity Study of V503 (GARDASIL™9, 9vHPV Vaccine) Administered to 9- to 26-Year-Old Females and Males in Vietnam (V503-017)
This study will evaluate the safety and immunogenicity of V503 (GARDASIL™9, 9vHPV vaccine) administered to 9- to 26-year-old females and males in Vietnam.
- Conditions
- Papillomavirus Infections, Uterine Cervical Neoplasms, Vulvar Neoplasms, Vaginal Neoplasms
- Trial name
- NCT03546842
- Testing
- 9vHPV vaccine
- Where
- Vietnam
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Prostate Cancer
Impact of New Hormonotherapy Drugs in Prostatic Cancer on the Risk of Cardiovascular Events : a Pharmacoepidemiology Study Using the French Health Care Claims Database
In prostate cancer, whether advanced or localized, hormone therapy is a key treatment. These therapies work by lowering male hormone levels to slow the growth of cancer.
- Trial name
- NCT06902441
- Where
- France
- Volunteers
- 52,000 people
- Sponsor
- University Hospital, Caen
Adolescent Idiopathic Scoliosis
The Effects of Scoliosis-Specific Exercises Before Surgery
The aim of this study is to investigate the effects of scoliosis-specific exercises in adolescent idiopathic scoliosis patients, who had surgical indication, on functional capacity, cosmetic deformity perception, quality of life…
- Trial name
- NCT04357561
- Testing
- Exercise group (Schroth best practice)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma
Effect of Androgen Receptor Signaling Inhibitors on 68Ga-PSMA-11 PET/CT Imaging in Patients With Castration-Resistant Prostate Cancer
This trial studies the effect of androgen receptor signaling inhibitors on 68Ga-PSMA-11 PET/CT imaging in patients with castration-resistant prostate cancer that has spread to other places in the body (metastatic).
- Conditions
- Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer American Joint Committee on Cancer (AJCC) v8, Stage IVA Prostate Cancer AJCC v8
- Trial name
- NCT04279561
- Testing
- Computed Tomography, Gallium Ga 68 Gozetotide, Positron Emission Tomography
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Prostate Cancer, Bone Metastases
Androgen Deprivation Therapy +/- Radium-223 Dichloride in Metastatic Prostate Cancer With Bone Metastases
Newly diagnosed metastatic prostate cancer subjects with bone metastases will be accrued to this stratified randomized 2-arm Phase II trial. Subjects will be randomized 1:2 to ADT or ADT with Radium-223 dichloride respectively.
- Conditions
- Prostate Cancer, Bone Metastases, Prostate Neoplasms
- Trial name
- NCT02582749
- Testing
- LHRH agonist/antagonist, Bicalutamide, Radium-223 dichloride
- Where
- 12 sites in United States
- Volunteers
- 16 people
- Sponsor
- Ajjai Alva, MD
Scoliosis
Predictive Progressive Factors of Adolescent Idiopathic Scoliosis
The hypothesis of this study is that progressive AIS is characterized by a disorder of orthostatic postural control. The analysis and the treatment of posturographic signal on computerized integrate force plates, coupled to…
- Trial name
- SCOLEVOL (NCT02862392)
- Where
- 4 sites in France
- Volunteers
- 95 people
- Sponsor
- Lille Catholic University
Adolescent Idiopathic Scoliosis (AIS)
Effects of Body Awareness Therapy on Posture, Trunk Movement, Scoliosis & Body Awareness in Adolescents With Scoliosis
Adolescent idiopathic scoliosis (AIS) is a complex deformity of the spine, and its cause remains unknown. AIS can have negative physical, psychological, and social effects on an individual's health.
- Trial name
- NCT06855030
- Testing
- Scoliosis Specific Exercise, Basic Body Awareness Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gözde Yagci (Gür)
Adolescent Idiopathic Scoliosis, Patient Engagement
Designing Multimedia Patient Education for Adolescent Idiopathic Scoliosis
The goal of this triple-masked three-armed feasibility randomised controlled trial is to compare patient education materials for participants with adolescent idiopathic scoliosis.
- Trial name
- PEMAIS (NCT06090344)
- Testing
- Traditional video format, Evidence-informed video format
- Where
- Ireland
- Volunteers
- 46 people
- Sponsor
- University College Dublin
Acute Ischemic Stroke
Effect of Human Urinary Kallidinogenase on Inflammatory Factors in Acute Ischemic Stroke (KIF-AIS)
The goal of this clinical trial is to explore the changes in the expression levels of inflammatory factors before and after the early treatment of Human Urinary Kallidinogen (HUK) in the acute ischemic stroke.
- Trial name
- NCT06696703
- Testing
- Human urinary kininogenase(HUK)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Acute Ischemic Stroke
Long-term Outcome of RIPC After IV Thrombolysis in AIS Patients
The goal of this observational study is to learn about the long-term efficacy of our previous study in acute ischemic stroke(AIS) patients who underwent either remote ischemic postconditioning(RIPC) or sham treatment after…
- Trial name
- RESPONTH (NCT05614401)
- Testing
- functional and medical information
- Where
- China
- Volunteers
- 62 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Adolescent Idiopathic Scoliosis
Scoliosis-Specific Exercises for At-Risk AIS Curves
This study will be a multi-center, dual-arm randomized control study evaluating skeletally immature patients with mild AIS curves.
- Trial name
- EX (NCT02807545)
- Testing
- Scoliosis Specific Exercises
- Where
- 6 sites in United States
- Volunteers
- 98 people
- Sponsor
- Texas Scottish Rite Hospital for Children
Adolescent Idiopathic Scoliosis
Investigation of Muscle Activity With sEMG, Surface Topography and Radiographic Changes of Paraspinal Muscles in Individuals With Adolescent Idiopathic Scoliosis.
The aim of this study is to examine paraspinal muscle activity, body surface topography, posture, and radiographic characteristics in adolescents with idiopathic scoliosis.
- Trial name
- NCT07804836
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Adolescent Idiopathic Scoliosis, Postural Balance
Feedback-Based Balance Training for Adolescents With Idiopathic Scoliosis
Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis occurring during the growth period and is associated with significant alterations in postural balance compared with healthy peers.
- Trial name
- NCT07430098
- Testing
- HUBER® 360 Balance Training, Home-Based Balance Exercise Program, Individualized Conservative Scoliosis Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ankara Etlik City Hospital
Cervical Cancer, Genital Wart
A Phase Ⅲ Study to Evaluate the Efficacy, Immunogenicity, Safety of Quadrivalent HPV Recombinant Vaccine in Chinese Healthy Females
This study is designed to evaluate the vaccine efficacy, immunogenicity and safety of the 4-valent Human Papillomavirus (Types 6, 11, 16, and 18) Recombinant Vaccine (Hansenula Polymorpha) in Chinese Female Subjects Aged 18-45…
- Conditions
- Cervical Cancer, Genital Wart, CIN1, CIN2
- Trial name
- NCT05584332
- Testing
- Quadrivalent Human Papillomavirus (Types 6, 11, 16, and 18) Recombinant Vaccine (Hansenula Polymorpha)
- Where
- China
- Volunteers
- 3,131 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Arterial Ischemic Stroke (AIS) in Children
Umbilical Cord Blood in the Treatment of Stroke in Children.
The specific aims of this study are: 1. To determine if Human Umbilical Cord Blood (hUCB) infusion is safe in children with perinatal arterial ischemic stroke (AIS). 2.
- Trial name
- Pedi Stroke (NCT01700166)
- Testing
- Autologous Human Cord Blood derived Stem Cell injection
- Where
- United States
- Sponsor
- Aryn Knight
Adolescent Idiopathic Scoliosis
Orthopaedic Manipulation in Treatment of Adolescent Idiopathic Scoliosis
To examine the clinical efficacy of the Orthopaedic Manipulation Techniques of the Lin School of Lingnan Region in the treatment of Adolescent Idiopathic Scoliosis
- Trial name
- NCT05639023
- Testing
- Manipulation Techniques, Physiotherapy Scoliosis-Specific Exercise
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong