Clinical trials: AFib
Atrial Fibrillation, Persistent
First-line Cryoablation for Early Treatment of Persistent Atrial Fibrillation
The goal of this multicentre, prospective, randomized, open, blinded for evaluation of end point (PROBE) controlled parallel-group superiority trial, is to compare the efficacy of antiarrhythmic drug (AAD) therapy and cryoballoon…
- Trial name
- NCT05939076
- Testing
- Pulmonary vein isolation, dronedarone - Multaq™ OR flecainide - Tambocor™ OR propafenone - Rytmonorm™ OR sotalol - Sotacor™
- Where
- 6 sites in Hungary, Slovakia and 2 more
- Volunteers
- 220 people
- Sponsor
- Region Örebro County
Atrial Fibrillation (AF)
Medical and Surgical Hybrid Treatment of Atrial Fibrillation.
The objective of the study is to investigate the feasibility of a hybrid procedure removal of the atrial fibrillation. This is a single procedure for both surgical epicardial by minimally invasive route (Thoracoscopy) without…
- Trial name
- HT2AF (NCT02630914)
- Testing
- The AtriCure Synergy Ablation System
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Toulouse
Atrial Fibrillation Recurrent
Exploring P-Wave Duration in Arrhythmia Recurrence in Patients Undergoing AF Ablation
The aim of this study is to investigate whether P-wave duration in a baseline surface 12-lead ECGs correlates with recurrence of AF recurrence post successful ablation at the time of the procedure.
- Trial name
- NCT04968678
- Testing
- P-wave duration measurement on 12 lead ECG with standard parameters
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Nik Spinthakis
Atrial Fibrillation
The Influence of Catheter Ablation for Atrial Fibrillation on Atrial Electrical
This study explored the influence of radiofrequency catheter ablation and cryoballoon ablation on atrial electrical remodeling in patients with atrial fibrillation,the relationship between atrial electrical remodeling and…
- Trial name
- NCT03322085
- Testing
- radiofrequency ablation or cryoballoon
- Where
- China
- Volunteers
- 126 people
- Sponsor
- The Second Hospital of Hebei Medical University
Atrial Fibrillation
Tailored Treatment of Permanent Atrial Fibrillation
The purpose of this trial is to evaluate the safety and efficacy of the Medtronic Cardiac Ablation System compared to medical therapy in the persistent and long-standing persistent atrial fibrillation population.
- Trial name
- TTOP-AF (NCT00514735)
- Testing
- Medtronic Cardiac Ablation System, Class I or III Antiarrhythmic Medications
- Where
- 24 sites in United States, Netherlands
- Volunteers
- 210 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Stroke, Ischemic, Atrial Fibrillation
Wearable Devices for Secondary Prevention of Ischemic Stroke
Ischemic stroke is an important cause of death and disability in Western countries. Different risk factors have been identified such as hypertension, diabetes, dyslipidemia, smoke, atrial fibrillation, obesity, and sedentary.
- Trial name
- NCT04282993
- Testing
- Wearable devices for identifying and measuring risk factors for ischemic stroke, Standard of care monitoring
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Campus Bio-Medico University
Atrial Fibrillation
REal-worLd vAlidaTION of PhotoPlehtysmoGraphy (for Atrial Fibrillation Detection)
Mobile health solutions for rhythm monitoring (e.g. atrial fibrillation detection) using photoplethysmography (PPG) technology on a smartphone have been developed.
- Trial name
- RELATION PPG (NCT06028893)
- Testing
- Heart rhythm measurements with FibriCheck®, Heart rhythm measurements with Kardia Mobile®
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Ziekenhuis Oost-Limburg
Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB)
FENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants)
Background Non-vitamin K antagonist oral anticoagulants (NOACs) are recommended for stroke prevention in non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB), Gastrointestinal Hemorrhage (Clinically Important, Upper), Drug-Related Side Effects and Adverse Reactions
- Trial name
- FENOX (NCT07497893)
- Testing
- Fexuprazan, NOAC therapy
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Atrial Fibrillation, Risk Factors
Secondary Prevention of Atrial Fibrilation
Atrial fibrillation (AF) is the most common arrhythmia affecting over 3 million Americans and about 33.5 million individuals globally. The lifetime risk of developing AF is 1 in 4 for adults over age 40 years.
- Conditions
- Atrial Fibrillation, Risk Factors, Risk Reduction Behavior
- Trial name
- NCT03259893
- Testing
- AliveCor mobile ECG cardiac monitor, AF Program, Standard of care
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston Medical Center
Atrial Fibrillation
Feasibility Study of a Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation
The purpose of this study is to assess the safety and function of the Aegis Sierra Ligation System in accessing and closing off the left atrial appendage (LAA) using a minimally invasive epicardial access approach.
- Trial name
- LASSO-AF (NCT02583178)
- Testing
- Aegis Sierra Ligation System
- Where
- 7 sites in United States, Canada
- Volunteers
- 7 people
- Sponsor
- Aegis Medical Innovations
Atrial Fibrillation Rapid
Benefit of Permanent Stimulation of the Left Branch of the His Bundle Versus Right Ventricular Stimulation After Atrioventricular Node Ablation for Rapid Atrial Fibrillation
The objective of the study is to evaluate the functional benefit of left bundle branch of His pacing compared to right ventricular pacing in patients implanted with a pacemaker prior to a atrioventricular node ablation procedure…
- Trial name
- LEANA (NCT06061978)
- Testing
- left bundle branch of His pacing, right ventricular pacing
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Rouen
Atrial Fibrillation, Atrial Appendage
AntiPlatelet theraPy stratEgy followiNg Left Atrial appenDAGe closurE
The APPENDAGE study is a phase 4 multicentre randomized opened clinical trial comparing 2 different antithrombotic strategies following left atrial appendage closure (LAAC) in patients with non valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Atrial Appendage, Anticoagulants, Stroke
- Trial name
- APPENDAGE (NCT04796714)
- Testing
- Double antiplatelet therapy, Aspirin, Brain MRI
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Atrial Fibrillation, Rheumatic Mitral Stenosis
Rate Control Efficacy in Atrial Fibrillation With Rheumatic Mitral Stenosis: Lenient vs Strict Rate Control Strategies
The goal of this clinical trial is to learn if different types of heart rate control work to improve the clinical outcomes of patients with atrial fibrillation related to rheumatic mitral stenosis in terms of reducing…
- Conditions
- Atrial Fibrillation, Rheumatic Mitral Stenosis, Arrhythmias, Cardiac
- Trial name
- RACE-MS (NCT06409533)
- Testing
- Rate control
- Where
- 3 sites in Indonesia
- Volunteers
- 100 people
- Sponsor
- University of Brawijaya
Atrial Fibrillation (AF), Atrial Premature Complexes
Clinical Safety and Efficacy Testing of a Medical Device Kardi Ai, an ECG Telemetry Monitoring System
The goal of this clinical trial is to evaluate the safety and efficacy of medical device Kardi Ai, an ECG telemetry monitoring device in adult population.
- Conditions
- Atrial Fibrillation (AF), Atrial Premature Complexes, Ventricular Premature Complexes, Bradycardia
- Trial name
- Kardi Ai (NCT07018648)
- Testing
- Medical device
- Where
- 2 sites in Czechia
- Volunteers
- 115 people
- Sponsor
- KARDI AI Technologies s.r.o.
Atrial Fibrillation
A Prospective Multi Centre Trial on Bipolar Radiofrequency Ablation of Atrial Fibrillation
The study is a prospective multi-centre study to investigate the effect of a new bipolar ablation strategy of the left atrium in patients with paroxysmal or permanent atrial fibrillation over time.
- Trial name
- NCT00184249
- Testing
- Bipolar radiofrequency ablation
- Sponsor
- Norwegian University of Science and Technology
Fibrillation, Atrial
Detecting Atrial Fibrillation in Patients With an Embolic Stroke of Undetermined Source (From the DAF-ESUS Registry)
The presence of interatrial block (IAB) is associated with the development of atrial fibrillation (AF). The aim of this study was to determine whether P-wave duration and presence of IAB before the implantation of a cardiac…
- Trial name
- NCT04761315
- Volunteers
- 380 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Atrial Fibrillation Recurrence
Atrial Fibrillation Recurrence Prediction
We aimed to develop an dual-branch deep learning network that integrates feature representations extracted from medical texts using large language models, with structured data features derived from perioperative records of AF…
- Trial name
- NCT06977516
- Where
- 5 sites in China
- Volunteers
- 2,508 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Atrial Fibrillation (AF), Bleeding
Concomitant PFA Bsaed PVI Plus LAAC
A multicenter, prospective registry of concomitant Farapulse (Boston scientific) based PVI and Watchman Flx device (Boston scientific) based LAAC procedures was planned in order to assess the acute and mid-time safety, efficacy…
- Conditions
- Atrial Fibrillation (AF), Bleeding, Stroke
- Trial name
- COCONUT_2 (NCT07450755)
- Testing
- Interventional LAA Closure, Pulmonary vein isolation
- Volunteers
- 150 people
- Sponsor
- Asklepios proresearch
Atrial Fibrillation
Correlation of Atrial Fibrillation Recurrence After Bipolar Radiofrequency Ablation With microRNA Expression
The recurrence rate of atrial fibrillation (AF) after bipolar radiofrequency ablation was about 30%. Besides the factors, left atrium diameter, the duration of AF, NT-proBNP, and ejection fraction(EF), some studies demonstrated…
- Trial name
- NCT04134793
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Atrial Fibrillation (AF)
FARAPULSE Workflow Assessment Registry
The study is designed to determine the best practices in the patient pathway, and to analyze pre-procedural, procedural and follow-up workflow data related with ablation of atrial fibrillation where the FARAPULSE™ Pulsed Field…
- Trial name
- FARAWAY (NCT06656884)
- Where
- 28 sites in Austria, Belgium and 8 more
- Volunteers
- 524 people
- Sponsor
- Boston Scientific Corporation