Clinical trials: ACL
Knee Injuries, Anterior Cruciate Ligament Injuries
Effects of Blood Flow Restriction (BFR) Therapy on ACL Graft Maturation
This is a study comparing the effects of blood flow restriction (BFR) therapy on the maturation of the Anterior Cruciate Ligament (ACL) graft after reconstruction surgery compared to physical therapy without the use of BFR.
- Trial name
- NCT04528992
- Testing
- Blood Flow Restriction Therapy, Standard Postoperative Physical Therapy
- Where
- United States
- Sponsor
- Stanford University
Infection, Bacterial
Parenteral Versus Combined Parenteral With Vancomycin-soaked Graft in ACL Reconstruction
An anterior cruciate ligament (ACL) tear is one of the knee joint's most common soft tissue injuries [1]. It is frequently injured in non-contact and some contact competition sports and even during ordinary life activities.
- Trial name
- NCT06166381
- Testing
- Parenteral Antibacterial Agents, Parenteral Antibacterial Agents plus Vancomycin pre-soaked graft
- Where
- Iraq
- Volunteers
- 288 people
- Sponsor
- University of Duhok
Anterior Cruciate Ligament Injuries
Blood Flow Restriction Training in ACL Surgery
This will be a randomized pilot study to determine the effectiveness of Personalized Blood Flow Restriction (PBFR) technique in conjunction with prescribed physical therapy (PT) in a cohort of anterior cruciate ligament (ACL)…
- Trial name
- NCT05245864
- Testing
- blood flow restriction, physical therapy standard of care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Arkansas
ACL Injury
Andrews Return to Sport ACL Score
This project will develop a data-driven decision making model to assess a competitive athlete's readiness to return to sport after ACL injury and surgery safely.
- Trial name
- NCT05578248
- Testing
- Magnetic Resonance Imaging (MRI), ACL reconstruction
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Andrews Research & Education Foundation
Anterior Cruciate Ligament (ACL) Reconstruction
Subdermal Implant-bioabsorbable Oxandrolone Pellet For Rehabilitation Following Anterior Cruciate Ligament (ACL) Surgical Reconstruction
Rehabilitation of knee stability and function after anterior cruciate ligament (ACL) reconstruction is slow and costly. The use of anabolic steroids, such as oxandrolone, may aid in the recovery of muscle mass and strength, as…
- Trial name
- IMOX (NCT06974526)
- Testing
- Oxandrolone
- Where
- 6 sites in Brazil
- Volunteers
- 96 people
- Sponsor
- Science Valley Research Institute
Meniscus Lesion, Cartilage Injury
Assessment Micro-anatomy of the Menisci and Cartilage After Isolated Acute ACL Injury With MRI at 7T
Study population The investigator set the sample size to 200 patients. Primary outcome Diagnostic accuracy of ultrahigh field MRI (T7) compared to high field MRI (T3 or less) for detection of meniscal injuries associated with…
- Conditions
- Meniscus Lesion, Cartilage Injury, ACL Injury
- Trial name
- NCT05433012
- Testing
- Ultrahigh Field MRI at 7T
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Balgrist University Hospital
ACL Tear
Psychological Factors Influencing the Patient-reported and Functional Outcome of ACL Reconstruction and Their Sex-specific Differences
Psychological parameters among patients undergoing ACL reconstruction and their impact on the patient-reported and functional outcome of reconstruction will be prospectively evaluated
- Trial name
- NCT06156501
- Testing
- ACL Reconstruction
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Anterior Cruciate Ligament Reconstruction Rehabilitation
Effects of Core Exercises on Balance in People With and Without ACL Surgery
The main purpose of this study is to evaluate and compare the effects of an 8-week core stabilization exercise program on balance, trunk muscle endurance, and lower body strength.
- Trial name
- NCT07328139
- Testing
- Core Stabilization Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biruni University
ACL Injury
Effectiveness of a Novel Warm-up in Decreasing Risk Factors for ACL Injury in Female Youth Soccer Players
There is a large number of young women who sustain serious knee injuries from playing soccer. Female athletes are at high risk of knee injuries from soccer than males.
- Trial name
- NCT01591941
- Testing
- Core-PAC
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
ACL Surgery, Pain Management
Efficacy of Methylprednisolone for Pain Control After ACL Repair
Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder.
- Trial name
- NCT07158476
- Testing
- Meloxicam 15 mg, Medrol 4 MG Oral Tablet Includes Medrol Dosepak, Gabapentin 300 mg
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- St. Louis University
Sports Physical Therapy
Comparative Effects of Neuromuscular Training Vs Close Chain Exercises in Athletes With Post Operative ACL Injury
The aim of this study is to determine the effects of close chain exercises and neuromuscular training on pain, range of motion, strength and endurance in athletes with post operative ACL injury The study will be randomized…
- Trial name
- NMTvsCC-ACL (NCT06797102)
- Testing
- Neuromuscular Exercises, Close Chain Exercises
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
ACL Injury, ACL Tear
The Pediatric ALL Evaluation and Trial
The overall aim of this multicenter RCT is to determine whether concomitant ALL reconstruction in children undergoing and ACL reconstruction will longitudinally result in a lower rate of graft failure than ACL reconstruction…
- Trial name
- PALLET (NCT04825587)
- Testing
- Patients will be randomized into one of two study arms: (1) concomitant ACL and ALL reconstruction or (2) ACL reconstruction alone.
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Anterior Cruciate Ligament Injuries, Muscle Weakness
Changes in the Force-velocity Relationship of Knee Muscles After ACL Reconstruction
Anterior cruciate ligament (ACL) tear is a frequent and devastating injury in sport, especially in pivoting-contact disciplines.
- Trial name
- FoVeA (NCT05712109)
- Testing
- Follow-up after Anterior cruciate ligament reconstruction
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Caen
ACL Injury, Graft Failure
Differences in Outcomes and Failure Rates Between Allografts and Autografts in Revision Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament (ACL) rupture is one of the most common knee injuries, particularly in young and physically active individuals.
- Trial name
- ACLREV_GRAFT (NCT07671235)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Stefano Zaffagnini
Anterior Cruciate Ligament Rupture, Rehabilitation
Evaluation of the Effects of Home-based Functional Exercise on Patients With ACL
This study will evaluate the effect of home-based functional exercise on patients with anterior cruciate ligament rupture reconstruction based on the health belief model.
- Trial name
- NCT03890848
- Testing
- Wechat application reminder intervention, routine guidance during discharge
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peking University Third Hospital
ACL Injury
Post-ACL Reconstruction Rehab UPSCALER App RCT HPUPM
EXECUTIVE SUMMARY Research Title An Android Application-Based Delivery of Guided Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Randomised Single-Blinded Pilot Study Investigators Principle Investigator…
- Trial name
- NCT05498285
- Testing
- UPSCALER app
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Rupture of Anterior Cruciate Ligament
Multicenter ACL Revision Study (MARS)
The purpose of this study is to determine the effects of modifiable risk factors on patient-reported quality of life, physical activity levels, and risk of early osteoarthritis following revision anterior cruciate ligament (ACL)…
- Trial name
- MARS (NCT00625885)
- Where
- 49 sites in United States, Canada
- Volunteers
- 1,234 people
- Sponsor
- Vanderbilt University Medical Center
Anterior Cruciate Ligament Rupture, Femoral Nerve Block
FNB in ACL Recon Under GA
The investigators will compare the results of sono-guided femoral nerve block in arthroscopic surgery for anterior cruciate ligament reconstruction under general anesthesia.
- Trial name
- NCT06048848
- Testing
- Sono-guided injection, Ropivacaine injection, Saline injection
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Anterior Cruciate Ligament Injury
Motor Imagery to Facilitate Sensorimotor Relearning After ACL Injury
Anterior cruciate ligament injury is a common issue in sports involving cutting and jumping. Treatment may include surgical intervention followed by physical therapy, or no surgical intervention with the main treatment being…
- Trial name
- MOTIFS (NCT03473821)
- Testing
- MOTIFS
- Where
- Sweden
- Volunteers
- 106 people
- Sponsor
- Lund University
ACL Injury, ACL Tears
Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction
This is a prospective, multi-center, randomized, double-blind, placebo-controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in improving postoperative outcomes following anterior cruciate ligament reconstruction…
- Conditions
- ACL Injury, ACL Tears, ACL Surgery
- Trial name
- NCT07115056
- Testing
- Tranexamic Acid (TXA)
- Where
- 6 sites in United States
- Sponsor
- Campbell Clinic