Clinical trials: ACL
Anterior Cruciate Ligament Injuries
The Impact of Germanium-Embedded Knee Brace on Patient Recovery After ACL Reconstruction
Anti-inflammatory brace technology has demonstrated superior clinical outcomes in the management of knee osteoarthritis and accelerate recovery time for Major League Soccer players.
- Trial name
- NCT05068297
- Testing
- Incrediwear Germanium-Embedded Knee Brace following ACL reconstruction, Replica Knee Brace
- Volunteers
- 100 people
- Sponsor
- Total Sports Medicine & Orthopedics
Anterior Cruciate Ligament Injuries
Neuromuscular Rehab for ACL Reconstruction: Knee Function & Brain Plasticity
This study focuses on patients with anterior cruciate ligament (ACL) rupture and reconstruction, aiming to systematically investigate the clinical efficacy and underlying mechanisms of neuromuscular training in restoring knee…
- Trial name
- NCT07243860
- Testing
- Neuromuscular Training, Conventional Rehabilitation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
ACL Injury, Stiffness of Knee, Not Elsewhere Classified
Hamstring Stiffness After Anterior Cruciate Ligament Reconstruction
The role of hamstring has been studied in anterior cruciate ligament (ACL) injury prevention, mainly to counteract the anterior tibial translation , especially when contracting eccentrically, but also with passive stiffness.
- Conditions
- ACL Injury, Stiffness of Knee, Not Elsewhere Classified, Sport Injury
- Trial name
- ACLSTIFF (NCT05264597)
- Where
- France
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Anterior Cruciate Ligament Injuries
External Focus of Attention Feedback to Reduce Risk of Non-contact ACL Injury
Knee injuries, especially those to the ACL, are common among physically active people. Preventing these injuries from happening is critical to limiting the long-term pain, disability, and arthritis associated with these injuries.
- Trial name
- NCT04914689
- Testing
- Internal focus of attention feedback, Visual internal focus of attention feedback, Auditory external focus of attention feedback
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Charlotte
ACL - Anterior Cruciate Ligament Rupture, Activation Failure
Activation Failure of Knee Extensors After Anterior Cruciate Ligament Rupture Depending on the Contraction Mode
The primary objective of the study is to evaluate the impact of ACL injury and ACL reconstruction on voluntary activation during maximal voluntary contraction (measured by neurophysiological parameters) according to the…
- Conditions
- ACL - Anterior Cruciate Ligament Rupture, Activation Failure, Contraction Mode
- Trial name
- QUADFAIL (NCT06783062)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- La Tour Hospital
ACL, ACL Injury
Evaluation Of Clinical Results And Imaging Of Anterior Cruciate Ligament Reconstruction With Orthopure Xt
The purpose of this study is to evaluate subjective and objective clinical outcomes and imaging data of subjects undergoing reconstruction or revision of LCA reconstruction using OrthoPure XT
- Trial name
- NCT06091488
- Testing
- Orthopure
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Istituto Ortopedico Rizzoli
ACL, ACL Injury
Reduced Knee Flexion Strength 18 Years After ACL Reconstruction in Hamstring Group Compared to Patellar Tendon Group
Background: Bone-patellar tendon-bone (BPTB) and a double-looped semitendinosus gracilis (hamstring group) graft are commonly used for ACL reconstruction.
- Conditions
- ACL, ACL Injury, Cruciate Ligament Rupture, ACL Tear
- Trial name
- Studie ACL (NCT05876013)
- Testing
- ACL reconstruction
- Where
- Norway
- Volunteers
- 114 people
- Sponsor
- St. Olavs Hospital
Osteoarthritis, Arthritis
Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up
In this study the investigators will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction…
- Conditions
- Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT02717559
- Volunteers
- 225 people
- Sponsor
- Vanderbilt University Medical Center
ACL, Anterior Curciate Ligament
Risk of Osteoarthritis of the Knee at Least 5 Years After ACL Reconstruction: Comparative Study Between an Isolated ACL Reconstruction and a Reconstruction Combining ACL and ALL
The main objective of this study is to compare, with a minimum follow-up of 5 years, the prevalence of femoro-tibial osteoarthritis after an isolated ACL ligamentoplasty or after an ACL ligamentoplasty combining ACL and ALL.
- Conditions
- ACL, Anterior Curciate Ligament, Anterolateral Ligament, Knee Injuries
- Trial name
- NCT05123456
- Testing
- Radiography
- Where
- France
- Volunteers
- 180 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Postoperative Pain Management
Suzetrigine Versus Usual-care Opioids for Postop Pain in Sports
The goal of this clinical trial is to learn if a Suzetrigine-based multimodal pain regimen can reduce the volume of opioid consumption while maintaining non-inferior pain control compared to an opioid-based multimodal pain…
- Trial name
- NCT07355166
- Testing
- Suzetrigine, Multimodal Pain Regimen
- Volunteers
- 140 people
- Sponsor
- University of California, Los Angeles
Anterior Cruciate Ligament Injury
Synthetic Bone Graft Substitute vs. Autologous Spongiosa in Revision Anterior Cruciate Ligament Reconstruction
The overall objective is the histological and radiological assessment of bony consolidation of the tibial/femoral tunnel using either bone graft substitute (Actifuse) or autologous spongiosa in patients undergoing revision…
- Trial name
- NCT02845141
- Testing
- Actifuse, bone graft
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Berufsgenossenschaftliche Unfallklinik Ludwigshafen
Knee Injuries, Anterior Cruciate Ligament
Medical and Economical Evaluation of Computer-assisted Reconstruction of the Anterior Cruciate Ligament (ACL)
A poor outcome in anterior cruciate ligament (ACL) reconstruction is often related to tunnel position. The researchers believe that improving the accuracy of tunnel position will lead to an improved outcome in ACL surgery.
- Conditions
- Knee Injuries, Anterior Cruciate Ligament, Arthroscopy
- Trial name
- NCT00492609
- Where
- France
- Volunteers
- 285 people
- Sponsor
- University Hospital, Grenoble
Anterior Cruciate Ligament (ACL) Reconstruction
M-ARS ACL Post-marketing Surveillance Study
The goal of this study is to evaluate the performance of Medacta Anatomic Ribbon Surgery (M-ARS) in patients requiring anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT04462458
- Testing
- Medacta Anatomic Ribbon Surgery (M-ARS ACL)
- Where
- 3 sites in Austria, Germany
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Anterior Cruciate Ligament Injury
Maximum Oxygen Uptake in ACL-injured Professional Soccer Players
Our purpose is to evaluate maximum oxygen uptake (VO2max) in ACL-injured professional soccer players and after a six-month period of post-operative rehabilitation, compared to a control group of healthy professional soccer…
- Trial name
- NCT02674282
- Testing
- ACL reconstruction
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Anterior Cruciate Ligament (ACL) Reconstruction Surgery
KRONOS Versus Breg T-Scope Post-operative Knee Braces Following Anterior Cruciate Ligament (ACL) Reconstruction
The purpose of this study is to evaluate how well the KRONOS postoperative knee brace reduces pain and enhances recovery compared with the standard Breg T-scope hinged brace following anterior cruciate ligament (ACL)…
- Trial name
- NCT07090616
- Testing
- Arm 1-Kronos brace, Arm 2-Breg T-Scope brace
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rush University Medical Center
Pain, Postoperative
A Multicentre, Double-Blind, Double-Dummy, Randomised Study of the Analgesic Efficacy and Safety of Valdecoxib Compared to Diclofenac Sodium in Patients Undergoing Knee Arthroscopy for Anterior Cruciate Ligament (ACL) Reconstruction
To demonstrate non-inferiority of valdecoxib 20 mg twice daily (BID) (with an initial loading dose of 40 mg followed by a second dose of 20 mg on the first day only) with diclofenac sodium delayed release 75 mg BID in analgesic…
- Trial name
- NCT00650598
- Testing
- valdecoxib, diclofenac
- Where
- 25 sites in Australia, Hong Kong and 7 more
- Volunteers
- 328 people
- Sponsor
- Pfizer
ACL
LIVing Donor Allograft for Anterior Cruciate Ligament Reconstruction Study
The Anterior Cruciate Ligament (ACL) is a major stabiliser of the knee. ACL rupture is being increasingly identified in children and skeletally immature patients.
- Trial name
- LivD_ACLR (NCT05395767)
- Testing
- Endoscopic Anterior Cruciate Ligament reconstruction using living donor hamstring allograft from a parent donor
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maidstone & Tunbridge Wells NHS Trust
ACL Injury, ACL Reconstruction
Comparative Effectiveness of Blood Flow Restriction With or Without Total Motion Release in ACL Rehabilitation
The aim of this clinical trial is to compare the effectiveness of combined Blood Flow Restriction (BFR) and Total Motion Release (TMR) versus BFR alone in the restoration of muscular strength, balance and knee functionality in…
- Trial name
- BFR-TMR-ACL (NCT07589309)
- Testing
- Blood Flow Restriction, Total Motion Release
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Green International University
ACL Injuries
Exercise Program for Knee Recovery in Football Players with ACL Injuries
This study aims to evaluate the effectiveness of a structured exercise program in improving knee function, muscle strength, and range of motion in football players recovering from anterior cruciate ligament (ACL) injuries.
- Trial name
- NCT06808763
- Testing
- Knee Rehabilitation Exercise Program
- Where
- Saudi Arabia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- King Saud University
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Reliability and Validity of Inline Dynamometry Study for Measuring Knee Extensor Torque
This study will investigate the reliability and validity of an inline 'pull-type' dynamometer for measuring peak knee extensor torque.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05109871
- Testing
- KForce Link
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust