Clinical trials: A Randomized Controlled Trial
Migraine
Intravenous Metoclopramide Versus Dexketoprofen Trometamol Versus Metoclopramide+ Dexketoprofen Trometamol in Migraine
Acute headache is one of the most common reasons for presentation to the emergency department (ED), accounting for 2-3% of all emergency visits.
- Trial name
- NCT04252521
- Testing
- metoclopramide, dexketoprofen trometamol, metoclopramide+dexketoprofen trometamol
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Adiyaman University Research Hospital
Pain
Pain Control After Cardiac Surgery Using Intravenous Acetaminophen
Evaluate the efficacy of IV acetaminophen; compared to a placebo, in reducing opioid consumption and/or pain intensity scores after cardiac surgery.
- Trial name
- NCT01822821
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Cleveland Clinic
Breast Cancer
Comparing the Safety and Cosmetic Outcomes Between Laparoscopic Versus Traditional Open Breast-conserving Surgery
In recent years, laparoscopic breast cancer surgery has received wide attention. It has advantages of minimal invasiveness, clear anatomical exposure, and good aesthetic effects.
- Trial name
- NCT06671249
- Testing
- Laparoscopic breast-conserving surgery, Traditional open breast-conserving surgery
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Periodontal Disease
Randomized Controlled Trial of a Novel Laser-aided Orthodontic-periodontal Treatment Strategy
The aim of the study is to assess the effects of low-level laser therapy (LLLT) in patients with periodontitis during orthodontic-periodontal treatment for 12 months on the following aspects: (1) Effects on periodontal status…
- Trial name
- NCT02352038
- Testing
- low-level laser therapy, orthodontic treatment
- Where
- Hong Kong
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Colorectal Adenoma
Spectral Focused Imaging Versus White Light Imaging in Colorectal Adenoma Detection
Spectral Focused Imaging (SFI) is newly developed image-enhancing endoscopy technology that enhances the contrast of target tissue structures while improving color contrast because spectral signal energy is further concentrated…
- Trial name
- SFI verus WLI (NCT06603948)
- Testing
- Spectral Focused Imaging, White Light Imaging
- Where
- 8 sites in China
- Volunteers
- 698 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetic Neuropathies, Diabetic Neuropathy, Painful
Effect of TENS on Sensory Parameters in Diabetic Polyneuropathy
Diabetic polyneuropathy is a common complication of diabetes that damages the nerves of the feet and legs. Besides causing pain, it gradually reduces the ability to feel light touch on the sole of the foot.
- Conditions
- Diabetic Neuropathies, Diabetic Neuropathy, Painful, Peripheral Nervous System Diseases
- Trial name
- NCT07807748
- Testing
- High-Frequency TENS, Low-Frequency TENS
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Secondary Sclerosing Cholangitis
Biliary Interventions in Critically Ill Patients With Secondary Sclerosing Cholangitis (BISCIT)
This is a randomized, open-label, controlled, parallel group, multicenter clinical trial. Patients with confirmed secondary sclerosing cholangitis (SSC-CIP) will be randomized either in the intervention group undergoing scheduled…
- Trial name
- BISCIT (NCT05396755)
- Testing
- Endoscopic retrograde cholangiography (ERC)
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Hannover Medical School
Critical Illness
Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support
Background Intraoperative hypotension is a common problem that significantly contributes to perioperative mortality and morbidity.
- Trial name
- KATECHOL (NCT02414555)
- Testing
- vasopressor, fluid bolus, oesophagus doppler (CardioQ)
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Postpartum Depression (PPD)
SAINT in Postpartum Depression (PPD)
This study is a large, multi-site clinical trial testing whether Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT), a fast-acting form of repetitive transcranial magnetic stimulation (rTMS), can more effectively…
- Trial name
- NCT07210255
- Testing
- SAINT Neuromodulation System
- Where
- 4 sites in United States
- Volunteers
- 192 people
- Sponsor
- Magnus Medical
Forward Head Posture
Effects of Nordic Pole Walking in Adults With Forward Head Posture
This randomized controlled trial aims to investigate the effects of Nordic pole walking on pain, neck-related disability, pulmonary function, respiratory muscle strength, and postural alignment in adults with forward head posture…
- Trial name
- NCT07840755
- Testing
- Nordic Pole Walking, General Walking
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Sahmyook University
Subacromial Impingement Syndrome
Effects of Exercise Trainings on Pain, Function and AHD in Patients With SPS
Abnormal reduction of the AHD has been considered as one of the possible mechanisms in the aetiology of subacromial pain syndrome.
- Trial name
- NCT03494192
- Testing
- Scapula Retraction Exercise Group, Scapula Retraction +Glenohumeral Rotational Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Ulcer
H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection
This study will evaluate the effect of Helicobacter pylori eradication therapy on the healing of iatrogenic gastric ulcer caused by endoscopic mucosal resection of gastric neoplastic lesions and is a multicenter, randomized…
- Trial name
- NCT00926809
- Testing
- Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin
- Where
- 6 sites in South Korea
- Volunteers
- 232 people
- Sponsor
- Korean College of Helicobacter and Upper Gastrointestinal Research
Stress Disorders, Post-Traumatic
Computer Monitor vs Augmented Reality 3MDR for PTSD PTSD: A Randomized Controlled Trial
This is a prospective randomized controlled trial comparing two ways of delivering Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR) therapy for posttraumatic stress disorder (PTSD).
- Trial name
- CARE4PTSD (NCT05244564)
- Testing
- Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Uniformed Services University of the Health Sciences
HIV Infections
Comprehensive HIV and Harm Prevention Via Telehealth
The purpose of this study is to test 2 different ways to offer medications to prevent human immunodeficiency virus (HIV), cure hepatitis C virus (HCV) (if applicable) and treat substance use disorder (if desired) in people who…
- Trial name
- CHARIOT (NCT05897099)
- Testing
- Comprehensive Tele-harm Reduction, Off-site Linkage to HIV Prevention
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Miami
Protein Malnutrition
Comparison of Clinical Outcomes According to High-protein Provision in Critically Ill Patients After Abdominal Surgery
Protein malnutrition in critically ill patients is a global concern due to its association with prolonged hospital stays, and higher morbidity rates.
- Trial name
- NCT06458387
- Testing
- Active protein supplementation, Conventional protein supplementation
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Seoul St. Mary's Hospital
Cardiac Rehabilitation
Cardiac Rehabilitation Mobile-Health Fall Risk Prevention Intervention
The purpose of this research is to see if taking part in a structured exercise plan that is designed to improve balance and muscle strength and one that can done at home helps to improve the ability to perform standard physical…
- Trial name
- NCT05826587
- Testing
- Home-based, m-Health Delivered Physical Function Training, Cardiac Rehabilitation & Exercise Prescription, Connected mHealth mobile application
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Mayo Clinic
Hyperglycemia, Critical Illness
Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE - SUGAR STUDY)
The primary aim of the study is to compare the effects of the two blood glucose targets on 90 day all-cause mortality in Intensive Care patients who are predicted on admission to stay in the ICU for at least one full calendar…
- Trial name
- NCT00220987
- Testing
- Intensive Insulin Therapy, Conventional Insulin therapy
- Where
- Australia
- Volunteers
- 6,104 people
- Sponsor
- The George Institute
Drug Safety, Respiratory Syncytial Virus Infections
A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of MDT-637 in Healthy Volunteers
The purpose of this study is to determine the range of single inhaled doses of a new dry powder product, MDT-637, that are safe and well-tolerated.
- Trial name
- NCT01355016
- Testing
- MDT-637
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- MicroDose Therapeutx, Inc
Multiple Sclerosis
REbif FLEXible Dosing in Early Multiple Sclerosis (MS)
The study is a 24 months randomized, double-blind, Placebo-controlled, multi-center clinical trial with an optional 12 months open label extension.
- Trial name
- REFLEX (NCT00404352)
- Testing
- RNF
- Where
- 67 sites in Argentina, Australia and 25 more
- Volunteers
- 517 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Iron Deficiency Anemia
A Trial Comparing Ferumoxytol With Iron Sucrose for the Treatment of Iron Deficiency Anemia
The purpose of the study is to evaluate the efficacy and safety of intravenous (IV) ferumoxytol compared to IV iron sucrose for the treatment of iron deficiency anemia (IDA).
- Trial name
- NCT01114204
- Testing
- Ferumoxytol, Iron Sucrose
- Where
- 96 sites in Australia, France and 12 more
- Volunteers
- 605 people
- Sponsor
- AMAG Pharmaceuticals, Inc.