Clinical trials: open to volunteers
ADHD
An Open-Label Study to Assess the Long-Term Safety of Solriamfetol in Children and Adolescents With ADHD
This study is a Phase 3, multi-center, open-label trial to evaluate the long-term safety of solriamfetol in children and adolescents with ADHD.
- Trial name
- NCT07773883
- Testing
- Solriamfetol
- Where
- 10 sites in United States
- Volunteers
- 300 people
- Sponsor
- Axsome Therapeutics, Inc.
Physical Activity, Body Image
THE EFFECTS OF GAME-BASED EXERCISE PROGRAMS
Studies comparing aerobic exercise with virtual reality or video game technologies to traditional games and classical exercise have been conducted in healthy adolescents, but no studies comparing virtual reality and video game…
- Conditions
- Physical Activity, Body Image, Exercise Perception, Balance
- Trial name
- NCT07660822
- Testing
- Conventional Physical Exercise Program, Xbox Console-Based Exercise Program, Virtual Reality-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Gaziantep Islam Science and Technology University
Secondary Malignancies of T-cell Origin
A Non-Interventional Study PASS to Characterize Secondary Malignancies of Tcell Origin Following Tisagenlecleucel Therapy
The study aims to provide an adequate procedural framework to support and facilitate collection of existing participant samples from patients who were diagnosed with secondary malignancy of T-cell origin any time after…
- Trial name
- Lythesia (NCT07378969)
- Where
- 4 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Cerebral Palsy
Feasibility of a Robot-Guided Active Play Intervention for Children With Cerebral Palsy
Cerebral palsy can make it difficult for children and adolescents to participate consistently in enjoyable physical activity. This study will examine whether a small humanoid robot called NAO can deliver a short, story-based…
- Trial name
- REACT (NCT07842328)
- Testing
- Humanoid Robot-Guided Active Play Intervention
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Pyelonephritis
Population Pharmacokinetics of Temocillin in Acute Enterobacterial Pyelonephritis in Children
Temocillin, a 6-alpha-methoxypenicillin derivative of ticarcillin, is a narrow-spectrum antibiotic, primarily restricted to Enterobacterales.
- Trial name
- TEMOKID-POP (NCT07070102)
- Testing
- blood samples
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adverse Childhood Experience, Depression / Major Depressive Disorder
Preventive and Personalized Digital Emotion Regulation Skills Intervention to Reduce Depression and Anxiety in Youths With Adverse Childhood Experiences
The present study aims to determine whether a personalized digital psychoeducation intervention (active intervention group) is more effective than self-monitoring of one's mood (control group) in reducing emotion regulation…
- Conditions
- Adverse Childhood Experience, Depression / Major Depressive Disorder, Anxiety Depression, Anxiety
- Trial name
- PREVENT-DERS (NCT07921446)
- Testing
- Lifestyle psychoeducation intervention, Personalized digital psychoeducation intervention on emotion regulation
- Volunteers
- 140 people
- Sponsor
- Institute of Mental Health, Singapore
Hematopoietic Stem Cell Transplant
Prevalence and Development of Liver Dysfunction in Hematopoietic Stem Cell Transplant
Background: Hematopoietic stem cell transplant (HSCT) is a common treatment for many cancers and other illnesses. But many people who have HSCT go on to develop liver dysfunction.
- Trial name
- NCT05722210
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cancer
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
The purpose of this extension study is to provide continued treatment with Roche investigational medicinal product (IMP[s]) monotherapy or Roche IMP(s) combined with other agent(s) or comparator agent(s) for eligible participants…
- Trial name
- UmbrellaMAX (NCT05862285)
- Testing
- Ipatasertib, Tiragolumab, Atezolizumab
- Where
- 85 sites in Belgium, Canada and 13 more
- Volunteers
- 200 people
- Sponsor
- Hoffmann-La Roche
Thrombotic Thrombocytopenic Purpura (TTP)
A Study in Children and, Adults With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Treated With Adzynma
Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare blood disorder that some people are born with. It is caused by a problem in a gene passed down from parents to children, which affects the body's ability to produce…
- Trial name
- NCT07353099
- Testing
- No Intervention
- Where
- 7 sites in Austria, Germany
- Volunteers
- 50 people
- Sponsor
- Takeda
Cardiomyopathies, Cardiac Arrest
AI-powered ECG Analysis Using Willem™ Software in High-risk Cardiac Patients (WILLEM)
WILLEM is a multi-center, prospective and retrospective cohort study. The study will assess the performance of a cloud-based and AI-powered ECG analysis platform, named Willem™, developed to detect arrhythmias and other abnormal…
- Conditions
- Cardiomyopathies, Cardiac Arrest, Cardiac Arrhythmias, Sudden Cardiac Death
- Trial name
- WILLEM (NCT05890716)
- Testing
- AI-powered ECG analysis to detect cardiac arrhythmic episodes
- Where
- 13 sites in Netherlands, Spain
- Volunteers
- 5,342 people, healthy volunteers welcome
- Sponsor
- Idoven 1903 S.L.
Suicidal Ideas, Suicidal Ideation
A Pre-post Study of a Lethal Means Safety Planning Intervention for Youth at Elevated Suicide Risk in the Emergency Department
The purpose of this study is to test whether a lethal means safety planning intervention, TEEN LENS ED, is acceptable to teens at elevated suicide risk and their caregivers in the Emergency Department.
- Conditions
- Suicidal Ideas, Suicidal Ideation, Suicidal Thoughts, Firearm Safety
- Trial name
- TEEN LENS ED (NCT07916792)
- Testing
- TEEN LENS, Usual Care
- Volunteers
- 200 people
- Sponsor
- University of Colorado, Denver
Neoplasms, Cancer
Data Collection, Clinical Care and Interventions in CCR, NCI
This study provides cancer care through the National Cancer Institute's Medical Oncology Branch (MOB) to patients who are not enrolled in an active treatment research protocol.
- Trial name
- NCT00923065
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Berger Disease, Bergers Disease
Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Atrasentan in Pediatric Patients With Primary IgAN
A Phase III, single-arm, multicenter pediatric clinical study evaluating atrasentan in children and adolescents aged 2 to <18 years with primary immunoglobulin A nephropathy (IgAN).
- Conditions
- Berger Disease, Bergers Disease, IgA Nephropathy, Immunoglobulin A Nephropathy
- Trial name
- ADVANCE (NCT07498335)
- Testing
- Drug: Atrasentan
- Where
- 23 sites in United States, China and 6 more
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Renal Failure Congenital, Congenital Renal Anomaly Nos
Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia
Congenital lower urinary tract obstruction (LUTO) is a heterogeneous group of congenital anomalies that lead bladder outlet obstruction.
- Conditions
- Renal Failure Congenital, Congenital Renal Anomaly Nos, Renal Agenesis and Dysgenesis, Lower Urinary Tract Obstructive Syndrome
- Trial name
- NCT03723564
- Testing
- Lactated Ringers Solution for Injection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Respiratory Syncytial Virus (RSV)
Study to Learn About a Respiratory Syncytial Virus Vaccine in Children at High Risk of RSV Disease
The purpose of the study is to evaluate the safety, tolerability, and immunogenicity of RSVpreF in children 5 to <18 years of age at high risk for RSV disease, including those who are immunocompromised.
- Trial name
- NCT07839871
- Testing
- RSVpreF
- Where
- 20 sites in United States, Japan and 2 more
- Volunteers
- 920 people, healthy volunteers welcome
- Sponsor
- Pfizer
Diplegic Cerebral Palsy
Additional Effects on tDCS With AOT on Lower Limb Functions on Children With Diplegic CP
The goal of this clinical trial is to evaluate the therapeutic effects of combining active transcranial direct current stimulation (tDCS) with Action Observation Therapy (AOT) in pediatric patients diagnosed with spastic Cerebral…
- Trial name
- tDCS (NCT07921095)
- Testing
- Action Observation Therapy, Transcranial Direct Current Stimulation
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Vestibular Dysfunction, Hearing Loss
Impact of Vestibular Function on Deaf Infants' Activities of Daily Living
This non-interventional study aims to assess the impact of vestibular impairments on the daily life activities of deaf children aged 0 to 2 years old.
- Conditions
- Vestibular Dysfunction, Hearing Loss, Motor Development
- Trial name
- IVANS (NCT06909266)
- Testing
- OT Hope 0 - 5 ans Therapeutic tool, Qualitative interviews with parents
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rectal Neoplasms
Pre- and On-treatment Multi-omics Profiling of Locally Advanced Rectal Cancer
This prospective observational study characterises the tumour immune microenvironment and microbial ecology of locally advanced rectal cancer before and during neoadjuvant therapy.
- Trial name
- NCT07920770
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University Union Hospital
Substance Use Risk, Structural Stressors
Structural Stressors, Reward Related Decision Making and Substance Use Risk
The goal of this observational study, which has a pilot phase (R61) and a second, larger phase (R33), is to learn about the impact of indicators of structural stressors (SS) on substance use risk in Puerto Rican adolescents…
- Trial name
- NCT06221839
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Columbia University
Conduct Disorder
Lisdexamfetamine For the Treatment of Conduct Disorder in Children
About 2 in every 100 Australian children have conduct disorder, a serious mental health condition characterised by antisocial behaviours like aggression and rule breaking.
- Trial name
- LiFT-CD (NCT07923617)
- Testing
- Lidexamfetamine
- Volunteers
- 30 people
- Sponsor
- Orygen
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