Clinical trials: Phase 4, open to volunteers
Infection, Sepsis
A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients
The goal of this clinical trial is to examine the success and safety of administering certain antibiotics (beta-lactams) given in a longer 3-hour infusion to children (0-17 years) who are critically ill and have severe infection.
- Conditions
- Infection, Sepsis, NICU, PICU
- Trial name
- PEBBLE (NCT07484633)
- Testing
- Extended infusion time of the following beta-lactam: meropenem, Short-term infusion time of the following beta-lactam: meropenem, Extended infusion time of the following beta-lactam: piperacillin/tazobactam
- Where
- 2 sites in Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Hip Disease, Hip Dysplasia
PENG With LFCB vs. ESP Blocks for Pediatric Hip Surgery
This randomized controlled trial (RCT) compares the analgesic effectiveness of two regional anesthesia techniques-Pericapsular Nerve Group (PENG) block combined with Lateral Femoral Cutaneous Nerve Block (LFCB) versus Lumbar and…
- Conditions
- Hip Disease, Hip Dysplasia, Hip Arthropathy
- Trial name
- NCT07023094
- Testing
- Ropivacaine 0.2% for PENG Block, Ropivacaine 0.2% for LFCB, Ropivacaine 0.2% for L-ESPB
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Bloodstream Infection, Bloodstream Infection Due to Central Venous Catheter
Oral Switch in Bloodstream Infections in Immunocompromised Children
This nationwide, multicenter, randomized non-inferiority trial aims to determine whether an switch to oral antibiotic therapy (experimental arm) is non-inferior to standard intravenous antibiotic therapy (control arm) with…
- Conditions
- Bloodstream Infection, Bloodstream Infection Due to Central Venous Catheter, Immunocompromised Patients, Bacteremia Sepsis
- Trial name
- Oral_Switch (NCT07923266)
- Testing
- Oral antibiotic therapy, Standard IV antibiotic therapy
- Where
- 4 sites in Denmark
- Volunteers
- 114 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Neonatal Seizure
Study of Electrocardiogram (ECG) Safety of Sezaby in Neonatal Seizures
This Phase 4, multicenter, single-arm, open-label study evaluates the effect of intravenous Sezaby (phenobarbital sodium) on electrocardiographic safety, including the QT interval, in neonates with seizures.
- Trial name
- NCT07923734
- Testing
- Sezaby
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Sun Pharma Advanced Research Company Limited
HIV-1-infection
A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments
The goal of this clinical study is to provide continued access to the study drug(s) to children and adolescents with human immunodeficiency virus type 1 (HIV-1) who completed their participation in an applicable parent study and…
- Trial name
- NCT06337032
- Testing
- F/TAF (High Dose Tablet), F/TAF (Low Dose Tablet), F/TAF (Lowest Dose Tablet)
- Where
- 17 sites in Argentina, Panama and 4 more
- Volunteers
- 350 people
- Sponsor
- Gilead Sciences
Acne
Safety, Tolerability, and Clinical Effectiveness of Adapalene/Clindamycin Phosphate Gel (Klenzit®-C) in Vietnamese Patients With Mild to Moderate Acne Vulgaris
The CLEAN ACNE Study is a prospective, observational, Phase IV, open-label, multicenter, single-arm study at 3-5 sites in Vietnam.
- Trial name
- Clean Acne (NCT07918001)
- Testing
- Klenzit®-C (Adapalene/Clindamycin Phosphate Gel)
- Where
- 3 sites in Vietnam
- Volunteers
- 225 people
- Sponsor
- IR INNOVATE RESEARCH PRIVATE LIMITED
Labor Pain
Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor
This randomized, double-blind, placebo-controlled trial aims to compare the analgesic efficacy and obstetric effects of tramadol (100 mg IV) versus paracetamol (1 g IV) versus placebo (saline solution) in nulliparous women during…
- Trial name
- TRAMPA (NCT07440069)
- Testing
- Tramadol Hydrochloride, Paracetamol (acetaminophen)
- Where
- 2 sites in Honduras
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Honduras
Lactation, Inflammatory Bowel Disease
A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants Receiving Mirikizumab Therapeutically for an Approved Indication
The main purpose of this study is to assess the amount of mirikizumab in breast milk in women who are breastfeeding who are receiving stable maintenance doses of mirikizumab for an approved indication.
- Trial name
- NCT07612267
- Testing
- Mirikizumab
- Where
- 20 sites in United States, Canada and 5 more
- Volunteers
- 14 people
- Sponsor
- Eli Lilly and Company
SARS-CoV-2
A Study to Investigate the Immunogenicity and Safety of mRNA COVID-19 Variant-containing Formulations
The purpose of this study is to evaluate the immunogenicity and safety of mRNA-1283 and mRNA-1273 (variant formulations) within the current epidemiological environment
- Trial name
- NCT07863635
- Testing
- mRNA-1273, mRNA-1283
- Where
- 5 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Febrile Neutropenia
Adjustment of Antibiotic Dosage in Pediatric Oncology Patients With Febrile Neutropenia and Augmented Renal Clearance
This clinical trial focuses on children with cancer who face infections after receiving chemotherapy. Chemotherapy affects the bone marrow, leading to a decrease in the production of certain white blood cells, particularly those…
- Trial name
- DAR-ARC (NCT06293677)
- Testing
- Dosage Adjustment Rules for Augmented Renal Clearance (DAR-ARC) for piperacillin-tazobactam and meropenem, Standard dosages of piperacillin-tazobactam or meropenem
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Ureteropelvic Junction Obstruction, Hypospadias
Effect of Oxybutynin on Opioid Use After Urologic Surgery in Children
The goal of this clinical trial is to determine whether giving oxybutynin before urologic reconstruction surgery reduces the amount of opioid pain medication needed in children.
- Trial name
- NCT07911137
- Testing
- Oxybutynin
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
Propofol, Ketamine
Propofol-Ketamine Versus Sevoflurane for Laryngeal Mask Anesthesia in Pediatric Cardiac Catheterization
Children undergoing cardiac catheterization will be given anesthesia using either a combination of propofol and ketamine or sevoflurane gas. The time taken to fall asleep will be recorded.
- Conditions
- Propofol, Ketamine, General Anesthetic Drug Adverse Reaction
- Trial name
- NCT07907796
- Testing
- Ketamine-Propofol, Sevoflurane
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Rawalpindi Institute of Cardiology
Pheochromocytoma and Paraganglioma (PPGL)
Safety and Efficacy of Belzutifan in Preoperative Preparation for Patients With Pheochromocytoma/Paraganglioma (PPGL)
It is preliminarily clarified that belzutifan exerts an inhibitory effect on catecholamine synthesis in pheochromocytoma and paraganglioma (PPGL), and its safety is simultaneously confirmed, thereby providing preliminary…
- Trial name
- NCT07907341
- Testing
- Belzutifan
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Longfei Liu，MD
Thigh Muscle Injury, Thigh Injury
PPP Versus Corticosteroid for Thigh Muscle Injuries
The purpose of this study is to compare the number of days it takes for a sport participant to return to play between ultrasound guided intramuscular corticosteroid injections and platelet-poor plasma (PPP) injections for thigh…
- Conditions
- Thigh Muscle Injury, Thigh Injury, Musculoskeletal, Musculoskeletal Injury Trauma
- Trial name
- NCT07513142
- Testing
- Corticosteroid, Platelet Poor Plasma
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Andrews Research & Education Foundation
Spinal Muscular Atrophy
ASsessing The REAl-world Safety & Effectiveness of Spinal Muscular Atrophy Participants Treated With Intrathecal Onasemnogene Abeparvovec-brve (OAV101B) (ITVISMA®): A U.S. Pragmatic Multicenter Study (STREAM)
The primary purpose is to address critical evidence in the treatment landscape for Spinal Muscular Atrophy (SMA), specifically focusing on the intrathecal formulation of onasemnogene abeparvovec-brve (ITVISMA®). U.S.
- Trial name
- NCT07448610
- Testing
- Onasemnogene Abeparvovec-brve
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- Novartis Pharmaceuticals
Obesity, Overweight
FutureShape Family
The number of adults and children living with obesity is increasing worldwide. Once childhood obesity has developed, more than 80% of children carry the obesity into adulthood, with a high risk of cardiometabolic disease, poor…
- Trial name
- NCT07872904
- Testing
- Family Care, Standard Care, Semaglutide (administered by PDS290 pen-injector)
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Signe Torekov
Congenital Diaphragmatic Hernia
De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia
The purpose of this study is to determine if de-implementation of inhaled nitric oxide (iNO) in the post-natal resuscitation/stabilization phase affects the composite outcome of extracorporeal life support (ECLS) use and/or…
- Trial name
- NCT05213676
- Testing
- Inhaled Nitric Oxide (iNO) use, De-implementation of Inhaled Nitric Oxide (iNO) use
- Where
- 19 sites in United States
- Volunteers
- 900 people
- Sponsor
- The University of Texas Health Science Center, Houston
Juvenile Idiopathic Arthritis (JIA)
Withdrawal Versus Continued TNF Inhibitor Monotherapy Treatment in Children With Inactive Juvenile Idiopathic Arthritis
The goal of this clinical trial is to learn whether children and adolescents with juvenile idiopathic arthritis (JIA) who have had inactive disease for a long time can safely discontinue treatment with a tumour necrosis factor…
- Trial name
- The Treat-JIA (NCT07904780)
- Testing
- Adalimumab, Etanercept, Golimumab
- Where
- 3 sites in Norway
- Volunteers
- 90 people
- Sponsor
- Oslo University Hospital
Food Allergy
Oral Food Challenge After One to Two Doses of Omalizumab Treatment for Food Allergy
The goal of this clinical trial is to learn how quickly omalizumab begins to work in people with food allergy. The main question it aims to answer is: Does omalizumab begin to work as early as 2 to 4 weeks after after starting…
- Trial name
- NCT07845552
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Herpes Simplex 2, Meningitis, Viral
Aciclovir Versus Placebo for HSV-2 Meningitis
To determine whether active treatment with (val)acyclovir is superior for treatment of viral meningitis compared with placebo assessed by numbers meeting a primary, objective endpoint at 7 days after randomisation
- Trial name
- AMEN (NCT05452928)
- Testing
- Acyclovir 50 MG/ML
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jacob Bodilsen