Clinical trials: withdrawn
SH2B1 Deficiency Obesity, Obesity Associated With PCSK1 Mutation (rs6232 Variant)
An Open-Label Study of Diazoxide Choline in Patients With Genetic Obesities
This is a phase 2 open-label, one-arm, clinical study to evaluate the efficacy and safety of DCCR (diazoxide choline) extended-release tablets over 1 year of treatment, in patients with genetic obesities.
- Conditions
- SH2B1 Deficiency Obesity, Obesity Associated With PCSK1 Mutation (rs6232 Variant), SIM1 Deficiency Obesity
- Trial name
- NCT05532020
- Testing
- DCCR (diazoxide choline) extended-release tablets
- Sponsor
- Soleno Therapeutics, Inc.
Pediatric Chronic Neuropathic Pain
Gabapentin and Oxcarbazepine for Chronic Neuropathic Pain in Children and Adolescents: A Clinical Effectiveness Study
Given the widespread use of anticonvulsants in the pediatric chronic pain population and the absence of scientific data supporting their use, the investigators propose a randomized, double blind, two group parallel design in…
- Trial name
- NCT02219373
- Testing
- Gabapentin, Oxcarbazepine
- Where
- United States
- Sponsor
- Boston Children's Hospital
Patellar (or Kneecap) Instability and Mal-alignment, Patellar Dislocation
MPFL Reconstruction Versus Rehabilitation
This study involves patients between the ages of 16 and 25 and have been diagnosed with a first-time traumatic patellar dislocation within the past 3 months.
- Trial name
- ANTI-GLIDE (NCT06926699)
- Testing
- Medial Patellofemoral Ligament Reconstruction, Rehabilitation
- Sponsor
- McMaster University
Pediatric ALL, Appendix Diseases
The Effectiveness of the Training Given With Audio and Picture Book Before the Surgery
Behavioral practices applied to the child in the preoperative period; It includes methods such as introducing the hospital and operating room to children and their parents, reading storybooks, giving training books, an…
- Trial name
- NCT04960761
- Testing
- İntervention Group
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Intubated Patients
Pilot Study of the Sage Guard for Oral Cavity Protection
The study will evaluate how safe the device is and how easy it is for healthcare providers to use in patients receiving care in the Intensive Care Unit (ICU).
- Trial name
- NCT07806812
- Testing
- Sage Guard oral protection device
- Sponsor
- Wake Forest University Health Sciences
Otosclerosis, Tympanic Membrane Perforation
Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease
We study audiometric parameters including Transient Otoacoustic emissions, pure-tone audiometry for air- and bone-conduction, and spondaic speech recognition thresholds for air- and bone conduction in a pre- and postoperative…
- Trial name
- NCT00222417
- Testing
- myringoplasty, Stapes surgery
- Where
- Norway
- Sponsor
- University Hospital of North Norway
Spinal Muscular Atrophy (SMA)
Real World Clinical Effectiveness & Safety of Vesemnogene Lantuparvovec for Spinal Muscular Atrophy (SMA) in Low-middle Income Countries (LMIC).
The study objective is to determine the real-world safety and effectiveness of Vesemnogene lantuparvovec for the treatment of SMA.
- Trial name
- NCT07265232
- Testing
- vesemnogene lantuparvovec
- Where
- Indonesia
- Sponsor
- Lantu Biopharma
Pediatric Acute Leukemia
A Phase Ia/Ib Trial of Revumenib Combined With Cytarabine, Daunorubicin, and Gemtuzumab Ozogamicin (GO) in Frontline and Relapsed /Refractory Pediatric Acute Leukemia Patients
The goal of Phase 1a of this clinical research study is to find the highest tolerable dose of revumenib that can be given in combination with cytarabine, daunorubicin, and gemtuzumab ozogamicin to patients who have acute…
- Trial name
- NCT07052994
- Testing
- Revumenib, Cytrabine, Daunorubicin
- Sponsor
- M.D. Anderson Cancer Center
Spinal Cord Injuries
"UroMonitor Trial" in Spinal Cord Injury.
This study aims to determine if a non-functioning UroMonitor device can be safely inserted, monitored, and removed in patients with SCI.
- Trial name
- NCT04800523
- Testing
- UroMonitor System
- Where
- Canada
- Sponsor
- University of British Columbia
Aging
PUER ("Previously Unrecognized Emerging Risks") Life Clinical Study (PUER) in Ages 6 Through 18
The goal of this observational study is to learn about changes in health in children that develop over time that may impact overall health and a healthy lifespan.
- Trial name
- NCT06802029
- Testing
- Whole Genome Sequencing Analysis
- Where
- United States
- Sponsor
- Puer Research, LLC
Orthodontic Appliances
Benefits of an Orthodontic Device Removable Functional Appliance in the Management of Malocclusions/Orofacial Dysfunctions
The removable functional appliance's goal is to restore functional balance (breathing, swallowing, chewing, etc.) and muscular balance (facial muscles, etc.) in the child.
- Trial name
- NCT07127328
- Testing
- Patient with removable funcitonal appliance
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Shoulder Dislocation
Conservative Versus Operative - First Time Shoulder Dislocations
There is no consensus regarding whether rehabilitation or surgical stabilization leads to optimized outcomes for treatment of primary anterior shoulder dislocations.
- Trial name
- NCT05532150
- Testing
- Arthroscopic Bankart repair, Physical therapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
ACL Tear
Anterior Cruciate Ligament (ACL) Reconstruction With Bone Tendon Bone Autograft With Versus Without Internal Bracing
There is no consensus regarding the best surgical management of primary ACL tears. Recent evidence suggests that internal brace augmentation may increase load failure and therefore stabilize the graft in-situ at the time of ACL…
- Trial name
- NCT05532189
- Testing
- ACL reconstruction with BTB autograft with internal brace augmentation (suture tape), ACL reconstruction with BTB autograft without internal brace augmentation (suture tape), Standardized Rehabilitation Protocol
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Patella Dislocation
Conservative Versus Operative - First Time Patella Dislocations
There is no consensus regarding whether rehabilitation or surgical management is best for the management of a primary patellar dislocation.
- Trial name
- NCT05533671
- Testing
- medial patellofemoral reconstruction, Non-operative group
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Adolescent Health, Minority Health
Screening and Support for Youth (SASY)
To adapt the Screening and Support for Youth (SASY) intervention and approach to recruitment for racial, ethnic and linguistic diverse youth aged 12-17 in the Denver Health catchment area
- Conditions
- Adolescent Health, Minority Health, Mental Health, Community Health Services
- Trial name
- SASY (NCT06419595)
- Testing
- Behavioral: Screening and Support for Youth (SASY) Multi-component Platform: includes screening, feedback, single session intervention, and resource information
- Sponsor
- Cambridge Health Alliance
Ganglioneuroblastoma, Ganglioneuroblastoma, Nodular
Comparing 123I-MIBG and 18F-MFBG Imaging in Patients With Newly Diagnosed, High Risk Neuroblastoma
This phase II trial evaluates whether an investigational scan (18F-MFBG positron emission tomography [PET]/computed tomography [CT] or PET/magnetic resonance imaging [MRI]) can accurately detect tumors in patients with newly…
- Conditions
- Ganglioneuroblastoma, Ganglioneuroblastoma, Nodular, High Risk Neuroblastoma
- Trial name
- NCT06858501
- Testing
- Biospecimen Collection, Computed Tomography, Florbenguane F18
- Sponsor
- Children's Oncology Group
Human Immunodeficiency Virus (HIV)
ComBaCaL HIV Prevention TwiCs
This cluster-randomized intervention is embedded in the ComBaCaL (Community-Based Chronic disease care Lesotho) cohort study (EKNZ ID AO_2022-00058, clinicaltrials.gov ID NCT05596773, Lesotho NH-REC ID 210-2022), a platform for…
- Trial name
- CoPrev (NCT07581600)
- Testing
- CoPrev model, Referral to the nearest responsible health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Malaria
Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1)
Background: Malaria is a disease that affects many people in Africa. It is caused by germs carried by some mosquitoes. A person bitten by an infected mosquito will get malaria.
- Trial name
- NCT05652504
- Testing
- PfSPZ Vaccine, PfSPZ Diluent, Normal Saline
- Where
- Mali
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphoma, Myeloma
CD70.CAR for CD70+ Lymphoma, Myeloma and Solid Tumors
This study is for patients who have a type of cancer that expresses the protein CD70, which includes lymphoma (lymph gland cancer), myeloma and solid tumors including some sarcomas and kidney cancers, and the cancer has come back…
- Conditions
- Lymphoma, Myeloma, Solid Tumors, Sarcoma
- Trial name
- CALySSEY (NCT07297160)
- Testing
- Dose Level -1, Dose Level 1 (starting dose level), Dose Level 2
- Where
- 2 sites in United States
- Sponsor
- Baylor College of Medicine
Breast Carcinoma, Colorectal Carcinoma
Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting
This trial assesses current biomarker testing practices for common solid cancers in precision oncology in the community setting.
- Conditions
- Breast Carcinoma, Colorectal Carcinoma, Community Practice, Lung Carcinoma
- Trial name
- NCT03804255
- Testing
- Survey Administration
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- ECOG-ACRIN Cancer Research Group
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.