Clinical trials: sponsored by University of Colorado, Denver
Obesity, Adolescent Obesity
Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents
The study plans to learn more about what happens to the body after bariatric surgery in people 12 to 24 years old. The study aims to understand why people respond differently to bariatric surgery and how to define success beyond…
- Conditions
- Obesity, Adolescent Obesity, Body-Weight Trajectory, Weight Loss Trajectory
- Trial name
- PRESSURE (NCT06575738)
- Testing
- Injectable semaglutide or injectable tirzepatide, Standard postoperative care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Irritable Mood, Temper Tantrum
Parent Management Training to Treat Irritability
The goal of this clinical trial is to see if 12 sessions of a Parent Management Training program can treat irritability in children aged 10-14 years old.
- Conditions
- Irritable Mood, Temper Tantrum, Anger
- Trial name
- PMT (NCT06020261)
- Testing
- Parent Management Training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial
In primary pediatric Anterior cruciate ligament (ACL) reconstruction, the quadriceps tendon with either tendon and patellar bone or an all-tendon graft is commonly employed.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT04039971
- Testing
- ACL Reconstruction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
ACL Tear
Comparison of Methods in Post Operative Knee Arthroscopy Rehabilitation
The aim of this study is to investigate the efficacy of blood flow restriction (BFR) therapy in post-operative rehabilitation following knee arthroscopy for primary ACL reconstruction.
- Trial name
- ACL BFR (NCT05735236)
- Testing
- BFR Cuff
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Colorado, Denver
Non-Hodgkin Lymphoma, B-cell Non-Hodgkin Lymphoma (B-NHL)
Preliminary Safety and Tolerability of CD19x22 CAR T Cells in Adolescent and Adult R/R B-NHL Patients
This open-label, single arm phase 1 trial aims to determine the safety and tolerability of anti-CD19 and anti-CD22 chimeric antigen receptor-expressing (CAR) T cells (CD19x22 CAR T) in adolescents and adults with…
- Conditions
- Non-Hodgkin Lymphoma, B-cell Non-Hodgkin Lymphoma (B-NHL), Mantle Cell Lymphoma (MCL), CNS Lymphoma
- Trial name
- NCT05098613
- Testing
- CD19x22 CAR T Cells
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Colorado, Denver
Obesity/Therapy
Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity
Glucagon-like peptide 1 receptor agonists (GLP-1RA), such as Ozempic and Wegovy, have been rapidly adopted for the treatment of obesity in both youth and adults.
- Trial name
- PLASTIC (NCT07021937)
- Testing
- Semaglutide 1.7mg subcutaneous
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Adolescent Idiopathic Scoliosis (AIS), Neuromuscular Scoliosis
UNderstanding the Causes Of Idiopathic Scoliosis Through the Longitudinal Analysis of Proteomic Markers: the UNCOIL Study
The goal of this observational study is to find clinical, demographic, and protein biomarkers that scoliosis progression (scoliosis curve increases) and/or differ between participants with scoliosis versus those without…
- Trial name
- UNCOIL (NCT07634627)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury
Multidimensional Sleep Health Intervention to Optimize Concussion Recovery
Following adolescent concussion, poor sleep health is common and relates to the development of persisting post-concussion symptoms, and uninjured adolescents (independent of concussion) also commonly experience sleep…
- Conditions
- Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury, Treatment, Sleep Health
- Trial name
- SCORE (NCT07082218)
- Testing
- Sleep Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Accuracy of Continuous Glucose Monitors During the Perioperative Period in Youth With Type 1 Diabetes
This study is assessing the accuracy of continuous glucose monitors during surgical procedures requiring anesthesia.
- Trial name
- NCT06575842
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Otitis Media
Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®)
The purpose of this study is to evaluate Pulmozyme® (dornase) as compared to a standard ear drop Floxin® (ofloxicin) to dissolve clogged tubes.
- Trial name
- NCT00419380
- Testing
- dornase alfa (Pulmozyme®)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Kidney Disease, Pediatric Urology
Safety of Short-course of NSAIDs in Pediatric Patients With CKD
The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney…
- Trial name
- NCT06860711
- Testing
- NSAIDs
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes (T1D), Sleep Health
Type 1 Diabetes REst for Metabolic Health
Research has shown a link between poor sleep health and late circadian timing with cardiometabolic health in adolescents with type 1 diabetes (T1D).
- Trial name
- T1DREaM (NCT06627504)
- Testing
- Sleep Health and Circadian Timing Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Harm Reduction, Naloxone
Vending Machine Naloxone Distribution for Your Community (VENDY)
Vending machines are an innovative strategy shown to increase access to naloxone, a medication used to reverse opioid overdose. The aim of this proposal is to study the reach of a community-initiated, stakeholder engaged…
- Conditions
- Harm Reduction, Naloxone, Opioid Overdose
- Trial name
- NCT06429436
- Testing
- VENDY
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- University of Colorado, Denver
Neonatal Infection
Oral Amoxicillin and Cephalexin PK/PD in Neonates
The goal of this study is to figure out the best doses for two oral antibiotics (called amoxicillin and cephalexin) when they are used to treat infections in newborns and young infants.
- Trial name
- NCT04916951
- Testing
- Amoxicillin, Cephalexin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
Posterior Column Ataxia With Retinitis Pigmentosa
Antisense Oligonucleotide Treatment for PCARP Disease Due to Mutation in FLVCR1
The goal of this clinical trial is to evaluate a specific antisense oligonucleotide medication in one patient with posterior column ataxia with retinitis pigmentosa.
- Trial name
- NCT06565572
- Testing
- nL-FLVC-001
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Gut Microbiome
Developing Interventions for Protecting HIV-Exposed Uninfected Infants Against Severe Infections
Research has shown that babies who are exposed to HIV, but are uninfected (negative HIV status), have a bigger risk of developing severe infections.
- Trial name
- NCT07052409
- Testing
- Inkomazi
- Where
- South Africa
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
Eosinophilic Esophagitis
Esophageal String Test in Eosinophilic Esophagitis
The overall goal of this study is to develop a novel minimally invasive device, the Esophageal String Test (EST) to monitor esophageal inflammation during treatment of the rare disease Eosinophilic Esophagitis (EoE) in a safe and…
- Trial name
- NCT02008903
- Where
- 6 sites in United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Dravet Syndrome (DS), Children Under 2 Years
Assessment of Safety of the Use of Fenfluramine in Children With Dravet Syndrome Under 24 Months of Age
Dravet syndrome is a genetic epilepsy associated with pathogenic variants in SCN1A that codes for Nav1.1, a protein necessary for sodium channels.
- Trial name
- NCT06598449
- Testing
- fenfluramine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Colorado, Denver
Orthodontic Discomfort, Pain, Orofacial
Comparison of Patient-reported Pain After Initial Archwire Placement
Three different types of 'archwires' can be used in Orthodontic treatment, wire choice is decided by treating Orthodontist based on professional preference since research shows that all types are equally effective.
- Trial name
- Archwires (NCT03906422)
- Testing
- 3M Unitek 0.016 orthodontic archwire, Device: 0.016" Ormco 27oC NiTi orthodontic archwire, Device: 0.016" Ormco 35oC NiTi orthodontic archwire
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Inflammation Caused by the Placement of a Temporary Anchorage Device
Miniscrew Stability and Peri-implant Inflammation When Precoated K21 vs Ethanol Control
To determine if coating miniscrews with K21 would increase the success rate of orthodontic miniscrews by reducing adjacent tissue inflammation.
- Trial name
- NCT05639907
- Testing
- K21 Cavity cleanser, Ethanol control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver