Clinical trials: sponsored by Samsung Medical Center
Non-infectious Anterior Uveitis, Non-infectious Intermediate Uveitis
Efficacy and Safety of Adalimumab for the Treatment of Ocular Inflammation
This study aims to evaluate the clinical efficacy and safety of adalimumab in pediatric non-infectious uveitis and to generate domestic real-world evidence (RWE), thereby establishing a clinical foundation for label expansion and…
- Conditions
- Non-infectious Anterior Uveitis, Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis, Panuveitis
- Trial name
- PANDA-U (NCT07913750)
- Testing
- Adalimumab PFS and Pen
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Gastric Cancer, Colorectal Cancer
Development and Utilization of an Integrated Clinical Genomic Database
This observational study aims to develop an integrated genomic and clinical database to support the discovery and validation of biomarkers for cancer diagnosis, treatment selection, and prediction of treatment response.
- Conditions
- Gastric Cancer, Colorectal Cancer, Lung Cancer (NSCLC), Liver Cancer
- Trial name
- SMC-4S (NCT07911267)
- Where
- South Korea
- Volunteers
- 118,750 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Cerebral Palsy
Feasibility of Vision-Language Models for Detecting Physical Assistance as an Observable Criterion Defining GMFCS Levels in Children Aged 2 to 6 Years With Cerebral Palsy
The GMFCS sorts children with cerebral palsy into five levels of gross motor function. What mainly separates one level from the next is two things an observer can see: whether another person has to physically help the child move…
- Trial name
- NCT07824531
- Testing
- Vision-language model assessment of movement video
- Where
- 2 sites in South Korea
- Volunteers
- 26 people
- Sponsor
- Samsung Medical Center
Lymphoma
Prospective Cohort Study for Lymphoma: Samsung Lymphoma Cohort Study IV
This prospective study enrolls patients who are diagnosed with aggressive lymphoma including Hodgkin and non-Hodgkin lymphomas. Enrolled patients will be treated according to our institution' treatment policy in clinical…
- Trial name
- SMCLYM-IV (NCT07032103)
- Testing
- Immunochemotherapy
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Samsung Medical Center
Pediatric Intensive Care Units
A Korean Point Prevalence Study of Acute Rehabilitation for Kids in the PICU (PARK-PICU)
This study investigates the prevalence of acute rehabilitation practices among children in pediatric intensive care units (PICUs).
- Trial name
- NCT07629297
- Testing
- Acute Rehabilitation (Observed Practice)
- Where
- 13 sites in South Korea
- Volunteers
- 396 people
- Sponsor
- Samsung Medical Center
Cerebral Palsy (CP)
Wearable Eye Tracking During Bimanual Tasks in Children With Cerebral Palsy
This observational pilot study will include 40 children and adolescents aged 6 to 12 years: 20 with cerebral palsy and 20 with typical development.
- Trial name
- NCT07806994
- Testing
- Wearable Eye-Tracking Assessment During Structured Bimanual Tasks
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Pediatric Advanced Life Support (PALS)
Comparing the Effectiveness of Large Language Model-Based and Video-Based Refresher Education on Knowledge Retention After Simulation-Based Pediatric Cardiopulmonary Resuscitation Training: A Six-Month Follow-Up Study
This study aims to compare the effectiveness of large language model (LLM)-based refresher education and video-based refresher education for maintaining knowledge and performance after simulation-based Pediatric Advanced Life…
- Trial name
- NCT07783932
- Testing
- LLM-Based Refresher Education, Video-Based Refresher Education
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Duchene Muscular Dystrophy
Home-Based Tele-Rehabilitation for Respiratory Function in Children With Duchenne Muscular Dystrophy
This study evaluates the feasibility and preliminary clinical effects of a home-based tele-rehabilitation program aimed at improving respiratory function in children with Duchenne Muscular Dystrophy (DMD).
- Trial name
- NCT07629284
- Testing
- Home-Based Respiratory Telerehabilitation Program
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Samsung Medical Center
Borderline Intellectual Functioning (BIF), Intellectual Disability
Co-design of an AI Rehabilitation Program for Children With Borderline Intellectual Disorder
Co-design of an AI Rehabilitation Program for Children With Borderline Intellectual Disorder
- Trial name
- NCT07625592
- Testing
- Tablet-Based AI Cognitive and Language Rehabilitation Program
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Atrial Fibrillation (AF), Tricuspid Regurgitation (TR)
Efficacy of Early Rhythm Control in AF With TR Patients
Atrial fibrillation is frequently accompanied by tricuspid regurgitation and may contribute to right atrial and tricuspid annular remodeling, leading to progression of tricuspid regurgitation and adverse clinical outcomes.
- Trial name
- TRAF (NCT07607093)
- Testing
- Anti-arrhythmic drugs for rhythm control, DC cardioversion, catheter ablation for rhythm control, Usual care
- Where
- South Korea
- Volunteers
- 5,800 people
- Sponsor
- Samsung Medical Center
Asthma, Immunogenicity
Real-world Immunogenicity of Anti-IL5/5a Antibody
This study aims to evaluate the immunogenicity of the drug by measuring anti-drug antibody (ADA) formation and titers. The presence of ADAs will be assesses to determine their potential impact on the drug's efficacy and safety.
- Conditions
- Asthma, Immunogenicity, Biologics
- Trial name
- NCT07567690
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Cardiovascular Diseases (CVD), Cerebro Vascular Disease
Identifying Risk Factors and Predicting Future Health Outcomes for Korean Patients With Heart and Blood Vessel Diseases: A Long-term Follow-up Study
This study aims to establish a comprehensive, long-term clinical registry infrastructure for heart and brain vascular diseases (cardiovascular diseases and stroke) at Samsung Medical Center.
- Trial name
- NCT07393412
- Testing
- Standard Medical Therapy, Revascularization Procedures, Lifestyle Modification
- Where
- South Korea
- Volunteers
- 800,000 people
- Sponsor
- Samsung Medical Center
Pediatric Respiratory Distress
Development of an AI Assessment System for Pediatric Respiratory Distress : A Prospective Study
This is a multicenter, prospective observational study designed to collect clinical data for the development of a vision-language model-based artificial intelligence system for automated assessment of pediatric respiratory…
- Trial name
- NCT07370623
- Where
- 3 sites in South Korea
- Volunteers
- 2,200 people
- Sponsor
- Samsung Medical Center
Cerebral Palsy
Development of a Remote Therapy Protocol for Upper Limb Function Enhancement in Children With Cerebral Palsy
The perpose of this study: Development and demonstration of a teletherapy protocol to improve upper limb function in children with cerebral palsy.
- Trial name
- NCT06272760
- Testing
- Home-based hand-arm bimanual intensive training (Tele-HABIT)
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Samsung Medical Center
Critical Illness, Pediatric Intensive Care Unit
COPM-Based Goal Setting Strategies in the PICU
COPM-Based Goal Setting Strategies in the PICU
- Trial name
- NCT07128446
- Testing
- Standard physical and occupational therapy
- Where
- 2 sites in South Korea
- Volunteers
- 5 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Drug Coated Balloon vs. Drug-eluting Stent in Patients With Coronary Artery Disease
Studies exploring the feasibility of drug-eluting balloon (DCB) in de-novo coronary lesions are limited. There are scarce data comparing DCB with drug-eluting stent (DES) in patients with high bleeding risk (HBR), a situation in…
- Trial name
- DCB_DES (NCT07442500)
- Testing
- Drug coated balloon, Drug-eluting stent
- Where
- South Korea
- Volunteers
- 470,000 people
- Sponsor
- Samsung Medical Center
Pediatric Patients, Pediatric Patients in Hospital Settings
Impact of Conversational Approaches in Pediatric Social Robot-Mediated Interventions
This study examines how different robot dialogue systems (rule-based vs. large language model-based) and content types (emotional support vs.
- Conditions
- Pediatric Patients, Pediatric Patients in Hospital Settings, Hospitalized Children
- Trial name
- PRIA (NCT07389902)
- Testing
- Robot-Mediated Emotional Support Activity, Robot-Mediated Safety Education Activity
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Pulmonary Arterial Hypertension (PAH), Premature Infants
PNEUMOSTEM® for Improving Respiratory Outcomes in Very Premature Infants Diagnosed With Early Pulmonary Arterial Hypertension
The goal of this clinical trial is to evaluate the safety and potential efficacy of PNEUMOSTEM® for improving respiratory outcomes in very premature infants diagnosed with Early Pulmonary Arterial Hypertension.
- Trial name
- REVIVE-PH (NCT07368088)
- Testing
- PNEUMOSTEM®
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Samsung Medical Center
Oesophageal Squamous Cell Carcinoma
A Retrospective Cohort Study of Patients Who Underwent Curative-intent Esophagectomy for ESCC at a Tertiary Referral Center in South Korea
This retrospective cohort study was conducted using the Registry for Thoracic Cancer Surgery at Samsung Medical Center (Seoul, South Korea), which has included all patients who underwent thoracic surgery
- Trial name
- NCT07201571
- Volunteers
- 3,131 people
- Sponsor
- Samsung Medical Center
Breast Cancer Related Lymphedema
Factors Associated With Health-related Quality of Life in Patients With Breast Cancer-Related Lymphedema Undergoing Prospective Surveillance
Breast cancer-related lymphedema (BCRL) is a chronic condition that affects more than 1 in 5 breast cancer survivors. It causes swelling, pain, and reduced arm function, which can significantly impact quality of life.
- Trial name
- NCT07165275
- Where
- South Korea
- Volunteers
- 203 people
- Sponsor
- Samsung Medical Center