Clinical trials: open to volunteers, sponsored by Karolinska Institutet
Suicide Attempt, Suicidal and Self-injurious Behavior
Suicide Preventive Psychosocial Treatment for Youths
Suicide is the leading cause of death amongst 10-18-year-olds in Sweden. Suicide attempts are the strongest predictor of subsequent death by suicide, often lead to inpatient care, and are associated with substantial societal…
- Conditions
- Suicide Attempt, Suicidal and Self-injurious Behavior, Suicide Attempted, Suicide, Attempted
- Trial name
- NCT06931639
- Testing
- Safe Alternatives for Teens and Youth (SAFETY), Enhanced Treatment As Usual
- Where
- 5 sites in Sweden
- Volunteers
- 282 people
- Sponsor
- Karolinska Institutet
Anorexia Nervosa, Atypical Anorexia Nervosa
Specialist Supportive Clinical Management (SSCM) for Children and Adolescents With Anorexia Nervosa and Atypical Anorexia Nervosa
This study evaluates an adaptation of Specialist Supportive Clinical Management (SSCM) for children and adolescents aged 13-17 years with anorexia nervosa or atypical anorexia nervosa receiving outpatient treatment at the…
- Trial name
- SSCM-Youth (NCT07893145)
- Testing
- Specialist Supportive Clinical Management for Children and Adolescents (SSCM-Youth)
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Gait Disorders, Neurologic, Atypical Parkinson Disease
Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills.
- Conditions
- Gait Disorders, Neurologic, Atypical Parkinson Disease, fNIRS, Aging
- Trial name
- NCT06906276
- Testing
- Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Anxiety Mild to Moderate, Inhibition (Psychology)
Tiny Heroes Compared to Treatment as Usual to Decrease and Prevent Anxiety Problems in Young Children - a Randomized Controlled Study
The aim of this randomized controlled trial is to evaluate the effectiveness and cost-effectiveness of Tiny Heroes, a parent-directed internet-delivered cognitive behavioral therapy (iCBT) program for anxiety problems in children…
- Trial name
- NCT07870213
- Testing
- Parent-directed online cognitive behavioral therapy, Treatment as Usual (TAU)
- Volunteers
- 350 people
- Sponsor
- Karolinska Institutet
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Bone and Soft Tissue Tumors
Molecular and Clinical Studies of Bone and Soft Tissue Tumors
The goal of this observational study is to learn whether tumors of bone and soft tissue can be sorted into groups by their genes. Today these tumors are named mainly by how they look under a microscope.
- Trial name
- NCT07822204
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska Institutet
Nonsuicidal Self Injury, Nonsuicidal Self-Injury
Psychological Treatment for Adolescents With Self-injury Within Intensive Mental Health Outpatient Services: Randomized Controlled Pilot Trial
The overarching aim of this study is to develop and evaluate a new blended treatment format, which combines face-to-face and digital treatment components, for Emotion Regulation Individual Therapy for Adolescents (ERITA).
- Conditions
- Nonsuicidal Self Injury, Nonsuicidal Self-Injury, Self-Harm
- Trial name
- NCT07755774
- Testing
- Blended ERITA, Treatment as Usual (TAU), Concomitant care
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Obsessive-Compulsive Disorder, Autism Spectrum Disorder
ICBT for OCD in Children With Autism
The purpose of this trial is to evaluate the clinical efficacy, the cost-effectiveness and the effect durability of a therapist-guided, internet-delivered cognitive-behavior therapy intervention for obsessive-compulsive disorder…
- Trial name
- NCT06582225
- Testing
- Internet-delivered exposure and response prevention (I-ERP), Internet-delivered stress management (I-SM)
- Where
- 3 sites in Sweden
- Volunteers
- 220 people
- Sponsor
- Karolinska Institutet
Childhood Obesity, Treatment Adherence
The Evira Study: Additional Support During Obesity Treatment
The goal of this clinical trial is to evaluate the effect of adding a digi-physical treatment tool as a complement to the local treatment with obesity medication in adolescents with obesity.
- Trial name
- NCT06836284
- Testing
- Digi-physical treatment tool, Evira, Obesity medication with liraglutide or semaglutide
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Idiopathic Scoliosis
Brace Treatment for Idiopathic Scoliosis; PReventing Idiopathic SCOliosis PROgression
Idiopathic scoliosis is the most common spinal deformity in children and adolescents with an estimated prevalence of 3%. About one tenth of the children with scoliosis develop a deformity that requires treatment with brace or…
- Trial name
- PRISCOPRO (NCT04805437)
- Testing
- 3D TLSO, Standard TLSO
- Where
- 2 sites in Sweden
- Volunteers
- 170 people
- Sponsor
- Karolinska Institutet
Idiopathic Scoliosis
Scoliosis-specific Exercises for Mild Idiopathic Scoliosis
Idiopathic scoliosis is the most common spinal deformity in children and adolescents with an estimated prevalence of 3%. About one tenth of the children with scoliosis develop a deformity that requires treatment with brace or…
- Trial name
- NCT05138393
- Testing
- Active self-corrective exercises, Observation
- Where
- 2 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Critical Illness, Gender Equality
Ethnic and Gender Based Admittance Patterns in the ICU
The dominating proportion of patients in the ICU are men. Studies indicate that men receive more mechanical ventilation, vasoactive drugs, renal replacement therapy, invasive monitoring and have longer length of stay in the ICU.
- Conditions
- Critical Illness, Gender Equality, Discrimination, Sex, Discrimination, Racial
- Trial name
- EGAP-ICU (NCT05513456)
- Testing
- Randomization to a different factors in the case descriptions
- Where
- Sweden
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Anti Social Behavior
Evaluating the Feasibility and Effects of PULS
Background Youth involved in criminal groups represent a growing, high-risk population within Swedish institutional care, with elevated rates of recidivism and poor long-term outcomes.
- Trial name
- PULS on SiS (NCT07772128)
- Testing
- PULS, TAU
- Volunteers
- 224 people
- Sponsor
- Karolinska Institutet
Self-Harm, Self-Harm, Deliberate
Group Treatment for Self-harming Adolescents and Their Parents: a Randomized Controlled Trial
Adolescent non-suicidal self-injury (NSSI) is common, strongly associated with psychiatric comorbidity and an increased risk of future suicide attempt.
- Conditions
- Self-Harm, Self-Harm, Deliberate, Self-harm Behavior, Non-Suicidal Self Injury
- Trial name
- ERA (NCT07720063)
- Testing
- Emotion Regulation Group Therapy for Self-harming Adolescents, ERA, Functional habits for mental health, FUNK
- Volunteers
- 180 people
- Sponsor
- Karolinska Institutet
Dental Caries, Dental Cavities
Evaluation of Selective and Stepwise Excavation in Young Permanent Teeth With Deep Caries Lesions.
The purpose of this clinical trial is to evaluate and compare the outcomes of selective carious tissue removal versus stepwise carious tissue removal in young permanent teeth with deep carious lesions.
- Trial name
- SELECT (NCT06944028)
- Testing
- Selective excavation, Stepwise excavation
- Where
- Sweden
- Volunteers
- 666 people
- Sponsor
- Karolinska Institutet
Asthma (Part 1), COPD
APP-based Medical Device for Education and Training of Inhalation Technique
Primary aim: To investigate if app-based education and training of inhalation technique improves the rate of successful inhalation techniques compared with control group at 6-12 weeks follow-up visit.
- Trial name
- APPETITE (NCT07145632)
- Testing
- App-based education and training of inhalation technique
- Where
- 3 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Stroke
Prevention and Rehabilitation of Stroke in Uganda
Stroke is increasing in low-income countries in Africa, and knowledge is lacking on risk factors and how to prevent stroke as well as how to best use the resources for rehabilitation after stroke which are very limited.
- Trial name
- NCT05807269
- Where
- 2 sites in Uganda
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Early Childhood Caries (ECC)
Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment
The goal of this observational study is to learn if the composition of salivary proteins in 3-year-old children, from communities with documented varying caries risks, can be used to identify future diagnostic predictors for…
- Trial name
- DecodECC (NCT06957509)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Ceserean Section, Lower Limb Fractures
Infection Prevention for "Bellwether" Surgery in Ethiopia
The study examines surgical site infections and antimicrobial resistance following life-saving surgeries like C-sections and leg fracture repairs in Ethiopia.
- Conditions
- Ceserean Section, Lower Limb Fractures, Surgical Site Infection (SSI)
- Trial name
- NCT07647796
- Testing
- Surgical Site Infection Prevention and Control (IPC) Bundle
- Where
- Ethiopia
- Volunteers
- 1,000 people
- Sponsor
- Karolinska Institutet
Cancer
Evaluation of a Psychosocial Support Model for Adolescents and Young Adults Newly Diagnosed With Cancer
Rational: Adolescents and young adults (AYAs) newly diagnosed with cancer is a small but vulnerable group with many psychosocial needs persisting for a long time.
- Trial name
- NCT06979843
- Testing
- A psychosocial model
- Where
- 2 sites in Sweden
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet