Clinical trials: Ibuprofen
Pain
Fixed-dose Combination of Oxycodone [OXIcodona] + IbuproFEN in Pain Relief After Third Molar Extraction
A clinical, multicenter, randomized, parallel-group, double-blind, double-dummy, comparative study of non-inferiority. ⚠️Study will only be conducted in research centers in Brazil (please do not send e-mail if your center is…
- Trial name
- OXIFEN (NCT05081102)
- Testing
- FDC of oxycodone 5 mg/ibuprofen 400 mg, Tylex
- Where
- Brazil
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Eurofarma Laboratorios S.A.
Surgery, Pain, Post Operative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll.
- Trial name
- CARES for Kids (NCT06671002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 9 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Acute Pain
A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain
Combogesic® IV is an intravenous medicine (given by vein) containing a combination of two pain relief (analgesic) medicines called ibuprofen and acetaminophen.
- Trial name
- NCT07225634
- Testing
- Combogesic® IV (fixed-dose combination containing acetaminophen 10 mg/ml + ibuprofen 3 mg/ml in 100 ml solution for infusion)
- Where
- 4 sites in Hungary
- Volunteers
- 60 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Patent Ductus Arteriosus After Premature Birth
Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants
Patent ductus arteriosus (PDA), the most common cardiovascular complication of prematurity, is associated with higher mortality and morbidities in extremely low gestational age neonates (ELGANs, < 27+0 weeks).
- Trial name
- NCT05340582
- Testing
- Acetaminophen Injection, Ibuprofen 20 mg/mL oral suspension or Ibuprofen lysine 10 mg/mL injection solution (Neoprofen), Sodium chloride 0.9% injection
- Where
- 9 sites in Australia, Canada and 2 more
- Volunteers
- 310 people
- Sponsor
- Mount Sinai Hospital, Canada
Patent Ductus Arteriosus
Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)
Very premature infants with a large ductus, selected by an early echocardiogram, will receive either ibuprofen or placebo before 12 hours of life.
- Trial name
- TRIOCAPI (NCT01630278)
- Testing
- Ibuprofen
- Where
- 11 sites in France
- Volunteers
- 363 people
- Sponsor
- Nantes University Hospital
Cesarean Delivery, Postpartum Comfort
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks.
- Conditions
- Cesarean Delivery, Postpartum Comfort, Postpartum Pain, Post-operative Pain
- Trial name
- PACESS (NCT07102641)
- Testing
- Acetaminophen, NSAID (Ketorolac/Ibuprofen)
- Where
- United States
- Volunteers
- 825 people
- Sponsor
- Thomas Jefferson University
Pain, Postoperative
Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
The purpose of this study is to investigate the effectiveness of various oral analgesic regimens in minimizing post-operative pain and discomfort in young children following dental rehabilitation under general anesthesia (DRGA).
- Trial name
- NCT06757075
- Testing
- Ibuprofen, Acetominophen
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Boston University
Pediatric Anesthesia, Premedication
Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery
This prospective, three-arm study aims to evaluate the effects of different oral premedication regimens on venipuncture tolerance in pediatric patients undergoing ambulatory surgery.
- Trial name
- NCT07410078
- Testing
- Oral Midazolam Premedication, Oral Midazolam plus Ibuprofen Premedication, Oral Midazolam plus Ketamine Premedication
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Post Operative Pain, Acute
A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery
Combogesic® 325 contains a combination of ibuprofen and acetaminophen. The purpose of this study is to compare the pain relief effects of Combogesic® 325mg and acetaminophen and to evaluate the safety of Combogesic® 325mg in…
- Trial name
- NCT07225140
- Testing
- Combogesic® tablets, Acetaminophen 500mg
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Preeclampsia Severe, Preeclampsia Postpartum
Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial
A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on…
- Trial name
- PANDA (NCT03978767)
- Testing
- Ibuprofen 600 mg, Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- Washington University School of Medicine
Malocclusion
Comparison of Acupressure, Ibuprofen, and Chewing Gum for the Management of Post-Archwire Orthodontic Pain
The goal of this clinical trial is to find out which method works best to reduce pain after braces are adjusted for the first time (when the first archwire is placed).
- Trial name
- NCT07638644
- Testing
- Acupressure, Ibuprofen 400 mg (if necessary), Chewing Gum
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Bahria University
Hip Arthroscopy
Nonopioid Pain Control Regimen After Arthroscopic Hip Procedures
This study is being conducted to evaluate the effectiveness of post-operative pain control without using narcotic pain medications.
- Trial name
- NCT05076110
- Testing
- Oxycodone, Ibuprofen, Gabapentin
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Mayo Clinic
Pain, Orofacial
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management
The purpose of this study is to compare the effectiveness of a combined ibuprofen and acetaminophen regimen in controlling discomfort for 4 days after initial orthodontic appliance placement as compared to ibuprofen alone or a…
- Trial name
- NCT04059172
- Testing
- Ibuprofen 200 mg and acetaminphen 650 mg, Ibuprofen 200 mg
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Patent Ductus Arteriosus, Preterm Infant
Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus
The purpose of the present study is to determine whether treatment of hemodynamically significant patent ductus arteriosus with a combined therapy of intravenous Ibuprofen and oral acetaminophen has higher success rate in closing…
- Conditions
- Patent Ductus Arteriosus, Preterm Infant, Bronchopulmonary Dysplasia
- Trial name
- NCT03701074
- Testing
- Ibuprofen and acetaminophen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of South Alabama
Patent Ductus Arteriosus, Infant, Premature
Ibuprofen vs Expectant Management for hsPDA in Preterm Infants: Retrospective Cohort
This retrospective cohort study compares ibuprofen treatment versus expectant management for hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants.
- Trial name
- IMPACT-PDA (NCT07533721)
- Testing
- Ibuprofen
- Where
- China
- Volunteers
- 541 people
- Sponsor
- Shengjing Hospital
Musculoskeletal Injury, Pediatrics
Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children
The TOP-MAP pilot trial has multiple goals. The first goal of this pilot clinical trial is to find out if it will be possible to carry out a study at multiple pediatric emergency department sites (Peds ED) comparing Non-Steroidal…
- Conditions
- Musculoskeletal Injury, Pediatrics, Sprain and Strain of Ankle, Sprain Knee
- Trial name
- TOP-MAP (NCT07145645)
- Testing
- Voltaren Topical Gel, Ibuprofen Oral Suspension 100 mg/5mL, ORA-Blend Oral Suspension
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Supracondylar Humerus Fracture
Supracondylar Post-Operative Pain Study
The purpose of this study to investigate post-operative pain control in pediatric patients with closed supracondylar humerus fracture who undergo closed reduction and percutaneous pinning.
- Trial name
- NCT03759028
- Testing
- Ibuprofen, Oxycodone, Acetaminophen
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Supracondylar Humerus Fracture
Supracondylar Humerus Fracture (SCHF) Post-Op Study Between Opioid and Non-Opioid Pain Management
This purpose of this study is to determine the efficacy of nonopioid versus opioid analgesic regimens following surgical fixation of Gartland Type III Supracondylar Humoral Fractures (SCHFs) to assist in the development of a…
- Trial name
- NCT06187584
- Testing
- Hydrocodone/acetaminophen, Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Children's Mercy Hospital Kansas City
Supracondylar Humerus Fracture
Post-operative Pain Management in Children With Supracondylar Humerus Fractures
There are two common and concurrently used strategies for pain management following surgical treatment of supracondylar humerus (elbow) fractures in children: opioids vs over the counter pain medications.
- Trial name
- NCT05640674
- Testing
- Ibuprofen, Hydrocodone/acetaminophen, Acetaminophen
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Baylor College of Medicine
Recurrent Acute Leukemia, Recurrent B Acute Lymphoblastic Leukemia
Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies
This phase I trial studies the best dose and side effects of flotetuzumab for the treatment of patients with blood cancers (hematological malignancies) that have spread to other places in the body (advanced) and have come back…
- Conditions
- Recurrent Acute Leukemia, Recurrent B Acute Lymphoblastic Leukemia, Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm, Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Trial name
- NCT04681105
- Testing
- Acetaminophen, Dexamethasone, Diphenhydramine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- City of Hope Medical Center