Clinical trials: Dexmedetomidine
Appendectomy, Pediatric
The Effectiveness of Dexmedetomidine as an Adjuvant for Bupivacaine Caudal Block in Pediatric Open Appendectomy Under General Anesthesia
This study aims to evaluate if adding dexmedetomidine to bupivacaine in a caudal block can provide longer and better quality pain relief for children after open appendectomy surgery.
- Trial name
- NCT07088900
- Testing
- caudal block using dexmedetomidine with bupivacaine, caudal block with bupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Behavior Problem
Intranasal Dexmedetomidine or Esketamine for Negative Postoperative Behavioral Changes in Children
The goal of this clinical trial is to learn whether intranasal dexmedetomidine or esketamine given before anesthesia can reduce negative postoperative behavioral changes in children undergoing day surgery.
- Trial name
- PEDI-NPOBCs (NCT07570160)
- Testing
- Dexmedetomidine, Esketamine, Normal Saline
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Nanjing Children's Hospital
Cleft Lip Palate, Orofacial Cleft
Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery
Orofacial clefts are among the most common congenital malformations, affecting approximately 1 in 700-1500 live births worldwide.
- Conditions
- Cleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia Assessment
- Trial name
- NCT07557576
- Testing
- Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Iva Smiljanić
Autism Spectrum Disorder
The Effects of Preoperative Intranasal Administration of Dexmedetomidine and Esketamine on Negative Postoperative Behavioral Changes in Children With Autism Spectrum Disorder
The goal of this clinical trial is to learn whether intranasal sedation given before anesthesia can lower negative postoperative behavioral changes in children with autism spectrum disorder who undergo elective surgery.
- Trial name
- NPOBCs (NCT07324057)
- Testing
- Intranasal dexmedetomidine, Intranasal Esketamine, saline control
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Fei
Familial Dysautonomia
Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia
The purpose of this placebo controlled interventional study is to collect preliminary data on administering dexmedetomidine in patients with Familial Dysautonomia (FD) during a rapid cessation of autonomic crisis.
- Trial name
- NCT06148311
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Scoliosis Idiopathic, Scoliosis
Dexmedetomidine for ESPB in Pain Management After Pediatric Idiopathic Scoliosis Surgery
Effect of perineurial dexmedetomidine on erector spinal plane block duration for pediatric, idiopathic scoliosis surgery.
- Conditions
- Scoliosis Idiopathic, Scoliosis, Scoliosis; Adolescence
- Trial name
- NCT06789016
- Testing
- Dexmedetomidine, 0.9%NaCl
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Adenotonsillectomy, Children
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Postoperative pain after adenoid and tonsil surgery is significant, with approximately 75% of pediatric patients experiencing severe postoperative pain.
- Conditions
- Adenotonsillectomy, Children, Intranasal Administration, Dexmedetomidine
- Trial name
- NCT07479602
- Testing
- Intranasal dexmedetomidine-esketamine
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Peking University First Hospital
Emergence Delirium in Pediatric Anesthesia
The Effect of Dormicum-Ketamine Versus Dexmedetomidine on Emergence Delirium During Deep Sedation in Paediatric Burn Patients
The aim of this study is to compare the effects of dormicum-ketamine versus dexmedetomidine on postoperative emergence delirium in pediatric patients undergoing deep sedation for burn-related procedures
- Trial name
- NCT07519863
- Testing
- Midazolam + Ketamine, Dexmedetomidine (DEX)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Medical Thoracoscopy
Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy
Medical thoracoscopy can be performed under procedural sedation (conscious sedation) in most of the cases. Procedural sedation is a state where the patient lies comfortably without much movement, does not feel pain and has a…
- Trial name
- DEMISE-MT (NCT07184801)
- Testing
- Dexmedetomidine, Midazolam
- Where
- India
- Volunteers
- 56 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Postoperative Pain, Opioid Use
Dexmedetomidine Use in SZMN Blocks for Pediatric T&A Pain Control
The suprazygomatic maxillary nerve (SZMN) block is a well-established, safe and effective regional technique for pain management following cleft palate procedures.
- Trial name
- NCT05208892
- Testing
- SZMN block, SZMN block with Dexmedetomidine
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Stanford University
Hypoxic-Ischemic Encephalopathy, Pain
Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)
Management of neonatal pain and sedation often includes opioid therapy. A growing body of evidence suggests long-term harm associated with neonatal opioid exposure.
- Trial name
- DICE (NCT04772222)
- Testing
- Dexmedetomidine Hydrochloride, Morphine Sulfate
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Emergence Delirium
Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium
Fifty children undergoing heart catheterization without local anesthesia in the skin will be randomly divided into two groups. Group DM (Dexmedetomidine + Midazolam) and Group KM (Ketamine + Midazolam)
- Trial name
- NCT07427446
- Testing
- Dexmedetomidine and Midazolam, Ketamine and Midazolam
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
PreTerm Neonate, Sedation for Invasive Mechanical Ventilation
Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants
Very preterm neonates (born before 32 weeks' gestation) often require invasive mechanical ventilation (IMV) to manage respiratory insufficiency.
- Conditions
- PreTerm Neonate, Sedation for Invasive Mechanical Ventilation, Very Preterm Neonates With Sedation for Invasive Mechanical Ventilation
- Trial name
- DEXPRE (NCT06878703)
- Testing
- Midazolam, Dexmedetomidine
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Emergence Agitation
Comparison of Effect of Dexmedetomidine and Midazolam on Emergence Agitation
Since the frequency of emergence agitation (EA) is relatively high in children while undergoing nasal surgery, and there is not much data available in Pakistan regarding EA in adults undergoing functional endoscopic sinus surgery…
- Trial name
- NCT07392983
- Testing
- Dexmedetomidine, Midazolam
- Where
- 2 sites in Pakistan
- Volunteers
- 146 people
- Sponsor
- Muhammad Aamir Latif
Opioid Free Anesthesia
Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis
Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids.
- Trial name
- NCT07389096
- Testing
- Dexmedetomidine, Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nashwa Ahmed
Developmental Dysplasia of the Hip
Caudal Dexmedetomidine vs Ketamine for Postoperative Analgesia in Pediatric DDH Surgery
This study compares two medicines, Dexmedetomidine and Ketamine, added to caudal Bupivacaine to control pain after hip surgery in children.
- Trial name
- CDK-DDH (NCT07385352)
- Testing
- Dexmedetomidine, Ketamine, Bupivacaine
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Assiut University
Ankle Disease, Foot Diseases
Dexamethasone vs Dexmedetomidine vs Combination as Adjuvants to Popliteal Sciatic Nerve Block in Children
This clinical study will evaluate three commonly used medications that can be added to local anesthetic during a popliteal sciatic nerve block in children undergoing surgery of the lower leg or foot.
- Trial name
- NCT07289620
- Testing
- Dexamethasone, Dexmedetomidine, Dexamethasone + Dexmedetomidine
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Poznan University of Medical Sciences
Fiberoptic Bronchoscopy
Dexmedetomidine Nasal Spray and Pediatric Bronchoscopy
To observe the sedative effect of using dexmedetomidine nasal spray combined with remimazolam for pediatric bronchoscopy diagnosis and treatment, provide a safer and more comfortable anesthesia plan for pediatric bronchoscopy…
- Trial name
- NCT06755996
- Testing
- Dexmedetomidine injection, Remimazolam
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tongji Hospital
Oral Melatonin, Nebulized Dexmedetomidine
Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy
This study aims to compare the efficacy of using oral Melatonin versus nebulized Dexmedetomidine in limitation of emergence agitation in children undergoing adenotonsillectomy.
- Conditions
- Oral Melatonin, Nebulized Dexmedetomidine, Emergence Agitation, Children
- Trial name
- NCT07345715
- Testing
- Normal saline, Oral melatonin syrup, Nebulized dexmedetomidine
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Tanta University
Orofacial Clefts, Cleft Lip and Palate
Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery
This prospective, randomized study is designed to compare the efficacy and safety of three sedative-analgesic agents-intramuscular ketamine, intranasal nalbuphine, and intranasal dexmedetomidine-for procedural sedation in…
- Conditions
- Orofacial Clefts, Cleft Lip and Palate, Alveolar Ridge Defect
- Trial name
- KID-CLEFT (NCT07340008)
- Testing
- ketamine, Nalbuphine, Dexmedetomidine
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana