Clinical trials: sponsored by Karolinska Institutet
- Lead sponsor (exact) Karolinska Institutet
- Age group Children (under 18)
- Accepts healthy volunteers yes
Functional Abdominal Pain Syndrome
ICBT for Children With FAPDs - the Child's Pain Regulation
Functional abdominal pain disorders (FAPDs) in children are common (14%) and abdominal pain has increased rapidly in children during the last ten years in Sweden.
- Trial name
- NCT05945251
- Testing
- Internet-delivered cognitive behavioral therapy
- Where
- Sweden
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Mental Health Issue, Mental Disorder
A Trial of Two Universal Programs for Parents of Teenagers
Group-based and internet-delivered parenting programs may help parents improve their communication and relationships with their children.
- Conditions
- Mental Health Issue, Mental Disorder, Adolescent Behavior, Adolescent Development
- Trial name
- NCT06366438
- Testing
- ABC-teen, ParentWeb
- Where
- 58 sites in Sweden
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Mental Illness, Depression
Identifying Parents in Child Welfare Services Who Need Mental Health Support: Depression and Anxiety Symptoms
The main aim of this study is to examine the occurrence of mental health symptoms among parents referred to the Swedish child welfare services for child maltreatment and other family related risks.
- Conditions
- Mental Illness, Depression, Anxiety
- Trial name
- NCT06572865
- Testing
- Screening for depression and anxiety
- Where
- 6 sites in Sweden
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Mental Disorder, Depression
Screening to Identify Parents in Need of Mental Health Support: A Feasibility Study in Child Welfare Services
The main aim of this study is to evaluate the feasibility, preliminary effects and experiences of the Collaboration-Screening-Referral approach (in Swedish: Samverkan-Screening-Hänvisning - SSH) when used with parents referred to…
- Conditions
- Mental Disorder, Depression, Anxiety, Child Abuse
- Trial name
- NCT06600139
- Testing
- The Collaboration-Screening-Referral (SSH) model
- Where
- 4 sites in Sweden
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Critical Illness, Gender Equality
Ethnic and Gender Based Admittance Patterns in the ICU
The dominating proportion of patients in the ICU are men. Studies indicate that men receive more mechanical ventilation, vasoactive drugs, renal replacement therapy, invasive monitoring and have longer length of stay in the ICU.
- Conditions
- Critical Illness, Gender Equality, Discrimination, Sex, Discrimination, Racial
- Trial name
- EGAP-ICU (NCT05513456)
- Testing
- Randomization to a different factors in the case descriptions
- Where
- Sweden
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Identification of Family Violence
Evaluation of a Child Health Care Program for Early Identification of Family Violence
The aim of this mixed methods study is to gain knowledge about how a program for identification of family violence works within child health services.
- Trial name
- NCT07158983
- Testing
- Registry review, Interviews
- Where
- Sweden
- Volunteers
- 90,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Sarcopenia, Physical Fitness
Swedish Physical Activity and Fitness Longitudinal Study
Aging means loss of strength, which can affect the ability to lead an active life and be independent. Physical activity can counteract the loss of strength to some extent, but individual differences are large and the mechanisms…
- Conditions
- Sarcopenia, Physical Fitness, Muscle Strength, Dynapenia
- Trial name
- SPAF (NCT06496204)
- Where
- Sweden
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Early Childhood Caries (ECC)
Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment
The goal of this observational study is to learn if the composition of salivary proteins in 3-year-old children, from communities with documented varying caries risks, can be used to identify future diagnostic predictors for…
- Trial name
- DecodECC (NCT06957509)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Healthy, Gastrointestinal Cancer
Dietary Nitrate and Nitrite Intake and Phosphate Biomarkers and Risk of Chronic Diseases
Nitrate, nitrite, and phosphate (NO3, NO2, P) are at all age stages ubiquitous in our everyday foods, including naturally occurring and as food additives, and in our drinking water.
- Conditions
- Healthy, Gastrointestinal Cancer, Cardiovascular Diseases, Chronic Obstructive Airway Disease
- Trial name
- NCT07746310
- Where
- Sweden
- Volunteers
- 86,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cancer
Evaluation of a Psychosocial Support Model for Adolescents and Young Adults Newly Diagnosed With Cancer
Rational: Adolescents and young adults (AYAs) newly diagnosed with cancer is a small but vulnerable group with many psychosocial needs persisting for a long time.
- Trial name
- NCT06979843
- Testing
- A psychosocial model
- Where
- 2 sites in Sweden
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
HPV, Vaccine Acceptance
Addressing HPV Vaccine Hesitancy by Co-Designing a Digital Health Intervention
This study looks at a digital platform that supports HPV vaccination in schools. The goal is to see if it is useful, easy to use, and practical in real school settings, especially in areas where fewer people get vaccinated.
- Conditions
- HPV, Vaccine Acceptance, Vaccine Decision Making, HPV Vaccination
- Trial name
- HPV-END-IT (NCT07632963)
- Testing
- HPV-Kompassen
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Dementia With Lewy Bodies (DLB), Mild Cognitive Impairment (MCI)
Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression
The goal of this observational study is to improve the detection of dementia with Lewy bodies (DLB) and its prodromal phases, as well as advancing our current understanding of biological mechanisms and therapeutic options.
- Conditions
- Dementia With Lewy Bodies (DLB), Mild Cognitive Impairment (MCI), Cognitively Unimpaired, Other Dementias
- Trial name
- Find-DLB (NCT07629349)
- Where
- Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Contraception
Structured Online Contraceptive Counseling (LOWE Trial) at Emergency Contraception (EC) Pharmacy Provision LOWE+EC=LOWEC
To increase sexual and reproductive health and rights through the improvement of contraceptive counseling and easy access to service and, thus, women's use of effective contraceptives after purchase of an emergency contraceptive…
- Trial name
- LOWEC (NCT06299475)
- Testing
- Online counseling and invitation
- Where
- Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Dietary Behaviors, Fruit Consumption
A Comparative Intervention Study on Strategies for Fruit Distribution and Awareness Campaigns in Schools
This implementation study evaluates two strategies to increase fruit consumption among Swedish students. (1) installing fruit stands in schools and (2) combining fruit stands with a health-awareness campaign.
- Conditions
- Dietary Behaviors, Fruit Consumption, Dietary Habits, Healthy Eating
- Trial name
- NCT07385820
- Testing
- Fruit Stand Availability, Awareness Campaign
- Where
- 2 sites in Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Chronic Kidney Diseases
Electronic Decision-support System to Improve Detection and Care of Patients With Chronic Kidney Disease in Stockholm
One in 10 adults in Region Stockholm have chronic kidney disease (CKD), which dramatically increases healthcare costs and the risk of medication errors or adverse health outcomes, including cardiovascular disease and death.
- Trial name
- ALMA-CKD (NCT06386172)
- Testing
- Clinical decision support trigger
- Where
- Sweden
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cleft Palate Children
Length of Hospital Stay and Postoperative Analgesic Requirements After Introduction of a Specific Maxillary Nerve Block in Children Undergoing Cleft Palate Surgery
Cleft lip and palate (CLP) is one of the most common congenital malformations and requires repeated surgical correction during childhood.
- Trial name
- NCT07279883
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Epilepsy, Microbiota
EPIGUT: EPILEPSY AND GASTROINTESTINAL MICROBIOTA: UNDERSTANDING THERAPY RESPONSE
The goal of this observational study is to learn how the bacteria in the gut and mouth (called the microbiota) are linked to different types of epilepsy and how they may affect how well seizure medicines work.
- Conditions
- Epilepsy, Microbiota, Proteomics, Metabolomics
- Trial name
- EpiGUT (NCT07253701)
- Where
- 6 sites in Sweden
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Behavior Change Interventions, Work Environment Adverse Effects
From Yearly Checks to Daily Progress: Evaluating Goal Attainment Scaling (GAS) in Systematic Work Environment Management (SAM) Within the Municipal Sector
The goal of this project is to evaluate a practical method for improving systematic work environment management (SAM) by focusing on health-promoting factors rather than identifying risk-factors, and deficiencies.
- Conditions
- Behavior Change Interventions, Work Environment Adverse Effects, Health Factors, Goal Attainment Scaling
- Trial name
- GAS for SAM (NCT06893471)
- Testing
- GAS for SAM
- Where
- Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
SEQUAR SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction
Randomized control trial comparing two different Anterior Cruciate Ligament (ACL) grafts in Anterior Cruciate Ligament Reconstruction: the semitendinosus hamstrings graft and the quadriceps graft.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- SEQUAR (NCT04295148)
- Testing
- ACL Reconstruction with Semitendinosus graft, ACL Reconstruction with Quadriceps tendon-bone graft
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet