Clinical trials: sponsored by Brigham and Women's Hospital
- Lead sponsor (exact) Brigham and Women's Hospital
- Age group Children (under 18)
- Accepts healthy volunteers yes
Obstructive Sleep Apnea
Design and Usability Testing of a Tailored Intervention About Sleep and Sleep Disorders Among Transportation Workers
The objective of this protocol is to conduct a focus group to identify OSA beliefs, attitudes, and knowledge among employees in the transportation industry on shift schedules.
- Trial name
- NCT05039528
- Testing
- Personalized OSA messages, Control
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Genetic Predisposition to Disease, Hereditary Diseases
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
This research study is exploring the use of genomic sequencing in the newborn period to screen healthy babies for current and future health risks.
- Trial name
- NCT05161169
- Testing
- Genome Sequencing
- Where
- 3 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Indication for Care or Intervention Related to Labor or Delivery With Baby Delivered
Incidence of Difficult Airway and Difficult Neuraxial Placement in Obstetric Patients
Anesthesiologists commonly administer pain relief during labor or providing anesthesia for cesarean delivery. Two main methods are used to achieve these goal: "Regional anesthesia" where the mother is given medication through a…
- Trial name
- DADB (NCT02193542)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Labor Pain
ED90 of Bupivacaine After Lidocaine Test Dose With DPE and EPL
The primary objective of our study is to use a biased coin up-down allocation methodology to estimate the dose of bupivacaine required after the lidocaine test dose to achieve initial effective comfort in 90% of patients (post…
- Trial name
- NCT06146842
- Testing
- Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Breast Cancer, Early Detection of Cancer
Strategies to Decentralize Breast Ultrasound in Rwanda
Diagnosing breast cancer early is critical to reduce preventable breast cancer deaths in sub-Saharan Africa. This can be done in part through increasing patients' access to breast ultrasound, which is essential for evaluating…
- Conditions
- Breast Cancer, Early Detection of Cancer, Ultrasonography
- Trial name
- NCT06812208
- Testing
- Teleultrasound with Philips Lumify ultrasound probes and Reacts software, Asynchronous virtual feedback
- Where
- Rwanda
- Volunteers
- 1,792 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Development, Child, Behavior, Social
Bahir Dar Child Development Study, Ethiopia
The goal of this observational study is to learn about typical neurodevelopment in children aged 6 months to 5 years who live in Bahir Dar, Ethiopia.
- Trial name
- BCD (NCT06648863)
- Where
- Ethiopia
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
SARS-CoV-2 Infection, Covid19
Prospective COVID-19 Cohort Study, Dominican Republic
This project will build on an existing CDC funded cooperative agreement in the Dominican Republic with the Brigham and Women's Hospital (2018-2023) that includes (i) prospective COVID-19 and AFI surveillance at two health…
- Trial name
- NCT04898738
- Testing
- Alcohol based hand sanitizer
- Where
- Dominican Republic
- Volunteers
- 1,043 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Parents of Healthy Newborns
Surveying Parents About Genome Screening of Newborns
A 10 minute baseline survey will be administered to parents of healthy newborn infants while in the hospital after delivery at Brigham and Women's Hospital, to be followed by a 25 minute survey 3-24 months later.
- Trial name
- BabySeq (NCT01736501)
- Testing
- Genetics education at baseline, Hypothetical genomic scenarios at follow-up
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Clinical High Risk, Psychosis
AMP SCZ® Observational Study: PREDICT-DPACC
The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) is a large international collaboration to develop algorithms using a set of clinical and cognitive assessments, multi-modal biomarkers, and clinical endpoints that…
- Conditions
- Clinical High Risk, Psychosis, Remission, Conversion
- Trial name
- AMP SCZ (NCT05905003)
- Where
- 42 sites in United States, Australia and 12 more
- Volunteers
- 2,617 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
HPV
Multi-level School-based Intervention to Improve HPV Vaccine Uptake and Completion in South Africa
Human Papillomavirus (HPV) is the most common sexually transmitted infection globally, and is causally linked to cervical, anogenital, and oropharyngeal cancers.
- Trial name
- NCT05919901
- Testing
- HPV Vaccine Communication Strategy
- Where
- South Africa
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Lyme Disease
A School-Based Intervention to Reduce Lyme Disease
Our overall purpose of this study is evaluate whether a short in-class Lyme Disease education program based on social learning theory and the Health Belief Model can impact a child's knowledge, attitude, and preventive behavior.
- Trial name
- NCT00594997
- Testing
- Education, Control (pre and post surveys)
- Volunteers
- 3,570 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Water, Child Nutrition
Water is K'é: Multi-level Intervention to Promote Healthy Beverage Choices Among Navajo Families
The goal of this clinical trial is to understand if a cultural intervention for Navajo families will improve healthy beverage habits, health outcomes, and family cohesion.
- Conditions
- Water, Child Nutrition, Family Dynamics, Healthy Nutrition
- Trial name
- NCT06020027
- Testing
- Water is K'é
- Where
- United States
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Breast Cancer, Benign Breast Disease
Evaluating Scaleup of an Adapted Breast Cancer Early Diagnosis Program in Rwanda
Breast cancer incidence is increasing in low- and middle-income countries (LMICs) and breast cancer mortality is high in these regions largely due to late stage diagnoses.
- Conditions
- Breast Cancer, Benign Breast Disease, Cervix Cancer
- Trial name
- NCT05364138
- Where
- Rwanda
- Volunteers
- 2,357 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pregnancy, Childbirth
Adapted Safe Childbirth Checklist in Chiapas, Mexico
The purpose of this mixed methods study is to evaluate the implementation of an adapted Safe Childbirth Checklist in a rural hospital in Chiapas, Mexico. The study aims are: 1.
- Conditions
- Pregnancy, Childbirth, Quality of Care, Puerperium
- Trial name
- SCC-Chiapas (NCT02886364)
- Testing
- Adapted Safe Childbirth Checklist
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Rheumatic Heart Disease
RhEumatiC Heart diseAse Genetics
Rheumatic fever (RF) is an autoimmune disease that is mediated by the cellular and humoral immune response that follows an untreated pharyngeal Streptococcus pyogenes infection.
- Trial name
- RECHARGE (NCT02118818)
- Testing
- Next generation sequencing
- Where
- Rwanda
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Arthritis, Rheumatoid
Treat-to-target in RA: Collaboration To Improve adOption and adhereNce
The purpose of this study is to determine if a Learning Collaborative is an effective tool to improve adoption and adherence to a Treat-to-Target (TTT) treatment strategy in U.S.
- Trial name
- TRACTION (NCT02260778)
- Testing
- Learning Collaborative
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Vitamin d Deficiency
Blue Sky Study: Impact of Milk and Vitamin D for Child Growth and Health
This intervention study will address the impact of vitamin D fortified milk and vitamin D supplements on the growth, levels of vitamin D, insulin-like growth factor 1, growth hormone, academic attention, respiratory infections…
- Trial name
- BSS (NCT00886379)
- Testing
- Mongolian milk without vitamin D, Mongolian milk with vitamin D, UHT milk
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Low Birthweight, Preterm Birth
Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia
The ENAT study will test the impact of packages of antenatal interventions to enhance maternal nutrition and manage pregnancy infections on the outcomes of infant birth size, gestational length, and infant growth in the first 6…
- Conditions
- Low Birthweight, Preterm Birth, Maternal; Malnutrition, Affecting Fetus, Sexually Transmitted Diseases
- Trial name
- ENAT (NCT04171388)
- Testing
- Azithromycin 500 mg, Multiple Micronutrient or Fortified Balanced Energy Protein Supplement, Enhanced Infection Management Package (EIMP)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Breast Cancer
Nutrition-Related Biomarkers in Predicting Breast Cancer Risk in Women
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about nutrition-related changes that identify biomarkers related to cancer.
- Trial name
- NCT00900367
- Testing
- high performance liquid chromatography, laboratory biomarker analysis, spectroscopy
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Adolescent Development
Evaluation of Yoga for Substance Use Risk Factors in a School Setting
This study will evaluate the efficacy of yoga taught during school to positively influence risk and protective factors of substance use and the initiation and severity of substance use.
- Trial name
- NCT01821950
- Testing
- Yoga during physical education
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital