Clinical trials: in Croatia
Multisystem Inflammatory Syndrome in Children (MIS-C)
Quality of Life in Children After Multisystem Inflammatory Syndrome in Children
The aim of this observational study is to assess whether Multisystem Inflammatory Syndrome (MIS-C) in children affects their quality of life.
- Trial name
- MIS-C (NCT07126028)
- Where
- Croatia
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Kristina Lah Tomulić
Compliance, Periodontitis
Association Between Periodontal Status and the Interrupted Supportive Periodontal Therapy During the COVID-19 Pandemic
This cross-sectional observational study compared the clinical periodontal status and oral health-related quality of life between patients who continued regular supportive periodontal therapy (SPT) visits during the COVID-19…
- Conditions
- Compliance, Periodontitis, Periodontal Therapy
- Trial name
- NCT07866664
- Testing
- Prolonged interruption of supportive periodontal therapy (≥24 months)
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Crohn Disease
Decoding Personalized Nutritional, Microbiome and Host Patterns Impacting Clinical and Prognostic Features in Crohn's Disease
This is a three-arm, non-interventional observational study designed to investigate the relationship between Crohn's disease (CD), the microbiome, and diet in children.
- Trial name
- NCT04283864
- Testing
- endoscopy examination
- Where
- 8 sites in Canada, Croatia and 5 more
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Weizmann Institute of Science
Pediatric Hypertension, Primary Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial…
- Conditions
- Pediatric Hypertension, Primary Hypertension, Endothelial Dysfunction
- Trial name
- HYPER-endoEV-c (NCT07728643)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Plaque Induced Gingival Disease, Oral Health
Effect of Benzydamine Hydrochloride Mouthrinse on Plaque Accumulation in Periodontally Healthy Female Subjects
The goal of this clinical trial is to evaluate the effect of a mouthrinse containing an active ingredient benzydamine hydrochloride in the absence of daily oral hygiene.
- Trial name
- BHCl-PLAQUE (NCT07565766)
- Testing
- Benzydamine hydrochloride mouthrinse
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Gingivitis, Malocclusion
Dental Biofilm Control During Orthodontic Treatment
Orthodontic appliances can affect changes in the relationships of members of the oral microbiome. Microbiome imbalance can result in oral infections and complicate treatment.
- Trial name
- ORTHOBIOFILM (NCT05532241)
- Testing
- fixed metal orthodontic appliance, fixed non-metal orthodontic appliance, oral hygiene
- Where
- 3 sites in Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Keratoconus
The K-Map Study, Global Prevalence of KC
Keratoconus is a ocular disease classified under ectatic diseases which often results in bilateral and asymmetrical corneal distortion. It usually affects patients at young age and can cause severe visual loss.
- Trial name
- NCT03115710
- Testing
- Rotating Scheimpflug camera (Pentacam HR)
- Where
- 12 sites in United States, China and 10 more
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Acute Appendicitis, Acute Appendicitis With Rupture
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)
- Trial name
- NCT07008092
- Testing
- Blood specimen collection, Urine collection
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KBC Split
Food Hypersensitivity, Asthma in Children
Toxicity of Micro and Nano Plastics Combined With Environmental Contaminants on the Risk of Allergic Disease
Single-center, cross-sectional, longitudinal, observational, population based cohort study with stratified sample (by age group, gender, and residential area).
- Conditions
- Food Hypersensitivity, Asthma in Children, Rhinitis, Allergic, Dermatitis, Atopic
- Trial name
- Imptox (NCT05177744)
- Where
- Croatia
- Volunteers
- 1,156 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Srebrnjak
Narrow Maxilla
Effect of the Palatal Expansion Treatment on Reported Sleeping Disorders in Children
The goal of this clinical trial is to see if expanding the upper jaw with orthodontic therapy can help improve sleep related breathing problems in children.
- Trial name
- RPE PSQ HR (NCT06725979)
- Testing
- maxillary expansion using hyrax expander
- Where
- Croatia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
SARS-CoV-2 Infection
EuGeni Rapid Antigen Test for the Qualitative Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Causing COVID19 Disease in Compliance With the World Health Organization (WHO)
Rapid antigen detection (RAD) tests are used to perform rapid diagnosis of SARS-CoV-2 infection based on a qualitative approach.
- Trial name
- WHO (NCT05618561)
- Testing
- EuGeni SARS-CoV-2 Antigen Rapid Diagnostic Test
- Where
- 5 sites in Croatia, Greece and 1 more
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- AnteoTech Ltd
Skin Hyperpigmentation, Dry Skin; Eczema
Efficacy and Safety Assessment of Niacinamide Cosmetic Preparation: a Randomized Controlled Trial
Niacinamide in lower concentrations has been recognized as a cosmetic ingredient with hydrating properties. Therefore, aim was to test the efficacy and safety of niacinamide cosmetic preparation in A Randomized, Controlled Trial.
- Trial name
- NCT06189105
- Testing
- miss alice face it you love me serum, No treatment (usual skincare rutine)
- Where
- Croatia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Contact Dermatitis, Contact Dermatitis Irritant
Testing an Intervention in Irritative Contact Dermatitis
An eczematous reaction is an inflammatory intolerance response of the skin. In acute phase the reaction is characterized by erythema and blistering while in the chronic phase it presents as dryness, itchiness and lichenification.
- Trial name
- NCT06189144
- Testing
- Emollient cream treatment, no treatment
- Where
- Croatia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Total Hip Arthroplasty, Functional Recovery
Comparison of Three Different Surgical Approaches on the Functional Outcome After Total Hip Arthroplasty
This study aimed to determine differences in functional recovery after total hip arthroplasty between a group of patients operated on using a direct lateral approach, an anterolateral minimally invasive approach, and a posterior…
- Trial name
- NCT06141928
- Testing
- Functional recovery analysis
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Clinic for Orthopedics Lovran
Laryngeal Dystonia, Spasmodic Dysphonia
Cortical Silent Period in Laryngeal Dystonia
The goal of this observational study is to evaluate the cortical silent period (cSP) in cricothyroid muscle (CT) in laryngeal dystonia and control healthy subjects.
- Trial name
- cSPDystonia (NCT05580302)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Croatia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Asthma in Children, Pollution; Exposure
Evidence Driven Indoor Air Quality Improvement
The aim is to identify the underlying disease mechanisms driving specific asthma phenotypes as well as certain disease outcomes and their relation to impaired indoor air quality.
- Trial name
- NCT05992389
- Where
- Croatia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Srebrnjak
Lower Urinary Tract Symptoms, Voiding Disorders
The Efficacy of Tamsulosin and Tadalafil Compared to Placebo in the Treatment and Prevention of Urinary Disorders After Transperineal Prostate Biopsy
The purpose of this study is to evaluate the therapeutic efficacy of tamsulosin and tadalafil compared to placebo in the treatment and prevention of urinary disorders after transperineal prostate biopsy
- Conditions
- Lower Urinary Tract Symptoms, Voiding Disorders, Pain, Quality of Life
- Trial name
- NCT05537272
- Testing
- Tadalafil 5mg, Tamsulosin Hydrochloride 400 Microgram Prolonged-Release Oral Capsule
- Where
- Croatia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital of Split
Child Allergy, Allergic Reaction
Development of Personalized Balanced Nutrition Concept Through an IT Platform
By achieving effective cooperation between the Children's Hospital Srebrnjak (CHS), the Reference center for clinical allergology in children of the ministry of health, and IN2 Ltd., part of Constellation Software Inc., it is…
- Trial name
- NCT05462444
- Testing
- Skin prick test
- Where
- Croatia
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Srebrnjak
Smoking, Excessive Drinking
WHO-HPH Recognition Project on Fast-Track Implementation of Clinical Health Promotion
The project's background is the notion that patient centred clinical health promotion has been shown to significantly improve both outcomes and patient safety.
- Conditions
- Smoking, Excessive Drinking, Lack of Physical Activity, Malnutrition
- Trial name
- RP (NCT01563575)
- Testing
- fast-track implementation process
- Where
- 11 sites in Canada, Croatia and 9 more
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Caries; Enamel, Gingivitis
Immunological and Regenerative Implications of Corrosion of Dental Materials
During orthodontic treatment intraoral corrosion results with release of nickel and titanium ions from orthodontic appliances in surrounding tissues.
- Trial name
- IMUNODENT (NCT03334461)
- Testing
- Exposure to oral antiseptics or enamel remineralisation agent
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rijeka