Clinical trials: Uterine Hemorrhage, open to volunteers
Heavy Menstrual Bleeding
Delivering tAN to Reduce HMB: The LUNA Study
The LUNA study is a prospective, randomized, double-blind, sham-controlled, decentralized clinical trial in participants with heavy menstrual bleeding of no known structural cause.
- Trial name
- LUNA (NCT07326722)
- Testing
- Sparrow Link
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Spark Biomedical, Inc.
Hemophilia A, Hemophilia A, Severe
Hemophilia A Research Program
This study longitudinally observes the intergenerational (mother-child) continuum in hemophilia A from pregnancy through early childhood.
- Conditions
- Hemophilia A, Hemophilia A, Severe, Factor VIII (FVIII), FVIII Deficiency
- Trial name
- HARP (NCT07414511)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Washington
Simulation Training, Nursing
The EFFECT of SIMULATION-BASED TRAINING on POSTPARTUM HAEMORRHAGE MANAGEMENT SKILLS
This study was planned to determine the effect of simulation-based training using two different reality levels-visually enhanced mental simulation (VEMS) and hybrid simulation-on postpartum haemorrhage (PPH) management skills in…
- Conditions
- Simulation Training, Nursing, Postpartum Hemorrhage
- Trial name
- (SBT) (NCT06872879)
- Testing
- VEMS Simulation, Hybrit Simulation
- Volunteers
- 64 people
- Sponsor
- Bandırma Onyedi Eylül University
Menorrhagia
Prevalence and Impact on Quality of Life, Academic Performance, and Blood Indices of Heavy Menstrual Bleeding Among Female Students in Assiut University, Egypt
The cause of menstrual disorders is unknown because many female students, embarrassed or unsure of what is "normal," never seek care.
- Trial name
- menorrhagia (NCT07188259)
- Where
- Egypt
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hysteroscopy, Assessment Methods in Medical Training
Assessment of Hysteroscopy Skills With a New Assessment Tool
Objective To investigate validity of the hysteroscopy assessment tool (HYSAT) for assessment of competence in a clinical environment.
- Conditions
- Hysteroscopy, Assessment Methods in Medical Training, Medical Education, Diagnostic Hysteroscopy
- Trial name
- NCT07672288
- Testing
- Evaluation score based on assessment tool
- Where
- 2 sites in Canada, Denmark
- Volunteers
- 24 people
- Sponsor
- Odense University Hospital
Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children
Clinical Spectrum and Management of Von Willebrand Disease Among Children in Assiut Governorate
Von Willebrand disease (VWD) is the most common inherited bleeding disorder in children. It occurs due to a deficiency or dysfunction of von Willebrand factor, a protein that plays an essential role in blood clotting.
- Conditions
- Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children, Pediatric Hemostatic Disorders
- Trial name
- VWD-ASSIUT (NCT07410130)
- Testing
- Tranexamic Acid, Von Willebrand Factor-Containing Concentrates
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Assiut University
Postmenopausal Bleeding
Evaluation of DNA Methylation Markers for Endometrial Cancer Risk-stratification Using Patient-collected Urine and Vaginal Samples and Clinician-collected Cervical Samples From Women With Postmenopausal Bleeding
The goal of this observational study is to investigate the clinical utility of DNA-methylation testing in urine and vaginal samples collected by patients and cervical samples collected by clinicians, to determine the risk of…
- Trial name
- NCT07400835
- Testing
- DNA-methylation testing in patient-collected urine and vaginal samples and clinician-collected cervical samples
- Where
- 3 sites in Denmark
- Volunteers
- 600 people
- Sponsor
- University of Aarhus
Heavy Menstrual Bleeding, Bleeding Disorder
Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study
The goal of this multicenter prospective observational study and registry of U.S. adolescents and young adults with heritable bleeding disorders is to determine the bleeding outcomes, satisfaction, hemostatic parameter changes…
- Conditions
- Heavy Menstrual Bleeding, Bleeding Disorder, Von Willebrand Diseases
- Trial name
- HMB-BD (NCT05916469)
- Testing
- Levonorgestrel Intrauterine System, Norethindrone Acetate
- Where
- 8 sites in United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Von Willebrand Disease (VWD), Heavy Menstrual Bleeding (HMB)
HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB
The purpose of this study is to evaluate the safety, tolerability, efficacy, and pharmacodynamics (PD) of multiple doses of ALN-6400 in adult and adolescent patients with VWD and HMB
- Trial name
- HMBeacon (NCT07575308)
- Testing
- ALN-6400
- Where
- 21 sites in United States, Netherlands and 3 more
- Volunteers
- 24 people
- Sponsor
- Alnylam Pharmaceuticals
Hysterectomy for Abnormal Uterine Bleeding
Comparison of Performing V-Notes Hysterectomy Under Spinal Anesthesia and General Anesthesia
Vaginal natural orifice transluminal endoscopic surgery is recognized as a significant advancement in women's health, representing an extension of minimally invasive surgery.
- Trial name
- COPVNHSGA (NCT07758504)
- Testing
- Vnotes hysterectomy under spinal anesthesia, Vnotes hysterectomy under general anesthesia
- Volunteers
- 28 people
- Sponsor
- Cukurova University
Heavy Menstrual Bleeding, Bleeding Disorder
Hormonal Management of Heavy Menstrual Bleeding in Adolescents
The goal of this study is to evaluate whether hormonal medications (such as contraceptive pill, patch, injectable progestins and hormonal intra-uterine device) have similar efficacy at managing heavy menstrual bleeding in…
- Trial name
- JAdoRE (NCT06740929)
- Where
- Switzerland
- Volunteers
- 163 people
- Sponsor
- University Hospital, Geneva
Heavy Menstrual Bleeding
Evaluating the Reliability and Validity of the Arabic Version of the SAMANTA Questionnaire: A Step Toward Improved Diagnosis of Heavy Menstrual Bleeding
Heavy menstrual bleeding (HMB) significantly impacts women's quality of life (QoL). However, despite the high prevalence of HMB, culturally adapted screening tools remain scarce in our locality.
- Trial name
- NCT07267611
- Volunteers
- 120 people
- Sponsor
- Assiut University
Midwifery Student
The Effect of Gamification-Based Instructional Design Developed
Turkish) Abstract: Purpose: Considering the importance of postpartum hemorrhage management in reducing preventable maternal deaths and the key role midwives play in providing this care, it is important to increase the knowledge…
- Trial name
- PPH-GamEd (NCT07207590)
- Testing
- web-based gamification application, control group: traditional classroom learning techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Pregnancy Related, Post Partum Hemorrhage
Postpartum Ultrasound Evaluation to Assess Risk of Hemorrhage
Up to 5% of patients in the United States have a postpartum hemorrhage. "Postpartum hemorrhage" means excessive bleeding after delivery. The majority of these bleeds occur immediately with delivery.
- Trial name
- NCT06898034
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 1,725 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Postpartum Hemorrhage
THUMB: Multi-centre Cluster Trial for Caesarean Section Haemorrhage
The quality improvement project evaluating the delivery of a perioperative care complex intervention to improve haemorrhage-related outcomes in patients undergoing caesarean section.
- Trial name
- NCT07005349
- Testing
- Quality improvement program
- Where
- South Africa
- Volunteers
- 2,400 people
- Sponsor
- Bruce Biccard
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Uterine Fibroids (Leiomyoma), Uterine Myoma
Terlipressin vs Placebo to Reduce Bleeding in Fibroid Surgery
A myomectomy is a surgery to remove noncancerous growths (fibroids) from the uterus while keeping the uterus in place. This surgery can cause significant blood loss.
- Conditions
- Uterine Fibroids (Leiomyoma), Uterine Myoma, Leiomyoma
- Trial name
- NCT07746349
- Testing
- terlipressin (vasoconstrictor)
- Volunteers
- 80 people
- Sponsor
- Sevil Cankaya
Cesarean Delivery
The Effectiveness of a Care Bundle to Prevent Postpartum Hemorrhage After Cesarean Delivery
Delays in the detection or inconsistent use of effective interventions of postpartum hemorrhage can result in complications or death.
- Trial name
- RE-TEAM (NCT06684080)
- Testing
- A care bundle
- Volunteers
- 52,000 people
- Sponsor
- Dunjin Chen
Pregnancy of Unknown Location (PUL)
Expediting Pregnancy of Unknown Location Risk Stratification Using the ROM-Plus Point of Care Test
The goal of this study is to learn if the ROM-Plus bedside test can effectively triage patients who present with pregnancy of unknown location (PUL) and vaginal bleeding as high or low risk for ectopic pregnancy.
- Trial name
- NCT07519954
- Testing
- ROM-Plus bedside test
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Abnormal Uterine Bleeding (AUB), Ovulation Dysfunction
Clinical Efficacy And Safety of Dydrogesterone In The Treatment Of Abnormal Uterine Bleeding During Puberty
This multicenter prospective cohort study evaluates the clinical efficacy and safety of dydrogesterone versus drospirenone and ethinylestradiol in adolescents aged 10-19 years with abnormal uterine bleeding-ovulatory dysfunction…
- Trial name
- NCT07703488
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Guangdong Women and Children Hospital