Clinical trials: Treatment-resistant Depression
Unipolar Depression
Ketamine Trial for the Treatment of Depression
This study is a Randomized Controlled Trial, investigating the safety and efficacy of administration of ketamine as a potential treatment for depression.
- Trial name
- NCT02401139
- Testing
- Ketamine
- Where
- 2 sites in Australia
- Volunteers
- 10 people
- Sponsor
- The University of New South Wales
Patients With Resistant Depressive Disorders
Monocentric Pilot Study, for a Randomized, Crossover, Blinded Trial: Comparison of the Therapeutic Efficacy of Low Frequency Repeated Transcranial Magnetic Stimulation on Cortical Area 9 Compared to Brodmann Area 46 in the Treatment of Depressive Disorders.
Repetitive transcranial magnetic stimulation (rTMS) is a new therapeutic tool used in psychiatry. Non-invasive, well tolerated and requiring no premedication, it is performed on an outpatient basis.
- Trial name
- rTMS (NCT03656900)
- Testing
- rTMS BA9/BA46, rTMS BA46/BA9, brain MRI
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Bipolar Disorder
Clinical Trial of Felbamate for Treatment-Resistant Bipolar Depression
The purpose of this study is to evaluate the safety and effectiveness of the drug felbamate for treating depression in patients with bipolar disorder that has not responded to standard treatments.
- Trial name
- NCT00034229
- Testing
- Felbamate
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Mental Health (NIMH)
Treatment Resistant Depression
Linear Asymmetric rTMS in Adolescent Treatment-Resistant Depression: Tolerability of Treatment Durations Ranging From Ten Days to One Day
This is a pilot interventional study to investigate the acceptability, tolerability, and side effect profile for varying numbers of treatment sessions/day of a new rTMS treatment in adolescents with treatment-resistant depression…
- Trial name
- NCT03986658
- Testing
- Linear Asymmetric rTMS System
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- NeuroQore Inc.
Treatment-resistant Depression, Major Depressive Disorder
Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression
In the past decades, the prevalence of adolescent depression and suicide increased significantly in Taiwan and worldwide. To date, the suicide mortality is the second mortality cause in the adolescent and young adult population…
- Trial name
- NCT05045378
- Testing
- Ketamine
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Bipolar Disorder
Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder
The investigators plan to evaluate the efficacy and safety of intranasal Ketalar (ketamine hydrochloride) in the treatment of primary symptom manifestations of pediatric bipolar disorder; Fear of Harm (FOH) phenotype.
- Trial name
- IKBP (NCT01504659)
- Testing
- Ketamine hydrochloride injection, Flat tonic water (e.g., Canada Dry Tonic Water)
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Juvenile Bipolar Research Foundation
Autism Spectrum Disorder, Major Depressive Disorder
Transcranial Magnetic Stimulation for Depression in Autism Spectrum Conditions
In this research study the investigators aim to learn more about the therapeutic effects of a newer form of non-invasive transcranial magnetic stimulation (TMS), called theta burst simulation (TBS), on refractory depression in…
- Trial name
- RESTORE (NCT05271357)
- Testing
- Bilateral TMS, Unilateral TMS
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Insulin Resistance, Depression
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group…
- Conditions
- Insulin Resistance, Depression, Depressive Disorder, Mood Disorders
- Trial name
- CBTeX (NCT05543083)
- Testing
- Cognitive-Behavioral Therapy followed by Exercise Training, Exercise Training followed by Cognitive-Behavioral Therapy, Cognitive-Behavioral Therapy Only
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Major Depressive Disorder
Dose-Ranging Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The purpose of this study is to see if creatine, which is a naturally occurring chemical in the body, is effective for treating Major Depressive Disorder (MDD) in female teenagers.
- Trial name
- NCT01601210
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Perry Renshaw
Depressive Disorder
An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression
This study will examine whether a highly specific and powerful 5-hydroxytryptamine 2A (5-HT2A) antagonist, M100907, combined with escitalopram, is responsible for an antidepressant effect.
- Trial name
- NCT00070694
- Testing
- MDL100.907
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Treatment Resistant Depression
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
SHAKTI (from the Sanskrit word for "power") is a 5-year natural history, longitudinal, prospective study of a cohort of 6,000 participants that will help uncover the socio-demographic, lifestyle, clinical, psychological, and…
- Conditions
- Depression, Treatment Resistant Depression, Mood Disorders, Bipolar Disorder
- Trial name
- SHAKTI (NCT06002204)
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Treatment-Resistant Depression, Major Depressive Disorder
Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression
An observational-comparative study, without interfering with the treatment, based on an operationalized interview.
- Trial name
- NCT06232291
- Where
- Poland
- Volunteers
- 3 people
- Sponsor
- Medical University of Gdansk
Depression
Treatment of SSRI-Resistant Depression In Adolescents (TORDIA)
The purpose of the study is to determine how best to treat adolescents with depression that is "resistant" to the first SSRI antidepressant they have tried.
- Trial name
- TORDIA (NCT00018902)
- Testing
- Fluoxetine, Venlafaxine, Cognitive Behavioral Therapy (CBT)
- Where
- 6 sites in United States
- Volunteers
- 334 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The primary hypothesis is that compared to placebo, 10g of daily creatine monohydrate for eight weeks will be associated with significant increases in frontal lobe phosphocreatine and beta-nucleoside triphosphate (β-NTP)…
- Trial name
- NCT02134808
- Testing
- Creatine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Major Depressive Disorder
Transcranial Magnetic Stimulation for Youth With Treatment-Resistant Major Depressive Disorder
Background: Major depressive disorder (MDD) is one of the most impairing medical conditions in the world. Medication and some kinds of talk therapy are standard treatments for teens with MDD, but these do not work well for…
- Trial name
- NCT05652465
- Testing
- Intermittent theta burst repetitive transcranial magnetic stimulation (iTBS)
- Where
- United States
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder (MDD), Depression - Major Depressive Disorder
Efficacy and Safety of a Theta Burst Stimulation Protocol of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
This study will evaluate the efficacy and safety of a theta burst stimulation (TBS) protocol of repetitive transcranial magnetic stimulation (rTMS) in adults with treatment-resistant depression.
- Trial name
- NCT07529574
- Testing
- antidepressant therapy, Active rTMS Theta Burst Stimulation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Jung-Sun Lee
Depression, Electroencephalography
Intermittent Theta Burst Stimulation on Anhedonia in Depression
Study comparing the efficacy of two TMS patterns (intermittent theta-burst stimulation, iTBS, and repetitive transcranial magnetic stimulation, rTMS) in treating anhedonia and their associated brain network mechanisms.
- Conditions
- Depression, Electroencephalography, Transcranial Magnetic Stimulation
- Trial name
- NCT06552026
- Testing
- repeated transcranial magnetic stimulation
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Anhui Medical University
HIV, Metabolic Syndrome
Comorbidities and Virologic Outcome Among Patients on Anti-retroviral Therapy in Rural Lesotho
This study is conducted in a cohort of HIV-positive patients on first-line anti-retroviral therapy (ART) in rural health facilities in Lesotho, Southern Africa.
- Conditions
- HIV, Metabolic Syndrome, Depression, Alcoholism
- Trial name
- NCT02126696
- Where
- 2 sites in Lesotho
- Volunteers
- 1,754 people
- Sponsor
- Swiss Tropical & Public Health Institute
Adolescent Depression
Lamotrigine in Treatment Resistant Depression in Adolescents
The primary hypothesis of this study is that in fluoxetine (Prozac)-resistant adolescents with Major Depressive Disorder (MDD), Lamotrigine plus fluoxetine will be safe and as effective as sertraline (Zoloft).
- Trial name
- NCT00284791
- Testing
- Lamotrigine (drug), Fluoxetine (drug), sertraline (drug)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- MaineHealth