Clinical trials: Transcriptomics
Major Depressive Disorder
Optimize and Predict Antidepressant Efficacy for Patient With MDD Using Multi-omics Analysis and AI-predictive Tool
OPADE is a non-profit, observational, multicenter, open-label study aimed at defining personalized treatment for Major Depressive Disorder (MDD).
- Trial name
- OPADE (NCT06550037)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Alessio Fasano
Kidney Rejection Transplant
Molecular Transcriptomics in Diagnosing Pediatric Kidney Transplant Rejection: the PANDA-Kids-ATLAS Study
Children with kidney failure have markedly increased mortality and face repeated transplantation over their lifetime due to limited allograft half-life (12-15 years).
- Trial name
- NCT07091214
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Malaria
Trajectories and Mechanisms of Recovery From Malaria: An Observational Study
This observational research study aims to answer the question: 'Which aspects of human biology play an important role in recovery from symptomatic malaria?' In particular, the researchers aim to identify human genes for which the…
- Trial name
- SCRIPT (NCT05149157)
- Testing
- Symptomatic malaria
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- Imperial College London
Neurodevelopmental Disorders, Irritability
AP Metabolism Transcriptomics
It is known from the literature that treatment with antipsychotic drugs (AP) induces, even before changes in blood chemistry parameters, changes in gene transcription that are evident at the level of peripheral blood mononuclear…
- Trial name
- NCT06814314
- Testing
- Transcriptomic investigation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Eugenio Medea
CMT, CMT (Charcot Marie Tooth Disease)
A Multi-omic Approach to the Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease (CMT1A)
The most common inherited neuropathy is Charcot-Marie-Tooth disease type 1A (CMT1A), caused by a duplication of the gene expressing PMP22.
- Conditions
- CMT, CMT (Charcot Marie Tooth Disease), CMT - Charcot-Marie-Tooth Disease, CMT1A
- Trial name
- CMT-MODs (NCT07476365)
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Sepsis
Role of RNA Metabolism Alterations in Persistent Immune Dysfunction After Sepsis
This study includes adult ICU patients with sepsis (according to SEPSIS 3.0) or critically ill non-septic patients with severe non-infectious conditions at Louis Mourier Hospital.
- Trial name
- SEPSI-splice (NCT07418801)
- Where
- 2 sites in France
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Triple Negative Breast Cancer
Cellular Immune Responses in Triple-negative Breast Cancer - High Throughput Immunogenetic Studies
This project introduces a novel methodology for the in-depth immunogenetic characterization of the TR gene repertoire in solid tumors, holding the promise to offer unprecedented insights into the TR anti-tumor specificity and the…
- Trial name
- NCT06646263
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Institute of Applied Biosciences
Duchenne Muscular Dystrophy (DMD)
Research of Biomarkers in Duchenne Muscular Dystrophy Patients
The purpose of this study is to identify potential biomarkers for the diagnosis, disease progression assessment and response to treatment in patients with Duchenne Muscular Dystrophy.
- Trial name
- IBISD (NCT01380964)
- Where
- France
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Genethon
Autism Spectrum Disorder (ASD)
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study
The goal of this observational study is to investigate the genetic and epigenetic mechanisms that may contribute to the development of Autism Spectrum Disorder (ASD) in individuals of different age groups.
- Trial name
- ASD-Omics-TR (NCT06662591)
- Where
- 20 sites in Turkey (Türkiye)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Research and Treatment Society of Genetic Disorders
Asthma
Longitudinal Assessment of Children With Severe Asthma and Severe Pre-school Wheeze
Cross-sectional study to characterize cohorts of children with asthma and healthy controls in terms of clinical features, physiological measurements and non-invasive measurement of biomarkers and develop phenotype handprints for…
- Trial name
- NCT01982162
- Volunteers
- 300 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Physical Activity
Biomarkers of Physical Activity/health in Children and Adolescents
This clinical trial is aimed to recruit a core cohort of children and adolescents, and to perform an educational intervention and follow-up study in a subgroup of volunteers from this core cohort, to obtain specific measurements…
- Trial name
- INTEGRActiv (NCT05907785)
- Testing
- Educational intervention
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Epithelial Ovarian Cancer, Tumor Invasiveness
A Multi-omics Study of Epithelial Ovarian Cancer
This study aims to analyze the multi-omics results between epithelial ovarian cancer (EOC) patient with different FIGO stages and pathological subtypes.
- Conditions
- Epithelial Ovarian Cancer, Tumor Invasiveness, Whole Exome Sequencing, Transcriptomics
- Trial name
- NCT03742856
- Testing
- A multi-omics analysis
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Lei Li
Medulloblastoma
Targeting MYC in High-Risk Medulloblastoma
Medulloblastoma is the most common malignant brain tumor in children. Group 3 medulloblastoma (G3 MB) represents the most aggressive molecular subtype and is associated with poor prognosis, particularly in cases characterized by…
- Trial name
- MYCMB (NCT07694622)
- Testing
- Tumor tissue collection
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Respiratory Distress Syndrome, Respiratory Distress Syndrome, Adult
Identifying PARDS Endotypes
Pediatric acute respiratory distress syndrome (PARDS) is a severe and diffuse lung injury that is a common cause of admission and mortality in the pediatric intensive care unit (PICU).
- Trial name
- NCT03539783
- Testing
- Respiratory epithelial cell brushing
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Resistance Exercise, Muscle Hypertrophy
Muscle Adaptations in Children and Adults Following Twelve Weeks of Flywheel or Weight Stack Resistance Exercise
The goal of this trial is to compare resistance exercise using traditional techniques and flywheel training to controls in healthy children ages nine to 13 and adults ages 18 to 50.
- Conditions
- Resistance Exercise, Muscle Hypertrophy, Skeletal Muscle, EMG
- Trial name
- KidREx (NCT06698055)
- Testing
- Flywheel Resistance Exercise, Weight Stack Resistance Exercise
- Where
- Sweden
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Björn Alkner
Peritoneal Metastases
Single-Cell Transcriptomics of the Peritoneal Microenvironment of Colorectal PC
Single cell transcriptomics of CRC PC samples
- Trial name
- SingleCell (NCT05676372)
- Testing
- CRC+HIPEC
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Ghent
Multiple Myeloma
Transcriptomics and Epigenetics Analysis in Drug-Resistance of Multiple Myeloma
Multiple Myeloma (MM) is the more common hematological neoplastic disease second only to Hodgkin lymphoma. In MM patients, mutated genes are mainly KRAS (23%), NRAS (20%), FAM46C (11%), DIS3 (11%) e TP53 (8%).
- Trial name
- TEDROMM (NCT05888636)
- Testing
- ChIP-seq, NGS, ATAC-seq
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Regina Elena Cancer Institute
Gene Expression Profiles in CML Non-responders
Gene Expression Profiles in CML Non-responders
Chronic myeloid leukaemia (CML) is a haematological malignancy primarily driven by the fusion oncogene BCR-ABL1, resulting in a constitutively expressed tyrosine kinase.
- Trial name
- NCT04219111
- Testing
- Clariom
- Where
- United Kingdom
- Sponsor
- Sheffield Children's NHS Foundation Trust
Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis
Clinical Transcriptomics in Systemic Vasculitis (CUTIS)
Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.
- Conditions
- Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis, Eosinophilic Granulomatosis With Polyangiitis (EGPA), IgA Vasculitis
- Trial name
- CUTIS (NCT03004326)
- Where
- 10 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- Peter Merkel
Sarcoma, Biomarkers
The Exploration of OX40 (CD134) Expression Levels in Sarcoma Specimens and Its Clinical Application in Prognosis Determination
This study aims to investigate the expression of OX40 (CD134) in sarcomas and its impact on prognosis, with the goal of identifying novel biomarkers for early resistance detection and optimizing treatment strategies for sarcoma…
- Conditions
- Sarcoma, Biomarkers, Progression
- Trial name
- NCT06751251
- Testing
- IHC: Immunohistochemistry, RNA-seq
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital