Clinical trials: Trachoma
Trachoma, Lymphatic Filariasis
Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis
Trachoma and lymphatic filariasis (LF) are two 'Neglected Tropical Diseases' (NTDs), infectious diseases that affect millions of poor people in countries in the developing world.
- Trial name
- AZIVAL2 (NCT01903057)
- Testing
- azithromycin, ivermectin, albendazole
- Where
- Mozambique
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Trachoma
Water Uptake for Health in Amhara Pilot
Trachoma is a blinding disease caused by ocular strains of Chlamydia trachomatis. The Carter Center and Proctor Foundation have been jointly conducting trachoma research in the Goncha Siso Enese woreda of Amhara for the past 8…
- Trial name
- WUHA (NCT02373657)
- Testing
- instruction in soap-making and hygiene education
- Where
- Ethiopia
- Volunteers
- 4,068 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Trachoma
Enhancing the A in SAFE for Trachoma
This study will assess the cost and feasibility of two strategies of enhanced Mass Drug Administration (MDA) of Zithromax to treat trachoma in the Republic of South Sudan.
- Trial name
- NCT05634759
- Testing
- Azithromycin for Routine Community-wide MDA, Two Additional Rounds of Azithromycin for Children, Azithromycin for Second Community-wide MDA
- Where
- South Sudan
- Volunteers
- 34,630 people, healthy volunteers welcome
- Sponsor
- Emory University
Trachoma, Chlamydia Trachomatis
Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger
Trachoma is a disease of poverty, which in the hyperendemic areas affects all individuals by the time they are two years old. Active disease is concentrated in children and occurs sporadically in adults.
- Trial name
- NCT00618449
- Testing
- Azithromcyin, Azithromycin
- Where
- 2 sites in United States, Niger
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Trachoma
Kebele Elimination of Trachoma for Ocular Health
The investigators propose a cluster-randomized clinical trial to determine whether an intensive, targeted azithromycin distribution strategy is effective for elimination of trachoma at the kebele level compared to the World…
- Trial name
- KETFO (NCT03335072)
- Testing
- Azithromycin
- Where
- 2 sites in United States, Ethiopia
- Volunteers
- 320,000 people
- Sponsor
- University of California, San Francisco
Trachoma
A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial
Infection with C. Trachomatis has decreased substantially in trachoma endemic areas following repeated annual mass drug administration (MDA) with azithromycin, although not as rapidly as anticipated.
- Trial name
- ASANTE (NCT01767506)
- Testing
- Surveillance and treatment with azithromycin of newcomer and traveler families, Usual care
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Child Mortality, Azithromycin
Resiliency Through Azithromycin for Children (REACH), Côte d'Ivoire
The aim of the study is to gather preliminary evidence on the operational feasibility and acceptability of integrating bi-annual mass drug administration (MDA) of single-dose azithromycin for children ages 1 to 11 months in high…
- Trial name
- REACH (NCT04617626)
- Testing
- Azithromycin
- Where
- Côte d’Ivoire
- Volunteers
- 1,735 people, healthy volunteers welcome
- Sponsor
- FHI 360
Trachoma
Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma
To assess in children the efficacy and safety of 2 dosing regimens of T1225 1.5% eye drops, in comparison to a reference product, single-dose oral azithromycin (AZM) 20 mg/kg, for the treatment of active trachoma.
- Trial name
- NCT00356720
- Testing
- Azithromycin
- Sponsor
- Laboratoires Thea
Trachoma
Trachoma Elimination Study by Focused Antibiotic (TESFA)
The study population consists of all households residing in eligible kebeles (sub-districts) within districts in Amhara National Regional State which are identified as having a high prevalence of trachoma and infection measured…
- Trial name
- NCT03523156
- Testing
- Azithromycin mass treatment, Azithromycin targeted treatment
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Trachoma
Azithromycin Reduction to Reach Elimination of Trachoma
The investigators propose a randomized controlled trial of discontinuation versus continuation of annual mass azithromycin distribution in hypoendemic communities of Maradi, Niger.
- Trial name
- ARRET (NCT04185402)
- Testing
- Azithromycin
- Where
- Niger
- Volunteers
- 3,931 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Trachoma
Testing Insect Repellents Against Musca Sorbens, the Vector of Trachoma
Musca sorbens, a fly that feeds from ocular and nasal discharge on humans, is thought to be the vector of trachoma. We are developing methods of fly control that specifically target this species, in the hope of interrupting Ct…
- Trial name
- NCT03813069
- Testing
- IR3535, Permethrin lower dose, Permethrin higher dose
- Where
- 2 sites in Ethiopia, United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Trachoma
Nepal Elimination of Trachoma Study
The main purpose of this study is to determine if ocular Chlamydia trachomatis infection can be eliminated in communities in Nepal following mass antibiotic distributions with azithromycin.
- Trial name
- NETS (NCT02176057)
- Testing
- Azithromycin
- Where
- Nepal
- Sponsor
- University of California, San Francisco
Trachoma
Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania
After single, yearly, mass treatment of communities with azithromycin for active trachoma, what is the added effectiveness for reduction of trachoma and ocular C.
- Trial name
- NCT00347607
- Testing
- community surveillance and re-treatment
- Where
- 2 sites in United States, Tanzania
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Trachoma, Chlamydia
Trachoma Elimination Follow-up
The WHO has initiated a program to eliminate blinding trachoma by the year 2020, in large part by mass oral azithromycin distributions. It is not clear how frequently or for how long these treatments are necessary.
- Trial name
- TEF (NCT00221364)
- Testing
- Mass treatment with oral azithromycin to an entire village
- Where
- Ethiopia
- Volunteers
- 20,000 people
- Sponsor
- University of California, San Francisco
Trachoma
Sanitation, Water, and Instruction in Face-washing for Trachoma I/II
SWIFT I is a series of 3 cluster-randomized trials designed to assess several alternative strategies for trachoma control in communities that have been treated with many years of mass azithromycin distributions.
- Trial name
- SWIFT I/II (NCT02754583)
- Testing
- Water, sanitation, and hygiene (WASH) intervention, Standard of care WASH intervention, Azithromycin
- Where
- Ethiopia
- Volunteers
- 47,605 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Trachoma
Azithromycin Reduction to Reach Elimination of Trachoma B
The investigators propose a randomized controlled trial of discontinuation versus continuation of annual mass azithromycin distribution in hypoendemic communities of Maniema, DRC.
- Trial name
- ARRET (NCT06289647)
- Testing
- Azithromycin
- Where
- Democratic Republic of the Congo
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Childhood Mortality
Mortality Reduction After Oral Azithromycin: Morbidity Study
The long-term goal of this study is to more precisely define the role of mass azithromycin treatments as an intervention for reducing childhood morbidity and increasing growth, and for the potential selection of antibiotic…
- Trial name
- MORDORMorb (NCT02048007)
- Testing
- Azithromycin
- Where
- 6 sites in United States, Malawi and 3 more
- Volunteers
- 72,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Active Trachoma
The Effects of Hand and Face Washing With Soap on Active Trachoma Among Children 1-9 Years Old.
Active trachoma remains a major public health problem among children in Ethiopia. This clinical trial evaluates whether regular hand and face washing with soap reduces the prevalence of active trachoma among children aged 1-9…
- Trial name
- NCT07767578
- Testing
- A structured Health Belief Model (HBM)-based behavioural intervention delivered over 24 weeks, comprising interactive health education, behaviour change communication, skills training, and practical d
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- Bahir Dar University
Trachoma, Chlamydia
Trachoma Amelioration in Northern Amhara (TANA)
The WHO has initiated a program to eliminate trachoma, blinding eye infection caused by Chlamydia trachomatis, in large part by mass distributions of oral azithromycin.
- Trial name
- TANA (NCT00322972)
- Testing
- Mass treatment with oral azithromycin to an entire community
- Where
- Ethiopia
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Trachoma
Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania
The purpose of this community-based randomized trial was to determine, in trachoma hyper-endemic communities of Tanzania, the added value of intensive spraying to control flies on the fly population and on trachoma and ocular…
- Trial name
- NCT00347763
- Testing
- 10% permethrin in water applied as low volume spray
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University